timolol has been researched along with Disease Models, Animal in 64 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (10.94) | 18.7374 |
| 1990's | 13 (20.31) | 18.2507 |
| 2000's | 16 (25.00) | 29.6817 |
| 2010's | 25 (39.06) | 24.3611 |
| 2020's | 3 (4.69) | 2.80 |
| Authors | Studies |
|---|---|
| Almirante, N; Bastia, E; Blangetti, M; Chegaev, K; Durante, M; Fruttero, R; Gasco, A; Guglielmo, S; Impagnatiello, F; Lazzarato, L; Masini, E; Rolando, B | 1 |
| Andring, JT; Bua, S; Carta, F; Ceruso, M; Filippi, L; Gratteri, P; Lanzi, C; Lomelino, CL; Masini, E; Matucci, R; McKenna, R; Nocentini, A; Pecori, R; Selleri, S; Sgambellone, S; Supuran, CT | 1 |
| Braisted, J; Dranchak, P; Earnest, TW; Gu, X; Hoon, MA; Inglese, J; Oliphant, E; Solinski, HJ | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Gupta, N; Hanna, J; Irving, H; Kim, N; Yücel, YH; Zhou, X | 1 |
| Ferrier, W; Fierro, F; Fregoso, DR; Galang, KG; Gallegos, A; Isseroff, RR; Kurzrock, EA; Ma, BW; Medina Lopez, A; Nguyen, AV; Nolta, JA; Osborn, SL; Peavy, TR; Soulika, AM; Stewart, H; Talken, L; Yang, HY; Yoon, DJ | 1 |
| Kanai, K; Kawasaki, N; Nagai, N; Nakazawa, Y; Ogata, F; Okamoto, N; Otake, H; Shimomura, Y | 1 |
| Ambati, B; Cho, YK; Shin, EY; Uehara, H | 1 |
| Chen, XY; Lei, TC; Li, YF | 1 |
| Abdel-Hafez, SM; Amr, A; Ateyya, T; Gad, HA; Hathout, RM; Khalil, N; Metwally, AA; Nasr, S; Nasser, N; Yasser, N | 1 |
| Prokosch, V; Schallenberg, M; Thanos, S | 1 |
| Bhattacharya, SS; Ghosh, A; Hegde, RR; Verma, A | 1 |
| Can, B; Cicek, FA; Toy, A; Tuncay, E; Turan, B | 1 |
| Agarwal, P; Agarwal, R; Ismail, NM; Kannan Kutty, M; Kapitonova, MY; Razali, N; Salmah Bakar, N; Smirnov, A | 1 |
| Chatziralli, IP; Demopoulos, CA; Moschos, MM; Papakonstantinou, VD; Stamatakis, G; Tsatsos, M | 1 |
| Akaishi, T; Kawazu, K; Miyawaki, N; Shimazaki, A; Tonouchi, A; Ueda, K | 1 |
| Heo, JH; Kim, HM; Kwon, J; Song, JS | 1 |
| Akaishi, T; Fuwa, M; Kawazu, K; Kirihara, T; Mano, H; Shimazaki, A; Ueda, K; Yamashita, N | 1 |
| Anirudhan, TS; Nair, AS; Parvathy, J | 1 |
| Kim, JH; Lee, NY; Park, CK; Park, HY | 1 |
| Agarwal, R; Agrawal, SS; Gupta, SK; Saxena, R; Srivastava, S | 1 |
| Díaz, F; García-Campos, J; Moreno, M; Pérez de Vargas, I; Vidal, L; Villena, A | 1 |
| Campos, JG; Díaz, F; Moreno, M; Pérez de Vargas, I; Vidal, L; Villena, A | 1 |
| Huang, P; Li, H; Liu, J; Tang, Y; Wei, R; Xu, Y; Zhang, C; Zhang, SS | 1 |
| Baudouin, C; Brignole-Baudouin, F; Liang, H; Pauly, A; Riancho, L | 1 |
| Ben-Shlomo, A; Chauhan, A; Mackay, EO; Peng, CC; Plummer, CE | 1 |
| Chen, DF; Chen, H; Cho, KS; Guo, W; Luo, G; Pang, IH; Wang, WH; Yang, Q; Yu, D | 1 |
| Brown, RE; Wong, AA | 1 |
