Page last updated: 2024-11-05

ticlopidine and Gastroduodenal Ulcer

ticlopidine has been researched along with Gastroduodenal Ulcer in 43 studies

Ticlopidine: An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
ticlopidine : A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.

Research Excerpts

ExcerptRelevanceReference
"Among patients with atherosclerosis and a history of peptic ulcers, the combination of esomeprazole and clopidogrel reduced recurrence of peptic ulcers, compared with clopidogrel alone."9.15Esomeprazole with clopidogrel reduces peptic ulcer recurrence, compared with clopidogrel alone, in patients with atherosclerosis. ( Hsu, PI; Lai, KH; Liu, CP, 2011)
" As a result, clopidogrel's incidence of peptic ulcer disease (PUD) and ulcer bleeding is lower than aspirin's."9.15Randomised clinical trial: rabeprazole plus aspirin is not inferior to rabeprazole plus clopidogrel for the healing of aspirin-related peptic ulcer. ( Chen, LC; Hou, MC; Huang, KW; Lee, FY; Lee, SD; Leu, HB; Li, CP; Lin, HC; Lu, CL; Luo, JC, 2011)
"In patients with aspirin-associated peptic ulcer disease of low to moderate grade, both early conversion from aspirin to clopidogrel and continuation of aspirin are safe."9.11Clopidogrel plus omeprazole compared with aspirin plus omeprazole for aspirin-induced symptomatic peptic ulcers/erosions with low to moderate bleeding/re-bleeding risk -- a single-blind, randomized controlled study. ( Chang, CM; Chen, WH; Ng, FH; Wong, BC; Wong, SY, 2004)
"This survey depicts individual discrepancies in the clinical management of patients receiving NSAIDs and/or aspirin, regarding the prophylaxis of gastroduodenal ulcer disease."7.78[Current clinical practice among German Internists regarding the prophylaxis of gastroduodenal ulcers associated with NSAIDs, aspirin and Helicobacter pylori]. ( Armbruster, S; Mann, J; Schepp, W; Schneider, AR; Schuster, T; von Römer, W, 2012)
"This multicenter retrospective study investigated the management and outcome of patients with peptic ulcer/erosion-related aspirin and clopidogrel (A + C) cotherapy."7.74Management and outcome of peptic ulcers or erosions in patients receiving a combination of aspirin plus clopidogrel. ( Chan, P; Cheung, TK; Kng, C; Kwanching, CP; Lai, ST; Loo, CK; Ng, FH; Ng, KM; Wong, BC; Wong, SY, 2008)
"To evaluate the safety of clopidogrel in patients with peptic ulcer disease in a retrospective cohort longitudinal study."7.72High incidence of clopidogrel-associated gastrointestinal bleeding in patients with previous peptic ulcer disease. ( Chang, CM; Chen, WH; Kng, C; Lanas, AI; Ng, FH; Wong, BC; Wong, SY, 2003)
"From January 2012 to 2016, long-termed thienopyridine users with a peptic ulcer history who did not have peptic ulcers at initial endoscopy were randomly assigned to receive either famotidine (40 mg, before bedtime) or placebo (before bedtime) for 6 months."5.24Histamine-2 Receptor Antagonist Cannot Prevent Recurrent Peptic Ulcers in Patients With Atherosclerotic Diseases Who Receive Platelet ADP Receptor Antagonist Monotherapy: A Randomized-Controlled, Double-Blind, and Double-Dummy Trial. ( Chen, WC; Cheng, JS; Hsu, PI; Kao, SS; Lai, KH; Liu, CP; Tsai, KW; Tsai, TJ; Tsay, FW; Wang, HM; Wu, DC, 2017)
" Patients with Helicobacter pylori infection and a history of peptic ulcer were assigned dual antiplatelet combination with omeprazole."5.17Effect of clopidogrel with or without omeprazole in patients with carotid artery stenting. ( Chen, G; Du, Y; Hang, L; Ma, B, 2013)
