tilorone has been researched along with Malignant Melanoma in 3 studies
Tilorone: An antiviral agent used as its hydrochloride. It is the first recognized synthetic, low-molecular-weight compound that is an orally active interferon inducer, and is also reported to have antineoplastic and anti-inflammatory actions.
tilorone : A member of the class of fluoren-9-ones that is 9H-fluoren-9-one which is substituted by a 2-(diethylamino)ethoxy group at positions 2 and 7. It is an interferon inducer and a selective alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonist. Its hydrochloride salt is used as an antiviral drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| "When tilorone was given 7 days after tumor inoculation, it did not show any potentiation of antitumor activity of DFMO." | 1.27 | Potentiation of antitumor and antimetastatic activities of alpha-difluoromethylornithine by interferon inducers. ( Hagan, AC; Lachmann, PJ; Mayer, GD; Prakash, NJ; Rosenberger, AL; Sunkara, PS, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sunkara, PS | 1 |
| Prakash, NJ | 1 |
| Rosenberger, AL | 1 |
| Hagan, AC | 1 |
| Lachmann, PJ | 1 |
| Mayer, GD | 1 |
| Turner, EV | 1 |
| Wallace, JH | 1 |
| Schultz, RM | 1 |
| Howbert, JJ | 1 |
| Archer, RA | 1 |
3 other studies available for tilorone and Malignant Melanoma
| Article | Year |
|---|---|
Potentiation of antitumor and antimetastatic activities of alpha-difluoromethylornithine by interferon inducers.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Drug Synergism; Eflornithine; Fluorenes; L | 1984 |
Tilorone-mediated protection against murine B16 melanoma.
Topics: Animals; Ascitic Fluid; Cell Division; Cell Survival; Fluorenes; Immunity, Cellular; Male; Melanoma; | 1981 |
Potent inhibition of interleukin 1 beta-mediated human melanoma (A375.6) lysis by corticosteroids, staurosporine, and tilorone.
Topics: Adrenal Cortex Hormones; Alkaloids; Humans; Interleukin-1; Melanoma; Staurosporine; Tilorone; Tumor | 1989 |