Page last updated: 2024-11-05

ticlopidine and Thrombophilia

ticlopidine has been researched along with Thrombophilia in 37 studies

Ticlopidine: An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
ticlopidine : A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.

Thrombophilia: A disorder of HEMOSTASIS in which there is a tendency for the occurrence of THROMBOSIS.

Research Excerpts

ExcerptRelevanceReference
" We tested the hypothesis that combined pre-treatment with aspirin and clopidogrel is a risk factor for thrombolysis-related symptomatic intracerebral hemorrhage (sICH)."7.75Combined anti-platelet therapy with aspirin and clopidogrel: risk factor for thrombolysis-related intracerebral hemorrhage in acute ischemic stroke? ( Dzialowski, I; Gahn, G; Hermann, A; Koch, R, 2009)
"Hypercoagulability was seen 5 days after OPCAB and could not be demonstrated after 1 month."6.73Hypercoagulability and platelet inhibition after OPCAB. Randomized intervention with clopidogrel. ( Bochsen, L; Nielsen, AB; Steinbrüchel, DA, 2007)
"Stasis ulcers are commonly the result of chronic venous insufficiency."5.31Stasis ulcers refractory to therapy--accelerated healing by treatment with clopidogrel +/- dalteparin: a preliminary report. ( Bick, RL; Scott, RG, 2001)
"A total of 55 patients with a history of thrombosis and SPS phenotype were prospectively studied before and after treatment with aspirin and/or clopidogrel."5.20Primary thrombophilia in México X: a prospective study of the treatment of the sticky platelet syndrome. ( García-Chavez, J; Hernández-Reyes, J; Rosales-Padrón, J; Ruiz-Arguelles, A; Ruiz-Argüelles, GJ; Ruiz-Delgado, GJ; Vargas-Espinosa, J; Velázquez-Sánchez-de-Cima, S; Zamora-Ortiz, G, 2015)
" We tested the hypothesis that combined pre-treatment with aspirin and clopidogrel is a risk factor for thrombolysis-related symptomatic intracerebral hemorrhage (sICH)."3.75Combined anti-platelet therapy with aspirin and clopidogrel: risk factor for thrombolysis-related intracerebral hemorrhage in acute ischemic stroke? ( Dzialowski, I; Gahn, G; Hermann, A; Koch, R, 2009)
"TEG-Hypercoagulability is defined as a TEG maximum amplitude above 69 mm."2.77Thrombelastographic haemostatic status and antiplatelet therapy after coronary artery bypass surgery (TEG-CABG trial): assessing and monitoring the antithrombotic effect of clopidogrel and aspirin versus aspirin alone in hypercoagulable patients: study pr ( Johansson, PI; Kofoed, K; Lilleør, NB; Rafiq, S; Steinbrüchel, DA; Stissing, T; Zacho, M, 2012)
"Hypercoagulability was seen 5 days after OPCAB and could not be demonstrated after 1 month."2.73Hypercoagulability and platelet inhibition after OPCAB. Randomized intervention with clopidogrel. ( Bochsen, L; Nielsen, AB; Steinbrüchel, DA, 2007)
"Eptifibatide was administered as two 180 microg/kg boluses 10 minutes apart followed by a continuous infusion of 2."2.70Activated clotting times in the setting of eptifibatide use during percutaneous coronary intervention. ( Ball, SA; Dauerman, HL; Desourdy, MA; Furman, MI; Goldberg, RJ, 2002)
" In order to achieve the desired results and, as with all medications, PPIs should always be used appropriately taking care never to exceed correct dosage and duration."2.47Proton pump inhibitors in rheumatic diseases: clinical practice, drug interactions, bone fractures and risk of infections. ( Ferraccioli, GF; Gremese, E; Laria, A; Zoli, A, 2011)
"Stasis ulcers are commonly the result of chronic venous insufficiency."1.31Stasis ulcers refractory to therapy--accelerated healing by treatment with clopidogrel +/- dalteparin: a preliminary report. ( Bick, RL; Scott, RG, 2001)

