tilorone has been researched along with Disease Models, Animal in 7 studies
Tilorone: An antiviral agent used as its hydrochloride. It is the first recognized synthetic, low-molecular-weight compound that is an orally active interferon inducer, and is also reported to have antineoplastic and anti-inflammatory actions.
tilorone : A member of the class of fluoren-9-ones that is 9H-fluoren-9-one which is substituted by a 2-(diethylamino)ethoxy group at positions 2 and 7. It is an interferon inducer and a selective alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonist. Its hydrochloride salt is used as an antiviral drug.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A mouse model of encephalitis caused by herpes simplex virus was used to compare the antiviral activity of tilorone hydrochloride with that of phosphonoacetic acid." | 7.65 | Experimental encephalitis caused by herpes simplex virus: comparison of treatment with tilorone hydrochloride and phosphonoacetic acid. ( Fitzwilliam, JF; Griffith, JF, 1976) |
| "Inhibition of experimental tumor metastasis was dose-dependent and was observed when animals were treated the day before or the day after tumor-cell injection." | 5.29 | Generation and control of metastasis in experimental tumor systems; inhibition of experimental metastases by a tilorone analogue. ( Algarra, I; Gaforio, JJ; Garrido, F; Höglund, P; Ljunggren, HG; Pérez, M, 1993) |
| "A mouse model of encephalitis caused by herpes simplex virus was used to compare the antiviral activity of tilorone hydrochloride with that of phosphonoacetic acid." | 3.65 | Experimental encephalitis caused by herpes simplex virus: comparison of treatment with tilorone hydrochloride and phosphonoacetic acid. ( Fitzwilliam, JF; Griffith, JF, 1976) |
| "Inhibition of experimental tumor metastasis was dose-dependent and was observed when animals were treated the day before or the day after tumor-cell injection." | 1.29 | Generation and control of metastasis in experimental tumor systems; inhibition of experimental metastases by a tilorone analogue. ( Algarra, I; Gaforio, JJ; Garrido, F; Höglund, P; Ljunggren, HG; Pérez, M, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (57.14) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Lane, TR | 1 |
| Comer, JE | 1 |
| Freiberg, AN | 1 |
| Madrid, PB | 1 |
| Ekins, S | 1 |
| Grappel, SF | 1 |
| Polansky, MJ | 1 |
| Actor, P | 1 |
| Algarra, I | 1 |
| Pérez, M | 1 |
| Höglund, P | 1 |
| Gaforio, JJ | 1 |
| Ljunggren, HG | 1 |
| Garrido, F | 1 |
| Vargin, VV | 1 |
| Zschiesche, W | 1 |
| Semenov, BF | 1 |
| Fitzwilliam, JF | 1 |
| Griffith, JF | 1 |
| Arrigoni-Martelli, E | 1 |
| Bramm, E | 1 |
7 other studies available for tilorone and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Repurposing Quinacrine against Ebola Virus Infection
Topics: Animals; Antimalarials; Antiviral Agents; Caco-2 Cells; Chlorocebus aethiops; Disease Models, Animal | 2019 |
Effect of interferon inducers and purified mouse interferon on the susceptibility of mice to infection with Listeria monocytogenes.
Topics: Animals; Disease Models, Animal; Disease Susceptibility; Interferon Inducers; Interferons; Listeria | 1983 |
Generation and control of metastasis in experimental tumor systems; inhibition of experimental metastases by a tilorone analogue.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; G(M1) Gang | 1993 |
Effects of tilorone hydrochloride on experimental flavivirus infections in mice.
Topics: Animals; Antibodies, Viral; Arbovirus Infections; Cyclophosphamide; Dengue Virus; Disease Models, An | 1977 |
Experimental encephalitis caused by herpes simplex virus: comparison of treatment with tilorone hydrochloride and phosphonoacetic acid.
Topics: Acetates; Animals; Animals, Newborn; Antiviral Agents; Disease Models, Animal; Drug Therapy, Combina | 1976 |
Development of models for penicillamine-like drugs.
Topics: Animals; Arthritis, Rheumatoid; Disease Models, Animal; Levamisole; Penicillamine; Pertussis Vaccine | 1976 |