Page last updated: 2024-11-05

ticlopidine and Cerebral Hemorrhage

ticlopidine has been researched along with Cerebral Hemorrhage in 56 studies

Ticlopidine: An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
ticlopidine : A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.

Cerebral Hemorrhage: Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with HYPERTENSION and CRANIOCEREBRAL TRAUMA.

Research Excerpts

ExcerptRelevanceReference
"Dual clopidogrel-aspirin therapy was associated with a marked reduction in new strokes compared with the therapy of aspirin alone in patients with normal renal function (hazard ratio, 0."9.22Effect of Estimated Glomerular Filtration Rate Decline on the Efficacy and Safety of Clopidogrel With Aspirin in Minor Stroke or Transient Ischemic Attack: CHANCE Substudy (Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events). ( Johnston, SC; Li, H; Liu, L; Meng, X; Pan, Y; Wang, C; Wang, D; Wang, Y; Wu, Y; Zhao, X; Zhou, Y, 2016)
"To study whether Clopidogrel-Aspirin combined treatment for high risk transient ischaemic attack (TIA) or minor stroke results in increased number of lesions associated with anti-thrombotic cerebral haemorrhage or cerebral micro-bleeds (CMB) than aspirin alone treatment."9.20Combined clopidogrel-aspirin treatment for high risk TIA or minor stroke does not increase cerebral microbleeds. ( Wang, P; Wang, Y; Wang, Z; Xin, H; Xu, C, 2015)
"In ACTIVE-W, oral anticoagulation (OAC) was more efficacious than combined clopidogrel plus aspirin (C+A) in preventing vascular events in patients with atrial fibrillation."9.13Risks and benefits of oral anticoagulation compared with clopidogrel plus aspirin in patients with atrial fibrillation according to stroke risk: the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events (ACTIVE-W). ( Connolly, SJ; De Caterina, R; Flaker, G; Hart, RG; Healey, JS; Hohnloser, SH; Pfeffer, MA; Pogue, J; Yusuf, S, 2008)
"It seems that these results showed the safety and efficacy of the enteric-coated aspirin in acute stroke care in Japanese patients."7.80Enteric-coated aspirin versus other antiplatelet drugs in acute non-cardioembolic ischemic stroke: post-marketing study in Japan. ( Inuyama, L; Mizuno, O; Sakaguchi, T; Takahashi, S; Yamada, T, 2014)
"In stroke-free individuals, clopidogrel use was associated with a higher prevalence and higher number of CMBs."7.79Clopidogrel use is associated with an increased prevalence of cerebral microbleeds in a stroke-free population: the Rotterdam study. ( Akoudad, S; Darweesh, SK; Hofman, A; Ikram, MA; Leening, MJ; Loth, DW; Stricker, BH; Vernooij, MW, 2013)
"In our retrospective study, only pre-treatment with aspirin and clopidogrel was associated with thrombolysis-related intracerebral hemorrhage."7.75Combined anti-platelet therapy with aspirin and clopidogrel: risk factor for thrombolysis-related intracerebral hemorrhage in acute ischemic stroke? ( Dzialowski, I; Gahn, G; Hermann, A; Koch, R, 2009)
"To report a case of intracerebral hemorrhage following short-term, concomitant use of celecoxib and clopidogrel."7.71Intracerebral hemorrhage following possible interaction between celecoxib and clopidogrel. ( Fisher, AA; Le Couteur, DG, 2001)
