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ticlopidine and Hemolytic-Uremic Syndrome

ticlopidine has been researched along with Hemolytic-Uremic Syndrome in 15 studies

Ticlopidine: An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
ticlopidine : A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.

Hemolytic-Uremic Syndrome: A syndrome that is associated with microvascular diseases of the KIDNEY, such as RENAL CORTICAL NECROSIS. It is characterized by hemolytic anemia (ANEMIA, HEMOLYTIC); THROMBOCYTOPENIA; and ACUTE RENAL FAILURE.

Research Excerpts

ExcerptRelevanceReference
"Of 72 children with diarrhea associated hemolytic uremic syndrome, 88% were treated with platelet aggregation inhibitors (clopidogrel 56%, sulfinpyrazone 19%, dipyridamole 13%)."9.16Efficacy and safety of clopidogrel in children with diarrhea associated hemolytic uremic syndrome. ( Bakel, LA; Cadnapaphornchai, MA; Ford, D; Gao, D; Lum, G; Seltz, LB; Tiehen, J, 2012)
"Of 72 children with diarrhea associated hemolytic uremic syndrome, 88% were treated with platelet aggregation inhibitors (clopidogrel 56%, sulfinpyrazone 19%, dipyridamole 13%)."5.16Efficacy and safety of clopidogrel in children with diarrhea associated hemolytic uremic syndrome. ( Bakel, LA; Cadnapaphornchai, MA; Ford, D; Gao, D; Lum, G; Seltz, LB; Tiehen, J, 2012)
"Hemolytic uremic syndrome (HUS), thrombotic thrombocytopenic purpura (TTP), and several other conditions are associated with TMA."2.44The thrombotic microangiopathies. ( Copelovitch, L; Kaplan, BS, 2008)
"Drug-associated thrombotic thrombocytopenic purpura and hemolytic uremic syndrome (TTP/HUS) has been recognized for several years."2.43Drug-induced thrombotic microangiopathy. ( Bennett, C; Zakarija, A, 2005)
"Ticlopidine therapy is an important risk factor for TTP."2.41Thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome. ( Baker, KR; Moake, JL, 2000)
"Ticlopidine has been reported to have major hematologic adverse effects, including neutropenia and thrombotic thrombocytopenic purpura or hemolytic uremic syndrome (HUS)."1.31Hemolytic uremic syndrome associated with clopidogrel: a case report. ( Marcoux, JP; Moy, B; Raffel, GD; Wang, JC, 2000)
"We present a case report of thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) developing in a kidney/pancreas transplant recipient after the initiation of treatment with clopidogrel for symptomatic coronary artery disease."1.31Clopidogrel-associated thrombotic thrombocytopenic purpura/hemolytic uremic syndrome in a kidney/pancreas transplant recipient. ( Chinnakotla, S; Fidler, ME; Hammeke, MD; Leone, JP; Tarantolo, S, 2000)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's14 (93.33)29.6817
2010's1 (6.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Seltz, LB1
Bakel, LA1
Tiehen, J1
Gao, D1
Cadnapaphornchai, MA1
Lum, G1
Ford, D1
Griffiths, C1
Fisher, M1
Evens, AM1
Kwaan, HC1
Kaufman, DB1
Bennett, CL1
Manor, SM1
Guillory, GS1
Jain, SP1
Andersohn, F1
Hagmann, FG1
Garbe, E1
Szułdrzyński, K1
Dropiński, J1
Szczeklik, W1
Zakarija, A1
Bennett, C1
Yagi, H1
Matsumoto, M1
Fujimura, Y1
Copelovitch, L1
Kaplan, BS1
Baker, KR1
Moake, JL1
Moy, B1
Wang, JC1
Raffel, GD1
Marcoux, JP1
Oomen, PH1
Tulleken, JE1
Zijlstra, JG1
Chinnakotla, S1
Leone, JP1
Fidler, ME1
Hammeke, MD1
Tarantolo, S1
Mauro, M1
Kim, J1
Costello, C1
Laurence, J1
Medina, PJ1
Sipols, JM1
George, JN1

Reviews

5 reviews available for ticlopidine and Hemolytic-Uremic Syndrome

ArticleYear
Drug-induced thrombotic microangiopathy.
    Seminars in thrombosis and hemostasis, 2005, Volume: 31, Issue:6

    Topics: ADAM Proteins; ADAMTS13 Protein; Antibiotics, Antineoplastic; Cyclosporine; Endothelium, Vascular; F

2005
[Brain nerve symptoms due to thrombotic microangiopathy].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2007, Feb-10, Volume: 96, Issue:2

