ticlopidine has been researched along with Wounds and Injuries in 12 studies
Ticlopidine: An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
ticlopidine : A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.
Wounds and Injuries: Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study sought to determine if trauma patients on preinjury clopidogrel with a higher degree of platelet inhibition (PI), as determined by the VerifyNow P2Y12 Test, experienced bleeding complications more frequently than did patients with a lower degree of PI." | 7.79 | Effect of platelet inhibition on bleeding complications in trauma patients on preinjury clopidogrel. ( Ali, K; Cheng, J; Kram, B; Short, S; Taylor, S; Vasquez, D, 2013) |
| "This study indicates that the preinjury use of clopidogrel may cause significant morbidity in patients with closed-head injuries." | 7.73 | The effects of preinjury clopidogrel use on older trauma patients with head injuries. ( Dunn, EL; Jones, K; Mangram, AJ; Sharp, C, 2006) |
| " This study sought to determine if trauma patients on preinjury clopidogrel with a higher degree of platelet inhibition (PI), as determined by the VerifyNow P2Y12 Test, experienced bleeding complications more frequently than did patients with a lower degree of PI." | 3.79 | Effect of platelet inhibition on bleeding complications in trauma patients on preinjury clopidogrel. ( Ali, K; Cheng, J; Kram, B; Short, S; Taylor, S; Vasquez, D, 2013) |
| "This study indicates that the preinjury use of clopidogrel may cause significant morbidity in patients with closed-head injuries." | 3.73 | The effects of preinjury clopidogrel use on older trauma patients with head injuries. ( Dunn, EL; Jones, K; Mangram, AJ; Sharp, C, 2006) |
| "The number of anticoagulated trauma patients is increasing." | 1.46 | Novel oral anticoagulants and trauma: The results of a prospective American Association for the Surgery of Trauma Multi-Institutional Trial. ( Barmparas, G; Bosarge, P; Brown, CV; Bukur, M; Carrick, MM; Catalano, RD; Coimbra, R; Holly-Nicolas, J; Inaba, K; Kaminski, S; Klein, AL; Kobayashi, L; Kopelman, T; Ley, EJ; Martinez, EM; Moore, FO; Murry, J; Nirula, R; Paul, D; Quick, J; Rivera, O; Schreiber, M, 2017) |
| "An increasing proportion of trauma patients are on anticoagulation or antiplatelet therapy." | 1.37 | A new clopidogrel (Plavix) point-of-care assay: rapid determination of antiplatelet activity in trauma patients. ( Bansal, V; Coimbra, R; Doucet, J; Fortlage, D; Lee, J; Potenza, B, 2011) |
| "Dorsal 1 cm2 skin wounds were excised on genetically diabetic 8-week to 12-week-old, Lep/r-db/db male mice, and wound healing kinetics were determined." | 1.37 | Poly-N-acetyl glucosamine fibers induce angiogenesis in ADP inhibitor-treated diabetic mice. ( Demcheva, M; Fischer, TH; Gennaoui, A; Matthews, JC; Orgill, DP; Pietramaggiori, G; Scherer, SS; Valeri, CR, 2011) |
| "A total of 3,436 trauma patients were identified, of whom 456 were taking anticoagulants (warfarin, n = 91 patients; aspirin, n = 228; clopidogrel, n = 43; and various combinations, n = 94)." | 1.37 | Impact of preinjury warfarin and antiplatelet agents on outcomes of trauma patients. ( Arnold-Lloyd, T; Ata, A; Bonville, DJ; Jahraus, CB; Rosati, C; Salem, L; Stain, SC, 2011) |
| "We report on a severely injured trauma patient who suffered a high velocity motorcycle accident." | 1.36 | High-dose fibrinogen concentrate for haemostatic therapy of a major trauma patient with recent clopidogrel and aspirin intake. ( Hanke, A; Posch, A; Schöchl, H; Solomon, C; Voelckel, W, 2010) |
