ticlopidine has been researched along with Hemorrhage, Peptic Ulcer in 28 studies
Ticlopidine: An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
ticlopidine : A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " As a result, clopidogrel's incidence of peptic ulcer disease (PUD) and ulcer bleeding is lower than aspirin's." | 9.15 | Randomised clinical trial: rabeprazole plus aspirin is not inferior to rabeprazole plus clopidogrel for the healing of aspirin-related peptic ulcer. ( Chen, LC; Hou, MC; Huang, KW; Lee, FY; Lee, SD; Leu, HB; Li, CP; Lin, HC; Lu, CL; Luo, JC, 2011) |
| "Clopidogrel causes significantly less symptomatic peptic ulcer disease and gastrointestinal bleeding than low-dose aspirin in average-risk patients." | 9.11 | Clopidogrel plus omeprazole compared with aspirin plus omeprazole for aspirin-induced symptomatic peptic ulcers/erosions with low to moderate bleeding/re-bleeding risk -- a single-blind, randomized controlled study. ( Chang, CM; Chen, WH; Ng, FH; Wong, BC; Wong, SY, 2004) |
| "From January 2012 to 2016, long-termed thienopyridine users with a peptic ulcer history who did not have peptic ulcers at initial endoscopy were randomly assigned to receive either famotidine (40 mg, before bedtime) or placebo (before bedtime) for 6 months." | 5.24 | Histamine-2 Receptor Antagonist Cannot Prevent Recurrent Peptic Ulcers in Patients With Atherosclerotic Diseases Who Receive Platelet ADP Receptor Antagonist Monotherapy: A Randomized-Controlled, Double-Blind, and Double-Dummy Trial. ( Chen, WC; Cheng, JS; Hsu, PI; Kao, SS; Lai, KH; Liu, CP; Tsai, KW; Tsai, TJ; Tsay, FW; Wang, HM; Wu, DC, 2017) |
| " As a result, clopidogrel's incidence of peptic ulcer disease (PUD) and ulcer bleeding is lower than aspirin's." | 5.15 | Randomised clinical trial: rabeprazole plus aspirin is not inferior to rabeprazole plus clopidogrel for the healing of aspirin-related peptic ulcer. ( Chen, LC; Hou, MC; Huang, KW; Lee, FY; Lee, SD; Leu, HB; Li, CP; Lin, HC; Lu, CL; Luo, JC, 2011) |
| "Clopidogrel causes significantly less symptomatic peptic ulcer disease and gastrointestinal bleeding than low-dose aspirin in average-risk patients." | 5.11 | Clopidogrel plus omeprazole compared with aspirin plus omeprazole for aspirin-induced symptomatic peptic ulcers/erosions with low to moderate bleeding/re-bleeding risk -- a single-blind, randomized controlled study. ( Chang, CM; Chen, WH; Ng, FH; Wong, BC; Wong, SY, 2004) |
| " Cox proportional hazard regression models were developed to evaluate the predictors of LGIB with adjustments for age, gender, comorbidities including coronary artery disease, ischaemic stroke, diabetes, hypertension, chronic kidney disease, liver cirrhosis, chronic obstructive pulmonary disease, dyslipidemia, uncomplicated peptic ulcer disease, history of peptic ulcer bleeding, and concomitant use of clopidogrel, ticlopidine, warfarin, nonsteroidal anti-inflammatory drugs (NSAIDs), cyclooxygenase-2 inhibitors, steroids, proton pump inhibitors (PPIs), histamine-2 receptor antagonists (H2RAs), nitrates, alendronate, selective serotonin reuptake inhibitors (SSRIs) and calcium channel blockers." | 3.85 | The risk of lower gastrointestinal bleeding in low-dose aspirin users. ( Chen, WC; Chuah, SK; Hsu, PI; Huang, YT; Lin, KH; Sun, WC; Tsai, TJ; Wu, DC, 2017) |
| "Low-dose aspirin (ASA) has emerged as one of the most important causes of peptic ulcer bleeding in developed countries." | 3.78 | Anti-platelet therapy and managing ulcer risk. ( Chan, FK, 2012) |
