tilorone has been researched along with Mucopolysaccharidoses in 11 studies
Tilorone: An antiviral agent used as its hydrochloride. It is the first recognized synthetic, low-molecular-weight compound that is an orally active interferon inducer, and is also reported to have antineoplastic and anti-inflammatory actions.
tilorone : A member of the class of fluoren-9-ones that is 9H-fluoren-9-one which is substituted by a 2-(diethylamino)ethoxy group at positions 2 and 7. It is an interferon inducer and a selective alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonist. Its hydrochloride salt is used as an antiviral drug.
Mucopolysaccharidoses: Group of lysosomal storage diseases each caused by an inherited deficiency of an enzyme involved in the degradation of glycosaminoglycans (mucopolysaccharides). The diseases are progressive and often display a wide spectrum of clinical severity within one enzyme deficiency.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The experimental immunomodulatory agent tilorone was previously reported to induce generalized mucopolysaccharidosis (lysosomal storage of sulfated glycosaminoglycans) and lipidosis in rats." | 7.67 | Mucopolysaccharidosis and lipidosis in rats treated with tilorone analogues. ( Hein, L; Lüllmann-Rauch, R, 1989) |
| "The purpose of this study was to examine whether the aortic and mitral valves of rats are involved in the mucopolysaccharidosis-like disorder induced by tilorone." | 7.67 | Mucopolysaccharidosis-like alterations in cardiac valves of rats treated with tilorone. ( Horstmann, G; Lüllmann-Rauch, R, 1985) |
| "The dicationic amphiphilic compound tilorone was previously shown to interfere with the lysosomal degradation of sulfated glycosaminoglycans (GAGs) of cultured cells and to cause mucopolysaccharidosis-like alterations in several organs of rats." | 7.67 | Mucopolysaccharidosis-like cellular alterations in chondrocytes of rats treated with tilorone. ( Lüllmann-Rauch, R; Michel, G; Peters, A, 1988) |
| "The occurrence of lipidosis is not surprising, since by its molecular structure tilorone can be regarded as belonging to the group of amphiphilic cationic drugs which often have this side effect." | 5.27 | Tilorone-induced lysosomal storage mimicking the features of mucopolysaccharidosis and of lipidosis in rat liver. ( Lüllmann-Rauch, R, 1983) |
| "The immunostimulatory drug tilorone (2,7-bis(2- (diethylamino)ethoxy)-9H-fluorene-9-one) has previously been described to induce keratopathy in patients and in rats; in the latter, lysosomal storage of sulfated glycosaminoglycans (mucopolysaccharidosis, MPS) was found to be the reason for corneal clouding." | 3.68 | Mucopolysaccharidosis (MPS) in ocular tissues as induced by amphiphilic di-cationic drugs. ( Lüllmann-Rauch, R, 1990) |
| "The experimental immunomodulatory agent tilorone was previously reported to induce generalized mucopolysaccharidosis (lysosomal storage of sulfated glycosaminoglycans) and lipidosis in rats." | 3.67 | Mucopolysaccharidosis and lipidosis in rats treated with tilorone analogues. ( Hein, L; Lüllmann-Rauch, R, 1989) |
| "The cationic dyes Cuprolinic Blue (CB) and Toluidine Blue (TB) were used to preserve the intralysosomal storage material accumulating in tilorone-induced mucopolysaccharidosis." | 3.67 | Experimental mucopolysaccharidosis: preservation and ultrastructural visualization of intralysosomal glycosaminoglycans by use of the cationic dyes cuprolinic blue and toluidine blue. ( Lüllmann-Rauch, R, 1989) |
| "The purpose of this study was to examine whether the aortic and mitral valves of rats are involved in the mucopolysaccharidosis-like disorder induced by tilorone." | 3.67 | Mucopolysaccharidosis-like alterations in cardiac valves of rats treated with tilorone. ( Horstmann, G; Lüllmann-Rauch, R, 1985) |