| "The prognosis of traumatic dissection of the internal carotid artery is worse than for spontaneous dissections." | 1.33 | Endovascular stent-assisted angioplasty in the management of traumatic internal carotid artery dissections. ( Ben-Hur, T; Cohen, JE; Gomori, JM; Rajz, G; Umansky, F, 2005) |
| "Ticlopidine (200 mg/kg) was also effective (71% inhibition; P < ." | 1.29 | Inhibitory effect of clopidogrel on platelet adhesion and intimal proliferation after arterial injury in rabbits. ( Defreyn, G; Herbert, JM; Maffrand, JP; Tissinier, A, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 8 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kobayashi, L | 1 |
| Barmparas, G | 1 |
| Bosarge, P | 1 |
| Brown, CV | 1 |
| Bukur, M | 1 |
| Carrick, MM | 1 |
| Catalano, RD | 1 |
| Holly-Nicolas, J | 1 |
| Inaba, K | 1 |
| Kaminski, S | 1 |
| Klein, AL | 1 |
| Kopelman, T | 1 |
| Ley, EJ | 1 |
| Martinez, EM | 1 |
| Moore, FO | 1 |
| Murry, J | 1 |
| Nirula, R | 1 |
| Paul, D | 1 |
| Quick, J | 1 |
| Rivera, O | 1 |
| Schreiber, M | 1 |
| Coimbra, R | 2 |
| Taylor, G | 1 |
| Osinski, D | 1 |
| Thevenin, A | 1 |
| Devys, JM | 1 |
| Short, S | 1 |
| Kram, B | 1 |
| Taylor, S | 1 |
| Cheng, J | 1 |
| Ali, K | 1 |
| Vasquez, D | 1 |
| Coleman, J | 1 |
| Baldawi, M | 1 |
| Heidt, D | 1 |
| Schöchl, H | 1 |
| Posch, A | 1 |
| Hanke, A | 1 |
| Voelckel, W | 1 |
| Solomon, C | 1 |
| Bansal, V | 1 |
| Fortlage, D | 1 |
| Lee, J | 1 |
| Doucet, J | 1 |
| Potenza, B | 1 |
| Scherer, SS | 1 |
| Pietramaggiori, G | 1 |
| Matthews, JC | 1 |
| Gennaoui, A | 1 |
| Demcheva, M | 1 |
| Fischer, TH | 1 |
| Valeri, CR | 1 |
| Orgill, DP | 1 |
| Bonville, DJ | 1 |
| Ata, A | 1 |
| Jahraus, CB | 1 |
| Arnold-Lloyd, T | 1 |
| Salem, L | 1 |
| Rosati, C | 1 |
| Stain, SC | 1 |
| Cohen, JE | 1 |
| Ben-Hur, T | 1 |
| Rajz, G | 1 |
| Umansky, F | 1 |
| Gomori, JM | 1 |
| Jones, K | 1 |
| Sharp, C | 1 |
| Mangram, AJ | 1 |
| Dunn, EL | 1 |
| Tu, X | 1 |
| Chen, X | 1 |
| Xie, Y | 1 |
| Shi, S | 1 |
| Wang, J | 1 |
| Chen, Y | 1 |
| Li, J | 1 |
| Herbert, JM | 1 |
| Tissinier, A | 1 |
| Defreyn, G | 1 |
| Maffrand, JP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Haemocomplettan® P in Patients Experiencing Acute Bleeding While Undergoing Aortic Replacement Surgery[NCT00701142] | Phase 2 | 80 participants (Actual) | Interventional | 2008-06-30 | Completed | ||
| Clopidogrel After Surgery for Coronary Artery Disease (CASCADE Trial): Does Clopidogrel Prevent Saphenous Vein Graft Disease After Coronary Bypass?[NCT00228423] | Phase 2 | 113 participants (Actual) | Interventional | 2006-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00228423)
Timeframe: 1 year
| Intervention | Participants (Count of Participants) |
|---|---|
| 75mg Clopidogrel | 4 |
| Placebo | 5 |
(NCT00228423)
Timeframe: 1 year
| Intervention | Participants (Count of Participants) |
|---|---|
| 75mg Clopidogrel | 1 |
| Placebo | 0 |
Postoperative angiogram 12 months post-CABG (NCT00228423)
Timeframe: One year following surgery
| Intervention | percentage (Number) |
|---|---|
| 75mg Clopidogrel | 94.3 |
| Placebo | 93.2 |
IVUS imaging 12 months post-CABG, and the average intimal area in the proximal 40 mm of one vein graft per patient will be assessed (NCT00228423)
Timeframe: One year following surgery
| Intervention | mm (Mean) |
|---|---|
| 75mg Clopidogrel | 4.1 |
| Placebo | 4.5 |
12 other studies available for ticlopidine and Wounds and Injuries
| Article | Year |
|---|---|
Novel oral anticoagulants and trauma: The results of a prospective American Association for the Surgery of Trauma Multi-Institutional Trial.