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (5.41)18.2507
2000's20 (54.05)29.6817
2010's15 (40.54)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Adeeb, N1
Gupta, R1
Schneider, AM1
Leadon, M1
Enriquez, A1
Griessenauer, CJ1
Salem, M1
Alturki, A1
Schmalz, P1
Ogilvy, CS1
Thomas, AJ1
Moore, JM1
Wernly, B1
Lichtenauer, M1
Hoppe, UC1
Lauten, A1
Navarese, EP1
Jung, C1
Zhao, X1
Wu, H1
Xu, H1
Shen, L1
Fan, B1
Ge, J1
Velázquez-Sánchez-de-Cima, S1
Zamora-Ortiz, G1
Hernández-Reyes, J1
Vargas-Espinosa, J1
García-Chavez, J1
Rosales-Padrón, J1
Ruiz-Delgado, GJ1
Ruiz-Arguelles, A1
Ruiz-Argüelles, GJ1
Glenn, JR1
Dovlatova, N1
White, AE1
Dhillon, K1
Heptinstall, S1
Fox, SC1
Blann, AD1
Skjøth, F1
Rasmussen, LH1
Larsen, TB1
Lip, GY2
Siasos, G1
Oikonomou, E1
Zaromitidou, M1
Kioufis, S1
Kokkou, E1
Mourouzis, K1
Vlasis, K1
Vavuranakis, M1
Stone, PH1
Papavassiliou, AG1
Tousoulis, D1
Smilowitz, NR1
Berger, JS1
Wang, L1
Bi, Y1
Cao, M1
Ma, R1
Wu, X1
Zhang, Y2
Ding, W1
Liu, Y1
Yu, Q1
Jiang, H1
Sun, Y1
Tong, D1
Guo, L1
Dong, Z1
Tian, Y1
Kou, J1
Shi, J1
Damanti, S1
Artoni, A1
Lucchi, T1
Mannucci, PM1
Mari, D1
Bergamaschini, L1
Lee, R1
Hermann, A1
Dzialowski, I1
Koch, R1
Gahn, G1
Healey, JS1
Apostolakis, S1
Shantsila, E1
Lane, DA1
Albanese, A1
Esposito, G1
Puca, A1
Tuttolomondo, A1
Tirpakova, B1
Di Giuda, D1
Maira, G1
Di Lazzaro, V1
Kozuma, K1
Ota, Y1
Nagai, Y1
Katsuta, Y1
Nozaki, E1
Onodera, T1
Ikari, Y1
Kotani, J1
Kyo, E1
Yokoi, H1
Nakamura, M1
Laria, A1
Zoli, A1
Gremese, E1
Ferraccioli, GF1
Cardona, L1
Ana, G1
Luísa, B1
Leal, A1
António, F1
Lídia, S1
Cruz, FR1
Rafiq, S1
Johansson, PI1
Zacho, M1
Stissing, T1
Kofoed, K1
Lilleør, NB1
Steinbrüchel, DA2
Dauerman, HL1
Ball, SA1
Goldberg, RJ1
Desourdy, MA1
Furman, MI1
Bick, RL2
Alfar, H1
Goedecke, C1
Tsakiris, DA1
Brener, SJ1
Moliterno, DJ1
Lincoff, AM1
Steinhubl, SR1
Wolski, KE1
Topol, EJ1
Perneby, C1
Wallén, NH1
Hu, H1
Li, N1
Hjemdahl, P1
Leopold, JA1
Antman, EM1
Savi, P1
Herbert, JM1
Sick, PB1
Brosteanu, O1
Ulrich, M1
Thiele, H1
Niebauer, J1
Busch, I1
Schuler, G1
Di Nisio, M1
Bijsterveld, NR1
Meijers, JC1
Levi, M1
Büller, HR1
Peters, RJ1
Wallaschofski, H1
Lohmann, T1
Hild, E1
Kobsar, A1
Siegemund, A1
Spilcke-Liss, E1
Hentschel, B1
Stumpf, C1
Daniel, WG1
Garlichs, CD1
Eigenthaler, M1
Potapov, EV1
Hetzer, R1
Nielsen, AB1
Bochsen, L1
Linnemann, B1
Schwonberg, J1
Mani, H1
Prochnow, S1
Lindhoff-Last, E1
Landolfi, R1
Di Gennaro, L1
Ikeda, Y1
Holm, J1
Hillarp, A1
Erhardt, L1
Berntorp, E1
Scott, RG1
Undas, A1
Bazan-Socha, S1
Swadzba, J1
Musial, J1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Remote Ischemic Preconditioning on Myocardial Injury After Noncardiac Surgery in Patients at a High Risk of Cardiac Events[NCT05733208]766 participants (Anticipated)Interventional2023-05-06Recruiting
ThrombElastoGraphic Haemostatic Status and Antiplatelet Therapy After Coronary Artery Bypass Graft Surgery(TEG-CABG Trial):Does Intensified Postoperative Antiplatelet Therapy in Preoperatively Identified Hypercoagulable Patients Improve Outcome After CABG[NCT01046942]Phase 3250 participants (Anticipated)Interventional2008-11-30Recruiting
[NCT00000614]Phase 30 participants Interventional1998-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for ticlopidine and Thrombophilia