| " If both Clopidogrel and PPI need to be prescribed, a split dosage regimen of PPI in the morning and clopidogrel in the evening can be recommended." | 2.46 | [Dilemma between gastroprotection and cardiovascular prevention]. ( Kandulski, A; Malfertheiner, P; Venerito, M, 2010) |
| "When ticlopidine was administered 1h after EtOH, it significantly (p<0." | 1.34 | Ticlopidine prevents the formation but delays the healing of ethanol-induced gastric lesions in the rat. ( De Luca, V; Guidobono, F; Lattuada, N; Netti, C; Pagani, F; Sibilia, V; Soglian, A, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.57) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 16 (57.14) | 29.6817 |
| 2010's | 11 (39.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, WC | 2 |
| Lin, KH | 1 |
| Huang, YT | 1 |
| Tsai, TJ | 2 |
| Sun, WC | 1 |
| Chuah, SK | 1 |
| Wu, DC | 2 |
| Hsu, PI | 2 |
| Takeuchi, K | 1 |
| Izuhara, C | 1 |
| Takayama, S | 1 |
| Momode, T | 1 |
| Kojo, M | 1 |
| Hara, D | 1 |
| Amagase, K | 1 |
| García Rodríguez, LA | 1 |
| Johansson, S | 1 |
| Cea Soriano, L | 1 |
| Lin, CC | 1 |
| Hu, HY | 1 |
| Luo, JC | 2 |
| Peng, YL | 1 |
| Hou, MC | 2 |
| Lin, HC | 2 |
| Lee, FY | 2 |
| Tsay, FW | 1 |
| Cheng, JS | 1 |
| Liu, CP | 1 |
| Lai, KH | 1 |
| Wang, HM | 1 |
| Tsai, KW | 1 |
| Kao, SS | 1 |
| Nardulli, G | 1 |
| Lanas, A | 1 |
| Dai, X | 1 |
| Makaryus, AN | 1 |
| Makaryus, JN | 1 |
| Jauhar, R | 1 |
| Cryer, B | 2 |
| Beales, IL | 1 |
| Venerito, M | 1 |
| Kandulski, A | 1 |
| Malfertheiner, P | 1 |
| Komarov, AL | 1 |
| Schmidt, M | 1 |
| Riis, AH | 1 |
| Christiansen, CF | 1 |
| Lash, TL | 1 |
| Sørensen, HT | 1 |
| Huang, KW | 1 |
| Leu, HB | 1 |
| Chen, LC | 1 |
| Li, CP | 1 |
| Lu, CL | 1 |
| Lee, SD | 1 |
| Chan, FK | 2 |
| Dworzynski, K | 1 |
| Pollit, V | 1 |
| Kelsey, A | 1 |
| Higgins, B | 1 |
| Palmer, K | 1 |
| Ng, FH | 1 |
| Wong, BC | 2 |
| Wong, SY | 1 |
| Chen, WH | 1 |
| Chang, CM | 1 |
| Ching, JY | 1 |
| Hung, LC | 1 |
| Wong, VW | 1 |
| Leung, VK | 1 |
| Kung, NN | 1 |
| Hui, AJ | 1 |
| Wu, JC | 1 |
| Leung, WK | 1 |
| Lee, VW | 1 |
| Lee, KK | 1 |
| Lee, YT | 1 |
| Lau, JY | 1 |
| To, KF | 1 |
| Chan, HL | 1 |
| Chung, SC | 1 |
| Sung, JJ | 1 |
| Wolk, MJ | 1 |
| Jacobs, AK | 1 |
| Barski, PR | 1 |
| Wargo, KA | 1 |
| Baty, SR | 1 |
| Knowles, G | 1 |
| Kulbertus, H | 1 |
| Nitschmann, S | 1 |
| Mössner, J | 1 |
| Lai, KC | 1 |
| Chu, KM | 1 |
| Hui, WM | 1 |
| Hung, WK | 1 |
| Loo, CK | 1 |
| Hu, WH | 1 |
| Chan, AO | 1 |
| Kwok, KF | 1 |
| Fung, TT | 1 |
| Wong, J | 1 |
| Lam, SK | 1 |
| Stiefelhagen, P | 1 |
| Sibilia, V | 1 |
| Pagani, F | 1 |
| Lattuada, N | 1 |
| De Luca, V | 1 |
| Guidobono, F | 1 |
| Soglian, A | 1 |
| Netti, C | 1 |
| Rupprecht, HJ | 1 |
| Kumashiro, R | 1 |
| Pavlides, CA | 1 |
| Kholoussy, AM | 1 |
| Matsumoto, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Ulcer Healing in Patients Taking Rabeprazole Plus Aspirin Versus Rabeprazole Plus Clopidogrel for Acute Peptic Ulcer[NCT01037491] | 200 participants (Anticipated) | Interventional | 2009-10-31 | Recruiting | |||
| Gastrointestinal Ulceration in Patients on Dual Antiplatelet Therapy After Percutaneous Coronary Intervention[NCT00413309] | 30 participants (Anticipated) | Interventional | 2006-04-30 | Completed | |||
| Efficacy of H2 Receptor Antagonist in Prevention of Thienopyridine-related Peptic Ulcer[NCT02418312] | 228 participants (Actual) | Interventional | 2012-01-31 | Completed | |||
