ticlopidine has been researched along with Stomach Ulcer in 21 studies
Ticlopidine: An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
ticlopidine : A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.
Stomach Ulcer: Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gastric ulcers were induced in Sprague Dawley rats, and ulcer healing and angiogenesis of ulcer margin were compared between clopidogrel-treated rats and controls." | 7.83 | Clopidogrel inhibits angiogenesis of gastric ulcer healing via downregulation of vascular endothelial growth factor receptor 2. ( Chen, TS; Hou, MC; Huang, HC; Huo, TI; Lee, FY; Lin, HC; Luo, JC; Peng, YL, 2016) |
| "Gastric ulcer was induced in rats and the ulcer size, mucosal epithelial cell proliferation of the ulcer margin, expression of growth factors [epidermal growth factor (EGF), basic fibroblast growth factor] and their receptors, and signal transduction pathways for cell proliferation were measured and compared between the clopidogrel-treated group and untreated controls." | 5.38 | Clopidogrel delays gastric ulcer healing in rats. ( Chang, FY; Hou, MC; Huo, TI; Lee, FY; Li, CP; Lin, HC; Lin, HY; Luo, JC, 2012) |
| "A proton pump inhibitor (PPI) is often co-prescribed with clopidogrel to reduce the gastrointestinal risk of bleeding ulcers in patients following acute coronary syndrome or a stent implant." | 4.86 | Controversy of proton pump inhibitor and clopidogrel interaction: a review. ( Tan, HJ, 2010) |
| "Gastric ulcers were induced in Sprague Dawley rats, and ulcer healing and angiogenesis of ulcer margin were compared between clopidogrel-treated rats and controls." | 3.83 | Clopidogrel inhibits angiogenesis of gastric ulcer healing via downregulation of vascular endothelial growth factor receptor 2. ( Chen, TS; Hou, MC; Huang, HC; Huo, TI; Lee, FY; Lin, HC; Luo, JC; Peng, YL, 2016) |
| "In 674 upper gastrointestinal bleeders, we found that the odds ratio for the presence of erosive oesophagitis in aspirin users was 2 (95% CI, 1-3; P = 0." | 3.73 | Upper gastrointestinal mucosal abnormalities and blood loss complicating low-dose aspirin and antithrombotic therapy. ( Angerson, WJ; Blatchford, O; Knill-Jones, RP; Taha, AS, 2006) |
| " The data indicate that ticlopidine is better tolerated by the gastroduodenal mucosa than low dosage aspirin." | 2.67 | [A comparison of the gastroduodenal tolerance of ticlopidine and acetylsalicylic acid]. ( Kleinsorge, H; Müller, P; Simon, B, 1993) |
| " Proton pump inhibitors cause few adverse effects with short-term use; however, long-term use has been scrutinized for appropriateness, drug-drug interactions, and the potential for adverse effects (e." | 2.48 | Reducing adverse effects of proton pump inhibitors. ( Ament, PW; Dicola, DB; James, ME, 2012) |
| "The risk of postoperative hemorrhage following gastric ESD was higher in patients with antithrombotic therapy than in those without that therapy." | 1.39 | The postoperative bleeding rate and its risk factors in patients on antithrombotic therapy who undergo gastric endoscopic submucosal dissection. ( Edogawa, S; Harada, S; Higuchi, K; Kojima, Y; Ota, K; Takeuchi, T; Tokioka, S; Umegaki, E, 2013) |
| "Gastric ulcer was induced in rats and the ulcer size, mucosal epithelial cell proliferation of the ulcer margin, expression of growth factors [epidermal growth factor (EGF), basic fibroblast growth factor] and their receptors, and signal transduction pathways for cell proliferation were measured and compared between the clopidogrel-treated group and untreated controls." | 1.38 | Clopidogrel delays gastric ulcer healing in rats. ( Chang, FY; Hou, MC; Huo, TI; Lee, FY; Li, CP; Lin, HC; Lin, HY; Luo, JC, 2012) |
