tiopronin has been researched along with Brain Ischemia in 2 studies
Tiopronin: Sulfhydryl acylated derivative of GLYCINE.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objective of this trial was to establish the safety of tiopronin administration in patients with aneurysmal subarachnoid hemorrhage (aSAH) in preparation for further trials of its efficacy as a neuroprotective agent in this disease process." | 9.14 | A phase I clinical trial of tiopronin, a putative neuroprotective agent, in aneurysmal subarachnoid hemorrhage. ( Connolly, ES; Ducruet, AF; Fernandez, L; Hickman, ZL; Hwang, BY; Kellner, CP; Kim, GH; Mayer, SA; Starke, RM; Tracey, KJ; Zacharia, BE, 2010) |
| "The efficacy of free radical scavengers (mannitol and n-2-mercaptopropionyl glycine) and a vasodilator (sodium nitroprusside) on the EEG recovery following cerebral ischemia was studied in the anesthetized rat." | 7.68 | Effect of mannitol, n-2-mercaptopropionyl glycine and sodium nitroprusside on EEG recovery following cerebral ischemia and reperfusion in the rat. ( Huang, LL; Huang, TF, 1990) |
| "The objective of this trial was to establish the safety of tiopronin administration in patients with aneurysmal subarachnoid hemorrhage (aSAH) in preparation for further trials of its efficacy as a neuroprotective agent in this disease process." | 5.14 | A phase I clinical trial of tiopronin, a putative neuroprotective agent, in aneurysmal subarachnoid hemorrhage. ( Connolly, ES; Ducruet, AF; Fernandez, L; Hickman, ZL; Hwang, BY; Kellner, CP; Kim, GH; Mayer, SA; Starke, RM; Tracey, KJ; Zacharia, BE, 2010) |
| "The efficacy of free radical scavengers (mannitol and n-2-mercaptopropionyl glycine) and a vasodilator (sodium nitroprusside) on the EEG recovery following cerebral ischemia was studied in the anesthetized rat." | 3.68 | Effect of mannitol, n-2-mercaptopropionyl glycine and sodium nitroprusside on EEG recovery following cerebral ischemia and reperfusion in the rat. ( Huang, LL; Huang, TF, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, GH | 1 |
| Kellner, CP | 1 |
| Hickman, ZL | 1 |
| Zacharia, BE | 1 |
| Starke, RM | 1 |
| Hwang, BY | 1 |
| Ducruet, AF | 1 |
| Fernandez, L | 1 |
| Mayer, SA | 1 |
| Tracey, KJ | 1 |
| Connolly, ES | 1 |
| Huang, TF | 1 |
| Huang, LL | 1 |
1 trial available for tiopronin and Brain Ischemia
| Article | Year |
|---|---|
A phase I clinical trial of tiopronin, a putative neuroprotective agent, in aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Aldehydes; Brain Ischemia; Cohort Studies; Female; Humans; Male; Middle Aged; Neuroprot | 2010 |
1 other study available for tiopronin and Brain Ischemia
| Article | Year |
|---|---|
Effect of mannitol, n-2-mercaptopropionyl glycine and sodium nitroprusside on EEG recovery following cerebral ischemia and reperfusion in the rat.
Topics: Animals; Brain Ischemia; Electroencephalography; Male; Mannitol; Nitroprusside; Rats; Rats, Inbred S | 1990 |