tiopronin has been researched along with Cystinuria in 74 studies
Tiopronin: Sulfhydryl acylated derivative of GLYCINE.
Cystinuria: An inherited disorder due to defective reabsorption of CYSTINE and other BASIC AMINO ACIDS by the PROXIMAL RENAL TUBULES. This form of aminoaciduria is characterized by the abnormally high urinary levels of cystine; LYSINE; ARGININE; and ORNITHINE. Mutations involve the amino acid transport protein gene SLC3A1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Appropriate dosing of cystine-binding thiol drugs in the management of cystinuria has been based on clinical stone activity." | 9.30 | Effect of increasing doses of cystine-binding thiol drugs on cystine capacity in patients with cystinuria. ( Asplin, JR; Enders, FT; Goldfarb, DS; Malieckal, DA; Mara, K; Modersitzki, F, 2019) |
| "Thirty two patients with cystinuria were enrolled in this long-term study and 16 patients were treated with tiopronin for 24 weeks." | 9.10 | [Long-term study of tiopronin in patients with cystinuria]. ( Koide, T; Miyake, O; Okuyama, A; Yachiku, S; Yoshioka, T, 2003) |
| " We have studied the effect of a sodium-restricted diet on the urinary excretion of cystine in 13 patients with cystinuria, 7 of whom were treated with the SH compound tiopronin (2-mercaptopropionylglycine)." | 9.08 | The effect of sodium intake on cystinuria with and without tiopronin treatment. ( Denneberg, T; Edholm, E; Jeppsson, JO; Lindell, A, 1995) |
| "We report the results of a biochemical evaluation of long-term treatment of cystinuria with the SH compound tiopronin (2-mercaptopropionylglycine)." | 9.08 | Urinary excretion of free cystine and the tiopronin-cysteine-mixed disulfide during long term tiopronin treatment of cystinuria. ( Denneberg, T; Jeppsson, JO; Lindell, A, 1995) |
| " Pediatricians should be aware of this adverse effect of tiopronin, and therefore, testing of the urine with strips or sulfosalicylic acid at least once weekly at home may be very helpful for early detection of proteinuria." | 7.77 | Nephrotic syndrome occurring during tiopronin treatment for cystinuria. ( Gucev, Z; Lozanovski, VJ; Ristoska-Bojkovska, N; Sahpazova, E; Tasic, V, 2011) |
| "A case of nephrotic syndrome with ascites and heart failure in a patient who had received tiopronin for the treatment of cystinuria is presented." | 7.71 | [Nephrotic syndrome and anasarca status, secondary to treatment with tiopronin in a case of cystinuria]. ( Alvarez Navascués, R; Herrera Pérez de Villar, J; Rodríguez Suarez, C; Suarez Heiva, M; Vidau Argüelles, P, 2001) |
| "From 1987 to 1990, 719 subjects (385 males and 334 females) were screened, by means of urocystin-kit, for cystinuria and cystine lithiasis, in Epirus district (North-West Greece)." | 7.69 | [Results of treatment of cystinuria and cystine lithiasis with alpha-mercaptopropionylglycine. Apropos of 40 patients]. ( Chambilomatis, P; Evangelou, A; Giannakis, D; Giannakopoulos, X; Kalfakakou, V; Kallistratos, G; Karkabounas, S; Tsoumanis, P, 1994) |
| "We have compared 2-mercaptopropionylglycine (MPG) with D-penicillamine in its capacity to reduce the urinary excretion of cystine by patients with cystinuria." | 7.67 | Comparison of 2-mercaptopropionylglycine and D-penicillamine in the treatment of cystinuria. ( Cusworth, DC; Harbar, JA; Lawes, LC; Wrong, OM, 1986) |
| " Drug dosage was adjusted to maintain free urine cystine level below 100 micromol/mmol creatinine." | 6.73 | Cystinuria in children and young adults: success of monitoring free-cystine urine levels. ( Dello Strologo, L; Laurenzi, C; Legato, A; Pastore, A, 2007) |
| "Potassium citrate was shown to be effective as an alkalizing agent and, in this respect, not significantly different from sodium bicarbonate." | 6.70 | A comparison of the effects of potassium citrate and sodium bicarbonate in the alkalinization of urine in homozygous cystinuria. ( Denneberg, T; Fjellstedt, E; Jeppsson, JO; Tiselius, HG, 2001) |
