ticlopidine has been researched along with Elevated Cholesterol in 16 studies
Ticlopidine: An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
ticlopidine : A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a laboratory substudy of the PRAGUE-8 trial, the influences of nonmodifiable (age and sex) and modifiable (body mass index and tobacco smoke) factors, comorbidity (hypertension, hyperlipidemia, diabetes mellitus, and renal insufficiency) and cotherapy (statin, aspirin, and heparin), on the course of clopidogrel efficacy were investigated in 105 patients pretreated with clopidogrel >or=6 hours before coronary angiography +/- percutaneous coronary intervention." | 9.14 | Factors influencing clopidogrel efficacy in patients with stable coronary artery disease undergoing elective percutaneous coronary intervention: statin's advantage and the smoking "paradox". ( Bilkova, D; Kala, P; Marinov, I; Motovska, Z; Petr, R; Simek, S; Widimsky, P, 2009) |
| " The other 32 rats were subjected to induction of hypercholesterolemia by high-fat diet for 3 weeks, followed by induction of AMI by subcutaneous injections of isoproterenol (85 mg/kg/day, for 2 days)." | 7.80 | Assessment of the prophylactic role of aspirin and/or clopidogrel on experimentally induced acute myocardial infarction in hypercholesterolemic rats. ( El-Hadidy, WF; Mannaa, HF; Mohamed, AR, 2014) |
| "This study demonstrates that clopidogrel reduces inflammation and neointimal formation in balloon-denuded iliac arteries of hypercholesterolemic rabbits." | 7.74 | Effect of clopidogrel on neointimal formation and inflammation in balloon-denuded and radiated hypercholesterolemic rabbit iliac arteries. ( Baffour, R; Chan, R; Hellinga, D; Kolodgie, F; Pakala, R; Roy, P; Scheinowitz, M; Seabron, R; Virmani, R; Waksman, R, 2008) |
| "This study determines the antiplatelet effects of oral ticlopidine (100 mg/kg x day) in experimental hypercholesterolemia." | 7.69 | Antiplatelet effects of ticlopidine are reduced in experimental hypercholesterolemia. ( Braun, M; Hohlfeld, T; Scharnowski, F; Schrör, K, 1994) |
| "In a laboratory substudy of the PRAGUE-8 trial, the influences of nonmodifiable (age and sex) and modifiable (body mass index and tobacco smoke) factors, comorbidity (hypertension, hyperlipidemia, diabetes mellitus, and renal insufficiency) and cotherapy (statin, aspirin, and heparin), on the course of clopidogrel efficacy were investigated in 105 patients pretreated with clopidogrel >or=6 hours before coronary angiography +/- percutaneous coronary intervention." | 5.14 | Factors influencing clopidogrel efficacy in patients with stable coronary artery disease undergoing elective percutaneous coronary intervention: statin's advantage and the smoking "paradox". ( Bilkova, D; Kala, P; Marinov, I; Motovska, Z; Petr, R; Simek, S; Widimsky, P, 2009) |
| " The other 32 rats were subjected to induction of hypercholesterolemia by high-fat diet for 3 weeks, followed by induction of AMI by subcutaneous injections of isoproterenol (85 mg/kg/day, for 2 days)." | 3.80 | Assessment of the prophylactic role of aspirin and/or clopidogrel on experimentally induced acute myocardial infarction in hypercholesterolemic rats. ( El-Hadidy, WF; Mannaa, HF; Mohamed, AR, 2014) |