"With the increased incidence of intracerebral hemorrhage associated with dual antiplatelet therapy, this technique may provide a useful tool in the neurosurgical armamentarium."5.42A Novel Use of Direct Platelet Application During Surgery for Clopidogrel-Associated Intracerebral Hemorrhage. ( Kilbourn, KJ; Killory, BD; Ollenschleger, M, 2015)
"A cerebral hemorrhage was the first sign of the thrombocytopenia."5.28Cerebral hemorrhage and thrombotic thrombocytopenic purpura during ticlopidine treatment: case report. ( Capra, R; Capucci, M; Ferremi, P; Fieni, F; Marcianò, N; Orlandini, A, 1992)
"Dual clopidogrel-aspirin therapy was associated with a marked reduction in new strokes compared with the therapy of aspirin alone in patients with normal renal function (hazard ratio, 0."5.22Effect of Estimated Glomerular Filtration Rate Decline on the Efficacy and Safety of Clopidogrel With Aspirin in Minor Stroke or Transient Ischemic Attack: CHANCE Substudy (Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events). ( Johnston, SC; Li, H; Liu, L; Meng, X; Pan, Y; Wang, C; Wang, D; Wang, Y; Wu, Y; Zhao, X; Zhou, Y, 2016)
"To study whether Clopidogrel-Aspirin combined treatment for high risk transient ischaemic attack (TIA) or minor stroke results in increased number of lesions associated with anti-thrombotic cerebral haemorrhage or cerebral micro-bleeds (CMB) than aspirin alone treatment."5.20Combined clopidogrel-aspirin treatment for high risk TIA or minor stroke does not increase cerebral microbleeds. ( Wang, P; Wang, Y; Wang, Z; Xin, H; Xu, C, 2015)
"We identified 9 independent risk factors for SICH: baseline National Institutes of Health Stroke Scale, serum glucose, systolic blood pressure, age, body weight, stroke onset to treatment time, aspirin or combined aspirin and clopidogrel, and history of hypertension."5.16Predicting the risk of symptomatic intracerebral hemorrhage in ischemic stroke treated with intravenous alteplase: safe Implementation of Treatments in Stroke (SITS) symptomatic intracerebral hemorrhage risk score. ( Ahmed, N; Egido, JA; Ford, GA; Lees, KR; Mazya, M; Mikulik, R; Toni, D; Wahlgren, N, 2012)
"We analyzed MRI of 133 patients admitted consecutively for intra- and extracranial stenting for symptomatic large artery atherosclerosis who received aspirin and clopidogrel."5.16Risk of intracerebral hemorrhage in patients with cerebral microbleeds undergoing endovascular intervention. ( Abrigo, J; Ahuja, AT; Leung, TW; Ng, N; Siu, DY; Soo, YO; Wong, LK; Yu, S, 2012)
"In ACTIVE-W, oral anticoagulation (OAC) was more efficacious than combined clopidogrel plus aspirin (C+A) in preventing vascular events in patients with atrial fibrillation."5.13Risks and benefits of oral anticoagulation compared with clopidogrel plus aspirin in patients with atrial fibrillation according to stroke risk: the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events (ACTIVE-W). ( Connolly, SJ; De Caterina, R; Flaker, G; Hart, RG; Healey, JS; Hohnloser, SH; Pfeffer, MA; Pogue, J; Yusuf, S, 2008)