ArticleYear
Triple therapy: worth the risk?
    Minerva medica, 2018, Volume: 109, Issue:5

    Topics: Anticoagulants; Aspirin; Clopidogrel; Drug Synergism; Drug Therapy, Combination; Factor Xa Inhibitor

2018
Edoxaban versus placebo, aspirin, or aspirin plus clopidogrel for stroke prevention in atrial fibrillation. An indirect comparison analysis.
    Thrombosis and haemostasis, 2015, Volume: 114, Issue:2

    Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Brain Ischemia; Cerebral Hemorrhage; Clopidogrel; Drug

2015
Perioperative Management to Reduce Cardiovascular Events.
    Circulation, 2016, Mar-15, Volume: 133, Issue:11

    Topics: Adrenergic beta-Antagonists; Aged; Anesthesia; Anticoagulants; Arthroplasty, Replacement, Knee; Aspi

2016
Proton pump inhibitors in rheumatic diseases: clinical practice, drug interactions, bone fractures and risk of infections.
    Reumatismo, 2011, Volume: 63, Issue:1

    Topics: Anticoagulants; Aryl Hydrocarbon Hydroxylases; Aspirin; Calcium, Dietary; Clopidogrel; Clostridioide

2011
Relationship between activated clotting time and ischemic or hemorrhagic complications: analysis of 4 recent randomized clinical trials of percutaneous coronary intervention.
    Circulation, 2004, Aug-24, Volume: 110, Issue:8

    Topics: Abciximab; Aged; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Anticoagulants; Aspirin; Bl

2004
Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis.
    Seminars in thrombosis and hemostasis, 2005, Volume: 31, Issue:2

    Topics: Adenosine Diphosphate; Animals; Arteriosclerosis; Aspirin; Clinical Trials as Topic; Clopidogrel; Co

2005
[Antiplatelet therapy].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1999, Sep-10, Volume: 88, Issue:9

    Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Arteriosclerosis; Aspirin; Clinic

1999

Trials

8 trials available for ticlopidine and Thrombophilia

ArticleYear
Primary thrombophilia in México X: a prospective study of the treatment of the sticky platelet syndrome.
    Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2015, Volume: 21, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelet Disorders; Child; Clopidogrel; F

2015
Thrombelastographic haemostatic status and antiplatelet therapy after coronary artery bypass surgery (TEG-CABG trial): assessing and monitoring the antithrombotic effect of clopidogrel and aspirin versus aspirin alone in hypercoagulable patients: study pr
    Trials, 2012, Apr-27, Volume: 13

    Topics: Aspirin; Clinical Protocols; Clopidogrel; Coronary Artery Bypass; Humans; Platelet Aggregation Inhib

2012
Activated clotting times in the setting of eptifibatide use during percutaneous coronary intervention.
    Journal of thrombosis and thrombolysis, 2002, Volume: 13, Issue:3

    Topics: Angioplasty, Balloon, Coronary; Aspirin; Blood Coagulation; Blood Coagulation Tests; Clopidogrel; Dr

2002
Prothrombotic responses to exercise are little influenced by clopidogrel treatment.
    Thrombosis research, 2004, Volume: 114, Issue:4