"Among patients with atherosclerosis and a history of peptic ulcers, the combination of esomeprazole and clopidogrel reduced recurrence of peptic ulcers, compared with clopidogrel alone."5.15Esomeprazole with clopidogrel reduces peptic ulcer recurrence, compared with clopidogrel alone, in patients with atherosclerosis. ( Hsu, PI; Lai, KH; Liu, CP, 2011)
" As a result, clopidogrel's incidence of peptic ulcer disease (PUD) and ulcer bleeding is lower than aspirin's."5.15Randomised clinical trial: rabeprazole plus aspirin is not inferior to rabeprazole plus clopidogrel for the healing of aspirin-related peptic ulcer. ( Chen, LC; Hou, MC; Huang, KW; Lee, FY; Lee, SD; Leu, HB; Li, CP; Lin, HC; Lu, CL; Luo, JC, 2011)
"In patients with aspirin-associated peptic ulcer disease of low to moderate grade, both early conversion from aspirin to clopidogrel and continuation of aspirin are safe."5.11Clopidogrel plus omeprazole compared with aspirin plus omeprazole for aspirin-induced symptomatic peptic ulcers/erosions with low to moderate bleeding/re-bleeding risk -- a single-blind, randomized controlled study. ( Chang, CM; Chen, WH; Ng, FH; Wong, BC; Wong, SY, 2004)
"Long-term use of aspirin and severity of cerebral infarction are risk factors for gastrointestinal bleeding in cerebral infarction patients receiving dual antiplatelet therapy."4.31Risk factors for gastrointestinal bleeding in patients with cerebral infarction after dual antiplatelet therapy. ( Huang, J; Liao, F; Shu, X; Tang, J, 2023)
" Cox proportional hazard regression models were developed to evaluate the predictors of LGIB with adjustments for age, gender, comorbidities including coronary artery disease, ischaemic stroke, diabetes, hypertension, chronic kidney disease, liver cirrhosis, chronic obstructive pulmonary disease, dyslipidemia, uncomplicated peptic ulcer disease, history of peptic ulcer bleeding, and concomitant use of clopidogrel, ticlopidine, warfarin, nonsteroidal anti-inflammatory drugs (NSAIDs), cyclooxygenase-2 inhibitors, steroids, proton pump inhibitors (PPIs), histamine-2 receptor antagonists (H2RAs), nitrates, alendronate, selective serotonin reuptake inhibitors (SSRIs) and calcium channel blockers."3.85The risk of lower gastrointestinal bleeding in low-dose aspirin users. ( Chen, WC; Chuah, SK; Hsu, PI; Huang, YT; Lin, KH; Sun, WC; Tsai, TJ; Wu, DC, 2017)
"Increased incidence of coronary artery disease has led to the increased use of dual antiplatelet therapy composed of aspirin and clopidogrel."3.80[Clinical impact of dual antiplatelet therapy on peptic ulcer disease]. ( Ahn, DG; Kim, BJ; Kim, JG; Kim, JW, 2014)
"Low-dose aspirin (ASA) has emerged as one of the most important causes of peptic ulcer bleeding in developed countries."3.78Anti-platelet therapy and managing ulcer risk. ( Chan, FK, 2012)
" In the management of aspirin-related uncomplicated peptic ulcers in patients requiring antiplatelet therapies, continuing aspirin plus a powerful proton pump inhibitor is the choice of treatment."3.78New look at antiplatelet agent-related peptic ulcer: an update of prevention and treatment. ( Hsu, PI, 2012)
"This survey depicts individual discrepancies in the clinical management of patients receiving NSAIDs and/or aspirin, regarding the prophylaxis of gastroduodenal ulcer disease."3.78[Current clinical practice among German Internists regarding the prophylaxis of gastroduodenal ulcers associated with NSAIDs, aspirin and Helicobacter pylori]. ( Armbruster, S; Mann, J; Schepp, W; Schneider, AR; Schuster, T; von Römer, W, 2012)
