tinidazole has been researched along with Vaginosis, Bacterial in 18 studies
Tinidazole: A nitroimidazole alkylating agent that is used as an antitrichomonal agent against TRICHOMONAS VAGINALIS; ENTAMOEBA HISTOLYTICA; and GIARDIA LAMBLIA infections. It also acts as an antibacterial agent for the treatment of BACTERIAL VAGINOSIS and anaerobic bacterial infections.
tinidazole : 1H-imidazole substituted at C-1 by a (2-ethylsulfonyl)ethyl group, at C-2 by a methyl group and at C-5 by a nitro group. It is used as an antiprotozoal, antibacterial agent.
Vaginosis, Bacterial: Polymicrobial, nonspecific vaginitis associated with positive cultures of Gardnerella vaginalis and other anaerobic organisms and a decrease in lactobacilli. It remains unclear whether the initial pathogenic event is caused by the growth of anaerobes or a primary decrease in lactobacilli.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Women (n = 539) with bacterial vaginosis who meet the criteria were included in the study." | 2.78 | [Efficacy of combined 5-nitroimidazole and probiotic therapy of bacterial vaginosis: randomized open trial]. ( Kovachev, S; Vatcheva-Dobrevski, R, 2013) |
| "There were no differences in cure rates between metronidazole and either of the tinidazole dosing regimens that were studied." | 2.76 | Tinidazole vs metronidazole for the treatment of bacterial vaginosis. ( Desmond, RA; Schwebke, JR, 2011) |
| "Vaginitis is one of the most common causes of patient visits to gynecologists, primary care providers, and urgent care centers." | 2.66 | Noncandidal vaginitis: a comprehensive approach to diagnosis and management. ( Eckert, LO; Kus, LH; Neal, CM; Peipert, JF, 2020) |
| "Tinidazole is a 5-nitroimidazole active in vitro against a wide variety of anaerobic bacteria and protozoa." | 2.45 | [Tinidazole: a classical anaerobical drug with multiple potential uses nowadays]. ( Giménez, MJ; Granizo, JJ; Manso, FJ; Pía Rodicio, M, 2009) |
| "Tinidazole has been used for vaginal infection worldwide but not in the US for > 40 years." | 2.44 | Tinidazole for the treatment of vaginal infections. ( Nailor, MD; Sobel, JD, 2007) |
| "Tinidazole has been used for bacterial vaginosis (BV) outside the USA for almost four decades." | 2.44 | Tinidazole for bacterial vaginosis. ( Nailor, MD; Sobel, JD, 2007) |
| "Recurrent bacterial vaginosis is a difficult clinical condition." | 1.32 | Treatment of recurrent bacterial vaginosis with tinidazole. ( Baylson, FA; Nyirjesy, P; Weitz, MV, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 11 (61.11) | 29.6817 |
| 2010's | 4 (22.22) | 24.3611 |
| 2020's | 2 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, X | 1 |
| Boyd, P | 1 |
| Dallal Bashi, YH | 1 |
| McCoy, CF | 1 |
| Karl Malcolm, R | 1 |
| Neal, CM | 1 |
| Kus, LH | 1 |
| Eckert, LO | 1 |
| Peipert, JF | 1 |
| Kovachev, S | 2 |
| Vatcheva-Dobrevski, R | 1 |
| Amaya-Guio, J | 1 |
| Viveros-Carreño, DA | 1 |
| Sierra-Barrios, EM | 1 |
| Martinez-Velasquez, MY | 1 |
| Grillo-Ardila, CF | 1 |
| Wang, FM | 1 |
| Qian, XD | 1 |
| Xu, H | 1 |
| Yu, HY | 1 |
| Martinez, RC | 1 |
| Franceschini, SA | 1 |
| Patta, MC | 1 |
| Quintana, SM | 1 |
| Gomes, BC | 1 |
| De Martinis, EC | 1 |
| Reid, G | 1 |
| Granizo, JJ | 1 |
| Pía Rodicio, M | 1 |
| Manso, FJ | 1 |
| Giménez, MJ | 1 |
| Schwebke, JR | 1 |
| Desmond, RA | 1 |
| Vatcheva-Dobrevsky, R | 1 |
| Kovacheva-Aleksandrova, M | 1 |
| Milani, M | 1 |
| Barcellona, E | 1 |
| Agnello, A | 1 |
| Manes, G | 1 |
| Balzano, A | 1 |
| Baylson, FA | 1 |
| Nyirjesy, P | 2 |
| Weitz, MV | 1 |
| Villagrana-Zesati, R | 1 |
| Reyna-Figueroa, J | 1 |
| Ortiz-Ibarra, J | 1 |
| Nailor, MD | 2 |
| Sobel, JD | 2 |
| Livengood, CH | 1 |
| Ferris, DG | 1 |
| Wiesenfeld, HC | 1 |
| Hillier, SL | 1 |
| Soper, DE | 1 |
| Marrazzo, J | 1 |
| Chatwani, A | 1 |
| Fine, P | 1 |
| Sobel, J | 1 |
| Taylor, SN | 1 |
| Wood, L | 1 |
| Kanalas, JJ | 1 |
| Vutyavanich, T | 1 |
| Pongsuthirak, P | 1 |
| Vannareumol, P | 1 |
| Ruangsri, RA | 1 |
| Luangsook, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Probiotics on GBS Colonization Status During Pregnancy: A Pilot Randomized Controlled Trial[NCT02528981] | 114 participants (Actual) | Interventional | 2015-08-31 | Completed | |||
| A Phase III Randomized, Multi-center, Double-blind, Double-dummy, Placebo-controlled Treatment Trial of Bacterial Vaginosis With Tinidazole Oral Tablets.[NCT00229216] | Phase 3 | 200 participants (Actual) | Interventional | 2005-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for tinidazole and Vaginosis, Bacterial
| Article | Year |
|---|---|
Noncandidal vaginitis: a comprehensive approach to diagnosis and management.