| "This study demonstrates that clopidogrel reduces inflammation and neointimal formation in balloon-denuded iliac arteries of hypercholesterolemic rabbits." | 3.74 | Effect of clopidogrel on neointimal formation and inflammation in balloon-denuded and radiated hypercholesterolemic rabbit iliac arteries. ( Baffour, R; Chan, R; Hellinga, D; Kolodgie, F; Pakala, R; Roy, P; Scheinowitz, M; Seabron, R; Virmani, R; Waksman, R, 2008) |
| "This study determines the antiplatelet effects of oral ticlopidine (100 mg/kg x day) in experimental hypercholesterolemia." | 3.69 | Antiplatelet effects of ticlopidine are reduced in experimental hypercholesterolemia. ( Braun, M; Hohlfeld, T; Scharnowski, F; Schrör, K, 1994) |
| "These events, previously called apoplexy, are now called strokes." | 2.50 | Stroke: transient ischemic attack. ( Silver, B; Wulf Silver, R, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 8 (50.00) | 29.6817 |
| 2010's | 4 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| De Kam, PJ | 1 |
| Luo, WL | 1 |
| Wenning, L | 1 |
| Ratcliffe, L | 1 |
| Sisk, CM | 1 |
| Royalty, J | 1 |
| Radziszewski, W | 1 |
| Wagner, JA | 1 |
| Lai, E | 1 |
| Silver, B | 1 |
| Wulf Silver, R | 1 |
| Mohamed, AR | 1 |
| El-Hadidy, WF | 1 |
| Mannaa, HF | 1 |
| Bhindi, R | 1 |
| Ormerod, O | 1 |
| Newton, J | 1 |
| Banning, AP | 1 |
| Testa, L | 1 |
| Motovska, Z | 1 |
| Widimsky, P | 1 |
| Petr, R | 1 |
| Bilkova, D | 1 |
| Marinov, I | 1 |
| Simek, S | 1 |
| Kala, P | 1 |
| Krasznai, Z | 1 |
| Toth, P | 1 |
| Vishnevetsky, D | 1 |
| Kiyanista, VA | 1 |
| Gandhi, PJ | 1 |
| Hirsh, J | 1 |
| Bhatt, DL | 1 |
| Schaerlig, E | 1 |
| Dupliakov, DV | 1 |
| Waksman, R | 1 |
| Pakala, R | 1 |
| Roy, P | 1 |
| Baffour, R | 1 |
| Hellinga, D | 1 |
| Seabron, R | 1 |
| Chan, R | 1 |
| Scheinowitz, M | 1 |
| Kolodgie, F | 1 |
| Virmani, R | 1 |
| Hohlfeld, T | 1 |
| Scharnowski, F | 1 |
| Braun, M | 1 |
| Schrör, K | 1 |
| Fred, HL | 1 |
| Hariharan, R | 1 |
| Doucet, J | 1 |
| Mehta, N | 1 |
| Vera, M | 1 |
| Pou, M | 1 |
| Botey, A | 1 |
| Cases, A | 1 |
| Yamada, T | 1 |
| Tomioka, K | 1 |
| Horie, M | 1 |
| Sakurai, Y | 1 |
| Nagaoka, H | 1 |
| Mase, T | 1 |
| Pellegreffi, L | 1 |
| Branzoli, U | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Study to Evaluate the Effects of Laropiprant on the Antiplatelet Effects of Clopidogrel and Aspirin in Combination and to Evaluate Single Dose Pharmacokinetics of MK0524A in Subjects With Primary Hypercholesterolemia or Mixed Dyslipidemia[NCT01012219] | Phase 1 | 36 participants (Actual) | Interventional | 2009-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Cutaneous bleeding Time (BT) on Day 8 after daily administration of laropiprant with aspirin and clopidogrel for 7 days versus BT on Day 8 after daily administration of placebo with aspirin and clopidogrel for 7 days.~The model used included treatment, period and sequence as fixed effect variables and subjects as the random effect variable.~Period 3 was not analyzed as bleeding time was not an objective for this part of the study." (NCT01012219)
Timeframe: Day 8
| Intervention | Seconds (Least Squares Mean) |
|---|---|
| Clopidogrel + Aspirin +Laropiprant | 478 |
| Clopidogrel + Aspirin | 389 |
5 reviews available for ticlopidine and Elevated Cholesterol
| Article | Year |
|---|---|
Stroke: transient ischemic attack.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain; Clopidogrel; Diffusion Magnetic Resonance I | 2014 |
Interaction between statins and clopidogrel: is there anything clinically relevant?
