ticlopidine has been researched along with Out-of-Hospital Cardiac Arrest in 8 studies
Ticlopidine: An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
ticlopidine : A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.
Out-of-Hospital Cardiac Arrest: Occurrence of heart arrest in an individual when there is no immediate access to medical personnel or equipment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study suggests that impaired response to both intravenous and oral aspirin is frequent in comatose patients resuscitated from OHCA." | 9.22 | Impaired biological response to aspirin in therapeutic hypothermia comatose patients resuscitated from out-of-hospital cardiac arrest. ( Bal Dit Sollier, C; Deye, N; Dillinger, JG; Drouet, L; Henry, P; Llitjos, JF; Megarbane, B; Sideris, G; Voicu, S, 2016) |
| "This study suggests that impaired response to both intravenous and oral aspirin is frequent in comatose patients resuscitated from OHCA." | 5.22 | Impaired biological response to aspirin in therapeutic hypothermia comatose patients resuscitated from out-of-hospital cardiac arrest. ( Bal Dit Sollier, C; Deye, N; Dillinger, JG; Drouet, L; Henry, P; Llitjos, JF; Megarbane, B; Sideris, G; Voicu, S, 2016) |
| "VerifyNow® and Multiplate® aggregometry were used before, and 4, 12, 22 and 48 hours after 600 mg clopidogrel treatment in 28 post-cardiac arrest hypothermic patients and in 14 normothermic patients with acute coronary syndrome." | 3.81 | Platelet reactivity in comatose survivors of cardiac arrest undergoing percutaneous coronary intervention and hypothermia. ( Blinc, A; Bozic-Mijovski, M; Kranjec, I; Melkic, E; Noc, M; Steblovnik, K, 2015) |
| "A 36 year-old man, who had undergone a paclitaxel-eluting stent deployment into the left main (LM) coronary artery three years before, was admitted after successful resuscitation following out-of-hospital cardiac arrest due to an acute ST-segment elevation myocardial infarction." | 3.79 | Thrombocytosis as a potential cause of a very late stent thrombosis in the left main coronary artery. ( Janus, M; Lesiak, M; Lukawski, K; Prech, M, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tanriverdi, Z | 1 |
| Besli, F | 1 |
| Gungoren, F | 1 |
| Altiparmak, İH | 1 |
| Prech, M | 1 |
| Janus, M | 1 |
| Lukawski, K | 1 |
| Lesiak, M | 1 |
| Steblovnik, K | 2 |
| Blinc, A | 2 |
| Bozic-Mijovski, M | 1 |
| Kranjec, I | 1 |
| Melkic, E | 1 |
| Noc, M | 2 |
| Gouffran, G | 1 |
| Rosencher, J | 1 |
| Bougouin, W | 1 |
| Jakamy, R | 1 |
| Joffre, J | 1 |
| Lamhaut, L | 1 |
| Dumas, F | 1 |
| Cariou, A | 1 |
| Varenne, O | 1 |
| Kaufmann, J | 1 |
| Wellnhofer, E | 1 |
| Stockmann, H | 1 |
| Graf, K | 1 |
| Fleck, E | 1 |
| Schroeder, T | 1 |
| Stawowy, P | 1 |
| Storm, C | 1 |
| Llitjos, JF | 1 |
| Sideris, G | 1 |
| Voicu, S | 1 |
| Bal Dit Sollier, C | 1 |
| Deye, N | 1 |
| Megarbane, B | 1 |
| Drouet, L | 1 |
| Henry, P | 1 |
| Dillinger, JG | 1 |
| Mijovski, MB | 1 |
| Fister, M | 1 |
| Mikuz, U | 1 |
| Jiménez-Brítez, G | 1 |
| Freixa, X | 1 |
| Flores-Umanzor, E | 1 |
| San Antonio, R | 1 |
| Caixal, G | 1 |
| Garcia, J | 1 |
| Hernandez-Enriquez, M | 1 |
| Andrea, R | 1 |
| Regueiro, A | 1 |
| Masotti, M | 1 |
| Brugaletta, S | 1 |
| Martin, V | 1 |
| Sabaté, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Definite Stent Thrombosis in Comatose Out of Hospital Cardiac Arrest Survivors Treated With Percutaneous Coronary Intervention and Hypothermia[NCT03312296] | 151 participants (Actual) | Observational | 2016-08-01 | Completed | |||
| Comparison of Antiplatelet Therapy With Clopidogrel and Ticagrelor in Patients After Cardiac Arrest Treated With Therapeutic Hypothermia[NCT02224274] | Phase 4 | 57 participants (Actual) | Interventional | 2014-08-31 | Completed | ||
| Platelet Inhibition With Cangrelor in Comatose Survivors of Out-of-hospital Cardiac Arrest Undergoing Primary Percutaneous Coronary Intervention[NCT04005729] | Phase 4 | 30 participants (Actual) | Interventional | 2019-07-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Platelet activation by adenosine diphosphate (ADP) expressed in arbitrary aggregation units (U). P2Y12 inhibitors block ADP receptors and decrease platelet activation by ADP. Higher values mean less effect of P2Y12 inhibitors, lower values mean more effect of P2Y12 inhibitors on platelets.~High on-treatment platelet reactivity was defined as >46 U." (NCT02224274)