"The frequencies of hemorrhagic spots, erosions and peptic ulcers in the symptomatic clopidogrel users were 25%, 39% and 39%, respectively."3.78Upper gastrointestinal lesions in patients receiving clopidogrel anti-platelet therapy. ( Chan, HH; Chang, SN; Hsiao, SH; Hsu, PI; Huang, HR; Lai, KH; Lin, CH; Lin, CK; Lin, KH; Liu, CP; Tsai, TJ; Tsay, FW; Wang, HM; Wang, KM; Yu, HC, 2012)
"This study was conducted to compare the risk of recurrent hospitalization for major gastrointestinal (GI) complications (peptic ulcer, bleeding, and perforation) in patients at high GI risk who require ongoing antiplatelet therapy (aspirin [acetylsalicylic acid] or clopidogrel) with or without proton pump inhibitors (PPIs)."3.75A comparison of aspirin and clopidogrel with or without proton pump inhibitors for the secondary prevention of cardiovascular events in patients at high risk for gastrointestinal bleeding. ( Chang, PY; Chen, PF; Hsiao, FY; Huang, WF; Kuo, KN; Tsai, YW; Wen, YW, 2009)
"This multicenter retrospective study investigated the management and outcome of patients with peptic ulcer/erosion-related aspirin and clopidogrel (A + C) cotherapy."3.74Management and outcome of peptic ulcers or erosions in patients receiving a combination of aspirin plus clopidogrel. ( Chan, P; Cheung, TK; Kng, C; Kwanching, CP; Lai, ST; Loo, CK; Ng, FH; Ng, KM; Wong, BC; Wong, SY, 2008)
"To evaluate the safety of clopidogrel in patients with peptic ulcer disease in a retrospective cohort longitudinal study."3.72High incidence of clopidogrel-associated gastrointestinal bleeding in patients with previous peptic ulcer disease. ( Chang, CM; Chen, WH; Kng, C; Lanas, AI; Ng, FH; Wong, BC; Wong, SY, 2003)
"Randomized patients with available aspirin dosing information in COGENT (N = 3,752) were divided into "low-dose" (≤ 100 mg) and "high-dose" (>100 mg) aspirin groups."2.82Proton-Pump Inhibitors Reduce Gastrointestinal Events Regardless of Aspirin Dose in Patients Requiring Dual Antiplatelet Therapy. ( Bhatt, DL; Cannon, CP; Cohen, M; Cryer, BL; Doros, G; Goldsmith, MA; Hsieh, WH; Laine, L; Lanas, A; Lapuerta, P; Liu, Y; Schnitzer, TJ; Shook, TL; Vaduganathan, M, 2016)
" The grade of gastric mucosal injuries was evaluated by esophagogastroduodenoscopy before and after dosing (on day 0 and day 14), and the grade of gastric mucosal injury was assessed according to the modified Lanza score."2.79A randomized, double-blind, placebo-controlled study of rebamipide for gastric mucosal injury taking aspirin with or without clopidogrel. ( Fukui, H; Hida, N; Hori, K; Miwa, H; Nakamura, S; Ogawa, T; Ohda, Y; Okugawa, T; Oshima, T; Tomita, T; Tozawa, K; Watari, J, 2014)
"Many individuals with gastroduodenal ulcers require on-going, non-steroidal anti-inflammatory drug (NSAID) or anti-platelet therapy."2.74A randomized, placebo-controlled study of the effects of naproxen, aspirin, celecoxib or clopidogrel on gastroduodenal mucosal healing. ( Aisenberg, J; Bamji, N; Bodian, C; Brooks, A; Cohen, L; Desai, J; Dikman, A; Miller, K; Sanyal, S; VON Althann, C; Whitson, M, 2009)
"Regardless of dose, adjusted odds ratios associating clopidogrel use with the study endpoint were statistically significant and followed a dose-response pattern."1.39Gastrointestinal events with clopidogrel: a nationwide population-based cohort study. ( Grove, EL; Jørgensen, NR; Schwarz, P; Vestergaard, P; Würtz, M, 2013)

