tiliroside and Diabetes-Mellitus--Type-2

A series of new tiliroside derivatives were synthesized and characterized by analytical (1)H NMR, (13)C NMR and mass spectrometry. All of the compounds were evaluated for anti-diabetic properties in vitro using HepG2 cells. Compounds 3c, 3d, and 3i-l caused significant enhancements in glucose consumption by insulin-resistant HepG2 cells compared with control cells and cells that were exposed to metformin (an anti-diabetic drug). Moreover, compound 3l significantly activated adenosine 5'-monophosphate-activated protein kinase activity and reduced acetyl-CoA carboxylase activity. Thus, the tiliroside derivative 3l offers potential to be developed as a new approach for treating type II diabetes.

Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Diabetes Mellitus, Type 2; Enzyme Activation; Flavonoids; Glucose; Hep G2 Cells; Humans; Hypoglycemic Agents; Plant Extracts; Potentilla