Timeframe: 12 hours after P2Y12 inhibitor loading
| Intervention | U (Mean) |
|---|---|
| Clopidogrel | 28 |
| Ticagrelor | 15 |
% inhibition reflects P2Y12 inhibitor effect regarding basal platelet reactivity (defined as: (1- (platelet reactivity/basal platelet reactivity)) x 100). Higher values mean better P2Y12 inhibition response. High on-treatment platelet reactivity was defined as <11% inhibition. (NCT02224274)
Timeframe: 12 hours after P2Y12 inhibitor loading
| Intervention | % inhibition (Mean) |
|---|---|
| Clopidogrel | 4 |
| Ticagrelor | 55 |
Platelet reactivity reflects P2Y12 inhibitor effect. Higher values mean normal platelet reactivity due to low P2Y12 inhibition response, while lower values mean decreased platelet reactivity due to the effect of a P2Y12 inhibitor. High on-treatment platelet reactivity was defined as >208 PRU. (NCT02224274)
Timeframe: 12 h after P2Y12 inhibitor loading
| Intervention | PRU (Mean) |
|---|---|
| Clopidogrel | 238 |
| Ticagrelor | 101 |
2 trials available for ticlopidine and Out-of-Hospital Cardiac Arrest
| Article | Year |
|---|---|
Impaired biological response to aspirin in therapeutic hypothermia comatose patients resuscitated from out-of-hospital cardiac arrest.
Topics: Acute Coronary Syndrome; Administration, Intravenous; Administration, Oral; Adult; Aged; Aspirin; Ca | 2016 |
Ticagrelor Versus Clopidogrel in Comatose Survivors of Out-of-Hospital Cardiac Arrest Undergoing Percutaneous Coronary Intervention and Hypothermia: A Randomized Study.
Topics: Activation, Metabolic; Adenosine; Clopidogrel; Coma; Humans; Hypothermia, Induced; Out-of-Hospital C | 2016 |
6 other studies available for ticlopidine and Out-of-Hospital Cardiac Arrest
| Article | Year |
|---|---|
Effect of Antiplatelet Therapy on Cardiac Outcomes in Patients With Acute Coronary Syndrome.
Topics: Acute Coronary Syndrome; Clopidogrel; Humans; Out-of-Hospital Cardiac Arrest; Platelet Aggregation I | 2018 |
Thrombocytosis as a potential cause of a very late stent thrombosis in the left main coronary artery.
Topics: Adult; Clopidogrel; Coronary Angiography; Coronary Stenosis; Coronary Thrombosis; Drug-Eluting Stent | 2013 |
Platelet reactivity in comatose survivors of cardiac arrest undergoing percutaneous coronary intervention and hypothermia.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Blood Platelets; Cardiopulmonary Resuscitation; Ca | 2015 |
Platelet reactivity in comatose survivors of cardiac arrest undergoing percutaneous coronary intervention and hypothermia.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Blood Platelets; Cardiopulmonary Resuscitation; Ca | 2015 |
Platelet reactivity in comatose survivors of cardiac arrest undergoing percutaneous coronary intervention and hypothermia.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Blood Platelets; Cardiopulmonary Resuscitation; Ca | 2015 |
Platelet reactivity in comatose survivors of cardiac arrest undergoing percutaneous coronary intervention and hypothermia.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Blood Platelets; Cardiopulmonary Resuscitation; Ca | 2015 |
Stent thrombosis after primary percutaneous coronary intervention in comatose survivors of out-of-hospital cardiac arrest: Are the new P2Y12 inhibitors really more effective than clopidogrel?
Topics: Adenosine; Aspirin; Clopidogrel; Coma; Coronary Angiography; Coronary Thrombosis; Drug Therapy, Comb | 2016 |
Clopidogrel pharmacokinetics and pharmacodynamics in out-of-hospital cardiac arrest patients with acute coronary syndrome undergoing target temperature management.
Topics: Acute Coronary Syndrome; Aged; Cardiopulmonary Resuscitation; Clopidogrel; Female; Follow-Up Studies | 2016 |
Out-of-hospital cardiac arrest and stent thrombosis: Ticagrelor versus clopidogrel in patients with primary percutaneous coronary intervention under mild therapeutic hypothermia.
Topics: Adenosine; Aged; Clopidogrel; Coronary Thrombosis; Humans; Hypothermia, Induced; Male; Middle Aged; | 2017 |