| "The dicationic amphiphilic compound tilorone was previously shown to interfere with the lysosomal degradation of sulfated glycosaminoglycans (GAGs) of cultured cells and to cause mucopolysaccharidosis-like alterations in several organs of rats." | 3.67 | Mucopolysaccharidosis-like cellular alterations in chondrocytes of rats treated with tilorone. ( Lüllmann-Rauch, R; Michel, G; Peters, A, 1988) |
| " Dose-response curves were established for (a) the intracellular accumulation of 35S-GAGs and (b) the release of beta-hexosaminidase after exposure (72 hr) to tilorone (1-35 microM)." | 1.29 | Tilorone-induced lysosomal storage of sulphated glycosaminoglycans can be separated from tilorone-induced enhancement of lysosomal enzyme secretion. ( Lüllmann-Rauch, R; Pods, R; Von Witzendorff, B, 1995) |
| "The occurrence of lipidosis is not surprising, since by its molecular structure tilorone can be regarded as belonging to the group of amphiphilic cationic drugs which often have this side effect." | 1.27 | Tilorone-induced lysosomal storage mimicking the features of mucopolysaccharidosis and of lipidosis in rat liver. ( Lüllmann-Rauch, R, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (45.45) | 18.7374 |
| 1990's | 6 (54.55) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lüllmann-Rauch, R | 10 |
| Pods, R | 2 |
| Von Witzendorff, B | 2 |
| Grave, S | 1 |
| Lüllmann, H | 1 |
| Osterkamp, G | 1 |
| Prokopek, M | 2 |
| Burmester, J | 1 |
| Handrock, K | 1 |
| Hein, L | 1 |
| Horstmann, G | 1 |
| Michel, G | 1 |
| Peters, A | 1 |
11 other studies available for tilorone and Mucopolysaccharidoses
| Article | Year |
|---|---|
Tilorone-induced lysosomal storage mimicking the features of mucopolysaccharidosis and of lipidosis in rat liver.
Topics: Animals; Endothelium; Female; Fluorenes; Kupffer Cells; Lipidoses; Liver; Microscopy, Electron; Muco | 1983 |
Tilorone-induced lysosomal storage of sulphated glycosaminoglycans can be separated from tilorone-induced enhancement of lysosomal enzyme secretion.
Topics: Ammonium Chloride; Animals; beta-N-Acetylhexosaminidases; Cattle; Cells, Cultured; Chloroquine; Dose | 1995 |
The antimalarials quinacrine and chloroquine induce weak lysosomal storage of sulphated glycosaminoglycans in cell culture and in vivo.
Topics: Animals; Anti-Inflammatory Agents; Antimalarials; beta-N-Acetylhexosaminidases; Cattle; Cells, Cultu | 1996 |
Induction of mucopolysaccharidosis in rats by treatment with immunostimulatory acridine derivatives.
Topics: Acridines; Adjuvants, Immunologic; Animals; Female; Glycosaminoglycans; Liver; Lysosomes; Mucopolysa | 1992 |
The tilorone-induced mucopolysaccharidosis in rats. Biochemical investigations.
Topics: Animals; Chondroitinases and Chondroitin Lyases; Creatine; Electrophoresis; Female; Glycosaminoglyca | 1991 |
Cultured corneal fibroblasts as a model system for the demonstration of drug-induced mucopolysaccharidosis.
Topics: Animals; Cells, Cultured; Cornea; Dose-Response Relationship, Drug; Fibroblasts; Lysosomes; Male; Mu | 1990 |
Mucopolysaccharidosis (MPS) in ocular tissues as induced by amphiphilic di-cationic drugs.
Topics: Acridines; Animals; Conjunctiva; Cornea; Eye; Female; Mucopolysaccharidoses; Rats; Rats, Inbred Stra | 1990 |
Mucopolysaccharidosis and lipidosis in rats treated with tilorone analogues.
Topics: Animals; Female; Fluorenes; Lipidoses; Mucopolysaccharidoses; Rats; Rats, Inbred Strains; Structure- | 1989 |
Experimental mucopolysaccharidosis: preservation and ultrastructural visualization of intralysosomal glycosaminoglycans by use of the cationic dyes cuprolinic blue and toluidine blue.
Topics: Animals; Coloring Agents; Conjunctiva; Cornea; Female; Fixatives; Glycosaminoglycans; Indoles; Liver | 1989 |
Mucopolysaccharidosis-like alterations in cardiac valves of rats treated with tilorone.
Topics: Animals; Aortic Valve; Endocytosis; Female; Fibroblasts; Fluorenes; Histiocytes; Lysosomes; Male; Mi | 1985 |
Mucopolysaccharidosis-like cellular alterations in chondrocytes of rats treated with tilorone.
Topics: Animals; Cartilage; Female; Fluorenes; Growth Plate; Histocytochemistry; Microscopy, Electron; Mucop | 1988 |