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (20.93)29.6817
2010's33 (76.74)24.3611
2020's1 (2.33)2.80

Authors

AuthorsStudies
Huang, J1
Liao, F1
Tang, J1
Shu, X1
Chen, WC2
Lin, KH2
Huang, YT1
Tsai, TJ3
Sun, WC1
Chuah, SK1
Wu, DC2
Hsu, PI5
Amagase, K1
Yoshida, Y1
Hara, D1
Murakami, T1
Takeuchi, K1
Jiang, Z1
Wu, H1
Duan, Z1
Wang, Z1
Hu, K1
Ye, F1
Zhang, Z1
Ma, B1
Hang, L1
Chen, G1
Du, Y1
Tozawa, K1
Oshima, T1
Okugawa, T1
Ogawa, T1
Ohda, Y1
Tomita, T1
Hida, N1
Fukui, H1
Hori, K1
Watari, J1
Nakamura, S1
Miwa, H1
Wang, Q1
Ljung, R1
Lagergren, J1
Lu, Y1
Ahn, DG1
Kim, BJ1
Kim, JW1
Kim, JG1
Kim, JJ1
Kim, N1
Vaduganathan, M1
Bhatt, DL1
Cryer, BL1
Liu, Y1
Hsieh, WH1
Doros, G1
Cohen, M1
Lanas, A1
Schnitzer, TJ1
Shook, TL1
Lapuerta, P1
Goldsmith, MA1
Laine, L2
Cannon, CP1
Zhang, ZF1
Sha, WH1
Tan, GY1
Wang, QY1
Würtz, M2
Grove, EL2
Tsay, FW2
Cheng, JS1
Liu, CP3
Lai, KH3
Wang, HM2
Tsai, KW1
Kao, SS1
Ng, FH3
Chan, P1
Kwanching, CP1
Loo, CK1
Cheung, TK1
Wong, SY3
Kng, C2
Ng, KM1
Lai, ST1
Wong, BC3
Dikman, A1
Sanyal, S1
VON Althann, C1
Whitson, M1
Desai, J1
Bodian, C1
Brooks, A1
Bamji, N1
Cohen, L1
Miller, K1
Aisenberg, J1
Cryer, B1
Luo, JC2
Doherty, GA1
Cannon, MD1
Lynch, KM1
Ayoubi, KZ1
Harewood, GC1
Patchett, SE1
Murray, FE1
Hsiao, FY2
Tsai, YW2
Huang, WF2
Wen, YW2
Chen, PF2
Chang, PY1
Kuo, KN2
Mourad, JJ1
Marcucci, R1
Madanick, RD1
Hiraishi, H1
Maeda, M1
Sasai, T1
Kanke, K1
Shimada, T1
Bae, SE1
Kim, SE1
Jung, SA1
Yoon, SY1
Shim, KN1
Jung, HK1
Kim, TH1
Yoo, K1
Moon, IH1
Huang, KW1
Leu, HB1
Chen, LC1
Hou, MC1
Li, CP1
Lu, CL1
Lin, HC1
Lee, FY1
Lee, SD1
Labos, C1
Dasgupta, K1
Nedjar, H1
Turecki, G1
Rahme, E1
Messinger-Rapport, BJ1
Morley, JE1
Thomas, DR1
Gammack, JK1
Almadi, MA1
Barkun, A1
Brophy, J1
Chan, FK1
Struijk, M1
Postma, DF1
van Tuyl, SA1
van de Ree, MA1
Häuptle, R1
Weilenmann, D1
Schneider, T1
Haile, SR1
Ammann, P1
Knellwolf, C1
Borovicka, J1
Uotani, T1
Sugimoto, M1
Nishino, M1
Kodaira, C1
Yamade, M1
Sahara, S1
Yamada, T1
Osawa, S1
Sugimoto, K1
Tanaka, T1
Umemura, K1
Watanabe, H1
Miyajima, H1
Furuta, T1
Schwarz, P1
Jørgensen, NR1
Vestergaard, P1
Schneider, AR1
Armbruster, S1
Mann, J1
von Römer, W1
Schuster, T1
Schepp, W1
Lin, CK1
Chan, HH1
Yu, HC1
Wang, KM1
Chang, SN1
Hsiao, SH1
Huang, HR1
Lin, CH1
Chang, CM2
Chen, WH2
Lanas, AI1
Ziegelin, M1
Hoschtitzky, A1
Dunning, J1
Hooper, T1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Double-Blind, Double-Dummy, Parallel Group, Phase 3 Efficacy and Safety Study of CGT-2168 Compared With Clopidogrel to Reduce Upper Gastrointestinal Events Including Bleeding and Symptomatic Ulcer Disease[NCT00557921]Phase 35,000 participants (Anticipated)Interventional2007-12-31Terminated (stopped due to Terminated by Sponsor)
Efficacy of Proton Pump Inhibitor in Prevention of Clopidogrel-related Peptic Ulcer and Gastrointestinal Bleeding[NCT01138969]Phase 2165 participants (Actual)Interventional2008-08-31Completed
Efficacy of H2 Receptor Antagonist in Prevention of Thienopyridine-related Peptic Ulcer[NCT02418312]228 participants (Actual)Interventional2012-01-31Completed
Pantoprazole Versus Famotidine for the Prevention of Recurrent Peptic Ulcers in Thienopyridine Users - a Double-blind Randomized Controlled Trial[NCT02551744]101 participants (Actual)Interventional2012-07-31Completed
Institute of Emergency and Critical Care Medicine , School of Yang-Ming University[NCT01588886]9,000 participants (Actual)Observational2012-03-31Completed
Comparison of Ulcer Healing in Patients Taking Rabeprazole Plus Aspirin Versus Rabeprazole Plus Clopidogrel for Acute Peptic Ulcer[NCT01037491]200 participants (Anticipated)Interventional2009-10-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Peptic Ulcer Bleeding

participants with peptic ulcer bleeding within 6 months (NCT01138969)
Timeframe: 6 months