| "When ticlopidine was administered 1h after EtOH, it significantly (p<0." | 1.34 | Ticlopidine prevents the formation but delays the healing of ethanol-induced gastric lesions in the rat. ( De Luca, V; Guidobono, F; Lattuada, N; Netti, C; Pagani, F; Sibilia, V; Soglian, A, 2007) |
| "Ticlopidine treatment resulted in increased platelet endostatin content and release." | 1.31 | Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release. ( Buret, A; Cirino, G; Elliott, SN; Ignarro, LJ; Ma, L; Wallace, JL, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (9.52) | 18.7374 |
| 1990's | 1 (4.76) | 18.2507 |
| 2000's | 6 (28.57) | 29.6817 |
| 2010's | 12 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Takeuchi, K | 3 |
| Izuhara, C | 3 |
| Takayama, S | 3 |
| Momode, T | 1 |
| Kojo, M | 1 |
| Hara, D | 1 |
| Amagase, K | 2 |
| Takeuchi, T | 1 |
| Ota, K | 1 |
| Harada, S | 1 |
| Edogawa, S | 1 |
| Kojima, Y | 1 |
| Tokioka, S | 1 |
| Umegaki, E | 1 |
| Higuchi, K | 1 |
| Hashimoto, E | 2 |
| Itayama, M | 1 |
| Luo, JC | 2 |
| Peng, YL | 1 |
| Chen, TS | 1 |
| Huo, TI | 2 |
| Hou, MC | 2 |
| Huang, HC | 1 |
| Lin, HC | 2 |
| Lee, FY | 2 |
| Tan, HJ | 1 |
| Komarov, AL | 1 |
| Yamada, N | 1 |
| Yamanaka, S | 1 |
| Kaneko, S | 1 |
| Murata, T | 1 |
| Kawashima, M | 1 |
| Terayama, Y | 1 |
| Ament, PW | 1 |
| Dicola, DB | 1 |
| James, ME | 1 |
| Lin, HY | 1 |
| Li, CP | 1 |
| Chang, FY | 1 |
| Taha, AS | 1 |
| Angerson, WJ | 1 |
| Knill-Jones, RP | 1 |
| Blatchford, O | 1 |
| Lai, KC | 1 |
| Chu, KM | 1 |
| Hui, WM | 1 |
| Wong, BC | 1 |
| Hung, WK | 1 |
| Loo, CK | 1 |
| Hu, WH | 1 |
| Chan, AO | 1 |
| Kwok, KF | 1 |
| Fung, TT | 1 |
| Wong, J | 1 |
| Lam, SK | 1 |
| Sibilia, V | 1 |
| Pagani, F | 1 |
| Lattuada, N | 1 |
| De Luca, V | 1 |
| Guidobono, F | 1 |
| Soglian, A | 1 |
| Netti, C | 1 |
| Kojecký, V | 1 |
| Coufal, Z | 1 |
| Johnson, DA | 1 |
| Kumashiro, R | 2 |
| Pavlides, CA | 1 |
| Kholoussy, AM | 2 |
| Matsumoto, T | 2 |
| Simon, B | 1 |
| Kleinsorge, H | 1 |
| Müller, P | 1 |
| Ma, L | 1 |
| Elliott, SN | 1 |
| Cirino, G | 1 |
| Buret, A | 1 |
| Ignarro, LJ | 1 |
| Wallace, JL | 1 |
| Piotrowski, JJ | 1 |
| Hashimoto, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Gastrointestinal Ulceration in Patients on Dual Antiplatelet Therapy After Percutaneous Coronary Intervention[NCT00413309] | 30 participants (Anticipated) | Interventional | 2006-04-30 | Completed | |||
| Efficacy of H2 Receptor Antagonist in Prevention of Thienopyridine-related Peptic Ulcer[NCT02418312] | 228 participants (Actual) | Interventional | 2012-01-31 | Completed | |||
| Pantoprazole Versus Famotidine for the Prevention of Recurrent Peptic Ulcers in Thienopyridine Users - a Double-blind Randomized Controlled Trial[NCT02551744] | 101 participants (Actual) | Interventional | 2012-07-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Follow-up endoscopy was performed at the end of the 6th month (NCT02418312)
Timeframe: 6 months
| Intervention | participants (Number) |
|---|---|
| Histamine-2 Receptor Antagonist Group | 106 |
| Placebo Group | 101 |
Follow-up endoscopy was performed at the end of the 6th month (NCT02551744)
Timeframe: six month
| Intervention | participants (Number) |
|---|---|
| Proton Pump Inhibitor Group | 1 |
| Histamine-2 Receptor Antagonist Group | 7 |
4 reviews available for ticlopidine and Stomach Ulcer
| Article | Year |
|---|---|
Controversy of proton pump inhibitor and clopidogrel interaction: a review.
Topics: Acute Coronary Syndrome; Clopidogrel; Drug Interactions; Humans; Platelet Aggregation Inhibitors; Pr | 2010 |
[Efficacy and safety of various doses of acetylsalicylic Acid in prevention of complications of atherothrombosis].
