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tilorone and Neoplasms

tilorone has been researched along with Neoplasms in 7 studies

Tilorone: An antiviral agent used as its hydrochloride. It is the first recognized synthetic, low-molecular-weight compound that is an orally active interferon inducer, and is also reported to have antineoplastic and anti-inflammatory actions.
tilorone : A member of the class of fluoren-9-ones that is 9H-fluoren-9-one which is substituted by a 2-(diethylamino)ethoxy group at positions 2 and 7. It is an interferon inducer and a selective alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonist. Its hydrochloride salt is used as an antiviral drug.

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
"Retrospective study of 14 cancer patients who were taking tilorone HCl orally revealed that three patients had similar ophthalmic findings accompanied by the appearance of blue halos around pinpoint light sources."1.26Keratopathy after oral administration of tilorone hydrochloride. ( Regelson, W; Weinberg, RS; Weiss, JN, 1980)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19907 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Pollard, RB1
Weiss, JN1
Weinberg, RS1
Regelson, W3
Niblack, JF1
Woods, WA1
Palmieri, B1
De Martin, G1
Noera, G1
Aspiro, AM1

Reviews

3 reviews available for tilorone and Neoplasms

ArticleYear
The biological activity of the synthetic polyanion, pyran copolymer (diveema, MVE, 46015) and the heterocyclic bis DEAE fluorenone derivative, tilorone and congeners: clinical and laboratory effects of these agents as modulators of host resistance.
    Pharmacology & therapeutics, 1981, Volume: 15, Issue:1

    Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Anticoagulants; Cell Nucleus; Cytoplasm;

1981
Studies with low molecular weight inducers of interferon in man.
    Texas reports on biology and medicine, 1977, Volume: 35

    Topics: Animals; Clinical Trials as Topic; Common Cold; Diamines; Drug Evaluation; Female; Humans; Interfero

1977
Mechanisms of action of immunopotentiating agents in cancer therapy.
    Advances in pharmacology and chemotherapy, 1977, Volume: 14

    Topics: Animals; Dextrans; Endotoxins; Eukaryota; Humans; Immunity; Lentinan; Levamisole; Mycobacterium bovi

1977

Trials

1 trial available for tilorone and Neoplasms

ArticleYear
Studies with low molecular weight inducers of interferon in man.
    Texas reports on biology and medicine, 1977, Volume: 35

    Topics: Animals; Clinical Trials as Topic; Common Cold; Diamines; Drug Evaluation; Female; Humans; Interfero

1977

Other Studies

4 other studies available for tilorone and Neoplasms

ArticleYear
Usages of interferon and interferon inducers in man: the second half of 1980.
    Medical biology, 1981, Volume: 59, Issue:2

    Topics: Hepatitis B; Herpes Simplex; Herpesviridae Infections; Herpesvirus 4, Human; Humans; Interferon Indu

1981
Keratopathy after oral administration of tilorone hydrochloride.
    American journal of ophthalmology, 1980, Volume: 89, Issue:1

    Topics: Adult; Conjunctiva; Cornea; Corneal Opacity; Endothelium; Female; Fluorenes; Humans; Inclusion Bodie

1980
Clinical immunoadjuvant studies with tilorone, DEAA fluorene (RMI 11,002da), and Corynebacterium parvum and some observations on the role of host resistance and herpes-like lesions in tumor growth.
    Annals of the New York Academy of Sciences, 1976, Volume: 277, Issue:00

    Topics: Adjuvants, Immunologic; Animals; Chemical Phenomena; Chemistry; Diethylamines; Fluorenes; Herpesviri

1976
[Immunological surveillance and aspecific immunotherapy in neoplastic diseases].
    Recenti progressi in medicina, 1976, Volume: 61, Issue:6

    Topics: Animals; Antibody Formation; Breast Neoplasms; Dogs; Female; Guinea Pigs; Humans; Immunotherapy; Lev

1976