| Pantoprazole Versus Famotidine for the Prevention of Recurrent Peptic Ulcers in Thienopyridine Users - a Double-blind Randomized Controlled Trial[NCT02551744] | 101 participants (Actual) | Interventional | 2012-07-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Follow-up endoscopy was performed at the end of the 6th month (NCT02418312)
Timeframe: 6 months
| Intervention | participants (Number) |
|---|---|
| Histamine-2 Receptor Antagonist Group | 106 |
| Placebo Group | 101 |
Follow-up endoscopy was performed at the end of the 6th month (NCT02551744)
Timeframe: six month
| Intervention | participants (Number) |
|---|---|
| Proton Pump Inhibitor Group | 1 |
| Histamine-2 Receptor Antagonist Group | 7 |
5 reviews available for ticlopidine and Hemorrhage, Peptic Ulcer
| Article | Year |
|---|---|
[Risk of gastrointestinal bleeding with aspirin and platelet antiaggregants].
Topics: Age Factors; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal | 2009 |
Significant gastrointestinal bleeding in patients at risk of coronary stent thrombosis.
Topics: Aged, 80 and over; Angioplasty, Balloon, Coronary; Anti-Bacterial Agents; Aspirin; Clopidogrel; Coro | 2009 |
Management of patients with high gastrointestinal risk on antiplatelet therapy.
Topics: Aspirin; Clopidogrel; Gastrointestinal Hemorrhage; Humans; Peptic Ulcer; Peptic Ulcer Hemorrhage; Pi | 2009 |
[Dilemma between gastroprotection and cardiovascular prevention].
Topics: Alleles; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aryl Hydrocarbon Hydroxylases; | 2010 |
[Efficacy and safety of various doses of acetylsalicylic Acid in prevention of complications of atherothrombosis].
Topics: Aspirin; Blood Platelets; Blood Vessels; Cardiovascular Diseases; Cerebrovascular Disorders; Clinica | 2010 |
5 trials available for ticlopidine and Hemorrhage, Peptic Ulcer
| Article | Year |
|---|---|
Histamine-2 Receptor Antagonist Cannot Prevent Recurrent Peptic Ulcers in Patients With Atherosclerotic Diseases Who Receive Platelet ADP Receptor Antagonist Monotherapy: A Randomized-Controlled, Double-Blind, and Double-Dummy Trial.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Atherosclerosis; Clopidogrel; Double-Blind Method; F | 2017 |
Randomised clinical trial: rabeprazole plus aspirin is not inferior to rabeprazole plus clopidogrel for the healing of aspirin-related peptic ulcer.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Aged, 80 and over; Anti-Ulcer Agents; Aspirin; Clopid | 2011 |
Clopidogrel plus omeprazole compared with aspirin plus omeprazole for aspirin-induced symptomatic peptic ulcers/erosions with low to moderate bleeding/re-bleeding risk -- a single-blind, randomized controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Aspirin; Clopidogrel; Female; Humans; | 2004 |
Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding.
Topics: Aged; Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Clopidogrel; Double-Blind Method; Drug Th | 2005 |
Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding.
Topics: Aged; Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Clopidogrel; Double-Blind Method; Drug Th | 2005 |
Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding.
Topics: Aged; Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Clopidogrel; Double-Blind Method; Drug Th | 2005 |
Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding.
Topics: Aged; Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Clopidogrel; Double-Blind Method; Drug Th | 2005 |
Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding.
Topics: Aged; Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Clopidogrel; Double-Blind Method; Drug Th | 2005 |
Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding.