    Topics: Adenosine Diphosphate; Adult; Blood Platelets; Cell Adhesion; Clopidogrel; Cross-Over Studies; Exerc

2004
Prospective randomized comparison of early and late results of a carbonized stent versus a high-grade stainless steel stent of identical design: the PREVENT Trial [corrected].
    American heart journal, 2005, Volume: 149, Issue:4

    Topics: Adult; Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Biocompatibl

2005
Effects of clopidogrel on the rebound hypercoagulable state after heparin discontinuation in patients with acute coronary syndromes.
    Journal of the American College of Cardiology, 2005, Oct-18, Volume: 46, Issue:8

    Topics: Acute Disease; Angina, Unstable; Anticoagulants; Antithrombin III; Clopidogrel; Heparin; Humans; Myo

2005
Hypercoagulability and platelet inhibition after OPCAB. Randomized intervention with clopidogrel.
    Scandinavian cardiovascular journal : SCJ, 2007, Volume: 41, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Clopidogrel; Coronary Artery Bypass, Off-Pump; Femal

2007
Changes in levels of factor VII and protein S after acute myocardial infarction: effects of low-dose warfarin.
    Thrombosis research, 1999, Nov-01, Volume: 96, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Antigens; Aspirin; Brain Ischemia; Death, Sudden, Ca

1999

Other Studies

22 other studies available for ticlopidine and Thrombophilia

ArticleYear
Defining a Clopidogrel Response Cut-Off Value Using Light Transmission Aggregometry Before Pipeline Embolization of Unruptured Intracranial Aneurysms.
    World neurosurgery, 2018, Volume: 113

    Topics: Adult; Aged; Aged, 80 and over; Clopidogrel; Databases, Factual; Dose-Response Relationship, Drug; E

2018
Association Between Residual Platelet Reactivity on Clopidogrel Treatment and Severity of Coronary Atherosclerosis: Intrinsic Hypercoagulability as a Mediator.
    Advances in therapy, 2019, Volume: 36, Issue:9

    Topics: Aged; Clopidogrel; Coronary Artery Disease; Coronary Restenosis; Drug-Eluting Stents; Female; Humans

2019
'VASPFix' for measurement of VASP phosphorylation in platelets and for monitoring effects of P2Y12 antagonists.
    Thrombosis and haemostasis, 2014, Mar-03, Volume: 111, Issue:3

    Topics: Adenosine; Adenosine Diphosphate; Alprostadil; Biomarkers, Pharmacological; Blood Platelets; Buclade

2014
Clopidogrel response variability is associated with endothelial dysfunction in coronary artery disease patients receiving dual antiplatelet therapy.
    Atherosclerosis, 2015, Volume: 242, Issue:1

    Topics: Activation, Metabolic; Aged; Aspirin; Brachial Artery; Clopidogrel; Coronary Disease; Cytochrome P-4

2015
Microparticles and blood cells induce procoagulant activity via phosphatidylserine exposure in NSTEMI patients following stent implantation.
    International journal of cardiology, 2016, Nov-15, Volume: 223

    Topics: Aged; Aspirin; Blood Cells; Blood Coagulation; Cell-Derived Microparticles; Clopidogrel; Female; Hum

2016
A thrombotic storm.
    Internal and emergency medicine, 2017, Volume: 12, Issue:1

    Topics: Aged; Alprazolam; Amines; Amputation, Surgical; Atorvastatin; Cyclohexanecarboxylic Acids; Female; G

2017
Ask the doctor. In October 2007, I had three Cypher stents placed in my left anterior descending artery. My doctor told me to take Plavix and aspirin indefinitely. Now I need to have a hernia repaired. My surgeon refuses to operate while I'm taking Plavix
    Harvard heart letter : from Harvard Medical School, 2008, Volume: 18, Issue:12

    Topics: Aspirin; Clopidogrel; Contraindications; Platelet Aggregation Inhibitors; Stents; Thoracic Surgery;

2008
Combined anti-platelet therapy with aspirin and clopidogrel: risk factor for thrombolysis-related intracerebral hemorrhage in acute ischemic stroke?
    Journal of the neurological sciences, 2009, Sep-15, Volume: 284, Issue:1-2