    Topics: ADAM Proteins; ADAMTS13 Protein; Adult; Aged; Aged, 80 and over; Cerebrovascular Disorders; Clopidog

2007
The thrombotic microangiopathies.
    Pediatric nephrology (Berlin, Germany), 2008, Volume: 23, Issue:10

    Topics: Hematopoietic Stem Cell Transplantation; Hemolytic-Uremic Syndrome; HIV Infections; Humans; Lupus Er

2008
Thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome.
    Current opinion in pediatrics, 2000, Volume: 12, Issue:1

    Topics: Anti-Bacterial Agents; Child; Diagnosis, Differential; Erythropoietin; Hemolytic-Uremic Syndrome; Hu

2000
Drug-associated thrombotic thrombocytopenic purpura-hemolytic uremic syndrome.
    Current opinion in hematology, 2001, Volume: 8, Issue:5

    Topics: Antibiotics, Antineoplastic; Clopidogrel; Cyclosporine; Hemolytic-Uremic Syndrome; Humans; Immunosup

2001

Trials

1 trial available for ticlopidine and Hemolytic-Uremic Syndrome

ArticleYear
Efficacy and safety of clopidogrel in children with diarrhea associated hemolytic uremic syndrome.
    Thrombosis research, 2012, Volume: 130, Issue:3

    Topics: Adolescent; Child; Child, Preschool; Clopidogrel; Diarrhea; Female; Hemolytic-Uremic Syndrome; Human

2012

Other Studies

9 other studies available for ticlopidine and Hemolytic-Uremic Syndrome

ArticleYear
Abciximab-induced thrombocytopenia.
    QJM : monthly journal of the Association of Physicians, 2002, Volume: 95, Issue:9

    Topics: Abciximab; Antibodies, Monoclonal; Anticoagulants; Clopidogrel; Diagnosis, Differential; Hemolytic-U

2002
TTP/HUS occurring in a simultaneous pancreas/kidney transplant recipient after clopidogrel treatment: evidence of a nonimmunological etiology.
    Transplantation, 2002, Sep-27, Volume: 74, Issue:6

    Topics: Calcineurin; Clopidogrel; Graft Rejection; Hemolytic-Uremic Syndrome; Humans; Kidney Transplantation

2002
Clopidogrel-induced thrombotic thrombocytopenic purpura-hemolytic uremic syndrome after coronary artery stenting.
    Pharmacotherapy, 2004, Volume: 24, Issue:5

    Topics: Clopidogrel; Coronary Disease; Hemolytic-Uremic Syndrome; Humans; Male; Middle Aged; Platelet Aggreg

2004
Thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome associated with clopidogrel: report of two new cases.
    Heart (British Cardiac Society), 2004, Volume: 90, Issue:9

    Topics: Adult; Aged; Angina Pectoris; Carotid Artery, Internal; Carotid Stenosis; Clopidogrel; Hemolytic-Ure

2004
[Thrombotic thrombocytopenic purpura -- a rare complication associated with clopidogrel therapy. A case report].
    Kardiologia polska, 2005, Volume: 63, Issue:4

    Topics: Clopidogrel; Female; Hemolytic-Uremic Syndrome; Humans; Middle Aged; Platelet Aggregation Inhibitors

2005
Hemolytic uremic syndrome associated with clopidogrel: a case report.
    Archives of internal medicine, 2000, May-08, Volume: 160, Issue:9

    Topics: Angina, Unstable; Clopidogrel; Hemolytic-Uremic Syndrome; Humans; Male; Middle Aged; Plasmapheresis;

2000
Hemolytic uremic syndrome in a patient treated with clopidogrel.
    Annals of internal medicine, 2000, Jun-20, Volume: 132, Issue:12

    Topics: Aged; Clopidogrel; Hemolytic-Uremic Syndrome; Humans; Male; Myocardial Infarction; Platelet Aggregat

2000
Clopidogrel-associated thrombotic thrombocytopenic purpura/hemolytic uremic syndrome in a kidney/pancreas transplant recipient.
    Transplantation, 2000, Aug-15, Volume: 70, Issue:3

    Topics: Adult; Clopidogrel; Coronary Disease; Cyclosporine; Diabetes Mellitus, Type 1; Diabetic Nephropathie

2000
Role of transforming growth factor beta1 in microvascular endothelial cell apoptosis associated with thrombotic thrombocytopenic purpura and hemolytic-uremic syndrome.
    American journal of hematology, 2001, Volume: 66, Issue:1

    Topics: Apoptosis; Cell Cycle; Cell Lineage; Cells, Cultured; Coronary Vessels; Culture Media, Serum-Free; E

2001