| Ardell, JL; Girasole, AE; Hardwick, JC; Negrotto, S; Ryan, SE; Southerland, EM | 1 |
| Baratta, F; Battaglia, L; Bussano, R; Chirio, D; Gallarate, M; Peira, E; Trotta, M | 1 |
| Naskar, R; Quinto, K; Schuettauf, F; Zurakowski, D | 1 |
| Goto, W; Hara, H; Kawazu, K; Miyawaki, N; Morikawa, N; Ota, T; Otori, Y; Tano, Y | 1 |
| Abe, H; Fukuchi, T; Hashimoto, K; Matsuda, H; Seki, M; Tanaka, T; Togano, T; Ueda, J | 1 |
| de Vargas, IP; Díaz, F; García-Campos, J; Moreno, M; Parrado, C; Vidal, L; Villena, A | 1 |
| Chen, JL; Chiang, CH; Huang, SF; Yeh, MK | 1 |
| McEwan, GC; Patil, KA; Sarup, V; Sharma, SC; Thompson, C | 1 |
| Okada, Y | 1 |
| Avni, I; Barak, A; Ben-Shoshan, J; George, J; Levkovitch-Verbin, H; Luboshits, G; Rosner, M; Schwartz, S; Ziv, H | 1 |
| Agarwal, R; Agrawal, SS; Galpalli, ND; Gupta, SK; Saxena, R; Srivastava, S | 1 |
| Bartels, SP; Liu, JH; Neufeld, AH | 1 |
| Gherezghiher, T; Koss, M; March, WF; Nordquist, R | 1 |
| Catron, AC; Farber, JP; Krous, HF | 1 |
| Manfredi, A; Minicucci, G; Ricci, B; Santo, A | 1 |
| Deschenes, R; Lee, PY; Neufeld, AH; Podos, SM; Serle, JB; Wang, RF | 1 |
| Benoit, JP; Chetoni, P; Duval, O; Pech, B; Saettone, MF | 1 |
| Gallar, J; Liu, JH | 1 |
| Debon, C; Hariton, C; Percicot, CL; Schnell, CR | 1 |
| Benhamou, D; Lentschener, C; Leveque, JP; Mazoit, JX | 1 |
| Chiang, CH; Chou, PI; Lu, DW; Shang, ST | 1 |
| Schwartz, M; Wheeler, LA; Yoles, E | 1 |
| Gao, F; Gross, RL; Hensley, SH; Wu, SM | 1 |
| Maggiano, N; Ricci, B; Ricci, F | 1 |
| Abbott, M; Humphries, M; Pyne, K; Schmid, KL; Wildsoet, CF | 1 |
| Barbier, A; Elena, PP; Lacheretz, F; Le Fur, G; Maffrand, JP; Serradeil-Le Gal, C | 1 |
| Hosokawa, T; Inoue, T; Koike, H; Mori, Y; Sasaki, Y; Yanagisawa, H; Yokoyoma, T | 1 |
| Benozzi, J; Campanelli, JL; Nahum, LP; Rosenstein, RE | 1 |
| Le Douarec, JC; Plazonnet, B; Sears, ML; Silverstone, D; Stone, CA; Vareilles, P | 1 |
| Chen, YJ; Chiou, GC | 1 |
| Calogero, G; Caprilli, A; Quaranta-Leoni, FM; Ricci, B | 1 |
| Cruess, DF; Kao, SF; Kincaid, MC; Rabbani, R; Skuta, GL; Smith, DL | 1 |
| Haruta, Y; Hill, JM; Rootman, DS | 1 |
| Lathers, CM; Levin, RM; Spivey, WH | 1 |
| Andersen, KS; Grong, K; Lekven, J; Stangeland, L; Vik-Mo, H | 1 |
| Gherezghiher, T; Koss, MC; March, WF; Nordquist, RE | 1 |
64 other study(ies) available for timolol and Disease Models, Animal
| Article | Year |
|---|---|
New furoxan derivatives for the treatment of ocular hypertension.
Topics: Animals; Antihypertensive Agents; Disease Models, Animal; Glaucoma; Intraocular Pressure; Nitric Oxide; Ocular Hypertension; Oxadiazoles; Rabbits; Solubility; Timolol | 2017 |
Discovery of β-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy.