Topics: Aged; Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Clopidogrel; Double-Blind Method; Drug Th | 2005 |
Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding.
Topics: Aged; Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Clopidogrel; Double-Blind Method; Drug Th | 2005 |
Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding.
Topics: Aged; Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Clopidogrel; Double-Blind Method; Drug Th | 2005 |
Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding.
Topics: Aged; Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Clopidogrel; Double-Blind Method; Drug Th | 2005 |
Esomeprazole with aspirin versus clopidogrel for prevention of recurrent gastrointestinal ulcer complications.
Topics: Aged; Aged, 80 and over; Anti-Ulcer Agents; Aspirin; Clopidogrel; Cohort Studies; Double-Blind Metho | 2006 |
18 other studies available for ticlopidine and Hemorrhage, Peptic Ulcer
| Article | Year |
|---|---|
The risk of lower gastrointestinal bleeding in low-dose aspirin users.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studi | 2017 |
Animal models of gastric bleeding induced by dual antiplatelet therapy using aspirin and clopidogrel--prophylactic effect of antiulcer drugs.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Clopidogrel; Disease Models, Animal; Drug Synergism; Histamine | 2014 |
Use of clopidogrel and proton pump inhibitors after a serious acute coronary event: risk of coronary events and peptic ulcer bleeding.
Topics: Aged; Aged, 80 and over; Case-Control Studies; Clopidogrel; Cohort Studies; Coronary Vessels; Drug I | 2013 |
Risk factors of gastrointestinal bleeding in clopidogrel users: a nationwide population-based study.
Topics: Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Cohort Studies; Da | 2013 |
Clopidogrel. Patients with peptic ulcers.
Topics: Aspirin; Clopidogrel; Histamine H2 Antagonists; Humans; Peptic Ulcer Hemorrhage; Platelet Aggregatio | 2009 |
Clopidogrel use and short-term mortality after peptic ulcer bleeding: a population-based cohort study.
Topics: Adult; Aged; Aged, 80 and over; Atherosclerosis; Clopidogrel; Cohort Studies; Denmark; Female; Human | 2013 |
Anti-platelet therapy and managing ulcer risk.
Topics: Animals; Anti-Bacterial Agents; Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Combined Modali | 2012 |
Management of acute upper gastrointestinal bleeding: summary of NICE guidance.
Topics: Acute Disease; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspir | 2012 |
Reducing the risks of gastrointestinal bleeding with antiplatelet therapies.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Clopid | 2005 |
Clopidogrel versus aspirin and esomeprazole to prevent recurrent bleeding.
Topics: Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Gastroi | 2005 |
Clopidogrel versus aspirin and esomeprazole to prevent recurrent bleeding.
Topics: Anti-Ulcer Agents; Aspirin; Clopidogrel; Cost Savings; Drug Therapy, Combination; Fees, Pharmaceutic | 2005 |
Clopidogrel versus aspirin and esomeprazole to prevent recurrent bleeding.
Topics: Anti-Ulcer Agents; Aspirin; Clopidogrel; Contraindications; Drug Therapy, Combination; Humans; Pepti | 2005 |
[Aspirin and cardiovascular prevention: last minute information].
Topics: Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Female; Humans; Male; Peptic Ulcer Hemorrhage; | 2005 |
[ASS or clopidogrel plus esomeprazole after bleeding from an ulcer].
Topics: Aged; Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Do | 2005 |
[Gastroenterology in family practice. Updates for your "stomach patient"].
Topics: Anti-Ulcer Agents; Aspirin; Clopidogrel; Dyspepsia; Esophagitis, Peptic; Family Practice; Heartburn; | 2006 |
Ticlopidine prevents the formation but delays the healing of ethanol-induced gastric lesions in the rat.
Topics: Administration, Oral; Animals; Aspirin; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Ani | 2007 |
[Coronary heart disease patient does not tolerate acetylsalicylic acid. Can clopidogrel be prescribed?].
Topics: Aspirin; Clopidogrel; Contraindications; Coronary Disease; Drug Therapy, Combination; Humans; Peptic | 2007 |
Thrombotic etiology of stress ulcers. 1. The effect of anticoagulant and antiplatelet aggregators in the development of stress ulcers in rats.
Topics: Animals; Anticoagulants; Aspirin; Dipyridamole; Gastric Acidity Determination; Gastric Mucosa; Hepar | 1983 |