"Within 24 h of symptom onset, we randomly assigned, in a factorial design, 392 patients with TIA or minor stroke to clopidogrel (300 mg loading dose then 75 mg daily; 198 patients) or placebo (194 patients), and simvastatin (40 mg daily; 199 patients) or placebo (193 patients)."5.12Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial. ( Buchan, AM; Demchuk, AM; Eliasziw, M; Hill, MD; Kennedy, J; Ryckborst, KJ, 2007)
"DAPT with clopidogrel and aspirin compared with aspirin effectively reduces the risk of total and ischemic stroke in the overall cohort consisting of patients with cardiovascular disease without increase in intracranial hemorrhage, as well as decreases the risk of a recurrent total stroke in patients with a previous stroke/transient ischemic attack."4.90Antiplatelet treatment for prevention of cerebrovascular events in patients with vascular diseases: a systematic review and meta-analysis. ( Arrich, J; Gouya, G; Gurbel, PA; Huber, K; Pirker-Kees, A; Siller-Matula, JM; Verheugt, FW; Wolzt, M, 2014)
" Addition of clopidogrel was associated with an increase in fatal hemorrhage (OR, 1."4.88Effect of addition of clopidogrel to aspirin on mortality: systematic review of randomized trials. ( Benavente, OR; Hart, RG; Palacio, S; Pearce, LA, 2012)
" After multivariate logistic regression, 10 variables remained independent predictors of sICH to compose the STARTING-SICH (systolic blood pressure, age, onset-to-treatment time for thrombolysis, National Institutes of Health Stroke Scale score, glucose, aspirin alone, aspirin plus clopidogrel, anticoagulant with INR ≤1."3.88STARTING-SICH Nomogram to Predict Symptomatic Intracerebral Hemorrhage After Intravenous Thrombolysis for Stroke. ( Bonetti, B; Bovi, P; Cappellari, M; Forlivesi, S; Toni, D; Turcato, G; Zivelonghi, C, 2018)
"In patients with ischemic stroke of non-cardioembolic origin, acetylsalicylic acid, clopidogrel, or a combination of acetylsalicylic acid and dipyridamole are recommended for the prevention of a recurrent stroke."3.81Comparison of antiplatelet regimens in secondary stroke prevention: a nationwide cohort study. ( Carlson, N; Christiansen, CB; Gerds, TA; Gislason, G; Jørgensen, ME; Kristensen, SL; Numé, AK; Olesen, JB; Pallisgaard, J; Torp-Pedersen, C, 2015)
"It seems that these results showed the safety and efficacy of the enteric-coated aspirin in acute stroke care in Japanese patients."3.80Enteric-coated aspirin versus other antiplatelet drugs in acute non-cardioembolic ischemic stroke: post-marketing study in Japan. ( Inuyama, L; Mizuno, O; Sakaguchi, T; Takahashi, S; Yamada, T, 2014)
"In stroke-free individuals, clopidogrel use was associated with a higher prevalence and higher number of CMBs."3.79Clopidogrel use is associated with an increased prevalence of cerebral microbleeds in a stroke-free population: the Rotterdam study. ( Akoudad, S; Darweesh, SK; Hofman, A; Ikram, MA; Leening, MJ; Loth, DW; Stricker, BH; Vernooij, MW, 2013)
"In the context of neurointerventional procedures, clopidogrel hyper-responsiveness has been associated with hemorrhage; on the other hand, clopidogrel resistance has been associated with thromboembolism."3.79Platelet-function testing in patients undergoing neurovascular procedures: caught between a rock and a hard place. ( Comin, J; Kallmes, DF, 2013)