| "Cystinuria is an inherited autosomal recessive disease of the kidneys of recurring nature that contributes to frequent urinary tract infections due to bacterial growth and biofilm formation surrounding the stone microenvironment." | 5.91 | Chemical Modification of Tiopronin for Dual Management of Cystinuria and Associated Bacterial Infections. ( Estes Bright, LM; Garren, MRS; Handa, H; Kumar, A; Manuel, J; Shome, A, 2023) |
| "Appropriate dosing of cystine-binding thiol drugs in the management of cystinuria has been based on clinical stone activity." | 5.30 | Effect of increasing doses of cystine-binding thiol drugs on cystine capacity in patients with cystinuria. ( Asplin, JR; Enders, FT; Goldfarb, DS; Malieckal, DA; Mara, K; Modersitzki, F, 2019) |
| "The frequency of cystinuria is in the order of 1:10,000." | 5.26 | [Cystinuria therapy by ascorbic acid (author's transl)]. ( Asper, R; Schmucki, O, 1982) |
| "Thirty two patients with cystinuria were enrolled in this long-term study and 16 patients were treated with tiopronin for 24 weeks." | 5.10 | [Long-term study of tiopronin in patients with cystinuria]. ( Koide, T; Miyake, O; Okuyama, A; Yachiku, S; Yoshioka, T, 2003) |
| " We have studied the effect of a sodium-restricted diet on the urinary excretion of cystine in 13 patients with cystinuria, 7 of whom were treated with the SH compound tiopronin (2-mercaptopropionylglycine)." | 5.08 | The effect of sodium intake on cystinuria with and without tiopronin treatment. ( Denneberg, T; Edholm, E; Jeppsson, JO; Lindell, A, 1995) |
| " Pediatricians should be aware of this adverse effect of tiopronin, and therefore, testing of the urine with strips or sulfosalicylic acid at least once weekly at home may be very helpful for early detection of proteinuria." | 3.77 | Nephrotic syndrome occurring during tiopronin treatment for cystinuria. ( Gucev, Z; Lozanovski, VJ; Ristoska-Bojkovska, N; Sahpazova, E; Tasic, V, 2011) |
| "Fifty-two cystinuric patients (cystine SF) entering our programme since 1970 were compared with 3215 SF without cystinuria (routine SF), of whom 114 had a single functioning kidney (routine SF + nephrectomy)." | 3.73 | Reduced renal function and benefits of treatment in cystinuria vs other forms of nephrolithiasis. ( Coe, FL; Evan, AP; Parks, JH; Worcester, EM, 2006) |
| " To improve the medical treatment of patients with cystinuria, this strategy was performed to guide the fluid intake and the administration of SH compounds (tiopronin, D-penicillamine, and MESNA)." | 3.71 | Cystine analyses of separate day and night urine as a basis for the management of patients with homozygous cystinuria. ( Christensson, A; Denneberg, T; Fjellstedt, E; Jeppsson, JO; Tiselius, HG, 2001) |
| "A case of nephrotic syndrome with ascites and heart failure in a patient who had received tiopronin for the treatment of cystinuria is presented." | 3.71 | [Nephrotic syndrome and anasarca status, secondary to treatment with tiopronin in a case of cystinuria]. ( Alvarez Navascués, R; Herrera Pérez de Villar, J; Rodríguez Suarez, C; Suarez Heiva, M; Vidau Argüelles, P, 2001) |
| "From 1987 to 1990, 719 subjects (385 males and 334 females) were screened, by means of urocystin-kit, for cystinuria and cystine lithiasis, in Epirus district (North-West Greece)." | 3.69 | [Results of treatment of cystinuria and cystine lithiasis with alpha-mercaptopropionylglycine. Apropos of 40 patients]. ( Chambilomatis, P; Evangelou, A; Giannakis, D; Giannakopoulos, X; Kalfakakou, V; Kallistratos, G; Karkabounas, S; Tsoumanis, P, 1994) |
| "We have compared 2-mercaptopropionylglycine (MPG) with D-penicillamine in its capacity to reduce the urinary excretion of cystine by patients with cystinuria." | 3.67 | Comparison of 2-mercaptopropionylglycine and D-penicillamine in the treatment of cystinuria. ( Cusworth, DC; Harbar, JA; Lawes, LC; Wrong, OM, 1986) |
| "During a 4-year period 9 cases of severe recurrent cystine stones and cystinuria were treated with mercaptopropionylglycine." | 3.65 | Mercaptopropionylglycine: a progress in cystine stone therapy. ( Hautmann, R; Lutzeyer, W; Stuhlsatz, HW; Terhorst, B, 1977) |