Topics: Clopidogrel; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholest | 2008 |
CD40 ligand: a novel target in the fight against cardiovascular disease.
Topics: Cardiovascular Agents; Cardiovascular Diseases; CD40 Ligand; Clinical Trials as Topic; Clopidogrel; | 2004 |
Comparative benefits of clopidogrel and aspirin in high-risk patient populations: lessons from the CAPRIE and CURE studies.
Topics: Angina, Unstable; Aspirin; Clopidogrel; Comorbidity; Diabetes Mellitus; Humans; Hypercholesterolemia | 2004 |
[Clopidogrel and statins or once more on the danger of direct transfer of results of experimental studies in clinical practice].
Topics: Atorvastatin; Clopidogrel; Coronary Thrombosis; Diabetes Mellitus, Type 2; Heptanoic Acids; Humans; | 2008 |
2 trials available for ticlopidine and Elevated Cholesterol
| Article | Year |
|---|---|
The effects of laropiprant on the antiplatelet activity of co-administered clopidogrel and aspirin.
Topics: Adult; Aged; Aspirin; Clopidogrel; Cross-Over Studies; Double-Blind Method; Drug Interactions; Dysli | 2014 |
Factors influencing clopidogrel efficacy in patients with stable coronary artery disease undergoing elective percutaneous coronary intervention: statin's advantage and the smoking "paradox".
Topics: Age Factors; Aged; Angioplasty, Balloon, Coronary; Aspirin; Body Mass Index; Cell Adhesion Molecules | 2009 |
9 other studies available for ticlopidine and Elevated Cholesterol
| Article | Year |
|---|---|
Assessment of the prophylactic role of aspirin and/or clopidogrel on experimentally induced acute myocardial infarction in hypercholesterolemic rats.
Topics: Animals; Aspirin; C-Reactive Protein; Cholesterol; Clopidogrel; Creatine Kinase; Diet, High-Fat; Dru | 2014 |
Myocardial infarction in an young patient associated with oral contraceptive, smoking and elevated cholesterol level.
Topics: Abortion, Induced; Adult; Anticholesteremic Agents; Anticoagulants; Atorvastatin; Clopidogrel; Contr | 2012 |
[Highlights from the American College of Cardiology Annual Scientific Session 2005: March 5-9, 2005, Orlando, Florida].
Topics: Aspirin; Cardiovascular Diseases; Cholesterol, LDL; Clopidogrel; Humans; Hypercholesterolemia; Obesi | 2005 |
Effect of clopidogrel on neointimal formation and inflammation in balloon-denuded and radiated hypercholesterolemic rabbit iliac arteries.
Topics: Angioplasty, Balloon, Coronary; Animals; C-Reactive Protein; Clopidogrel; Endothelium, Vascular; Hyp | 2008 |
Antiplatelet effects of ticlopidine are reduced in experimental hypercholesterolemia.
Topics: Adenosine Diphosphate; Animals; Aortic Diseases; Arteriosclerosis; Biotransformation; Cholesterol, D | 1994 |
Jaundice and extreme hypercholesterolemia after a stroke.
Topics: Cerebrovascular Disorders; Female; Humans; Hypercholesterolemia; Jaundice; Middle Aged; Platelet Agg | 1996 |
[Massive rhabdomyolysis associated with the use of cerivastatin monotherapy].
Topics: Anticholesteremic Agents; Anuria; Clopidogrel; Coronary Artery Bypass; Humans; Hypercholesterolemia; | 2001 |
Effects of YM264, a novel PAF antagonist, on puromycin aminonucleoside-induced nephropathy in the rat.
Topics: Animals; Azepines; Disease Models, Animal; Glomerulonephritis, Membranous; Hypercholesterolemia; Mal | 1991 |
In vivo effect of indobufen and ticlopidine hydrochloride on aortic endothelial integrity of normo- or hyper-cholesterolemic rats.
Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Endothelium; Hypercholesterolemia; Isoindoles; Male; Phe | 1987 |