tinidazole has been researched along with Periodontitis in 17 studies
Tinidazole: A nitroimidazole alkylating agent that is used as an antitrichomonal agent against TRICHOMONAS VAGINALIS; ENTAMOEBA HISTOLYTICA; and GIARDIA LAMBLIA infections. It also acts as an antibacterial agent for the treatment of BACTERIAL VAGINOSIS and anaerobic bacterial infections.
tinidazole : 1H-imidazole substituted at C-1 by a (2-ethylsulfonyl)ethyl group, at C-2 by a methyl group and at C-5 by a nitro group. It is used as an antiprotozoal, antibacterial agent.
Periodontitis: Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fifty-two adult periodontitis patients were treated by the tablets of tinidazole (TNZ), and 23 patients treated by metronidazole (MNZ) served as control group." | 9.08 | [The effect of tinidazole in the treatment of adult periodontitis]. ( Chen, L; Ni, K; Wang, R, 1996) |
| "To investigate the effect of oxymatrine on periodontitis in rats and related mechanism." | 7.88 | Oxymatrine alleviates periodontitis in rats by inhibiting inflammatory factor secretion and regulating MMPs/TIMP protein expression1. ( Deng, N; Li, Y; Lin, H; Luo, R; Xie, L, 2018) |
| "To explore the effects of atovastatin and tinidazole on atherosclerosis and the levels of tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1) and matrix metalloproteinase-2 (MMP-2) in periodontitis." | 7.79 | [Impacts of atovastatin and tinidazole on cardiac muscle inflammation factors of tumor necrosis factor-α, interleukin-1 and metalloproteinase-2 of experimental rabbits with atherosclerosis and periodontitis]. ( Hou, XL; Liang, P; Zhang, Y; Zhang, YM, 2013) |
| "The efficacy of tinidazole in addition to a single course of scaling was studied in 14 dogs with periodontitis." | 7.68 | The efficacy of tinidazole in naturally occurring periodontitis in dogs: bacteriological and clinical results. ( Asikainen, SE; Jousimies-Somer, HR; Junttila, J; Kanervo, A; Sarkiala, EM, 1993) |
| "Periodontitis is caused by periodontopathic bacteria and antibacterial agents are placed in a periodontal pocket with the intention of enhancing the local effect." | 5.38 | Formulation and evaluation of in situ forming PLA implant containing tinidazole for the treatment of periodontitis. ( Li, L; Li, W; Qin, Y; Xue, J; Yuan, M, 2012) |
| "Tinidazole was not detected in the GCF in three of the patients." | 5.28 | Single-dose concentrations of tinidazole in gingival crevicular fluid, serum, and gingival tissue in adults with periodontitis. ( Buchanan, N; Cvejic, M; Hayden, M; Liew, V; Mack, G; Tseng, P, 1991) |
| "We have prepared tinidazole (TNZ) functionalized biodegradable chitosan (CH)/poly (ε-caprolactone) (PCL) mucoadhesive hybrid nanofiber membrane (TNZ-PCHNF) to alleviate existing shortcomings in treatment of periodontitis." | 5.24 | Tinidazole functionalized homogeneous electrospun chitosan/poly (ε-caprolactone) hybrid nanofiber membrane: Development, optimization and its clinical implications. ( Bansal, M; Khan, G; Kumar, N; Mishra, B; Patel, RR; Yadav, SK, 2017) |
| "Fifty-two adult periodontitis patients were treated by the tablets of tinidazole (TNZ), and 23 patients treated by metronidazole (MNZ) served as control group." | 5.08 | [The effect of tinidazole in the treatment of adult periodontitis]. ( Chen, L; Ni, K; Wang, R, 1996) |
| "To investigate the effect of oxymatrine on periodontitis in rats and related mechanism." | 3.88 | Oxymatrine alleviates periodontitis in rats by inhibiting inflammatory factor secretion and regulating MMPs/TIMP protein expression1. ( Deng, N; Li, Y; Lin, H; Luo, R; Xie, L, 2018) |