| " Drug dosage was adjusted to maintain free urine cystine level below 100 micromol/mmol creatinine." | 2.73 | Cystinuria in children and young adults: success of monitoring free-cystine urine levels. ( Dello Strologo, L; Laurenzi, C; Legato, A; Pastore, A, 2007) |
| "Cystinuria is the most common monogenic nephrolithiasis disorder." | 2.72 | [Cystinuria]. ( Courbebaisse, M; Daudon, M; Defazio, J; Dousseaux, MP; Knebelmann, B; Prot-Bertoye, C; Tostivint, I; Traxer, O, 2021) |
| "Potassium citrate was shown to be effective as an alkalizing agent and, in this respect, not significantly different from sodium bicarbonate." | 2.70 | A comparison of the effects of potassium citrate and sodium bicarbonate in the alkalinization of urine in homozygous cystinuria. ( Denneberg, T; Fjellstedt, E; Jeppsson, JO; Tiselius, HG, 2001) |
| "Captopril was added for failure of or intolerance to D-penicillamine or alpha-mercaptopropionylglycine." | 2.68 | Medical treatment of cystinuria: results of contemporary clinical practice. ( Chow, GK; Streem, SB, 1996) |
| "Nephrotic syndrome was suggested and renal biopsy was performed." | 2.38 | A case of nephrotic syndrome due to alpha-mercaptopropionyl glycine in a patient with familial cystinuria. ( Ishimoto, F; Kodama, K; Murai, S; Nakano, H; Sakai, O; Shibasaki, T, 1990) |
| "Cystinuria is an inherited autosomal recessive disease of the kidneys of recurring nature that contributes to frequent urinary tract infections due to bacterial growth and biofilm formation surrounding the stone microenvironment." | 1.91 | Chemical Modification of Tiopronin for Dual Management of Cystinuria and Associated Bacterial Infections. ( Estes Bright, LM; Garren, MRS; Handa, H; Kumar, A; Manuel, J; Shome, A, 2023) |
| "To evaluate medical treatments, in terms of adverse events (AEs) and therapeutic goals, in a large series of patients with cystinuria." | 1.51 | Adverse events associated with currently used medical treatments for cystinuria and treatment goals: results from a series of 442 patients in France. ( Bataille, P; Bridoux, F; Brignon, P; Choquenet, C; Cochat, P; Combe, C; Conort, P; Courbebaisse, M; Daudon, M; Decramer, S; Doré, B; Dussol, B; Essig, M; Friedlander, G; Frimat, M; Gaunez, N; Jais, JP; Joly, D; Knebelmann, B; Le Toquin-Bernard, S; Lebbah, S; Lillo-Le Louët, A; Méjean, A; Meria, P; Morin, D; N'Guyen, HV; Normand, M; Pietak, M; Pontoizeau, C; Prot-Bertoye, C; Ronco, P; Saussine, C; Tostivint, I; Traxer, O; Tsimaratos, M, 2019) |
| "Cystinuria is an inherited disorder characterized by defective renal reabsorption of cystine and dibasic amino acids leading to nephrolithiasis." | 1.46 | Genotype and Phenotype Analysis in Pediatric Patients with Cystinuria. ( Cheong, HI; Ha, IS; Hyun, HS; Kang, HG; Kim, GH; Kim, JH; Lee, BH; Lee, JH; Park, E; Park, YS, 2017) |
| "Cystinuria was diagnosed by stone analysis and increased urinary excretion of cystine." | 1.39 | An uncommon cause of acute kidney injury in young children: cystinuria. ( Genc, G; Nalcacioglu, H; Ozden, E; Ozkaya, O; Sarikaya, S; Yakupoglu, YK, 2013) |
| "Cystinuria is an autosomal recessive disorder, and primary manifestation is the repeated formation of cystine calculi." | 1.30 | [Clinical study on cystinuria in children--the stone management and the prevention of calculi recurrence]. ( Asanuma, H; Kawamura, T; Nagakura, K; Nakai, H; Shishido, S; Takeda, M; Yamafuji, M, 1998) |
| "The pharmacokinetic disposition of 2-mercaptopropionylglycine (2-MPG) given as a single intravenous injection and/or as a single oral dose was studied in 9 normal and 13 cystinuric dogs." | 1.28 | Pharmacokinetics and bioavailability of 2-mercaptopropionylglycine administered intravenously and orally in dogs. ( Denneberg, T; Emanuelsson, BM; Hoppe, A; Kågedal, B; Lindgren, S, 1991) |
| " We concluded that 2-MPG is well tolerated and promising for treatment of cystinuric dogs, but the pharmacokinetic studies should be expanded to include different dosage regimens, and results of long-term treatment should be evaluated." | 1.27 | Treatment of clinically normal and cystinuric dogs with 2-mercaptopropionylglycine. ( Denneberg, T; Hoppe, A; Kågedal, B, 1988) |