"In patients with ischemic stroke or transient ischemic attack, 43% (n=128) and 35% (n=54) were nonresponders to aspirin and clopidogrel, respectively."3.78Clinical outcomes using a platelet function-guided approach for secondary prevention in patients with ischemic stroke or transient ischemic attack. ( Bakdash, S; Bhatt, DL; Depta, JP; Fowler, J; Katzan, I; Kottke-Marchant, K; Novak, E, 2012)
"In our retrospective study, only pre-treatment with aspirin and clopidogrel was associated with thrombolysis-related intracerebral hemorrhage."3.75Combined anti-platelet therapy with aspirin and clopidogrel: risk factor for thrombolysis-related intracerebral hemorrhage in acute ischemic stroke? ( Dzialowski, I; Gahn, G; Hermann, A; Koch, R, 2009)
"To report a case of intracerebral hemorrhage following short-term, concomitant use of celecoxib and clopidogrel."3.71Intracerebral hemorrhage following possible interaction between celecoxib and clopidogrel. ( Fisher, AA; Le Couteur, DG, 2001)
"Patients with lacunar stroke and CMBs likely harbor a more advanced form of cerebral small vessel disease in need of efficacious therapeutic strategies."2.84Microbleeds in the Secondary Prevention of Small Subcortical Strokes Trial: Stroke, mortality, and treatment interactions. ( Anderson, DC; Bazan, C; Benavente, OR; Catanese, L; Hart, RG; Kase, CS; Marti-Fabregas, J; McClure, LA; Pearce, LA; Sharma, M; Shoamanesh, A, 2017)
" Larger studies are urgently needed to validate a clinically useful threshold to define clopidogrel hyper-response and to examine the clinical effects of antiplatelet dosage adjustment."2.78Clopidogrel hyper-response and bleeding risk in neurointerventional procedures. ( Churilov, L; Dowling, R; Goh, C; Mitchell, P; Yan, B, 2013)
"Various strategies are emerging for dosing antiplatelet therapies in preparation for pipeline stent embolization in adults."2.55Optimal pediatric dosing of anti-platelet agents for pipeline stent embolization -a case report and review of the literature. ( Cobb, MIH; Fernando Gonzalez, L; Hauck, EF; Smith, TP; Zomorodi, AR, 2017)
"Approximately 7000 intracerebral hemorrhages (ICHs) annually in the US are caused by use of antithrombotic therapies."2.43Avoiding central nervous system bleeding during antithrombotic therapy: recent data and ideas. ( Hart, RG; Pearce, LA; Tonarelli, SB, 2005)
"Aspirin (53."1.43Antithrombotic Medication Use and Misuse Among Patients with Intracranial Hemorrhage: A 16-Year, Lebanese, Single-Center Experience. ( Fahed, E; Ghauche, J; Maarrawi, J; Menassa-Moussa, L; Moussa, R; Nohra, G; Okais, N; Rahme, R; Rizk, T; Samaha, E, 2016)
" All patients received low-molecular-weight heparin in prophylactic dosage starting 24 hours after aneurysm treatment."1.42Ventriculostomy-Related Hemorrhage After Treatment of Acutely Ruptured Aneurysms: The Influence of Anticoagulation and Antiplatelet Treatment. ( Bruder, M; El-Fiki, A; Güresir, E; Konczalla, J; Lescher, S; Schuss, P; Seifert, V; Vatter, H, 2015)