Topics: Aspirin; Blood Platelets; Blood Vessels; Cardiovascular Diseases; Cerebrovascular Disorders; Clinica | 2010 |
Reducing adverse effects of proton pump inhibitors.
Topics: Anemia, Iron-Deficiency; Clopidogrel; Clostridioides difficile; Critical Care; Diarrhea; Drug Intera | 2012 |
Upper GI risks of NSAIDs and antiplatelet agents: key issues for the cardiologist.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Cardiology; Cardiovascular Dise | 2005 |
2 trials available for ticlopidine and Stomach Ulcer
| Article | Year |
|---|---|
Esomeprazole with aspirin versus clopidogrel for prevention of recurrent gastrointestinal ulcer complications.
Topics: Aged; Aged, 80 and over; Anti-Ulcer Agents; Aspirin; Clopidogrel; Cohort Studies; Double-Blind Metho | 2006 |
[A comparison of the gastroduodenal tolerance of ticlopidine and acetylsalicylic acid].
Topics: Adult; Aspirin; Double-Blind Method; Gastric Mucosa; Humans; Male; Purpura; Stomach Diseases; Stomac | 1993 |
15 other studies available for ticlopidine and Stomach Ulcer
| Article | Year |
|---|---|
Animal models of gastric bleeding induced by dual antiplatelet therapy using aspirin and clopidogrel--prophylactic effect of antiulcer drugs.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Clopidogrel; Disease Models, Animal; Drug Synergism; Histamine | 2014 |
The postoperative bleeding rate and its risk factors in patients on antithrombotic therapy who undergo gastric endoscopic submucosal dissection.
Topics: Adenoma; Aged; Anti-Ulcer Agents; Anticoagulants; Aspirin; Carcinoma; Case-Control Studies; Clopidog | 2013 |
Effect of rebamipide on gastric bleeding and ulcerogenic responses induced by aspirin plus clopidogrel under stimulation of acid secretion in rats.
Topics: Alanine; Animals; Anti-Ulcer Agents; Aspirin; Clopidogrel; Disease Models, Animal; Gastric Acid; Gas | 2014 |
Clopidogrel inhibits angiogenesis of gastric ulcer healing via downregulation of vascular endothelial growth factor receptor 2.
Topics: Animals; Cell Proliferation; Clopidogrel; Down-Regulation; Extracellular Signal-Regulated MAP Kinase | 2016 |
Controversial warning on Plavix and stomach-protecting medications.
Topics: Anti-Ulcer Agents; Clopidogrel; Drug Interactions; Drug Labeling; Health Knowledge, Attitudes, Pract | 2010 |
A new model of gastric bleeding induced in rats by aspirin plus clopidogrel under stimulation of acid secretion. Prophylactic effects of antiulcer drugs.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Clopidogrel; Drug Interactions; Famotidine; Gastric Acid; Gastr | 2012 |
[Case report: patient with central nervous system side effects due to lafutidine].
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acetamides; Anti-Ulcer Agents; Central Nervous System Disea | 2012 |
Side effects of proton pump inhibitors.
Topics: Clopidogrel; Diarrhea; Drug Interactions; Gastroesophageal Reflux; Hip Fractures; Humans; Platelet A | 2012 |
Clopidogrel delays gastric ulcer healing in rats.
Topics: Animals; Cell Line; Cell Proliferation; Clopidogrel; Epidermal Growth Factor; Epithelial Cells; ErbB | 2012 |
Upper gastrointestinal mucosal abnormalities and blood loss complicating low-dose aspirin and antithrombotic therapy.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Clopidogrel; Dipyrida | 2006 |
Ticlopidine prevents the formation but delays the healing of ethanol-induced gastric lesions in the rat.
Topics: Administration, Oral; Animals; Aspirin; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Ani | 2007 |
[Clinically manifest gastrointestinal bleeding in patients subject to coronary angiography].
Topics: Abciximab; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Anticoagulants; Clopidogrel; Coro | 2007 |
Thrombotic etiology of stress ulcers. 1. The effect of anticoagulant and antiplatelet aggregators in the development of stress ulcers in rats.
Topics: Animals; Anticoagulants; Aspirin; Dipyridamole; Gastric Acidity Determination; Gastric Mucosa; Hepar | 1983 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Antiplatelet aggregators inhibit development of stress ulcers in Sprague-Dawley rats.
Topics: Animals; Anticoagulants; Aspirin; Capillaries; Dipyridamole; Gastric Mucosa; Male; Platelet Aggregat | 1985 |