| "Cystinuria is a complex hereditary disorder characterized by excessive urinary excretion of cystine." | 1.27 | Management of the patient with cystinuria. ( Pahira, JJ, 1987) |
| "The frequency of cystinuria is in the order of 1:10,000." | 1.26 | [Cystinuria therapy by ascorbic acid (author's transl)]. ( Asper, R; Schmucki, O, 1982) |
| "No recurrence of renal calculi was observed." | 1.26 | [Clinical aspects of cystinuria and its treatment by thiola (author's transl)]. ( Gründig, E; Latal, D; Müller, M; Zechner, O, 1976) |
| "The causes of the recurrences in the other 2 children are discussed." | 1.26 | Cystinuria in children. ( Dussini, N; Pagano, F; Passerini, G; Pavanello, L; Rizzoni, G; Tasca, A; Zacchello, G, 1981) |
| " A relatively high dosage resulted in a reduction of the cytinuria." | 1.25 | [Cystine stone therapy with mercapto-propyonyl-glycine (MPG) (Thiola) (author's transl)]. ( Stuhlsatz, HW; Terhorst, B, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (44.59) | 18.7374 |
| 1990's | 18 (24.32) | 18.2507 |
| 2000's | 11 (14.86) | 29.6817 |
| 2010's | 5 (6.76) | 24.3611 |
| 2020's | 7 (9.46) | 2.80 |
| Authors | Studies |
|---|---|
| Micallef, S | 1 |
| Delicata, L | 1 |
| Agius, JF | 1 |
| Holwill, S | 1 |
| Mikel, CC | 1 |
| Goldfarb, DS | 4 |
| Ponte, A | 1 |
| Steigelman, K | 1 |
| Latyshev, S | 1 |
| Kumar, A | 1 |
| Estes Bright, LM | 1 |
| Garren, MRS | 1 |
| Manuel, J | 1 |
| Shome, A | 1 |
| Handa, H | 1 |
| Modersitzki, F | 2 |
| Goldstein, RL | 1 |
| Sur, RL | 1 |
| Penniston, KL | 1 |
| Melessen, IM | 1 |
| Henderickx, MM | 1 |
| Merkx, MM | 1 |
| van Etten-Jamaludin, FS | 1 |
| Homan van der Heide, JJ | 1 |
| Kamphuis, GM | 1 |
| Assimos, DG | 1 |
| Prot-Bertoye, C | 2 |
| Daudon, M | 2 |
| Tostivint, I | 2 |
| Dousseaux, MP | 1 |
| Defazio, J | 1 |
| Traxer, O | 2 |
| Knebelmann, B | 2 |
| Courbebaisse, M | 2 |
| Lebbah, S | 1 |
| Jais, JP | 1 |
| Lillo-Le Louët, A | 1 |
| Pontoizeau, C | 1 |
| Cochat, P | 1 |
| Bataille, P | 1 |
| Bridoux, F | 1 |
| Brignon, P | 1 |
| Choquenet, C | 1 |
| Combe, C | 1 |
| Conort, P | 1 |
| Decramer, S | 1 |
| Doré, B | 1 |
| Dussol, B | 1 |
| Essig, M | 1 |
| Frimat, M | 1 |
| Gaunez, N | 1 |
| Joly, D | 1 |
| Le Toquin-Bernard, S | 1 |
| Méjean, A | 1 |
| Meria, P | 1 |
| Morin, D | 1 |
| N'Guyen, HV | 1 |
| Normand, M | 1 |
| Pietak, M | 1 |
| Ronco, P | 1 |
| Saussine, C | 1 |
| Tsimaratos, M | 1 |
| Friedlander, G | 1 |
| Malieckal, DA | 1 |
| Mara, K | 1 |
| Enders, FT | 1 |
| Asplin, JR | 3 |
| Kim, JH | 1 |
| Park, E | 1 |
| Hyun, HS | 1 |
| Lee, BH | 1 |
| Kim, GH | 1 |
| Lee, JH | 1 |
| Park, YS | 1 |
| Kang, HG | 1 |
| Ha, IS | 1 |
| Cheong, HI | 1 |
| Tasic, V | 1 |
| Lozanovski, VJ | 1 |
| Ristoska-Bojkovska, N | 1 |
| Sahpazova, E | 1 |
| Gucev, Z | 1 |
| Nalcacioglu, H | 1 |
| Ozden, E | 1 |
| Genc, G | 1 |
| Yakupoglu, YK | 1 |
| Sarikaya, S | 1 |
| Ozkaya, O | 1 |
| Koide, T | 1 |
| Yoshioka, T | 1 |
| Miyake, O | 1 |
| Okuyama, A | 1 |
| Yachiku, S | 1 |
| Knoll, T | 1 |
| Janitzky, V | 1 |
| Michel, MS | 1 |
| Alken, P | 1 |
| Köhrmann, KU | 1 |
| Fjellstedt, E | 3 |
| Harnevik, L | 1 |
| Jeppsson, JO | 7 |
| Tiselius, HG | 4 |
| Söderkvist, P | 1 |
| Denneberg, T | 14 |
| Parvex, P | 1 |
| Rozen, R | 1 |
| Dziarmaga, A | 1 |
| Goodyer, P | 1 |
| Dolin, DJ | 1 |
| Flagel, L | 1 |
| Grasso, M | 1 |
| Worcester, EM | 1 |
| Coe, FL | 3 |
| Evan, AP | 1 |
| Parks, JH | 2 |
| Dello Strologo, L | 1 |
| Laurenzi, C | 1 |
| Legato, A | 1 |
| Pastore, A | 1 |
| Stenberg, P | 1 |
| Kallistratos, G | 5 |
| Dimopoulos, C | 2 |
| Kalfakakou-Vadalouka, V | 1 |
| Evangelou, A | 2 |
| Stockidis, D | 1 |
| Vezyraki, P | 1 |
| Charalambopoulos, C | 1 |
| Mita, I | 2 |
| Hales, DS | 1 |
| Scott, R | 1 |
| Lewi, HJ | 1 |
| Mansell, MA | 1 |
| Lucky, PA | 1 |
| Skovby, F | 1 |
| Thier, SO | 1 |
| Smith, A | 1 |
| Vidler, J | 1 |
| Asper, R | 1 |
| Schmucki, O | 1 |
