tiliacorinine and Tuberculosis--Multidrug-Resistant

tiliacorinine has been researched along with Tuberculosis--Multidrug-Resistant* in 1 studies

Other Studies

1 other study(ies) available for tiliacorinine and Tuberculosis--Multidrug-Resistant

Article	Year
Antimycobacterial activity of bisbenzylisoquinoline alkaloids from Tiliacora triandra against multidrug-resistant isolates of Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters, 2012, Apr-15, Volume: 22, Issue:8 Bisbenzylisoquinoline alkaloids, tiliacorinine (1), 2'-nortiliacorinine (2), and tiliacorine (3), isolated from the edible plant, Tiliacora triandra, as well as a synthetic derivative, 13'-bromo-tiliacorinine (4), were tested against 59 clinical isolates of multidrug-resistant Mycobacterium tuberculosis (MDR-MTB). The alkaloids 1-4 showed MIC values ranging from 0.7 to 6.2 μg/ml, but they exhibited the MIC value at 3.1 μg/ml against most MDR-MTB isolates. The present work suggests that bisbenzylisoquinoline alkaloids are potential new chemical scaffolds for antimycobacterial activity. Topics: Alkaloids; Antitubercular Agents; Benzylisoquinolines; Drug Resistance, Multiple, Bacterial; Humans; Magnetic Resonance Spectroscopy; Menispermaceae; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Plant Extracts; Plant Roots; Tuberculosis, Multidrug-Resistant	2012

Article

Year

Antimycobacterial activity of bisbenzylisoquinoline alkaloids from Tiliacora triandra against multidrug-resistant isolates of Mycobacterium tuberculosis.

Bioorganic & medicinal chemistry letters, 2012, Apr-15, Volume: 22, Issue:8

Bisbenzylisoquinoline alkaloids, tiliacorinine (1), 2'-nortiliacorinine (2), and tiliacorine (3), isolated from the edible plant, Tiliacora triandra, as well as a synthetic derivative, 13'-bromo-tiliacorinine (4), were tested against 59 clinical isolates of multidrug-resistant Mycobacterium tuberculosis (MDR-MTB). The alkaloids 1-4 showed MIC values ranging from 0.7 to 6.2 μg/ml, but they exhibited the MIC value at 3.1 μg/ml against most MDR-MTB isolates. The present work suggests that bisbenzylisoquinoline alkaloids are potential new chemical scaffolds for antimycobacterial activity.

Topics: Alkaloids; Antitubercular Agents; Benzylisoquinolines; Drug Resistance, Multiple, Bacterial; Humans; Magnetic Resonance Spectroscopy; Menispermaceae; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Plant Extracts; Plant Roots; Tuberculosis, Multidrug-Resistant

2012