    Topics: Aged; Aged, 80 and over; Aspirin; Brain Ischemia; Cerebral Hemorrhage; Clopidogrel; Female; Fibrinol

2009
Pro: "Anti-platelet therapy is an alternative to oral anticoagulation for atrial fibrillation".
    Thrombosis and haemostasis, 2009, Volume: 102, Issue:5

    Topics: Administration, Oral; Aged; Anticoagulants; Aspirin; Atrial Fibrillation; Clinical Trials as Topic;

2009
Contra: "Anti-platelet therapy is an alternative to oral anticoagulation for atrial fibrillation".
    Thrombosis and haemostasis, 2009, Volume: 102, Issue:5

    Topics: Administration, Oral; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Atrial Fibrillation; Clinica

2009
Positional brain ischemia with MCA occlusion successfully treated with extra-intracranial bypass.
    Cerebrovascular diseases (Basel, Switzerland), 2010, Volume: 29, Issue:4

    Topics: Aspirin; Cerebral Revascularization; Clopidogrel; Humans; Infarction, Middle Cerebral Artery; Ischem

2010
Clinical and angiographic outcomes with sirolimus-eluting stent for coronary bifurcation lesions. The J-PMS study.
    Circulation journal : official journal of the Japanese Circulation Society, 2011, Volume: 75, Issue:2

    Topics: Angioplasty; Aspirin; Calcinosis; Coronary Angiography; Coronary Restenosis; Coronary Stenosis; Coro

2011
Thrombus formation on a left atrial appendage closure device.
    Circulation, 2011, Oct-04, Volume: 124, Issue:14

    Topics: Aged; Anticoagulants; Aspirin; Atrial Appendage; Atrial Fibrillation; Clopidogrel; Equipment Design;

2011
Thrombophilic causes of retinal vascular thrombosis: etiology and treatment outcomes.
    Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2002, Volume: 8, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Clinical Laboratory Techniques; Clopidogrel; Da

2002
[New antiplatelet agents (platelet receptor blockers): has aspirin come out of place?].
    Praxis, 2004, Jun-02, Volume: 93, Issue:23

    Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combination; Huma

2004
Dual antiplatelet therapy for coronary stenting: a clear path for a research agenda.
    Circulation, 2005, Mar-08, Volume: 111, Issue:9

    Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Stenosis; Coronary Thrombosis; Drug A

2005
Enhanced platelet activation by prolactin in patients with ischemic stroke.
    Thrombosis and haemostasis, 2006, Volume: 96, Issue:1

    Topics: Aged; Aged, 80 and over; Aspirin; Brain Ischemia; Clopidogrel; Female; Humans; Ischemic Attack, Tran

2006
Impact of PlA polymorphism of platelet GP IIb/IIIa receptors on clinical course during long-term LVAD support is independent of type of LVAD.
    The Annals of thoracic surgery, 2006, Volume: 82, Issue:3

    Topics: Anticoagulants; Antigens, Human Platelet; Aspirin; Clopidogrel; Equipment Design; Genetic Predisposi

2006
Standardization of light transmittance aggregometry for monitoring antiplatelet therapy: an adjustment for platelet count is not necessary.
    Journal of thrombosis and haemostasis : JTH, 2008, Volume: 6, Issue:4

    Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Algorithms; Arachidonic Acid; Aspirin; Calibr

2008
Prevention of thrombosis in polycythemia vera and essential thrombocythemia.
    Haematologica, 2008, Volume: 93, Issue:3

    Topics: Arterial Occlusive Diseases; Aspirin; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Humans;

2008
Stasis ulcers refractory to therapy--accelerated healing by treatment with clopidogrel +/- dalteparin: a preliminary report.
    Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2001, Volume: 7, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Antiphospholipid Syndrome; Clopidogrel; Dalteparin;

2001
Hereditary hemorrhagic telangiectasia, factor V Leiden and antiphospholipid syndrome: a case report.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2002, Volume: 13, Issue:1

    Topics: Antibodies, Anticardiolipin; Antiphospholipid Syndrome; Autoantibodies; Factor V; Female; Humans; Is

2002