| Bruno, M | 1 |
| Fruttero, B | 1 |
| Marangella, M | 1 |
| Linari, F | 1 |
| Pavanello, L | 2 |
| Rizzoni, G | 2 |
| Dussini, N | 2 |
| Zacchello, G | 2 |
| Passerini, G | 1 |
| Tasca, A | 1 |
| Pagano, F | 1 |
| Johansen, K | 1 |
| Gammelgård, PA | 1 |
| Jørgensen, FS | 1 |
| Stokidis, D | 1 |
| Sidéris, C | 1 |
| Kyriakidis, A | 1 |
| Kollias, G | 1 |
| Joost, J | 1 |
| Jarosch, E | 1 |
| Lindell, A | 5 |
| Hellgren, E | 1 |
| Giannakopoulos, X | 1 |
| Kalfakakou, V | 1 |
| Tsoumanis, P | 1 |
| Karkabounas, S | 1 |
| Giannakis, D | 1 |
| Chambilomatis, P | 1 |
| Persu, A | 1 |
| Pirson, Y | 1 |
| Hoppe, A | 4 |
| Frank, A | 1 |
| Kågedals, B | 1 |
| Petersson, LR | 1 |
| Edholm, E | 1 |
| Chow, GK | 1 |
| Streem, SB | 1 |
| Pierides, AM | 1 |
| Deltas, CC | 1 |
| Owada, M | 1 |
| Watanabe, S | 1 |
| Tsuda, M | 1 |
| Berio, A | 3 |
| Piazzi, A | 1 |
| Asanuma, H | 1 |
| Nakai, H | 1 |
| Takeda, M | 1 |
| Shishido, S | 1 |
| Kawamura, T | 1 |
| Nagakura, K | 1 |
| Yamafuji, M | 1 |
| Akakura, K | 1 |
| Egoshi, K | 1 |
| Ueda, T | 1 |
| Nozumi, K | 1 |
| Kotake, T | 1 |
| Masai, M | 1 |
| Ito, H | 1 |
| Nakagawa, Y | 1 |
| Clark, C | 1 |
| Alvarez Navascués, R | 1 |
| Vidau Argüelles, P | 1 |
| Rodríguez Suarez, C | 1 |
| Herrera Pérez de Villar, J | 1 |
| Suarez Heiva, M | 1 |
| Christensson, A | 1 |
| Perfumo, F | 1 |
| Basile, G | 1 |
| Ginevri, F | 1 |
| Gusmano, R | 1 |
| Barbero, S | 1 |
| Domeneghetti, G | 1 |
| Sardi, R | 1 |
| Chiandetti, L | 1 |
| Vadaloyka-Kalfakakou, V | 1 |
| Terhorst, B | 2 |
| Stuhlsatz, HW | 2 |
| Hautmann, R | 1 |
| Lutzeyer, W | 1 |
| Zechner, O | 1 |
| Latal, D | 1 |
| Gründig, E | 1 |
| Müller, M | 1 |
| Carratù, A | 1 |
| Innocenti, MG | 1 |
| Rossi, R | 1 |
| Remien, A | 1 |
| Burchardt, P | 1 |
| Siskind, MS | 1 |
| Popovtzer, MM | 1 |
| Emanuelsson, BM | 1 |
| Kågedal, B | 4 |
| Lindgren, S | 1 |
| Eneström, S | 1 |
| Fich, C | 1 |
| Skogh, T | 1 |
| Shibasaki, T | 1 |
| Murai, S | 1 |
| Kodama, K | 1 |
| Nakano, H | 1 |
| Ishimoto, F | 1 |
| Sakai, O | 1 |
| Mårtensson, J | 2 |
| Textorius, O | 1 |
| Jaeger, P | 1 |
| de Temple, R | 1 |
| Brien, G | 1 |
| Hellmann, C | 1 |
| Otting, U | 1 |
| Schöpke, W | 1 |
| Schönberger, B | 1 |
| Pak, CY | 1 |
| Fuller, C | 1 |
| Sakhaee, K | 1 |
| Zerwekh, JE | 1 |
| Adams, BV | 1 |
| Pahira, JJ | 1 |
| Andersson, T | 1 |
| Carlsson, M | 1 |
| Harbar, JA | 1 |
| Cusworth, DC | 1 |
| Lawes, LC | 1 |
| Wrong, OM | 1 |
| Grunfeld Avellan, JA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Study of the Effects of Tiopronin on 3-Aminopropanal Level & Neurologic Outcome After Aneurysmal Subarachnoid Hemorrhage[NCT01095731] | Phase 2 | 60 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for tiopronin and Cystinuria
| Article | Year |
|---|---|
The effect of additional drug therapy as metaphylaxis in patients with cystinuria: a systematic review.
Topics: Captopril; Cystine; Cystinuria; Drug Therapy, Combination; Evidence-Based Medicine; Female; Humans; | 2020 |
[Cystinuria].
Topics: Cystine; Cystinuria; Humans; Kidney Calculi; Penicillamine; Tiopronin | 2021 |
[Cystinuria - Cystine Stones: Recommendations for Diagnosis, Therapy and Follow-up].
Topics: Adult; Age Factors; Angiotensin-Converting Enzyme Inhibitors; Ascorbic Acid; Captopril; Chelating Ag | 2003 |
[Current aspects of the medical treatment of cystinuria].
Topics: Ascorbic Acid; Captopril; Cystine; Cystinuria; Humans; Hydrogen-Ion Concentration; Penicillamine; So | 1994 |
[Cystinuria].
Topics: Amino Acid Transport Systems, Basic; Carrier Proteins; Citric Acid; Cystinuria; Diagnosis, Different | 1998 |
[The hyperaminoacidurias with special reference to cystinuria].
Topics: Amino Acids; Biological Transport; Carrier Proteins; Child; Cystinuria; Female; Humans; Microvilli; | 1979 |
A case of nephrotic syndrome due to alpha-mercaptopropionyl glycine in a patient with familial cystinuria.
Topics: Adult; Cystinuria; Glomerulonephritis, Membranous; Humans; Male; Nephrotic Syndrome; Tiopronin | 1990 |
Cystinuria: pathophysiology and treatment.