Topics: Administration, Oral; Aged; Anticoagulants; Aspirin; Clopidogrel; Dabigatran; Female; Humans; Injury | 2017 |
Is platelet transfusion efficient to restore platelet reactivity in patients who are responders to aspirin and/or clopidogrel before emergency surgery?
Topics: Aspirin; Blood Platelets; Clopidogrel; Hemorrhage; Humans; Platelet Aggregation; Platelet Aggregatio | 2013 |
Effect of platelet inhibition on bleeding complications in trauma patients on preinjury clopidogrel.
Topics: Adult; Blood Platelets; Clopidogrel; Female; Hemorrhage; Humans; Male; Platelet Aggregation Inhibito | 2013 |
The effect anticoagulation status on geriatric fall trauma patients.
Topics: Accidental Falls; Age Factors; Aged; Aged, 80 and over; Anticoagulants; Clopidogrel; Critical Care; | 2016 |
High-dose fibrinogen concentrate for haemostatic therapy of a major trauma patient with recent clopidogrel and aspirin intake.
Topics: Aspirin; Clopidogrel; Drug Interactions; Fibrinogen; Glasgow Coma Scale; Hemorrhage; Hemostatics; Hu | 2010 |
A new clopidogrel (Plavix) point-of-care assay: rapid determination of antiplatelet activity in trauma patients.
Topics: Aged; Clopidogrel; Female; Hemorrhage; Humans; Injury Severity Score; Male; Platelet Aggregation Inh | 2011 |
Poly-N-acetyl glucosamine fibers induce angiogenesis in ADP inhibitor-treated diabetic mice.
Topics: Acetylglucosamine; Animals; Clopidogrel; Diabetes Complications; Male; Mice; Mice, Inbred C57BL; Nan | 2011 |
Impact of preinjury warfarin and antiplatelet agents on outcomes of trauma patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Child; Child, Preschool; Clopid | 2011 |
Endovascular stent-assisted angioplasty in the management of traumatic internal carotid artery dissections.
Topics: Adult; Angiography; Angioplasty; Anticoagulants; Aspirin; Blood Platelets; Blood Vessel Prosthesis I | 2005 |
The effects of preinjury clopidogrel use on older trauma patients with head injuries.
Topics: Accidental Falls; Accidents, Traffic; Age Factors; Aged; Clopidogrel; Craniocerebral Trauma; Female; | 2006 |
Anti-inflammatory renoprotective effect of clopidogrel and irbesartan in chronic renal injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Biphenyl Compounds; Blood | 2008 |
Inhibitory effect of clopidogrel on platelet adhesion and intimal proliferation after arterial injury in rabbits.
Topics: Air; Animals; Arteries; Cell Division; Clopidogrel; Extracellular Matrix; Male; Microscopy, Electron | 1993 |