Interventionparticipants (Number)
Esomeprazole Plus Clopidogrel Group0
Clopidogrel Group1

Recurrent Peptic Ulcer

Number of participants with recurrent peptic ulcer within 6 months (NCT01138969)
Timeframe: 6 months

Interventionparticipants (Number)
Esomeprazole Plus Clopidogrel Group1
Clopidogrel Group9

Number of Participants With Healed Peptic Ulcer

Follow-up endoscopy was performed at the end of the 6th month (NCT02418312)
Timeframe: 6 months

Interventionparticipants (Number)
Histamine-2 Receptor Antagonist Group106
Placebo Group101

Number of Participants With Ulcer Recurrence

Follow-up endoscopy was performed at the end of the 6th month (NCT02551744)
Timeframe: six month

Interventionparticipants (Number)
Proton Pump Inhibitor Group1
Histamine-2 Receptor Antagonist Group7

Reviews

7 reviews available for ticlopidine and Gastroduodenal Ulcer

ArticleYear
Proton Pump Inhibitors in Cardiovascular Disease: Drug Interactions with Antiplatelet Drugs.
    Advances in experimental medicine and biology, 2017, Volume: 906

    Topics: Adenosine; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Administration Schedule; Drug Dosage

2017
PPI interactions with clopidogrel.
    The Medical letter on drugs and therapeutics, 2009, Jan-12, Volume: 51, Issue:1303

    Topics: Anti-Ulcer Agents; Cardiovascular Diseases; Clopidogrel; Drug Interactions; Gastroesophageal Reflux;

2009
Management of patients with high gastrointestinal risk on antiplatelet therapy.
    Gastroenterology clinics of North America, 2009, Volume: 38, Issue:2

    Topics: Aspirin; Clopidogrel; Gastrointestinal Hemorrhage; Humans; Peptic Ulcer; Peptic Ulcer Hemorrhage; Pi

2009
Proton pump inhibitor side effects and drug interactions: much ado about nothing?
    Cleveland Clinic journal of medicine, 2011, Volume: 78, Issue:1

    Topics: Anemia, Iron-Deficiency; Anti-Ulcer Agents; Clopidogrel; Drug Interactions; Fractures, Spontaneous;

2011
[Strategy to manage low dose aspirin-induced gastrointestinal injury].
    Nihon rinsho. Japanese journal of clinical medicine, 2011, Volume: 69, Issue:2

    Topics: Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Cerebrovascular Disorders; Clopidogrel; Famotid

2011
Optimal drug therapy after aspirin-induced upper gastrointestinal bleeding.
    European journal of internal medicine, 2012, Volume: 23, Issue:3

    Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Gastrointestinal Hemorrhage; Humans; Peptic Ulcer; Pl

2012
Does clopidogrel rather than aspirin plus a proton-pump inhibitor reduce the frequency of gastrointestinal complications after cardiac surgery?
    Interactive cardiovascular and thoracic surgery, 2007, Volume: 6, Issue:4

    Topics: Aspirin; Cardiac Surgical Procedures; Clopidogrel; Drug Therapy, Combination; Evidence-Based Medicin

2007

Trials

9 trials available for ticlopidine and Gastroduodenal Ulcer

ArticleYear
Effect of clopidogrel with or without omeprazole in patients with carotid artery stenting.
    The West Indian medical journal, 2013, Volume: 62, Issue:2

    Topics: Angiography; Aspirin; Breath Tests; Carotid Arteries; Carotid Stenosis; Clopidogrel; Drug Interactio

2013
A randomized, double-blind, placebo-controlled study of rebamipide for gastric mucosal injury taking aspirin with or without clopidogrel.
    Digestive diseases and sciences, 2014, Volume: 59, Issue:8

    Topics: Adult; Alanine; Anti-Ulcer Agents; Aspirin; Clopidogrel; Double-Blind Method; Gastric Mucosa; Gastro

2014
Proton-Pump Inhibitors Reduce Gastrointestinal Events Regardless of Aspirin Dose in Patients Requiring Dual Antiplatelet Therapy.
    Journal of the American College of Cardiology, 2016, Apr-12, Volume: 67, Issue:14

    Topics: Aged; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Dyspepsia;