Topics: Adrenergic beta-Antagonists; Animals; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Crystallography, X-Ray; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Glaucoma; Humans; Intraocular Pressure; Male; Molecular Targeted Therapy; Rabbits; Receptors, Adrenergic, beta; Structure-Activity Relationship | 2018 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Beta-adrenergic glaucoma drugs reduce lymphatic clearance from the eye: A sequential photoacoustic imaging study.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Animals; Aqueous Humor; Disease Models, Animal; Female; Glaucoma; Intraocular Pressure; Lymphatic Vessels; Male; Mice; Photoacoustic Techniques; Timolol | 2021 |
Combination product of dermal matrix, preconditioned human mesenchymal stem cells and timolol promotes wound healing in the porcine wound model.
Topics: Animals; Disease Models, Animal; Extracellular Matrix; Humans; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Swine; Timolol; Wound Healing | 2022 |
Co-instillation of nano-solid magnesium hydroxide enhances corneal permeability of dissolved timolol.
Topics: Animals; Antihypertensive Agents; Biological Availability; Cornea; Disease Models, Animal; Glaucoma; Intraocular Pressure; Magnesium Hydroxide; Nanoparticles; Permeability; Rabbits; Rats; Timolol | 2017 |
The Effect of 0.5% Timolol Maleate on Corneal(Lymph)Angiogenesis in a Murine Suture Model.
Topics: Animals; Corneal Neovascularization; Disease Models, Animal; Female; Mice; Mice, Inbred BALB C; Ophthalmic Solutions; Sutures; Timolol | 2018 |
Inhibitory effect of timolol on topical glucocorticoid‑induced skin telangiectasia.
Topics: Administration, Topical; Adult; Animals; Antimicrobial Cationic Peptides; Cathelicidins; Dermatitis, Atopic; Dermoscopy; Disease Models, Animal; Female; Glucocorticoids; Humans; Immunosuppressive Agents; Middle Aged; Rabbits; Skin; Telangiectasis; Timolol; Tissue Kallikreins; Young Adult | 2018 |
Gelatinized core liposomes: A new Trojan horse for the development of a novel timolol maleate glaucoma medication.
Topics: Adrenergic beta-Antagonists; Animals; Chemistry, Pharmaceutical; Cornea; Delayed-Action Preparations; Disease Models, Animal; Drug Liberation; Drug Stability; Gelatin; Glaucoma; Hydrophobic and Hydrophilic Interactions; Intraocular Pressure; Liposomes; Particle Size; Rabbits; Timolol | 2019 |
Crystallins are regulated biomarkers for monitoring topical therapy of glaucomatous optic neuropathy.
Topics: Animals; Biomarkers; Crystallins; Disease Models, Animal; Drug Combinations; Gene Expression Profiling; Gene Expression Regulation; Glaucoma; Intraocular Pressure; Ophthalmic Solutions; Optic Nerve Diseases; Proteome; Proteomics; Rats; Real-Time Polymerase Chain Reaction; Retina; Retinal Ganglion Cells; Sulfonamides; Thiophenes; Timolol | 2013 |
Physicochemical and pharmacological investigation of water/oil microemulsion of non-selective beta blocker for treatment of glaucoma.
Topics: Adrenergic beta-Antagonists; Animals; Biological Availability; Colloids; Cornea; Disease Models, Animal; Drug Delivery Systems; Electric Capacitance; Emulsions; Glaucoma; Goats; Intraocular Pressure; Oils; Particle Size; Polysorbates; Rabbits; Spectroscopy, Fourier Transform Infrared; Surface-Active Agents; Timolol; Water | 2014 |
Beta-blocker timolol alleviates hyperglycemia-induced cardiac damage via inhibition of endoplasmic reticulum stress.
Topics: Adrenergic beta-Antagonists; Animals; Apoptosis; Disease Models, Animal; Endoplasmic Reticulum Stress; Heart Diseases; Hyperglycemia; Male; Oxidative Stress; Rats; Rats, Wistar; Timolol | 2014 |
Anterior and posterior segment changes in rat eyes with chronic steroid administration and their responsiveness to antiglaucoma drugs.
Topics: Animals; Antihypertensive Agents; Brimonidine Tartrate; Catalase; Dexamethasone; Disease Models, Animal; Female; Glutathione; Intraocular Pressure; Latanoprost; Male; Ocular Hypertension; Oxidative Stress; Pilocarpine; Prostaglandins F, Synthetic; Quinoxalines; Rats, Sprague-Dawley; Retina; Sulfonamides; Superoxide Dismutase; Thiophenes; Timolol | 2015 |
In Vitro Effects of Anti-Glaucomatous Eye Drops on Platelet-Activating Factor and its Metabolism.
