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tilorone and Melanoma

tilorone has been researched along with Melanoma in 3 studies

Tilorone: An antiviral agent used as its hydrochloride. It is the first recognized synthetic, low-molecular-weight compound that is an orally active interferon inducer, and is also reported to have antineoplastic and anti-inflammatory actions.
tilorone : A member of the class of fluoren-9-ones that is 9H-fluoren-9-one which is substituted by a 2-(diethylamino)ethoxy group at positions 2 and 7. It is an interferon inducer and a selective alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonist. Its hydrochloride salt is used as an antiviral drug.

Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)

Research Excerpts

ExcerptRelevanceReference
"When tilorone was given 7 days after tumor inoculation, it did not show any potentiation of antitumor activity of DFMO."1.27Potentiation of antitumor and antimetastatic activities of alpha-difluoromethylornithine by interferon inducers. ( Hagan, AC; Lachmann, PJ; Mayer, GD; Prakash, NJ; Rosenberger, AL; Sunkara, PS, 1984)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19903 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sunkara, PS1
Prakash, NJ1
Rosenberger, AL1
Hagan, AC1
Lachmann, PJ1
Mayer, GD1
Turner, EV1
Wallace, JH1
Schultz, RM1
Howbert, JJ1
Archer, RA1

Other Studies

3 other studies available for tilorone and Melanoma

ArticleYear
Potentiation of antitumor and antimetastatic activities of alpha-difluoromethylornithine by interferon inducers.
    Cancer research, 1984, Volume: 44, Issue:7

    Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Drug Synergism; Eflornithine; Fluorenes; L

1984
Tilorone-mediated protection against murine B16 melanoma.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1981, Volume: 167, Issue:4

    Topics: Animals; Ascitic Fluid; Cell Division; Cell Survival; Fluorenes; Immunity, Cellular; Male; Melanoma;

1981
Potent inhibition of interleukin 1 beta-mediated human melanoma (A375.6) lysis by corticosteroids, staurosporine, and tilorone.
    Immunopharmacology and immunotoxicology, 1989, Volume: 11, Issue:2-3

    Topics: Adrenal Cortex Hormones; Alkaloids; Humans; Interleukin-1; Melanoma; Staurosporine; Tilorone; Tumor

1989