Topics: Captopril; Cystinuria; Humans; Penicillamine; Tiopronin | 1989 |
9 trials available for tiopronin and Cystinuria
| Article | Year |
|---|---|
Effect of increasing doses of cystine-binding thiol drugs on cystine capacity in patients with cystinuria.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cross-Over Studies; Cystine; Cystinuria; Dose-Response R | 2019 |
[Long-term study of tiopronin in patients with cystinuria].
Topics: Adult; Aged; Anorexia; Constipation; Cystinuria; Dose-Response Relationship, Drug; Drug Administrati | 2003 |
Cystinuria in children and young adults: success of monitoring free-cystine urine levels.
Topics: Adolescent; Adult; Alkalies; Chelating Agents; Child; Child, Preschool; Cystine; Cystinuria; Diureti | 2007 |
Clinical course and cystine stone formation during tiopronin treatment.
Topics: Adolescent; Adult; Child; Child, Preschool; Cystinuria; Female; Humans; Kidney Calculi; Male; Middle | 1995 |
Urinary excretion of free cystine and the tiopronin-cysteine-mixed disulfide during long term tiopronin treatment of cystinuria.
Topics: Adolescent; Adult; Aged; Cystine; Cystinuria; Disulfides; Dose-Response Relationship, Drug; Female; | 1995 |
The effect of sodium intake on cystinuria with and without tiopronin treatment.
Topics: Adolescent; Adult; Creatinine; Cystine; Cystinuria; Diet, Sodium-Restricted; Female; Humans; Kidney | 1995 |
Medical treatment of cystinuria: results of contemporary clinical practice.
Topics: Adolescent; Adult; Angiotensin-Converting Enzyme Inhibitors; Captopril; Child; Child, Preschool; Cys | 1996 |
A comparison of the effects of potassium citrate and sodium bicarbonate in the alkalinization of urine in homozygous cystinuria.
Topics: Adult; Aged; Alkalies; Cystinuria; Female; Homozygote; Humans; Hydrogen-Ion Concentration; Male; Mid | 2001 |
Management of cystine nephrolithiasis with alpha-mercaptopropionylglycine.
Topics: Adolescent; Adult; Aged; Amino Acids, Sulfur; Child; Clinical Trials as Topic; Cystine; Cystinuria; | 1986 |
57 other studies available for tiopronin and Cystinuria
| Article | Year |
|---|---|
Tiopronin-induced membranous nephropathy in a patient with refractory familial cystinuria.
Topics: Cystinuria; Glomerulonephritis, Membranous; Humans; Nephrotic Syndrome; Tiopronin | 2022 |
Accurate 24-h urine cystine quantification for patients on cystine-binding thiol drugs.
Topics: Cysteine; Cystine; Cystinuria; Humans; Quality of Life; Sulfhydryl Compounds; Tandem Mass Spectromet | 2022 |
Chemical Modification of Tiopronin for Dual Management of Cystinuria and Associated Bacterial Infections.
Topics: Animals; Bacterial Infections; Cystine; Cystinuria; Disulfides; Dogs; Escherichia coli; Mice; Nitric | 2023 |
Assessment of health-related quality of life in patients with cystinuria on tiopronin therapy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cross-Sectional Studies; Cystinuria; Female; Humans; Kid | 2020 |
Re: Assessment of Health-Related Quality of Life in Patients with Cystinuria on Tiopronin Therapy.
Topics: Cystinuria; Humans; Quality of Life; Tiopronin | 2020 |
Adverse events associated with currently used medical treatments for cystinuria and treatment goals: results from a series of 442 patients in France.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Cystinuria; Drug-Related Side Effects and Adverse | 2019 |
Genotype and Phenotype Analysis in Pediatric Patients with Cystinuria.
Topics: Adolescent; Amino Acid Transport Systems, Basic; Amino Acid Transport Systems, Neutral; Asian People | 2017 |
Nephrotic syndrome occurring during tiopronin treatment for cystinuria.
Topics: Amino Acids, Sulfur; Benzenesulfonates; Child, Preschool; Cystinuria; Edema; Humans; Lithotripsy; Ma | 2011 |
An uncommon cause of acute kidney injury in young children: cystinuria.
Topics: Acute Kidney Injury; Anuria; Child, Preschool; Cystinuria; Diagnosis, Differential; Diuretics; Femal | 2013 |
Urinary excretion of total cystine and the dibasic amino acids arginine, lysine and ornithine in relation to genetic findings in patients with cystinuria treated with sulfhydryl compounds.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alleles; Amino Acid Transport Systems, Basic; Amino Acid | 2003 |
Studies of urinary cystine precipitation in vitro: ontogeny of cystine nephrolithiasis and identification of meso-2,3-dimercaptosuccinic acid as a potential therapy for cystinuria.
Topics: Adolescent; Age Factors; Chemical Precipitation; Child; Child, Preschool; Cystine; Cystinuria; Dose- | 2003 |
Effect of cystine-binding thiol drugs on urinary cystine capacity in patients with cystinuria.
Topics: Administration, Oral; Adult; Captopril; Case-Control Studies; Cysteine; Cystinuria; Dose-Response Re | 2005 |
Reduced renal function and benefits of treatment in cystinuria vs other forms of nephrolithiasis.