2016
Histamine-2 Receptor Antagonist Cannot Prevent Recurrent Peptic Ulcers in Patients With Atherosclerotic Diseases Who Receive Platelet ADP Receptor Antagonist Monotherapy: A Randomized-Controlled, Double-Blind, and Double-Dummy Trial.
    The American journal of gastroenterology, 2017, Volume: 112, Issue:2

    Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Atherosclerosis; Clopidogrel; Double-Blind Method; F

2017
A randomized, placebo-controlled study of the effects of naproxen, aspirin, celecoxib or clopidogrel on gastroduodenal mucosal healing.
    Alimentary pharmacology & therapeutics, 2009, Apr-01, Volume: 29, Issue:7

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Clopidogrel; Drug Administ

2009
Esomeprazole with clopidogrel reduces peptic ulcer recurrence, compared with clopidogrel alone, in patients with atherosclerosis.
    Gastroenterology, 2011, Volume: 140, Issue:3

    Topics: Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Atherosclerosis; Clopidogrel; Cytochrome P-4

2011
Esomeprazole with clopidogrel reduces peptic ulcer recurrence, compared with clopidogrel alone, in patients with atherosclerosis.
    Gastroenterology, 2011, Volume: 140, Issue:3

    Topics: Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Atherosclerosis; Clopidogrel; Cytochrome P-4

2011
Esomeprazole with clopidogrel reduces peptic ulcer recurrence, compared with clopidogrel alone, in patients with atherosclerosis.
    Gastroenterology, 2011, Volume: 140, Issue:3

    Topics: Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Atherosclerosis; Clopidogrel; Cytochrome P-4

2011
Esomeprazole with clopidogrel reduces peptic ulcer recurrence, compared with clopidogrel alone, in patients with atherosclerosis.
    Gastroenterology, 2011, Volume: 140, Issue:3

    Topics: Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Atherosclerosis; Clopidogrel; Cytochrome P-4

2011
Esomeprazole with clopidogrel reduces peptic ulcer recurrence, compared with clopidogrel alone, in patients with atherosclerosis.
    Gastroenterology, 2011, Volume: 140, Issue:3

    Topics: Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Atherosclerosis; Clopidogrel; Cytochrome P-4

2011
Esomeprazole with clopidogrel reduces peptic ulcer recurrence, compared with clopidogrel alone, in patients with atherosclerosis.
    Gastroenterology, 2011, Volume: 140, Issue:3

    Topics: Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Atherosclerosis; Clopidogrel; Cytochrome P-4

2011
Esomeprazole with clopidogrel reduces peptic ulcer recurrence, compared with clopidogrel alone, in patients with atherosclerosis.
    Gastroenterology, 2011, Volume: 140, Issue:3

    Topics: Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Atherosclerosis; Clopidogrel; Cytochrome P-4

2011
Esomeprazole with clopidogrel reduces peptic ulcer recurrence, compared with clopidogrel alone, in patients with atherosclerosis.
    Gastroenterology, 2011, Volume: 140, Issue:3

    Topics: Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Atherosclerosis; Clopidogrel; Cytochrome P-4

2011
Esomeprazole with clopidogrel reduces peptic ulcer recurrence, compared with clopidogrel alone, in patients with atherosclerosis.
    Gastroenterology, 2011, Volume: 140, Issue:3

    Topics: Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Atherosclerosis; Clopidogrel; Cytochrome P-4

2011
Randomised clinical trial: rabeprazole plus aspirin is not inferior to rabeprazole plus clopidogrel for the healing of aspirin-related peptic ulcer.
    Alimentary pharmacology & therapeutics, 2011, Volume: 34, Issue:5

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Aged, 80 and over; Anti-Ulcer Agents; Aspirin; Clopid

2011
Ability of rabeprazole to prevent gastric mucosal damage from clopidogrel and low doses of aspirin depends on CYP2C19 genotype.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2012, Volume: 10, Issue:8

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Anti-Ulcer Agents; Aryl Hydrocarbon Hydroxylases; As

2012
Clopidogrel plus omeprazole compared with aspirin plus omeprazole for aspirin-induced symptomatic peptic ulcers/erosions with low to moderate bleeding/re-bleeding risk -- a single-blind, randomized controlled study.
    Alimentary pharmacology & therapeutics, 2004, Feb-01, Volume: 19, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Aspirin; Clopidogrel; Female; Humans;

2004

Other Studies

27 other studies available for ticlopidine and Gastroduodenal Ulcer

ArticleYear
Risk factors for gastrointestinal bleeding in patients with cerebral infarction after dual antiplatelet therapy.
    Clinical neurology and neurosurgery, 2023, Volume: 231

