tilorone has been researched along with 2019 Novel Coronavirus Disease in 6 studies
Tilorone: An antiviral agent used as its hydrochloride. It is the first recognized synthetic, low-molecular-weight compound that is an orally active interferon inducer, and is also reported to have antineoplastic and anti-inflammatory actions.
tilorone : A member of the class of fluoren-9-ones that is 9H-fluoren-9-one which is substituted by a 2-(diethylamino)ethoxy group at positions 2 and 7. It is an interferon inducer and a selective alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonist. Its hydrochloride salt is used as an antiviral drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tilorone has been long neglected by the west in many respects but it deserves further reassessment in light of current and future needs for broad-spectrum antivirals." | 1.56 | Tilorone: a Broad-Spectrum Antiviral Invented in the USA and Commercialized in Russia and beyond. ( Ekins, S; Lane, TR; Madrid, PB, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 6 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jeon, S | 1 |
| Ko, M | 1 |
| Lee, J | 1 |
| Choi, I | 1 |
| Byun, SY | 1 |
| Park, S | 1 |
| Shum, D | 1 |
| Kim, S | 1 |
| Ahamad, S | 1 |
| Branch, S | 1 |
| Harrelson, S | 1 |
| Hussain, MK | 1 |
| Saquib, M | 1 |
| Khan, S | 1 |
| Puhl, AC | 1 |
| Lane, TR | 2 |
| Ekins, S | 2 |
| Zhurinov, MZ | 1 |
| Miftakhova, AF | 1 |
| Keyer, V | 1 |
| Shulgau, ZT | 1 |
| Solodova, EV | 1 |
| Kalykberdiyev, MK | 1 |
| Abilmagzhanov, AZ | 1 |
| Talgatov, ET | 1 |
| Ait, S | 1 |
| Shustov, AV | 1 |
| Diesendorf, V | 1 |
| Roll, V | 1 |
| Geiger, N | 1 |
| Fähr, S | 1 |
| Obernolte, H | 1 |
| Sewald, K | 1 |
| Bodem, J | 1 |
| Madrid, PB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Silver Nanoparticles as an Oropharyngeal Product (Mouthwash) and Nasal Hygiene, by Health Personnel Working at the Tijuana General Hospital Exposed to Patients Diagnosed With Atypical Pneumonia Caused by SARS-CoV-2[NCT04894409] | 231 participants (Actual) | Interventional | 2020-04-24 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for tilorone and 2019 Novel Coronavirus Disease
| Article | Year |
|---|---|
Primed for global coronavirus pandemic: Emerging research and clinical outcome.
Topics: Antiviral Agents; Clinical Trials as Topic; COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Dr | 2021 |
5 other studies available for tilorone and 2019 Novel Coronavirus Disease
| Article | Year |
|---|---|
Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs.
Topics: Animals; Anti-Inflammatory Agents; Antiviral Agents; Betacoronavirus; Cell Line; Chlorocebus aethiop | 2020 |
Learning from COVID-19: How drug hunters can prepare for the next pandemic.
Topics: Antiviral Agents; COVID-19; Drug Repositioning; Humans; Pandemics; SARS-CoV-2; Tilorone | 2023 |
Topics: Animals; Antiviral Agents; COVID-19; Glycyrrhiza; Plant Extracts; SARS-CoV-2; Tilorone | 2023 |
Drug-induced phospholipidosis is not correlated with the inhibition of SARS-CoV-2 - inhibition of SARS-CoV-2 is cell line-specific.
Topics: Antiviral Agents; Cell Line; Chloroquine; COVID-19; Fluoxetine; Humans; SARS-CoV-2; Tilorone | 2023 |
Tilorone: a Broad-Spectrum Antiviral Invented in the USA and Commercialized in Russia and beyond.
Topics: Animals; Antiviral Agents; Betacoronavirus; Chikungunya virus; Coronavirus Infections; COVID-19; COV | 2020 |