Page last updated: 2024-11-05

ticlopidine and Hepatic Insufficiency

ticlopidine has been researched along with Hepatic Insufficiency in 2 studies

Ticlopidine: An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
ticlopidine : A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.

Hepatic Insufficiency: Conditions in which the LIVER functions fall below the normal ranges. Severe hepatic insufficiency may cause LIVER FAILURE or DEATH. Treatment may include LIVER TRANSPLANTATION.

Research Excerpts

ExcerptRelevanceReference
" Many medications (warfarin, heparin, clopidogrel) or physiological factors (elevated International Normalized Ratio [INR], thrombocytopenia, uremia) increase the risk for bleeding."3.79The safety of thoracentesis in patients with uncorrected bleeding risk. ( Araujo, KL; Argento, AC; Murphy, TE; Pisani, MA; Puchalski, JT, 2013)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Puchalski, JT1
Argento, AC1
Murphy, TE1
Araujo, KL1
Pisani, MA1
Lee, SA1
Suh, JW1
Park, JJ1
Yoon, CH1
Cho, YS1
Youn, TJ1
Chae, IH1
Kim, HS1
Kim, SH1
Choi, DJ1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Vacuum vs Manual Drainage During Unilateral Thoracentesis: A Randomized Trial[NCT03496987]100 participants (Actual)Interventional2015-12-01Completed
A Multicenter Randomized Trial Evaluating the Efficacy of Sarpogrelate on Ischemic Heart Disease After Drug-eluting Stent Implantation in Patients With Diabetes Mellitus or Renal Impairment[NCT02294643]Phase 3220 participants (Actual)Interventional2009-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Patients Who Had an Early Termination of Procedure

Patients who had procedure termination prior to complete evacuation of the pleural contents (usually as a result of refractory pain or another symptom that the patient perceived). (NCT03496987)
Timeframe: 5-20 minutes

InterventionParticipants (Count of Participants)
Manual Drainage1
Vacuum Bottle Drainage8

Pain Change

"Difference in pain between pre-procedural pain and during drainage pain as measured as the difference between a pre-procedural NPSS pain score (range from 0 (no pain) to 10 (maximum pain)). This was asked again during drainage and the difference between the two was recorded. The values ranged from -10 to 10 (with a more negative number representing a decrease in pain and a more positive number representing an increase in pain)~The scale used is called The Numeric Pain Rating Scale. With ratings from 0-10. Zero is the least amount of pain experienced while 10 is the worst pain possible." (NCT03496987)
Timeframe: 5-20 minutes

InterventionPre-post NPRS Pain Scale Score (Mean)
Manual Drainage0.53
Vacuum Bottle Drainage1.43

Time of Drainage

Actual time of drainage in seconds for each patient. (NCT03496987)
Timeframe: 5-20 minutes

Interventionseconds (Mean)
Manual Drainage498.5
Vacuum Bottle Drainage318.6

Volume of Effusion

Volume of effusion drained (in mL) (NCT03496987)
Timeframe: <20 minutes

Interventionmilliters (Mean)
Manual Drainage1023
Vacuum Bottle Drainage1143

Etiology of Effusion

Clinical etiology of effusion (NCT03496987)
Timeframe: <7 days

,
InterventionParticipants (Count of Participants)
MalignantParamalignantHeart FailureHepatic HydrothoraxPost-Cardiothoracic ProcedureParapneumonicUnknown
Manual Drainage137731333
Vacuum Bottle Drainage82851728

Number of Patients Who Had a Complication as a Result of the Procedure

Any complications that occur as a direct result of the procedure. We tracked patients for 7 days after the procedure to capture any complications (which is typical clinical practice) (NCT03496987)
Timeframe: <7 days

,
InterventionParticipants (Count of Participants)
PneumothoraxHemothoraxClinically Significant Pulmonary Edema
Manual Drainage000
Vacuum Bottle Drainage311

Trials

1 trial available for ticlopidine and Hepatic Insufficiency

ArticleYear
Study design of the influence of SErotonin inhibition on patients with RENAl impairment or diabetes undergoing drug-eluting stent implantation (SERENADE) study: A multicenter, open-label, prospective, randomized study.
    Contemporary clinical trials, 2015, Volume: 43

    Topics: Aspirin; Clopidogrel; Coronary Angiography; Coronary Restenosis; Diabetes Mellitus; Drug Therapy, Co

2015

Other Studies

1 other study available for ticlopidine and Hepatic Insufficiency

ArticleYear
The safety of thoracentesis in patients with uncorrected bleeding risk.
    Annals of the American Thoracic Society, 2013, Volume: 10, Issue:4

    Topics: Aged; Aged, 80 and over; Anticoagulants; Blood Coagulation Disorders; Clopidogrel; Cohort Studies; D

2013