tiopronin and Vasospasm, Intracranial studies

Vasospasm, Intracranial: Constriction of arteries in the SKULL due to sudden, sharp, and often persistent smooth muscle contraction in blood vessels. Intracranial vasospasm results in reduced vessel lumen caliber, restricted blood flow to the brain, and BRAIN ISCHEMIA that may lead to hypoxic-ischemic brain injury (HYPOXIA-ISCHEMIA, BRAIN).

Research Excerpts

Excerpt	Relevance	Reference
"The objective of this trial was to establish the safety of tiopronin administration in patients with aneurysmal subarachnoid hemorrhage (aSAH) in preparation for further trials of its efficacy as a neuroprotective agent in this disease process."	9.14	A phase I clinical trial of tiopronin, a putative neuroprotective agent, in aneurysmal subarachnoid hemorrhage. ( Connolly, ES; Ducruet, AF; Fernandez, L; Hickman, ZL; Hwang, BY; Kellner, CP; Kim, GH; Mayer, SA; Starke, RM; Tracey, KJ; Zacharia, BE, 2010)
"The objective of this trial was to establish the safety of tiopronin administration in patients with aneurysmal subarachnoid hemorrhage (aSAH) in preparation for further trials of its efficacy as a neuroprotective agent in this disease process."	5.14	A phase I clinical trial of tiopronin, a putative neuroprotective agent, in aneurysmal subarachnoid hemorrhage. ( Connolly, ES; Ducruet, AF; Fernandez, L; Hickman, ZL; Hwang, BY; Kellner, CP; Kim, GH; Mayer, SA; Starke, RM; Tracey, KJ; Zacharia, BE, 2010)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

tiopronin and Vasospasm, Intracranial

Research Excerpts

Research

Studies (1)

Authors

Trials

Authors	Studies
Kim, GH	1
Kellner, CP	1
Hickman, ZL	1
Zacharia, BE	1
Starke, RM	1
Hwang, BY	1
Ducruet, AF	1
Fernandez, L	1
Mayer, SA	1
Tracey, KJ	1
Connolly, ES	1