| "To explore the effects of atovastatin and tinidazole on atherosclerosis and the levels of tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1) and matrix metalloproteinase-2 (MMP-2) in periodontitis." | 3.79 | [Impacts of atovastatin and tinidazole on cardiac muscle inflammation factors of tumor necrosis factor-α, interleukin-1 and metalloproteinase-2 of experimental rabbits with atherosclerosis and periodontitis]. ( Hou, XL; Liang, P; Zhang, Y; Zhang, YM, 2013) |
| "Tinidazole 15 mg/kg was administered to eight Beagle dogs with gingivitis or periodontitis twice daily for 3 days." | 3.69 | Concentrations of tinidazole in gingival crevicular fluid and plasma in dogs after multiple dose administration. ( Asikainen, S; Järvinen, A; Nokelainen, M; Sarkiala-Kessel, EM, 1996) |
| "The efficacy of tinidazole in addition to a single course of scaling was studied in 14 dogs with periodontitis." | 3.68 | The efficacy of tinidazole in naturally occurring periodontitis in dogs: bacteriological and clinical results. ( Asikainen, SE; Jousimies-Somer, HR; Junttila, J; Kanervo, A; Sarkiala, EM, 1993) |
| "Tinidazole is a 5-nitroimidazole active in vitro against a wide variety of anaerobic bacteria and protozoa." | 2.45 | [Tinidazole: a classical anaerobical drug with multiple potential uses nowadays]. ( Giménez, MJ; Granizo, JJ; Manso, FJ; Pía Rodicio, M, 2009) |
| "Periodontitis is caused by periodontopathic bacteria and antibacterial agents are placed in a periodontal pocket with the intention of enhancing the local effect." | 1.38 | Formulation and evaluation of in situ forming PLA implant containing tinidazole for the treatment of periodontitis. ( Li, L; Li, W; Qin, Y; Xue, J; Yuan, M, 2012) |
| "Tinidazole was administered as a single oral dose of 15 mg kg-1 to 12 dogs, and its concentration in the plasma and gingival crevicular fluid (GCF) was measured at one and two hours by high performance liquid chromatography." | 1.28 | Penetration of tinidazole into the gingival crevicular fluid in dogs. ( Asikainen, S; Järvinen, A; Sarkiala, E; Sippola, T, 1992) |
| "Tinidazole was not detected in the GCF in three of the patients." | 1.28 | Single-dose concentrations of tinidazole in gingival crevicular fluid, serum, and gingival tissue in adults with periodontitis. ( Buchanan, N; Cvejic, M; Hayden, M; Liew, V; Mack, G; Tseng, P, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.76) | 18.7374 |
| 1990's | 6 (35.29) | 18.2507 |
| 2000's | 2 (11.76) | 29.6817 |
| 2010's | 6 (35.29) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Liang, G | 1 |
| Shi, H | 1 |
| Qi, Y | 1 |
| Li, J | 1 |
| Jing, A | 1 |
| Liu, Q | 1 |
| Feng, W | 1 |
| Li, G | 1 |
| Gao, S | 1 |
| Khan, G | 1 |
| Yadav, SK | 1 |
| Patel, RR | 1 |
| Kumar, N | 1 |
| Bansal, M | 1 |
| Mishra, B | 1 |
| Deng, N | 1 |
| Xie, L | 1 |
| Li, Y | 1 |
| Lin, H | 1 |
| Luo, R | 1 |
| Zhang, Y | 1 |
| Zhang, YM | 1 |
| Liang, P | 1 |
| Hou, XL | 1 |
| Tian, Y | 1 |
| Shen, Y | 2 |
| Jv, M | 1 |
| Nagaraju, R | 1 |
| Udupa, N | 1 |
| Mathew, J | 1 |
| Varma, BR | 2 |
| Granizo, JJ | 1 |
| Pía Rodicio, M | 1 |
| Manso, FJ | 1 |
| Giménez, MJ | 1 |
| Ju, ML | 1 |
| Wu, RR | 1 |
| Su, D | 1 |
| Luo, Y | 1 |
| Tu, JS | 1 |
| Qin, Y | 1 |
| Yuan, M | 1 |
| Li, L | 1 |
| Li, W | 1 |
| Xue, J | 1 |
| Wang, H | 1 |
| Luo, J | 1 |
| Su, W | 1 |
| He, Q | 1 |
| Huang, X | 1 |
| Nanda Kumar, K | 1 |
| Cheru, R | 1 |
| Bai, M | 1 |
| Sebastian, K | 1 |
| Sarkiala, EM | 1 |
| Asikainen, SE | 1 |
| Kanervo, A | 1 |
| Junttila, J | 1 |
| Jousimies-Somer, HR | 1 |
| Sarkiala-Kessel, EM | 1 |
| Järvinen, A | 2 |
| Nokelainen, M | 1 |
| Asikainen, S | 2 |
| Wang, R | 1 |
| Chen, L | 1 |
| Ni, K | 1 |
| Sarkiala, E | 1 |
| Sippola, T | 1 |
| Liew, V | 1 |
| Mack, G | 1 |
| Tseng, P | 1 |
| Cvejic, M | 1 |
| Hayden, M | 1 |
| Buchanan, N | 1 |
| Abo el-Fadl, KM | 1 |
| Ahmed, RA | 1 |
| el-Refai, MI | 1 |
| Abd el-All, MM | 1 |
1 review available for tinidazole and Periodontitis
| Article | Year |
|---|---|
[Tinidazole: a classical anaerobical drug with multiple potential uses nowadays].
