ticlopidine has been researched along with Liver Cirrhosis in 9 studies
Ticlopidine: An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
ticlopidine : A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Pharmacokinetic analysis of clopidogrel was limited due to low plasma concentrations arising from rapid hydrolysis to SR 26334." | 2.69 | Cirrhosis does not affect the pharmacokinetics and pharmacodynamics of clopidogrel. ( Much, DR; Necciari, J; Nichola, P; Slugg, PH; Smith, WB; Vargas, R, 2000) |
| "In 8 patients with liver cirrhosis who underwent hepatectomy, one patient with a prolonged T2 (260 secs) and a normal skin BT bled postoperatively, however, 3 patients with a prolonged skin BT (greater than 15 min) and a normal T2 had no hemorrhagic complications." | 1.27 | Clinical application of a new in vitro bleeding time device on surgical patients. ( Itoh, T; Kambayashi, J; Mori, T; Sakon, M; Tsujinaka, T; Uemura, Y, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 6 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ponzetto, A | 1 |
| Figura, N | 1 |
| Feagins, LA | 1 |
| Wan, YM | 1 |
| Li, YH | 1 |
| Wu, HM | 1 |
| Xu, ZY | 1 |
| Xu, Y | 1 |
| Yang, LH | 1 |
| Wu, XN | 1 |
| Yang, JH | 1 |
| Joshi, N | 1 |
| Kopec, AK | 1 |
| Ray, JL | 1 |
| Luyendyk, JP | 1 |
| Pivalizza, EG | 1 |
| Melnikov, V | 1 |
| Guzman-Reyes, S | 1 |
| Marasigan, B | 1 |
| Russo, MW | 1 |
| Pierson, J | 1 |
| Narang, T | 1 |
| Montegudo, A | 1 |
| Eskind, L | 1 |
| Gulati, S | 1 |
| Slugg, PH | 1 |
| Much, DR | 1 |
| Smith, WB | 1 |
| Vargas, R | 1 |
| Nichola, P | 1 |
| Necciari, J | 1 |
| Tsujinaka, T | 1 |
| Itoh, T | 1 |
| Uemura, Y | 1 |
| Sakon, M | 1 |
| Kambayashi, J | 1 |
| Mori, T | 1 |
| Mannucci, PM | 1 |
| Vicente, V | 1 |
| Vianello, L | 1 |
| Cattaneo, M | 1 |
| Alberca, I | 1 |
| Coccato, MP | 1 |
| Faioni, E | 1 |
| Mari, D | 1 |
2 trials available for ticlopidine and Liver Cirrhosis
| Article | Year |
|---|---|
Cirrhosis does not affect the pharmacokinetics and pharmacodynamics of clopidogrel.
Topics: Adult; Area Under Curve; Case-Control Studies; Clopidogrel; Female; Humans; Liver Cirrhosis; Male; M | 2000 |
Controlled trial of desmopressin in liver cirrhosis and other conditions associated with a prolonged bleeding time.
Topics: Adolescent; Adult; Aged; Aspirin; Bleeding Time; Clinical Trials as Topic; Deamino Arginine Vasopres | 1986 |
7 other studies available for ticlopidine and Liver Cirrhosis
| Article | Year |
|---|---|
Letter: bleeding in cirrhotics receiving coronary stenting and antiplatelet therapy.
Topics: Aspirin; Drug Therapy, Combination; Hemorrhage; Humans; Liver Cirrhosis; Platelet Aggregation Inhibi | 2017 |
Letter: bleeding in cirrhotics receiving coronary stenting and antiplatelet therapy - author's reply.
Topics: Aspirin; Drug Therapy, Combination; Hemorrhage; Humans; Liver Cirrhosis; Platelet Aggregation Inhibi | 2017 |
Portal vein thrombosis before and after transjugular intrahepatic portosystemic shunt placement: An observational study (STROBE compliant).
Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Clopidogrel; Female; Humans; Leukocyte Coun | 2017 |
Inhibition of PAR-4 and P2Y12 receptor-mediated platelet activation produces distinct hepatic pathologies in experimental xenobiotic-induced cholestatic liver disease.
Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Cholestasis; Clopidogrel; | 2016 |
Thrombelastograph platelet mapping in a patient receiving antiplatelet therapy.
Topics: Aspirin; Blood Coagulation Disorders; Blood Platelets; Clopidogrel; Dose-Response Relationship, Drug | 2010 |
Coronary artery stents and antiplatelet therapy in patients with cirrhosis.
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Fatty Liver; Female; Follow-Up Studies; Gastroi | 2012 |
Clinical application of a new in vitro bleeding time device on surgical patients.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aspirin; Bleeding Time; Epoprostenol; Hemorrhage; Hemostasis; H | 1988 |