    Topics: Aspirin; Cerebral Infarction; Clopidogrel; Drug Therapy, Combination; Gastrointestinal Hemorrhage; H

2023
The risk of lower gastrointestinal bleeding in low-dose aspirin users.
    Alimentary pharmacology & therapeutics, 2017, Volume: 45, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studi

2017
Prophylactic effect of egualen sodium, a stable azulene derivative, on gastrointestinal damage induced by ischemia/reperfusion, double antiplatelet therapy and loxoprofen in rats.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2013, Volume: 64, Issue:1

    Topics: Animals; Aspirin; Azulenes; Benzoquinones; Clopidogrel; Gastric Mucosa; Gastrointestinal Hemorrhage;

2013
Proton-pump inhibitors can decrease gastrointestinal bleeding after percutaneous coronary intervention.
    Clinics and research in hepatology and gastroenterology, 2013, Volume: 37, Issue:6

    Topics: Acute Coronary Syndrome; Age Factors; Aged; Alcohol Drinking; Angina, Stable; Aspirin; Case-Control

2013
Prognosis of concomitant users of clopidogrel and proton-pump inhibitors in a high-risk population for upper gastrointestinal bleeding.
    BMC pharmacology & toxicology, 2014, Apr-15, Volume: 15

    Topics: Aged; Aged, 80 and over; Cardiovascular Diseases; Clopidogrel; Cohort Studies; Drug Interactions; Fe

2014
[Clinical impact of dual antiplatelet therapy on peptic ulcer disease].
    The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2014, Volume: 64, Issue:2

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Coronary Angiography; Coronary

2014
[Does dual antiplatelet therapy increase the risk of peptic ulcer disease?].
    The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2014, Volume: 64, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Coronary Artery Disease; Female; Huma

2014
[The incidence, clinical characteristics and risk factors of upper gastrointestinal bleeding in patients taking dual antiplatelet therapy after percutaneous coronary intervention in south China].
    Zhonghua nei ke za zhi, 2016, Volume: 55, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; China; Clopidogrel; Coronary Artery Disease; Femal

2016
Management and outcome of peptic ulcers or erosions in patients receiving a combination of aspirin plus clopidogrel.
    Journal of gastroenterology, 2008, Volume: 43, Issue:9

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Coronary Disease; Female; Gastr

2008
Gastroprotective strategy in aspirin users.
    Journal of the Chinese Medical Association : JCMA, 2009, Volume: 72, Issue:7

    Topics: Aspirin; Clopidogrel; Gastrointestinal Hemorrhage; Helicobacter Infections; Helicobacter pylori; Hum

2009
Co-prescription of gastro-protectants in hospitalized patients: an analysis of what we do and what we think we do.
    Journal of clinical gastroenterology, 2010, Volume: 44, Issue:3

    Topics: Aged; Aged, 80 and over; Aspirin; Attitude of Health Personnel; Clopidogrel; Data Collection; Female

2010
A comparison of aspirin and clopidogrel with or without proton pump inhibitors for the secondary prevention of cardiovascular events in patients at high risk for gastrointestinal bleeding.
    Clinical therapeutics, 2009, Volume: 31, Issue:9

    Topics: Aged; Aged, 80 and over; Aspirin; Cardiovascular Diseases; Clopidogrel; Databases, Factual; Drug Cos

2009
Withdrawal of clopidogrel in active gastric bleeding.
    Annals of internal medicine, 2010, May-18, Volume: 152, Issue:10

    Topics: Aspirin; Cardiovascular Diseases; Cerebrovascular Disorders; Clopidogrel; Gastrointestinal Hemorrhag

2010
Cardiovascular and gastrointestinal events of three antiplatelet therapies: clopidogrel, clopidogrel plus proton-pump inhibitors, and aspirin plus proton-pump inhibitors in patients with previous gastrointestinal bleeding.
    Journal of gastroenterology, 2011, Volume: 46, Issue:1

    Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Aspirin; Cardiovascular Diseases; Clopidogrel; Dru

2011
[Does dual antiplatelet therapy always require gastroprotection? Tailored medical therapy should prevail over the generalized prescription of proton pump inhibitors in patients on dual antiplatelet therapy].
    Giornale italiano di cardiologia (2006), 2010, Volume: 11, Issue:6

    Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Elect

2010
Proton pump inhibitor co-therapy with clopidogrel: is there GI benefit or cardiovascular harm?
    Gastroenterology, 2011, Volume: 140, Issue:3

