tilorone has been researched along with Neoplasms in 7 studies
Tilorone: An antiviral agent used as its hydrochloride. It is the first recognized synthetic, low-molecular-weight compound that is an orally active interferon inducer, and is also reported to have antineoplastic and anti-inflammatory actions.
tilorone : A member of the class of fluoren-9-ones that is 9H-fluoren-9-one which is substituted by a 2-(diethylamino)ethoxy group at positions 2 and 7. It is an interferon inducer and a selective alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonist. Its hydrochloride salt is used as an antiviral drug.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Retrospective study of 14 cancer patients who were taking tilorone HCl orally revealed that three patients had similar ophthalmic findings accompanied by the appearance of blue halos around pinpoint light sources." | 1.26 | Keratopathy after oral administration of tilorone hydrochloride. ( Regelson, W; Weinberg, RS; Weiss, JN, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pollard, RB | 1 |
| Weiss, JN | 1 |
| Weinberg, RS | 1 |
| Regelson, W | 3 |
| Niblack, JF | 1 |
| Woods, WA | 1 |
| Palmieri, B | 1 |
| De Martin, G | 1 |
| Noera, G | 1 |
| Aspiro, AM | 1 |
3 reviews available for tilorone and Neoplasms
| Article | Year |
|---|---|
The biological activity of the synthetic polyanion, pyran copolymer (diveema, MVE, 46015) and the heterocyclic bis DEAE fluorenone derivative, tilorone and congeners: clinical and laboratory effects of these agents as modulators of host resistance.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Anticoagulants; Cell Nucleus; Cytoplasm; | 1981 |
Studies with low molecular weight inducers of interferon in man.
Topics: Animals; Clinical Trials as Topic; Common Cold; Diamines; Drug Evaluation; Female; Humans; Interfero | 1977 |
Mechanisms of action of immunopotentiating agents in cancer therapy.
Topics: Animals; Dextrans; Endotoxins; Eukaryota; Humans; Immunity; Lentinan; Levamisole; Mycobacterium bovi | 1977 |
1 trial available for tilorone and Neoplasms
| Article | Year |
|---|---|
Studies with low molecular weight inducers of interferon in man.
Topics: Animals; Clinical Trials as Topic; Common Cold; Diamines; Drug Evaluation; Female; Humans; Interfero | 1977 |
4 other studies available for tilorone and Neoplasms
| Article | Year |
|---|---|
Usages of interferon and interferon inducers in man: the second half of 1980.
Topics: Hepatitis B; Herpes Simplex; Herpesviridae Infections; Herpesvirus 4, Human; Humans; Interferon Indu | 1981 |
Keratopathy after oral administration of tilorone hydrochloride.
Topics: Adult; Conjunctiva; Cornea; Corneal Opacity; Endothelium; Female; Fluorenes; Humans; Inclusion Bodie | 1980 |
Clinical immunoadjuvant studies with tilorone, DEAA fluorene (RMI 11,002da), and Corynebacterium parvum and some observations on the role of host resistance and herpes-like lesions in tumor growth.
Topics: Adjuvants, Immunologic; Animals; Chemical Phenomena; Chemistry; Diethylamines; Fluorenes; Herpesviri | 1976 |
[Immunological surveillance and aspecific immunotherapy in neoplastic diseases].
Topics: Animals; Antibody Formation; Breast Neoplasms; Dogs; Female; Guinea Pigs; Humans; Immunotherapy; Lev | 1976 |