Topics: Anaerobiosis; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Antiprotozoal Agents; Bacteria | 2009 |
2 trials available for tinidazole and Periodontitis
| Article | Year |
|---|---|
Tinidazole functionalized homogeneous electrospun chitosan/poly (ε-caprolactone) hybrid nanofiber membrane: Development, optimization and its clinical implications.
Topics: Animals; Anti-Bacterial Agents; Cell Line; Cell Survival; Chitosan; Drug Liberation; Electricity; Hu | 2017 |
[The effect of tinidazole in the treatment of adult periodontitis].
Topics: Adult; Anti-Bacterial Agents; Bacteroidaceae Infections; Female; Humans; Male; Metronidazole; Middle | 1996 |
14 other studies available for tinidazole and Periodontitis
| Article | Year |
|---|---|
Specific Anti-biofilm Activity of Carbon Quantum Dots by Destroying
Topics: Animals; Anti-Bacterial Agents; Bacterial Adhesion; Biofilms; Carbon; Escherichia coli; Gene Express | 2020 |
Oxymatrine alleviates periodontitis in rats by inhibiting inflammatory factor secretion and regulating MMPs/TIMP protein expression1.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Dental Plaque Index; Dinoprostone; Female; Gingiva; In | 2018 |
[Impacts of atovastatin and tinidazole on cardiac muscle inflammation factors of tumor necrosis factor-α, interleukin-1 and metalloproteinase-2 of experimental rabbits with atherosclerosis and periodontitis].
Topics: Animals; Atherosclerosis; Atorvastatin; Heptanoic Acids; Interleukin-1; Male; Matrix Metalloproteina | 2013 |
Synthesis, characterization and evaluation of tinidazole-loaded mPEG-PDLLA (10/90) in situ gel forming system for periodontitis treatment.
Topics: Animals; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Carriers; Gels; Gingival Crevi | 2016 |
CLINICAL EFFICACY OF BIODEGRADABLE DENTAL IMPLANTS OF TINIDAZOLE IN PERIODONTITIS.
Topics: Dental Implants; Drug Implants; Gingival Crevicular Fluid; Humans; Periodontitis; Tinidazole | 1999 |
[Preparation and in vitro and in vivo study on tinidazole in situ forming sustained-release injection].
Topics: Animals; Antitrichomonal Agents; Delayed-Action Preparations; Drug Carriers; Drug Compounding; Endot | 2011 |
Formulation and evaluation of in situ forming PLA implant containing tinidazole for the treatment of periodontitis.
Topics: Animals; Antitrichomonal Agents; Dental Implants; Dogs; Humans; Periodontitis; Polyesters; Tinidazol | 2012 |
[Study of bacteriology on local application of Tinidazole stilus in treatment for periodontitis].
Topics: Administration, Topical; Adult; Aged; Anti-Bacterial Agents; Female; Humans; Male; Metronidazole; Mi | 2001 |
Efficacy of tinidazole in the treatment of acute phases of periodontal disease. A preliminary study.
Topics: Adult; Evaluation Studies as Topic; Female; Gingival Diseases; Humans; Male; Nitroimidazoles; Perico | 1984 |
The efficacy of tinidazole in naturally occurring periodontitis in dogs: bacteriological and clinical results.
Topics: Animals; Bacteria; Colony Count, Microbial; Dental Scaling; Dog Diseases; Dogs; Female; Male; Period | 1993 |
Concentrations of tinidazole in gingival crevicular fluid and plasma in dogs after multiple dose administration.
Topics: Administration, Oral; Animals; Antitrichomonal Agents; Chromatography, High Pressure Liquid; Dog Dis | 1996 |
Penetration of tinidazole into the gingival crevicular fluid in dogs.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Dog Diseases; Dogs; Female; Gin | 1992 |
Single-dose concentrations of tinidazole in gingival crevicular fluid, serum, and gingival tissue in adults with periodontitis.
Topics: Administration, Oral; Adult; Aged; Chromatography, High Pressure Liquid; Female; Gingiva; Gingival C | 1991 |
Clinical and laboratory comparison between minocycline and tinidazole as an adjunct to local therapy in treatment of refractory periodontitis.
Topics: Adult; Combined Modality Therapy; Humans; Middle Aged; Minocycline; Nitroimidazoles; Periodontitis; | 1987 |