tilorone has been researched along with Lipidoses in 7 studies
Tilorone: An antiviral agent used as its hydrochloride. It is the first recognized synthetic, low-molecular-weight compound that is an orally active interferon inducer, and is also reported to have antineoplastic and anti-inflammatory actions.
tilorone : A member of the class of fluoren-9-ones that is 9H-fluoren-9-one which is substituted by a 2-(diethylamino)ethoxy group at positions 2 and 7. It is an interferon inducer and a selective alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonist. Its hydrochloride salt is used as an antiviral drug.
Lipidoses: Conditions characterized by abnormal lipid deposition due to disturbance in lipid metabolism, such as hereditary diseases involving lysosomal enzymes required for lipid breakdown. They are classified either by the enzyme defect or by the type of lipid involved.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The experimental immunomodulatory agent tilorone was previously reported to induce generalized mucopolysaccharidosis (lysosomal storage of sulfated glycosaminoglycans) and lipidosis in rats." | 7.67 | Mucopolysaccharidosis and lipidosis in rats treated with tilorone analogues. ( Hein, L; Lüllmann-Rauch, R, 1989) |
| "The occurrence of lipidosis is not surprising, since by its molecular structure tilorone can be regarded as belonging to the group of amphiphilic cationic drugs which often have this side effect." | 5.27 | Tilorone-induced lysosomal storage mimicking the features of mucopolysaccharidosis and of lipidosis in rat liver. ( Lüllmann-Rauch, R, 1983) |
| "The experimental immunomodulatory agent tilorone was previously reported to induce generalized mucopolysaccharidosis (lysosomal storage of sulfated glycosaminoglycans) and lipidosis in rats." | 3.67 | Mucopolysaccharidosis and lipidosis in rats treated with tilorone analogues. ( Hein, L; Lüllmann-Rauch, R, 1989) |
| "Phospholipidosis (PLD) is a lysosomal storage disorder induced by compounds, notably cationic amphiphilic drugs, which although reversible interferes with cellular phospholipids." | 1.38 | In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets. ( Atzpodien, EA; Csato, M; Doessegger, L; Fischer, H; Lenz, B; Schmitt, G; Singer, T, 2012) |
| "Phospholipidosis is an adverse effect caused by numerous cationic amphiphilic drugs and can affect many cell types." | 1.36 | Predicting phospholipidosis using machine learning. ( Glen, RC; Lowe, R; Mitchell, JB, 2010) |
| "Tilorone caused moderate lipidosis in the ganglion cells and slight lipidosis in the pigment epithelium after 8 weeks of treatment with a stronger effect in Spontaneously-Hypertensive-Rats." | 1.31 | [Tilorone-induced functional changes in the rat retina]. ( Bredehorn, T; Duncker, GI, 2000) |
| "The occurrence of lipidosis is not surprising, since by its molecular structure tilorone can be regarded as belonging to the group of amphiphilic cationic drugs which often have this side effect." | 1.27 | Tilorone-induced lysosomal storage mimicking the features of mucopolysaccharidosis and of lipidosis in rat liver. ( Lüllmann-Rauch, R, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lowe, R | 1 |
| Glen, RC | 1 |
| Mitchell, JB | 1 |
| Fischer, H | 1 |
| Atzpodien, EA | 1 |
| Csato, M | 1 |
| Doessegger, L | 1 |
| Lenz, B | 1 |
| Schmitt, G | 1 |
| Singer, T | 1 |
| Lüllmann-Rauch, R | 3 |
| D'Amico, DJ | 1 |
| Kenyon, KR | 1 |
| Pods, R | 1 |
| von Witzendorff, B | 1 |
| Bredehorn, T | 1 |
| Duncker, GI | 1 |
| Hein, L | 1 |
7 other studies available for tilorone and Lipidoses
| Article | Year |
|---|---|
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Bio | 2010 |
In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets.
Topics: Animals; Cattle; Cells, Cultured; Computer Simulation; Cornea; Drug-Related Side Effects and Adverse | 2012 |
Tilorone-induced lysosomal storage mimicking the features of mucopolysaccharidosis and of lipidosis in rat liver.
Topics: Animals; Endothelium; Female; Fluorenes; Kupffer Cells; Lipidoses; Liver; Microscopy, Electron; Muco | 1983 |
Drug-induced lipidoses of the cornea and conjunctiva.
Topics: Amiodarone; Amodiaquine; Chloroquine; Conjunctival Diseases; Corneal Diseases; Fabry Disease; Female | 1981 |
The antimalarials quinacrine and chloroquine induce weak lysosomal storage of sulphated glycosaminoglycans in cell culture and in vivo.
Topics: Animals; Anti-Inflammatory Agents; Antimalarials; beta-N-Acetylhexosaminidases; Cattle; Cells, Cultu | 1996 |
[Tilorone-induced functional changes in the rat retina].
Topics: Animals; Electroretinography; Female; Humans; Interferon Inducers; Lipidoses; Rats; Rats, Inbred SHR | 2000 |
Mucopolysaccharidosis and lipidosis in rats treated with tilorone analogues.
Topics: Animals; Female; Fluorenes; Lipidoses; Mucopolysaccharidoses; Rats; Rats, Inbred Strains; Structure- | 1989 |