Topics: Animals; Disease Models, Animal; Drug Combinations; Glaucoma; Intraocular Pressure; Ophthalmic Solutions; Platelet Activating Factor; Platelet Aggregation; Rabbits; Sulfonamides; Thiophenes; Timolol | 2017 |
Benefits of Tafluprost and Timolol Fixed-Dose Combination for the Treatment of Glaucoma Are Confirmed by Studies on Experimental Animal Models.
Topics: Administration, Ophthalmic; Animals; Antihypertensive Agents; Aqueous Humor; Chromatography, Liquid; Disease Models, Animal; Drug Combinations; Female; Glaucoma; Intraocular Pressure; Macaca fascicularis; Male; Ocular Hypertension; Prostaglandins F; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Timolol | 2015 |
Comparison of Cytotoxic Effects on Rabbit Corneal Endothelium between Preservative-free and Preservative-containing Dorzolamide/timolol.
Topics: Animals; Anterior Chamber; Apoptosis; Corneal Edema; Disease Models, Animal; Drug Combinations; Endothelium, Corneal; In Situ Nick-End Labeling; Ophthalmic Solutions; Rabbits; Sulfonamides; Thiophenes; Timolol | 2015 |
Advantages of Efficacy and Safety of Fixed-Dose Tafluprost/Timolol Combination Over Fixed-Dose Latanoprost/Timolol Combination.
Topics: Animals; Antihypertensive Agents; Area Under Curve; Cell Line; Chromatography, Liquid; Disease Models, Animal; Drug Combinations; Female; Glaucoma; Humans; Intraocular Pressure; Latanoprost; Macaca fascicularis; Male; Metabolic Clearance Rate; Ocular Hypertension; Prostaglandins F; Prostaglandins F, Synthetic; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Time Factors; Timolol; Treatment Outcome | 2016 |
Extended wear therapeutic contact lens fabricated from timolol imprinted carboxymethyl chitosan-g-hydroxy ethyl methacrylate-g-poly acrylamide as a onetime medication for glaucoma.
Topics: Animals; Anti-Infective Agents; Cell Line; Cell Survival; Chitosan; Contact Lenses; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Elastic Modulus; Escherichia coli; Glaucoma; Humans; Kinetics; Methacrylates; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Spectroscopy, Fourier Transform Infrared; Staphylococcus aureus; Tears; Timolol | 2016 |
Intraocular pressure lowering, change of antiapoptotic molecule expression, and neuroretinal changes by dorzolamide 2%/timolol 0.5% combination in a chronic ocular hypertension rat model.
Topics: Animals; bcl-X Protein; Cell Survival; Disease Models, Animal; Drug Combinations; Glial Fibrillary Acidic Protein; Intraocular Pressure; Male; Ocular Hypertension; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells; RNA, Messenger; Sulfonamides; Thiophenes; Timolol | 2008 |
Intraocular pressure-lowering activity of topical application of Aegle marmelos fruit extract in experimental animal models.
Topics: Administration, Topical; Aegle; Animals; Antihypertensive Agents; Disease Models, Animal; Fruit; Glaucoma; Intraocular Pressure; Ocular Hypertension; Phytotherapy; Plant Extracts; Rabbits; Timolol; Tonometry, Ocular | 2009 |
Experimental model of ocular hypertension in the rat: study of the optic nerve capillaries and action of hypotensive drugs.
Topics: Administration, Topical; Animals; Antihypertensive Agents; Capillaries; Disease Models, Animal; Glucose Transporter Type 1; Immunoenzyme Techniques; Intraocular Pressure; Latanoprost; Male; Ocular Hypertension; Optic Disk; Optic Nerve; Prostaglandins F, Synthetic; Rats; Rats, Wistar; Timolol | 2010 |
Reaction of Müller cells in an experimental rat model of increased intraocular pressure following timolol, latanoprost and brimonidine.
Topics: Animals; Antihypertensive Agents; Brimonidine Tartrate; Disease Models, Animal; Glaucoma; Glial Fibrillary Acidic Protein; Gliosis; Intraocular Pressure; Latanoprost; Male; Neuroglia; Prostaglandins F, Synthetic; Quinoxalines; Rats; Rats, Wistar; Retina; Timolol; Tonometry, Ocular | 2010 |
Efficacy of tetrandrine on lowering intraocular pressure in animal model with ocular hypertension.
