tipifarnib has been researched along with Cancer of Lung in 15 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (80.00) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Fernandez-Juarez, G; Gimenez-Moyano, S; Guerrero-Marquez, C; Martinez de la Cruz, P; Mielgo-Rubio, X; Shabaka, A | 1 |
| Le Moulec, S; Loriot, Y; Soria, JC | 1 |
| Li, M; Liu, A; Liu, B; Luo, X; Yu, H; Zheng, H | 1 |
| Busceti, MT; Caraglia, M; Falcone, D; Fratto, D; Gallelli, L; Maselli, R; Pelaia, G; Renda, T; Savino, R; Terracciano, R; Vatrella, A | 1 |
| Sánchez De Cos Escuín, J | 1 |
| Smit, EF | 1 |
| Nishiyama, M; Tahara, E; Tsuruo, T; Yasui, W | 1 |
| Adjei, AA; Bruzek, L; Erlichman, C; Geyer, S; Hanson, LJ; Hillman, S; Kaufmann, SH; Marks, RS; Mauer, A; Vokes, EE; Wright, JJ | 1 |
| End, DW; Gunning, WT; Kramer, PM; Lubet, RA; Pereira, MA; Steele, VE; Wouters, W | 1 |
| Khuri, FR | 1 |
| Heymach, JV; Johnson, BE | 1 |
| De Porre, PM; DeVore, RF; Heymach, JV; Jia, X; Johnson, BE; Johnson, DH; Khuri, FR; Richards, HM; Safran, H; Schlabach, LL; Yunus, F; Zhang, S | 1 |
| Alyaqoub, FS; Gunning, WT; Kramer, PM; Lubet, RA; Pereira, MA; Steele, VE; Tao, L | 2 |
| Khuri, FR; Liu, X; Lonial, S; Qiu, Y; Sun, SY; Yue, P; Zou, W | 1 |
4 review(s) available for tipifarnib and Cancer of Lung
| Article | Year |
|---|---|
Concomitant Acute Tubular Necrosis and Acute Interstitial Nephritis Induced by Tipifarnib in a Patient with Squamous Cell Carcinoma of the Lung.
Topics: Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Humans; Kidney Cortex Necrosis; Lung Neoplasms; Male; Nephritis, Interstitial; Quinolones | 2021 |
[New therapeutic targets and strategies in lung cancer].
Topics: Alkyl and Aryl Transferases; Angiogenesis Inhibitors; Antineoplastic Agents; Benzamides; Benzodiazepines; Clinical Trials as Topic; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Endothelial Growth Factors; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Farnesyltranstransferase; Gefitinib; Humans; Imatinib Mesylate; Imidazoles; Intercellular Signaling Peptides and Proteins; Lung Neoplasms; Lymphokines; Metalloendopeptidases; Multicenter Studies as Topic; Piperazines; Polyisoprenyl Phosphates; Protein-Tyrosine Kinases; Pyrimidines; Quinazolines; Quinolones; Randomized Controlled Trials as Topic; Receptor Protein-Tyrosine Kinases; Sesquiterpenes; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2002 |
Primary and secondary prevention of non-small-cell lung cancer: the SPORE Trials of Lung Cancer Prevention.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Chemoprevention; Clinical Trials as Topic; Disease Progression; Epidermal Growth Factor; Gefitinib; Humans; Lung Neoplasms; Precancerous Conditions; Protein-Tyrosine Kinases; Quinazolines; Quinolones | 2003 |
Farnesyl transferase inhibitors for patients with lung cancer.
Topics: Alkyl and Aryl Transferases; Apoptosis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Clinical Trials as Topic; Farnesyltranstransferase; Humans; Imidazoles; Lung Neoplasms; Quinolones; Signal Transduction; Treatment Outcome | 2004 |
2 trial(s) available for tipifarnib and Cancer of Lung
| Article | Year |
|---|---|
Phase II study of the farnesyl transferase inhibitor R115777 in patients with advanced non-small-cell lung cancer.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Alkyl and Aryl Transferases; Anemia; Carcinoma, Non-Small-Cell Lung; Disease Progression; Farnesyltranstransferase; Female; Humans; Leukocytes, Mononuclear; Lung Neoplasms; Male; Middle Aged; Mouth Mucosa; Neutropenia; Quinolones; Survival | 2003 |
Phase II study of the farnesyl transferase inhibitor R115777 in patients with sensitive relapse small-cell lung cancer.