    Topics: Atherosclerosis; Clopidogrel; Drug Interactions; Humans; Omeprazole; Peptic Ulcer; Platelet Aggregat

2011
[The effect of aspirin alone or aspirin plus additional antiplatelets therapy on upper gastrointestinal hemorrhage].
    The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2011, Volume: 57, Issue:4

    Topics: Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents;

2011
Risk of bleeding associated with combined use of selective serotonin reuptake inhibitors and antiplatelet therapy following acute myocardial infarction.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2011, Nov-08, Volume: 183, Issue:16

    Topics: Adrenal Cortex Hormones; Age Factors; Aged; Anemia; Angioplasty; Anticoagulants; Antihypertensive Ag

2011
Clinical update on nursing home medicine: 2011.
    Journal of the American Medical Directors Association, 2011, Volume: 12, Issue:9

    Topics: Anti-Ulcer Agents; Anticoagulants; Atrial Fibrillation; Clopidogrel; Clostridioides difficile; Delir

2011
Antiplatelet and anticoagulant therapy in patients with gastrointestinal bleeding: an 86-year-old woman with peptic ulcer disease.
    JAMA, 2011, Dec-07, Volume: 306, Issue:21

    Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Drug Interaction

2011
Anti-platelet therapy and managing ulcer risk.
    Journal of gastroenterology and hepatology, 2012, Volume: 27, Issue:2

    Topics: Animals; Anti-Bacterial Agents; Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Combined Modali

2012
New look at antiplatelet agent-related peptic ulcer: an update of prevention and treatment.
    Journal of gastroenterology and hepatology, 2012, Volume: 27, Issue:4

    Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Interactions; Gastrointestinal Hemorrhage; Helic

2012
Individualised PPI prescription in patients on combination antiplatelet therapy and upper gastrointestinal events after percutaneous coronary intervention: a cohort study.
    Wiener medizinische Wochenschrift (1946), 2012, Volume: 162, Issue:3-4

    Topics: Acute Coronary Syndrome; Adrenal Cortex Hormones; Adverse Drug Reaction Reporting Systems; Aged; Ang

2012
Gastrointestinal events with clopidogrel: a nationwide population-based cohort study.
    Journal of general internal medicine, 2013, Volume: 28, Issue:2

    Topics: Aged; Cardiovascular Diseases; Clopidogrel; Cohort Studies; Denmark; Dose-Response Relationship, Dru

2013
[Current clinical practice among German Internists regarding the prophylaxis of gastroduodenal ulcers associated with NSAIDs, aspirin and Helicobacter pylori].
    Zeitschrift fur Gastroenterologie, 2012, Volume: 50, Issue:11

    Topics: Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Aspirin; Clopid

2012
Upper gastrointestinal lesions in patients receiving clopidogrel anti-platelet therapy.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2012, Volume: 111, Issue:12

    Topics: Aged; Aged, 80 and over; Aspirin; Clopidogrel; Endoscopy, Gastrointestinal; Female; Gastrointestinal

2012
High incidence of clopidogrel-associated gastrointestinal bleeding in patients with previous peptic ulcer disease.
    Alimentary pharmacology & therapeutics, 2003, Aug-15, Volume: 18, Issue:4

    Topics: Aged; Aspirin; Clopidogrel; Cohort Studies; Female; Follow-Up Studies; Gastrointestinal Hemorrhage;

2003
High incidence of clopidogrel-associated gastrointestinal bleeding in patients with previous peptic ulcer disease.
    Alimentary pharmacology & therapeutics, 2003, Aug-15, Volume: 18, Issue:4

    Topics: Aged; Aspirin; Clopidogrel; Cohort Studies; Female; Follow-Up Studies; Gastrointestinal Hemorrhage;

2003
High incidence of clopidogrel-associated gastrointestinal bleeding in patients with previous peptic ulcer disease.
    Alimentary pharmacology & therapeutics, 2003, Aug-15, Volume: 18, Issue:4

    Topics: Aged; Aspirin; Clopidogrel; Cohort Studies; Female; Follow-Up Studies; Gastrointestinal Hemorrhage;

2003
High incidence of clopidogrel-associated gastrointestinal bleeding in patients with previous peptic ulcer disease.
    Alimentary pharmacology & therapeutics, 2003, Aug-15, Volume: 18, Issue:4

    Topics: Aged; Aspirin; Clopidogrel; Cohort Studies; Female; Follow-Up Studies; Gastrointestinal Hemorrhage;

2003