Topics: Administration, Topical; Animals; Antihypertensive Agents; Benzylisoquinolines; Disease Models, Animal; Drugs, Chinese Herbal; Intraocular Pressure; Male; Ocular Hypertension; Rats; Rats, Sprague-Dawley; Timolol; Tonometry, Ocular; Treatment Outcome | 2011 |
Polyquad-preserved travoprost/timolol, benzalkonium chloride (BAK)-preserved travoprost/timolol, and latanoprost/timolol in fixed combinations: a rabbit ocular surface study.
Topics: Animals; Anti-Bacterial Agents; Antihypertensive Agents; Benzalkonium Compounds; Cell Survival; Cloprostenol; Conjunctiva; Disease Models, Animal; Drug Combinations; Epithelium, Corneal; Latanoprost; Male; Ocular Hypertension; Ophthalmic Solutions; Polymers; Preservatives, Pharmaceutical; Prostaglandins F, Synthetic; Rabbits; Timolol; Travoprost; Treatment Outcome | 2011 |
Drug delivery by contact lens in spontaneously glaucomatous dogs.
Topics: Animals; Antihypertensive Agents; Biological Availability; Contact Lenses, Hydrophilic; Disease Models, Animal; Dogs; Drug Delivery Systems; Glaucoma; Intraocular Pressure; Ophthalmic Solutions; Timolol; Vitamin E | 2012 |
Microbead-induced ocular hypertensive mouse model for screening and testing of aqueous production suppressants for glaucoma.
Topics: Animals; Antihypertensive Agents; Aqueous Humor; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Disease Models, Animal; Drug Evaluation, Preclinical; Feasibility Studies; Intraocular Pressure; Latanoprost; Mice; Mice, Inbred C57BL; Microspheres; Muscarinic Agonists; Ocular Hypertension; Optic Nerve; Pilocarpine; Prostaglandins F, Synthetic; Quinoxalines; Retinal Ganglion Cells; Sulfonamides; Thiazines; Timolol; Tomography, Optical Coherence | 2012 |
A neurobehavioral analysis of the prevention of visual impairment in the DBA/2J mouse model of glaucoma.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Aging; Animals; Behavior, Animal; Cell Count; Disease Models, Animal; Female; Glaucoma, Open-Angle; Intraocular Pressure; Male; Mice; Mice, Inbred DBA; Ophthalmic Solutions; Retinal Ganglion Cells; Superior Colliculi; Timolol; Treatment Outcome; Vision Disorders; Visual Perception; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate | 2012 |
Remodeling of intrinsic cardiac neurons: effects of β-adrenergic receptor blockade in guinea pig models of chronic heart disease.
Topics: Adrenergic Agonists; Adrenergic beta-Antagonists; Angiotensin II; Animals; Cholinergic Agents; Chronic Disease; Disease Models, Animal; Evoked Potentials; Guinea Pigs; Heart; Heart Diseases; Male; Myocardial Infarction; Neurons; Receptors, Adrenergic, beta; Timolol | 2012 |
Development of O/W nanoemulsions for ophthalmic administration of timolol.
Topics: Administration, Ophthalmic; Adrenergic beta-Antagonists; Animals; Biological Availability; Chitosan; Corneal Opacity; Disease Models, Animal; Drug Delivery Systems; Drug Stability; Emulsions; In Vitro Techniques; Nanotechnology; Rabbits; Sodium Hydroxide; Succinates; Timolol | 2013 |
Effects of anti-glaucoma medications on ganglion cell survival: the DBA/2J mouse model.
Topics: Aging; Analysis of Variance; Animals; Antihypertensive Agents; Brimonidine Tartrate; Cell Survival; Disease Models, Animal; Glaucoma; Memantine; Mice; Mice, Inbred DBA; Quinoxalines; Retinal Ganglion Cells; Timolol | 2002 |
Protective effects of timolol against the neuronal damage induced by glutamate and ischemia in the rat retina.
Topics: Action Potentials; Acute Disease; Animals; Cell Death; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Electroretinography; Excitatory Amino Acid Antagonists; Fetus; Glaucoma; Glutamic Acid; Hypoxia-Ischemia, Brain; Neuroprotective Agents; Rats; Rats, Wistar; Reperfusion Injury; Retinal Degeneration; Retinal Ganglion Cells; Timolol | 2002 |
Topically administered timolol and dorzolamide reduce intraocular pressure and protect retinal ganglion cells in a rat experimental glaucoma model.