"With the increased incidence of intracerebral hemorrhage associated with dual antiplatelet therapy, this technique may provide a useful tool in the neurosurgical armamentarium."1.42A Novel Use of Direct Platelet Application During Surgery for Clopidogrel-Associated Intracerebral Hemorrhage. ( Kilbourn, KJ; Killory, BD; Ollenschleger, M, 2015)
"Delayed intracerebral hemorrhage (DIH) was observed more often in the routine antiplatelet group (2/9 cases, 22."1.37Delayed intracranial hemorrhage associated with antiplatelet therapy in stent-assisted coil embolized cerebral aneurysms. ( Chai, WN; He, ZH; Sun, XC; Wu, HT; Zhang, XD; Zhu, J, 2011)
"We assessed the safety of thrombolysis under APs in 11,865 patients compliant with the European license criteria and recorded between 2002 and 2007 in the Safe Implementation of Treatments in Stroke (SITS) International Stroke Thrombolysis Register (SITS-ISTR)."1.36Safety of intravenous thrombolysis for acute ischemic stroke in patients receiving antiplatelet therapy at stroke onset. ( Ahmed, N; Diedler, J; Ford, GA; Lees, KR; Luijckx, GJ; Overgaard, K; Ringleb, P; Soinne, L; Sykora, M; Uyttenboogaart, M; Wahlgren, N, 2010)
"The underlying disease was paroxysmal nocturnal hemoglobinuria (PNH), a stem cell defect characterized by episodes of complement-induced hemolysis and thromboembolic events."1.36[Between thrombosis and bleeding - a case of paroxysmal nocturnal hemoglobinuria]. ( Reinhart, WH, 2010)
"A cerebral hemorrhage was the first sign of the thrombocytopenia."1.28Cerebral hemorrhage and thrombotic thrombocytopenic purpura during ticlopidine treatment: case report. ( Capra, R; Capucci, M; Ferremi, P; Fieni, F; Marcianò, N; Orlandini, A, 1992)

Research

Studies (56)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (5.36)18.2507
2000's15 (26.79)29.6817
2010's38 (67.86)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Shoamanesh, A1
Pearce, LA3
Bazan, C1
Catanese, L1
McClure, LA1
Sharma, M1
Marti-Fabregas, J2
Anderson, DC1
Kase, CS1
Hart, RG4
Benavente, OR2
Cappellari, M1
Turcato, G1
Forlivesi, S1
Zivelonghi, C1
Bovi, P1
Bonetti, B1
Toni, D2
Beynon, C1
Sakowitz, OW1
Unterberg, AW1
Darweesh, SK1
Leening, MJ1
Akoudad, S1
Loth, DW1
Hofman, A1
Ikram, MA1
Vernooij, MW1
Stricker, BH1
Zhao, R1
Feng, XY1
Zhang, M1
Shen, XL1
Su, JJ1
Liu, JR1
Delgado Almandoz, JE1
Kadkhodayan, Y1
Crandall, BM1
Scholz, JM1
Fease, JL1
Tubman, DE1
Gouya, G1
Arrich, J1
Wolzt, M1
Huber, K1
Verheugt, FW2
Gurbel, PA1
Pirker-Kees, A1
Siller-Matula, JM1
Takahashi, S1
Mizuno, O1
Sakaguchi, T1
Yamada, T1
Inuyama, L1
Kawano-Castillo, J1
Ward, E1
Elliott, A1
Wetzel, J1
Hassler, A1
McDonald, M1
Parker, SA1
Archeval-Lao, J1
Tremont, C1
Cai, C1
Pivalizza, E1
Rahbar, MH1
Grotta, JC1
Chalouhi, N1
Zanaty, M1
Jabbour, PM1
Starke, RM1
Tjoumakaris, SI1
Rosenwasser, RH1
Gonzalez, LF1
Zheng, H1
Chen, C1
Hu, Z1
Yang, L1
Martin-Yuste, V1
Alvarez-Contreras, L1
Sabaté, M1
Kelbaek, H1
Saunamäki, K1
Jørgensen, E1
Kocka, V1
Blann, AD1
Skjøth, F1
Rasmussen, LH1
Larsen, TB1
Lip, GY1
Bruder, M1
Schuss, P1
Konczalla, J1
El-Fiki, A1
Lescher, S1
Vatter, H1
Seifert, V1
Güresir, E1
Killory, BD1
Kilbourn, KJ1
Ollenschleger, M1
Wong, P1
Tesoro, E1
Aletich, V1
Alaraj, A1
Wang, Z1
Xu, C1
Wang, P1
Wang, Y3
Xin, H1
Christiansen, CB1
Pallisgaard, J1
Gerds, TA1
Olesen, JB1
Jørgensen, ME1
Numé, AK1
Carlson, N1
Kristensen, SL1