Topics: Administration, Intravaginal; Administration, Oral; Anti-Infective Agents; Anti-Inflammatory Agents; | 2020 |
Antibiotic treatment for the sexual partners of women with bacterial vaginosis.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Clindamycin; Female; Humans; Indazoles; Lincosamides; Male | 2016 |
[Tinidazole: a classical anaerobical drug with multiple potential uses nowadays].
Topics: Anaerobiosis; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Antiprotozoal Agents; Bacteria | 2009 |
Tinidazole: from protozoa to Helicobacter pylori--the past, present and future of a nitroimidazole with peculiarities.
Topics: Amebiasis; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Antitrichomonal Agents; Clinical | 2004 |
Tinidazole for the treatment of vaginal infections.
Topics: Anti-Bacterial Agents; Antitrichomonal Agents; Drug Administration Schedule; Drug Interactions; Drug | 2007 |
Tinidazole for bacterial vaginosis.
Topics: Anti-Bacterial Agents; Female; Humans; Microbial Sensitivity Tests; Tinidazole; Vaginosis, Bacterial | 2007 |
Tinidazole (Tindamax)--a new option for treatment of bacterial vaginosis.
Topics: Administration, Oral; Female; Humans; Tinidazole; Vaginosis, Bacterial | 2007 |
8 trials available for tinidazole and Vaginosis, Bacterial
| Article | Year |
|---|---|
[Efficacy of combined 5-nitroimidazole and probiotic therapy of bacterial vaginosis: randomized open trial].
Topics: Adolescent; Adult; Anti-Infective Agents; Female; Humans; Lacticaseibacillus rhamnosus; Lactobacillu | 2013 |
[Efficacy of 5-nitroimidazole derivatives in treatment of bacterial vaginosis].
Topics: Administration, Intravaginal; Administration, Oral; Adult; Delayed-Action Preparations; Drug Adminis | 2008 |
Improved cure of bacterial vaginosis with single dose of tinidazole (2 g), Lactobacillus rhamnosus GR-1, and Lactobacillus reuteri RC-14: a randomized, double-blind, placebo-controlled trial.
Topics: Adolescent; Adult; Brazil; Double-Blind Method; Female; Humans; Lacticaseibacillus rhamnosus; Limosi | 2009 |
Tinidazole vs metronidazole for the treatment of bacterial vaginosis.
Topics: Administration, Oral; Adult; Anti-Infective Agents; Double-Blind Method; Female; Humans; Metronidazo | 2011 |
Efficacy of the combination of 2 g oral tinidazole and acidic buffering vaginal gel in comparison with vaginal clindamycin alone in bacterial vaginosis: a randomized, investigator-blinded, controlled trial.
Topics: Administration, Intravaginal; Adult; Aged; Anti-Bacterial Agents; Buffers; Clindamycin; Female; Gels | 2003 |
Short-term therapy for mixed vaginal infections.
Topics: Administration, Oral; Antifungal Agents; Antiprotozoal Agents; Antitrichomonal Agents; Candidiasis, | 2006 |
Effectiveness of two tinidazole regimens in treatment of bacterial vaginosis: a randomized controlled trial.
Topics: Administration, Oral; Adult; Antitrichomonal Agents; Dose-Response Relationship, Drug; Double-Blind | 2007 |
A randomized double-blind trial of tinidazole treatment of the sexual partners of females with bacterial vaginosis.
Topics: Adolescent; Adult; Bacterial Infections; Double-Blind Method; Female; Follow-Up Studies; Humans; Mal | 1993 |
3 other studies available for tinidazole and Vaginosis, Bacterial
| Article | Year |
|---|---|
Physicochemical considerations in the formulation development of silicone elastomer vaginal rings releasing 5-nitroimidazole drugs for the treatment of bacterial vaginosis.
Topics: Administration, Intravaginal; Anti-Bacterial Agents; Contraceptive Devices, Female; Delayed-Action P | 2023 |
[Short - term combined 5-nitroimidazole treatment in vaginal dysbacteriosis with dominant anaerobic species].
Topics: Administration, Intravaginal; Adolescent; Adult; Anti-Infective Agents; Bacteria, Anaerobic; Drug Th | 2011 |
Treatment of recurrent bacterial vaginosis with tinidazole.
Topics: Adult; Antiprotozoal Agents; Antitrichomonal Agents; Female; Humans; Metronidazole; Recurrence; Tini | 2004 |