Topics: Animals; Antihypertensive Agents; Cell Count; Cell Survival; Cytoprotection; Disease Models, Animal; Glaucoma; Intraocular Pressure; Male; Ophthalmic Solutions; Rats; Rats, Wistar; Retinal Ganglion Cells; Sulfonamides; Thiophenes; Timolol | 2005 |
Effects of a non-selective beta-blocker on adult rat anterograde axonal transport and retinal ganglion layer after increased intraocular pressure.
Topics: Adrenergic beta-Antagonists; Animals; Axonal Transport; Disease Models, Animal; Glaucoma; Intraocular Pressure; Male; Ocular Hypertension; Rats; Rats, Wistar; Retina; Retinal Ganglion Cells; Timolol | 2005 |
Physicochemical properties and in vivo assessment of timolol-loaded poly(D,L-lactide-co-glycolide) films for long-term intraocular pressure lowering effects.
Topics: Adrenergic beta-Antagonists; Animals; Aqueous Humor; Chromatography, High Pressure Liquid; Disease Models, Animal; Drug Delivery Systems; Intraocular Pressure; Male; Ocular Hypertension; Polyglactin 910; Rabbits; Solubility; Surface Properties; Tensile Strength; Time Factors; Timolol; Treatment Outcome | 2005 |
Dorzolamide and timolol saves retinal ganglion cells in glaucomatous adult rats.
Topics: Animals; Antihypertensive Agents; Cell Count; Disease Models, Animal; Drug Combinations; Female; Glaucoma; Intraocular Pressure; Pilot Projects; Rats; Rats, Wistar; Retinal Ganglion Cells; Sulfonamides; Thiophenes; Time Factors; Timolol | 2005 |
Effects of topical antiglaucoma medications on corneal epithelium as evaluated by gene expression patterns.
Topics: Animals; Antihypertensive Agents; Cyclooxygenase 2; Disease Models, Animal; Epithelium, Corneal; Gene Expression; Genes, fos; Genes, jun; Glaucoma; Immunohistochemistry; In Situ Hybridization; Male; Ophthalmic Solutions; Prostaglandins; Rats; Rats, Wistar; RNA, Messenger; Severity of Illness Index; Timolol; Transcription Factor AP-1 | 2007 |
Drug modification of angiogenesis in a rat cornea model.
Topics: Animals; Antihypertensive Agents; Brimonidine Tartrate; Corneal Neovascularization; Corneal Stroma; Disease Models, Animal; Drug Implants; Fibroblast Growth Factor 2; Latanoprost; Prostaglandins F, Synthetic; Quinoxalines; Rats; Rats, Wistar; Sulfonamides; Thiophenes; Timolol | 2008 |
Comparative efficacy of pilocarpine, timolol and latanoprost in experimental models of glaucoma.
Topics: Adrenal Cortex Hormones; Animals; Anterior Chamber; Cholinergic Agonists; Conjunctival Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Glaucoma; Instillation, Drug; Intraocular Pressure; Latanoprost; Male; Ophthalmic Solutions; Pilocarpine; Prednisolone; Prostaglandins F, Synthetic; Rabbits; Timolol; Tonometry, Ocular; Treatment Outcome | 2007 |
Effects of l- and d-timolol on cyclic AMP synthesis and intraocular pressure in water-loaded, albino and pigmented rabbits.
Topics: Animals; Cyclic AMP; Disease Models, Animal; Hemodynamics; Intraocular Pressure; Propanolamines; Rabbits; Stereoisomerism; Time Factors; Timolol; Urethane; Water Intoxication | 1983 |
Ultrastructural and pharmacologic studies on laser-induced glaucoma in primates and rabbits.
Topics: Animals; Disease Models, Animal; Epinephrine; Glaucoma; Indomethacin; Intraocular Pressure; Lasers; Macaca mulatta; Male; Rabbits; Time Factors; Timolol; Trabecular Meshwork | 1984 |
Norepinephrine-induced pulmonary petechiae in the rat: an experimental model with potential implications for sudden infant death syndrome.
Topics: Animals; Blood Pressure; Catecholamines; Disease Models, Animal; Haloperidol; Humans; Lung Diseases; Male; Norepinephrine; Phentolamine; Purpura; Rats; Sudden Infant Death; Timolol | 1984 |
Oxygen-induced retinopathy in the newborn rat: effects of hyperbarism and topical administration of timolol maleate.