Topics: Adult; Chelating Agents; Cystine; Cystinuria; Drinking; Female; Humans; Male; Middle Aged; Nephrecto | 2006 |
Alternative treatment of cystinuria with alpha-merkaptopropionylglycine, Thiola.
Topics: Adolescent; Adult; Aged; Amino Acids, Sulfur; Cystine; Cystinuria; Dipeptides; Female; Humans; Male; | 1983 |
Familial cystinuria in Ioannina District (Greece). Diagnosis and treatment.
Topics: Adolescent; Adult; Child; Cystinuria; Female; Greece; Humans; Male; Middle Aged; Pedigree; Tiopronin | 1983 |
Myopathy due to mercaptopropionyl glycine.
Topics: Adult; Amino Acids, Sulfur; Cystinuria; Female; Humans; Muscular Diseases; Tiopronin | 1982 |
Myopathy due to mercaptopropionyl glycine.
Topics: Amino Acids, Sulfur; Cystinuria; Humans; Muscular Diseases; Penicillamine; Tiopronin | 1982 |
Pemphigus foliaceus and proteinuria induced by alpha-mercaptopropionylglycine.
Topics: Amino Acids, Sulfur; Cystinuria; Humans; Male; Middle Aged; Pemphigus; Proteinuria; Skin; Tiopronin | 1983 |
Evaluation of techniques to estimate binding of thiola to cystine in cystinuric patients.
Topics: Amino Acids; Amino Acids, Sulfur; Chromatography, Paper; Creatine; Crystallization; Cystine; Cystinu | 1981 |
[Cystinuria therapy by ascorbic acid (author's transl)].
Topics: Ascorbic Acid; Cysteine; Cystine; Cystinuria; Humans; Intestinal Absorption; Kidney; Penicillamine; | 1982 |
[Cystinuria: clinical and therapeutic aspects].
Topics: Adolescent; Adult; Aged; Child; Cystinuria; Drug Evaluation; Glycine; Humans; Kinetics; Middle Aged; | 1982 |
Cystinuria in children.
Topics: Amino Acids, Sulfur; Child; Child, Preschool; Cystinuria; Female; Humans; Infant; Kidney Calculi; Ma | 1981 |
Treatment of cystinuria with alpha-mercaptopropionylglycine.
Topics: Adult; Amino Acids, Sulfur; Cystine; Cystinuria; Female; Humans; Male; Recurrence; Tiopronin; Urinar | 1980 |
[The use of mercapto-propionyl-glycine in the treatment of cystine lithiasis (author's transl)].
Topics: Adult; Amino Acids, Sulfur; Cystinuria; Female; Humans; Kidney Calculi; Male; Recurrence; Tiopronin; | 1981 |
Glutamine: a new anticystinuric drug?
Topics: Adult; Ammonia; Cystinuria; Drug Combinations; Female; Glutamine; Humans; Time Factors; Tiopronin | 1981 |
[Results of treatment of cystinuria and cystine lithiasis with alpha-mercaptopropionylglycine. Apropos of 40 patients].
Topics: Adult; Aged; Cystine; Cystinuria; Female; Follow-Up Studies; Humans; Male; Middle Aged; Recurrence; | 1994 |
Urinary excretion of metals during treatment with D-penicillamine and 2-mercaptopropionylglycine in normal and cystinuric dogs.
Topics: Administration, Oral; Animals; Creatinine; Cystinuria; Dog Diseases; Dogs; Injections, Intravenous; | 1993 |
Clinical aspects of cystinuria.
Topics: Adolescent; Adult; Chelating Agents; Child; Child, Preschool; Cystine; Cystinuria; Diet; Female; Hum | 1997 |
Prophylaxis of cystine calculi by low dose of alpha-mercapto-propionyl-glycine administered every other day.
Topics: Adult; Cystinuria; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Kidney Ca | 1998 |
[Clinical study on cystinuria in children--the stone management and the prevention of calculi recurrence].
Topics: Adolescent; Adult; Child; Child, Preschool; Cystinuria; Female; Follow-Up Studies; Humans; Infant; L | 1998 |
The long-term outcome of cystinuria in Japan.
Topics: Adult; Chelating Agents; Cystine; Cystinuria; Female; Follow-Up Studies; Humans; Hydrogen-Ion Concen | 1998 |
A modified cyanide-nitroprusside method for quantifying urinary cystine concentration that corrects for creatinine interference.
Topics: Adult; Artifacts; Ascorbic Acid; Captopril; Chlorides; Colorimetry; Creatinine; Cyanides; Cysteine; | 1999 |
Solid phase assay of urine cystine supersaturation in the presence of cystine binding drugs.
Topics: Buffers; Captopril; Chemical Phenomena; Chemistry; Crystallization; Cystinuria; Humans; Penicillamin | 2001 |
[Nephrotic syndrome and anasarca status, secondary to treatment with tiopronin in a case of cystinuria].
Topics: Adult; Ascites; Cystinuria; Edema; Female; Humans; Nephrotic Syndrome; Tiopronin | 2001 |
Cystine analyses of separate day and night urine as a basis for the management of patients with homozygous cystinuria.
Topics: Adult; Aged; Circadian Rhythm; Cystinuria; Dose-Response Relationship, Drug; Female; Homozygote; Hum | 2001 |
[Cystinuria. Description of a case].
