timosaponin-aiii and Colonic-Neoplasms

timosaponin-aiii has been researched along with Colonic-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for timosaponin-aiii and Colonic-Neoplasms

ArticleYear
The Antitumor Effect of Timosaponin A3 through c-Myc Inhibition in Colorectal Cancer Cells and Combined Treatment Effect with 5-FU or Doxorubicin.
    International journal of molecular sciences, 2022, Oct-07, Volume: 23, Issue:19

    Timosaponin A3 (TA3), extracted from the rhizome of

    Topics: Apoptosis; Caspase 3; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Colorectal Neoplasms; Doxorubicin; Fluorouracil; HCT116 Cells; Humans; Poly(ADP-ribose) Polymerase Inhibitors; Repressor Proteins; Saponins; Steroids

2022
Cytotoxic and antineoplastic activity of timosaponin A-III for human colon cancer cells.
    Journal of natural products, 2011, Apr-25, Volume: 74, Issue:4

    The potential antitumor activity of timosaponin A-III (1), a steroidal saponin from the rhizomes of Anemarrhena asphodeloides, was investigated in human colorectal cancer HCT-15 cells both in cell culture and in an in vivo murine xenograft model. Compound 1 inhibited the proliferation of cancer cells with cell-cycle arrest and induction of apoptosis. Cell-cycle arrest in the G0/G1 and G2/M phase by 1 was correlated with the down-regulation of cyclin A, cyclin B1, cyclin-dependent kinase 2 (CDK2), CDK4, proliferating cell nuclear antigen, and c-Myc. The increase of the sub-G1 peak by 1 was also closely related to the induction of apoptosis, which was evidenced by the induction of DNA fragmentation, activation of caspases, induction of cleaved poly-(ADP ribose) polymerase, and suppression of Bcl-xL and Bcl-2 expression. In an in vivo xenograft model, treatment with 1 (2 or 5 mg/kg body weight, three times/week, ip administration) for four weeks significantly suppressed tumor growth in athymic nude mice bearing HCT-15 cells, without any overt toxicity. Cell-cycle arrest and induction of apoptosis might be plausible mechanisms of actions for the observed antineoplastic activity of 1.

    Topics: Anemarrhena; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Colonic Neoplasms; Cyclin-Dependent Kinase 2; Dose-Response Relationship, Drug; Humans; Mice; Mice, Nude; Molecular Structure; Poly(ADP-ribose) Polymerases; Rhizome; Saponins; Steroids; Xenograft Model Antitumor Assays

2011