Topics: Administration, Topical; Animals; Animals, Newborn; Blood Pressure; Combined Modality Therapy; Disease Models, Animal; Humans; Hyperbaric Oxygenation; Infant, Newborn; Intraocular Pressure; Ophthalmic Solutions; Oxygen; Rats; Rats, Wistar; Retinal Neovascularization; Retinal Vessels; Retinopathy of Prematurity; Timolol | 1995 |
Effects of topical ethacrynic acid ointment vs timolol on intraocular pressure in glaucomatous monkey eyes.
Topics: Administration, Topical; Animals; Disease Models, Animal; Drug Administration Schedule; Ethacrynic Acid; Evaluation Studies as Topic; Female; Glaucoma; Intraocular Pressure; Laser Therapy; Longitudinal Studies; Macaca fascicularis; Ointments; Ophthalmic Solutions; Timolol; Trabecular Meshwork | 1994 |
Preliminary evaluation of a series of amphiphilic timolol prodrugs: possible evidence for transscleral absorption.
Topics: Absorption; Animals; Cell Membrane Permeability; Cornea; Disease Models, Animal; Esters; Evaluation Studies as Topic; Intraocular Pressure; Isoproterenol; Ocular Hypertension; Pilot Projects; Prodrugs; Rabbits; Sclera; Solubility; Timolol | 1993 |
In vivo cAMP level in rabbit iris-ciliary body after topical epinephrine treatment.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Aqueous Humor; Ciliary Body; Cyclic AMP; Dinoprostone; Disease Models, Animal; Drug Therapy, Combination; Epinephrine; Glaucoma; Intraocular Pressure; Iris; Laser Coagulation; Ophthalmic Solutions; Rabbits; Radioimmunoassay; Timolol; Yohimbine | 1996 |
Continuous intraocular pressure measurement by telemetry in alpha-chymotrypsin-induced glaucoma model in the rabbit: effects of timolol, dorzolamide, and epinephrine.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Carbonic Anhydrase Inhibitors; Chymotrypsin; Circadian Rhythm; Disease Models, Animal; Epinephrine; Female; Glaucoma; Intraocular Pressure; Ophthalmic Solutions; Rabbits; Sulfonamides; Telemetry; Thiophenes; Timolol | 1996 |
The effect of pneumoperitoneum on intraocular pressure in rabbits with alpha-chymotrypsin-induced glaucoma.
Topics: Adjuvants, Anesthesia; Administration, Topical; Anesthesia, General; Animals; Antihypertensive Agents; Blood Pressure; Body Temperature; Carbon Dioxide; Central Venous Pressure; Chymotrypsin; Disease Models, Animal; Glaucoma; Head-Down Tilt; Heart Rate; Insufflation; Intraocular Pressure; Male; Ocular Hypertension; Pentobarbital; Pneumoperitoneum, Artificial; Posture; Pressure; Rabbits; Reproducibility of Results; Time Factors; Timolol; Tonometry, Ocular | 1998 |
A comparison of trabeculectomy with topically applied timolol in a rabbit ocular hypertension model.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Female; Fluorocarbons; Intraocular Pressure; Male; Ocular Hypertension; Ophthalmic Solutions; Rabbits; Timolol; Trabeculectomy; Treatment Outcome | 1998 |
Alpha2-adrenoreceptor agonists are neuroprotective in a rat model of optic nerve degeneration.
Topics: Action Potentials; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Axons; Brimonidine Tartrate; Cell Count; Cell Survival; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Nerve Degeneration; Neuroprotective Agents; Optic Nerve; Optic Nerve Diseases; Optic Nerve Injuries; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Retinal Ganglion Cells; Timolol; Yohimbine | 1999 |
Retinal ganglion cell dysfunction induced by hypoxia and glutamate: potential neuroprotective effects of beta-blockers.
Topics: Action Potentials; Adrenergic beta-Antagonists; Ambystoma; Animals; Betaxolol; Calcium Channels; Disease Models, Animal; Glutamic Acid; Hypoxia; Patch-Clamp Techniques; Photic Stimulation; Retinal Ganglion Cells; Sodium Channels; Timolol | 1999 |
Oxygen-induced retinopathy in the newborn rat: morphological and immunohistological findings in animals treated with topical timolol maleate.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Animals; Animals, Newborn; Blood Pressure; Disease Models, Animal; Endothelial Growth Factors; Humans; Immunoenzyme Techniques; Infant, Newborn; Intraocular Pressure; Lymphokines; Oxygen; Rats; Rats, Wistar; Retinopathy of Prematurity; Timolol; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
Timolol lowers intraocular pressure but does not inhibit the development of experimental myopia in chick.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Chickens; Disease Models, Animal; Intraocular Pressure; Male; Myopia; Time Factors; Timolol; Treatment Failure | 2000 |
Effect of SR121463, a selective non-peptide vasopressin V2 receptor antagonist, in a rabbit model of ocular hypertension.