Topics: Adult; Aged; Aged, 80 and over; Alkyl and Aryl Transferases; Carcinoma, Small Cell; Disease-Free Survival; Farnesyltranstransferase; Female; Humans; Lung Neoplasms; Male; Middle Aged; Quinolones; Recurrence; Signal Transduction; Treatment Outcome | 2004 |
9 other study(ies) available for tipifarnib and Cancer of Lung
| Article | Year |
|---|---|
[Targeting KRAS pathway in NSCLC therapy].
Topics: Animals; Antineoplastic Agents; Benzenesulfonates; Carcinoma, Non-Small-Cell Lung; Farnesyltranstransferase; Genes, ras; Humans; Lung Neoplasms; Mice; Mitogen-Activated Protein Kinase Kinases; Mutation; Neoplasm Proteins; Niacinamide; Phenylurea Compounds; Piperidines; Pyridines; Quinolones; raf Kinases; ras Proteins; Sorafenib | 2009 |
Ras homologue enriched in brain is a critical target of farnesyltransferase inhibitors in non-small cell lung cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cisplatin; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Lung Neoplasms; Mechanistic Target of Rapamycin Complex 1; Monomeric GTP-Binding Proteins; Multiprotein Complexes; Mutation; Neuropeptides; Phosphorylation; Piperidines; Prenylation; Proteins; Pyridines; Quinolones; Ras Homolog Enriched in Brain Protein; Ribosomal Protein S6; RNA Interference; RNA, Messenger; Signal Transduction; TOR Serine-Threonine Kinases; Transcription Factors; Transfection | 2010 |
Effects of statins and farnesyl transferase inhibitors on ERK phosphorylation, apoptosis and cell viability in non-small lung cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Caspase 3; Cell Line, Tumor; Cell Survival; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Farnesyltranstransferase; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lung; Lung Neoplasms; MAP Kinase Signaling System; Phosphorylation; Quinolones; Simvastatin | 2012 |
[New data presented at ASCO 2002 concerning small cell bronchial cancer].
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Carboplatin; Carcinoma, Small Cell; Cisplatin; Deoxycytidine; Etoposide; Gemcitabine; Humans; Imatinib Mesylate; Lung Neoplasms; Piperazines; Prognosis; Pyrimidines; Quinolones; Smoking; Smoking Prevention; Survival Analysis; Treatment Outcome | 2002 |
Molecular targeting therapy for cancer: the Twelfth International Symposium of the Hiroshima Cancer Seminar, November 2002.
Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Clinical Trials as Topic; DNA Repair; Drug Delivery Systems; Drug Design; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Inhibitors; ErbB Receptors; Farnesyltranstransferase; Gene Expression Profiling; Humans; Lung Neoplasms; Mice; Mice, SCID; Neoplasm Proteins; Neoplasms; Quinolones; Xenograft Model Antitumor Assays | 2003 |
Chemoprevention of benzo(a)pyrene-induced lung tumors in mice by the farnesyltransferase inhibitor R115777.
Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Benzo(a)pyrene; Chemoprevention; Enzyme Inhibitors; Female; Lung Neoplasms; Mice; Mice, Inbred A; Quinolones | 2003 |
Prevention of mouse lung tumors and modulation of DNA methylation by combined treatment with budesonide and R115777 (ZarnestraMT).
Topics: Animals; Anti-Inflammatory Agents; Budesonide; Disease Models, Animal; DNA Methylation; Drug Therapy, Combination; Female; Lung Neoplasms; Mice; Mice, Inbred A; Quinolones | 2006 |
Prevention of mouse lung tumors and modulation of DNA methylation by combined treatment with budesonide and R115777 (Zarnestra MT).
Topics: Animals; Anti-Inflammatory Agents; Budesonide; Chemoprevention; Disease Models, Animal; DNA Methylation; Drug Therapy, Combination; Female; Lung Neoplasms; Mice; Mice, Inbred A; Quinolones; Urethane | 2007 |
The farnesyltransferase inhibitor R115777 up-regulates the expression of death receptor 5 and enhances TRAIL-induced apoptosis in human lung cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Growth Processes; Cell Line, Tumor; Drug Synergism; Farnesyltranstransferase; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Quinolones; Receptors, TNF-Related Apoptosis-Inducing Ligand; RNA, Messenger; RNA, Small Interfering; TNF-Related Apoptosis-Inducing Ligand; Up-Regulation | 2007 |