Topics: Child, Preschool; Cystinuria; Female; Humans; Tiopronin; Urinary Calculi | 1979 |
Nephrotic syndrome during treatment with alpha-mercaptopropionylglycine.
Topics: Amino Acids, Sulfur; Child; Child, Preschool; Cystinuria; Humans; Male; Nephrotic Syndrome; Proteinu | 1979 |
Management of cystinuric disorders with sulfhydryl drugs.
Topics: Cystinuria; Humans; Sulfhydryl Compounds; Tiopronin | 1979 |
[Cystine-lysine-ornithine-argininuria. Current genetic and clinico-therapeutic problems].
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Amino Acids, Sulfur; Arginine; Child; Child, Presc | 1979 |
[Cystine stone therapy with mercapto-propyonyl-glycine (MPG) (Thiola) (author's transl)].
Topics: Adult; Amino Acids; Amino Acids, Sulfur; Cystinuria; Drug Tolerance; Female; Humans; Long-Term Care; | 1975 |
Mercaptopropionylglycine: a progress in cystine stone therapy.
Topics: Adult; Amino Acids, Sulfur; Cystine; Cystinuria; Female; Follow-Up Studies; Humans; Male; Penicillam | 1977 |
[Clinical aspects of cystinuria and its treatment by thiola (author's transl)].
Topics: Amino Acids; Amino Acids, Sulfur; Biological Transport; Cystinuria; Humans; Kidney Calculi; Tioproni | 1976 |
[Cystine lithiasis. Report of a case with severe neuro-psychic disturbances. Discussion of the effects of anti-lithiasic treatment].
Topics: Amino Acids, Sulfur; Child; Cystinuria; Epilepsy; Humans; Male; Mental Disorders; Tiopronin; Urinary | 1976 |
Treatment of cystinuria with Thiola (alpha-mercaptopropionyl glycine).
Topics: Amino Acids, Sulfur; Cystinuria; Dose-Response Relationship, Drug; Female; Humans; Male; Recurrence; | 1975 |
Hyperlipidemia associated with alpha-mercaptopropionylglycine therapy for cystinuria.
Topics: Adult; Cystinuria; Female; Humans; Hyperlipidemias; Tiopronin | 1992 |
Pharmacokinetics and bioavailability of 2-mercaptopropionylglycine administered intravenously and orally in dogs.
Topics: Administration, Oral; Animals; Biological Availability; Blood Proteins; Cystinuria; Dog Diseases; Do | 1991 |
Membranous glomerulonephritis induced by 2-mercaptopropionylglycine (2-MPG).
Topics: Antibodies, Antinuclear; Biopsy; Cystinuria; Female; Glomerulonephritis, Membranous; Humans; Kidney | 1990 |
Sulfur amino acid metabolism in cystinuria: a biochemical and clinical study of patients.
Topics: Acetylcysteine; Adult; Amino Acids, Sulfur; Cysteine; Cystinuria; Female; Homozygote; Humans; Male; | 1990 |
[Treatment and metaphylaxis of cystine urolithiasis in children].
Topics: Acetylcysteine; Administration, Oral; Adolescent; Cystinuria; Female; Humans; Kidney Calculi; Nephro | 1989 |
Tiopronin for cystinuria.
Topics: Cystine; Cystinuria; Gastrointestinal Diseases; Humans; Leukopenia; Solubility; Tiopronin; Urinary C | 1989 |
Treatment of clinically normal and cystinuric dogs with 2-mercaptopropionylglycine.
Topics: Administration, Oral; Amino Acids, Sulfur; Animals; Cystinuria; Dog Diseases; Dogs; Drug Tolerance; | 1988 |
Management of the patient with cystinuria.
Topics: Adult; Alkalies; Child; Cystinuria; Dietary Proteins; Female; Fluid Therapy; Humans; Kidney Calculi; | 1987 |
High-performance liquid chromatography of 2-mercaptopropionylglycine and its metabolite 2-mercaptopropionic acid in plasma and urine after treatment with thiopronine.
Topics: Amino Acids, Sulfur; Animals; Chromatography, High Pressure Liquid; Cystinuria; Dogs; Humans; Specie | 1987 |
Comparison of 2-mercaptopropionylglycine and D-penicillamine in the treatment of cystinuria.
Topics: Adult; Amino Acids, Sulfur; Cystinuria; Female; Humans; Male; Middle Aged; Penicillamine; Tiopronin | 1986 |
2-Mercaptopropionate, a novel metabolite formed during treatment with 2-mercaptopropionyl-glycine in cystinuria.
Topics: Amino Acids, Sulfur; Chromatography, Gas; Cystinuria; Humans; Mass Spectrometry; Sulfhydryl Compound | 1986 |
[Prophylaxis of cystinic calculosis with alpha mercapto propionylglycine. Personal cases].
Topics: Adolescent; Adult; Amino Acids, Sulfur; Cystinuria; Electrophoresis; Humans; Kidney Calculi; Male; M | 1985 |
[Cystine lithiasis in the adult. Apropos of an isolated case without familial antecedents].
Topics: Adult; Cystinuria; Diuresis; Female; Humans; Prognosis; Recurrence; Tiopronin; Ureteral Calculi; Uri | 1985 |