Topics: Administration, Oral; Administration, Topical; Animals; Antidiuretic Hormone Receptor Antagonists; Cell Membrane; Clonidine; Disease Models, Animal; Injections, Intravenous; Intraocular Pressure; Kidney; Male; Morpholines; Ocular Hypertension; Rabbits; Receptors, Vasopressin; Safety; Spiro Compounds; Timolol | 2000 |
The effect of topical CS-088, an angiotensin AT1 receptor antagonist, on intraocular pressure and aqueous humor dynamics in rabbits.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Animals; Aqueous Humor; Chymotrypsin; Disease Models, Animal; Imidazoles; Intraocular Pressure; Male; Ocular Hypertension; Ophthalmic Solutions; Rabbits; Receptor, Angiotensin, Type 1; Tetrazoles; Timolol | 2001 |
Effect of hyaluronic acid on intraocular pressure in rats.
Topics: Animals; Anterior Chamber; Antihypertensive Agents; Brimonidine Tartrate; Disease Models, Animal; Hyaluronic Acid; Injections; Intraocular Pressure; Latanoprost; Male; Ocular Hypertension; Prostaglandins F, Synthetic; Quinoxalines; Rats; Rats, Wistar; Timolol; Tonometry, Ocular | 2002 |
Comparison of the effects of timolol and other adrenergic agents on intraocular pressure in the rabbit.
Topics: Adrenergic beta-Antagonists; Animals; Aqueous Humor; Chymotrypsin; Disease Models, Animal; Epinephrine; Intraocular Pressure; Isoproterenol; Male; Propanolamines; Propranolol; Rabbits; Sympathomimetics; Timolol; Water | 1977 |
Effects of D- and L-isomers of timolol on retinal and choroidal blood flow in ocular hypertensive rabbit eyes.
Topics: Animals; Choroid; Ciliary Body; Disease Models, Animal; Iris; Microspheres; Ocular Hypertension; Rabbits; Regional Blood Flow; Retinal Vessels; Stereoisomerism; Timolol | 1992 |
Reduced severity of oxygen-induced retinopathy in the newborn rat after topical administration of timolol maleate. A preliminary study.
Topics: Administration, Topical; Animals; Animals, Newborn; Blood Pressure; Disease Models, Animal; Fundus Oculi; Humans; Infant, Newborn; Intraocular Pressure; Oxygen; Perfusion; Rats; Rats, Inbred Strains; Retinal Diseases; Retinal Vessels; Retinopathy of Prematurity; Timolol | 1991 |
The effects of glaucoma medications on Tenon's capsule and conjunctiva in the rabbit.
Topics: Administration, Topical; Animals; Antihypertensive Agents; Conjunctiva; Disease Models, Animal; Epinephrine; Eye; Fascia; Glaucoma; Pilocarpine; Pilot Projects; Rabbits; Timolol | 1991 |
Reactivation of HSV-1 in primates by transcorneal iontophoresis of adrenergic agents.
Topics: Animals; Disease Models, Animal; Epinephrine; Hydroxydopamines; Iontophoresis; Keratitis, Dendritic; Saimiri; Simplexvirus; Sympathomimetics; Timolol; Virus Activation | 1990 |
The effect of chronic timolol in an animal model for myocardial infarction.
Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Cats; Disease Models, Animal; Electrocardiography; Heart Rate; Myocardial Infarction; Receptors, Adrenergic, beta; Timolol | 1988 |
Is reduced cardiac performance the only mechanism for myocardial infarct size reduction during beta adrenergic blockade?
Topics: Animals; Autoradiography; Cardiac Output; Cats; Clonidine; Disease Models, Animal; Heart Rate; Myocardial Infarction; Myocardium; Random Allocation; Timolol | 1986 |
Laser-induced glaucoma in rabbits.
Topics: Animals; Aqueous Humor; Colforsin; Disease Models, Animal; Glaucoma; Lasers; Ocular Hypertension; Optic Disk; Pilocarpine; Rabbits; Timolol; Trabecular Meshwork | 1986 |