Gislason, G1
Torp-Pedersen, C1
Han, SW1
Kim, YJ1
Ahn, SH1
Seo, WK1
Yu, S2
Oh, SH1
Kim, YN1
Lee, KY1
Fahed, E1
Ghauche, J1
Rahme, R1
Okais, N1
Samaha, E1
Nohra, G1
Rizk, T1
Maarrawi, J1
Menassa-Moussa, L1
Moussa, R1
González-Pérez, A1
Sáez, ME1
Johansson, S1
Himmelmann, A1
García Rodríguez, LA1
Zhou, Y1
Pan, Y1
Wu, Y1
Zhao, X1
Li, H1
Wang, D1
Johnston, SC1
Liu, L1
Wang, C1
Meng, X1
Bykov, K1
Schneeweiss, S1
Donneyong, MM1
Dong, YH1
Choudhry, NK1
Gagne, JJ1
Cobb, MIH1
Zomorodi, AR1
Hauck, EF1
Smith, TP1
Fernando Gonzalez, L1
Selim, M1
Naidech, AM3
Bernstein, RA3
Levasseur, K1
Bassin, SL2
Bendok, BR2
Batjer, HH3
Bleck, TP3
Alberts, MJ3
Lindholm, PF1
Fung, CY1
Marcus, AJ1
Broekman, MJ1
Mahaut-Smith, MP1
Hermann, A1
Dzialowski, I1
Koch, R1
Gahn, G1
Garg, RK1
Goto, S1
Toda, E1
Diedler, J1
Ahmed, N2
Sykora, M1
Uyttenboogaart, M1
Overgaard, K1
Luijckx, GJ1
Soinne, L1
Ford, GA2
Lees, KR2
Wahlgren, N2
Ringleb, P1
Ducruet, AF1
Hickman, ZL1
Zacharia, BE1
Grobelny, BT1
DeRosa, PA1
Landes, E1
Lei, S1
Khandji, J1
Gutbrod, S1
Connolly, ES1
Reinhart, WH1
Zhang, XD1
Wu, HT1
Zhu, J1
He, ZH1
Chai, WN1
Sun, XC1
Lauer, A1
Schlunk, F1
Van Cott, EM1
Steinmetz, H1
Lo, EH1
Foerch, C1
Khan, M1
Kamal, AK1
Vidal-Jordana, A1
Barroeta-Espar, I1
Sáinz Pelayo, MP1
Mateo, J1
Delgado-Mederos, R1
Mascarenhas, L1
Mazya, M1
Egido, JA1
Mikulik, R1
Soo, YO1
Siu, DY1
Abrigo, J1
Ng, N1
Ahuja, AT1
Wong, LK1
Leung, TW1
Depta, JP1
Fowler, J1
Novak, E1
Katzan, I1
Bakdash, S1
Kottke-Marchant, K1
Bhatt, DL1
Palacio, S1
Comin, J1
Kallmes, DF1
Goh, C1
Churilov, L1
Mitchell, P1
Dowling, R1
Yan, B1
Tonarelli, SB1
Tiaden, JD1
Wenzel, E1
Berthold, HK1
Müller-Oerlinghausen, B1
Rabinstein, AA1
Kennedy, J1
Hill, MD1
Ryckborst, KJ1
Eliasziw, M1
Demchuk, AM1
Buchan, AM1
Healey, JS1
Pogue, J1
Pfeffer, MA1
Hohnloser, SH1
De Caterina, R1
Flaker, G1
Yusuf, S1
Connolly, SJ1
Kawamata, T1
Takeshita, M1
Kubo, O1
Izawa, M1
Kagawa, M1
Takakura, K1
Algra, A1
Koudstaal, PJ1
van Gijn, J1
ten Berg, JM1
Hutten, BA1
Kelder, JC1
Plokker, HW1
Haldemann, R1
Lüscher, TF1
Szucs, TD1
Fisher, AA1
Le Couteur, DG1
Capra, R1
Marcianò, N1
Fieni, F1
Capucci, M1
Ferremi, P1
Orlandini, A1

Clinical Trials (10)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Low-dose Aspirin Therapy in Patients With Non-Cardioembolic Ischemic Stroke and Microbleeds[NCT04504864]Phase 4400 participants (Anticipated)Interventional2020-10-01Recruiting
Improving Outcome in Subarachnoid Hemorrhage wIth Nadroparine[NCT04507178]Phase 2100 participants (Anticipated)Interventional2022-02-02Recruiting
Comparison of Triflusal and Clopidogrel Effect in Secondary Prevention of Stroke Based on the Cytochrome P450 2C19 Genotyping[NCT01174693]Phase 4795 participants (Actual)Interventional2010-03-31Completed
Randomized,Double-blind Trial Comparing the Effects of a 3-month Clopidogrel Regimen,Combined With ASA During the First 21days,Versus ASA Alone for the Acute Treatment of TIA or Minor Stroke[NCT00979589]Phase 35,100 participants (Actual)Interventional2009-12-31Completed
Antithrombotic Therapy After Left Atrial Appendage Occlusion: Double Antiplatelet Therapy vs Apixaban[NCT05632445]Phase 4160 participants (Actual)Interventional2019-05-01Completed
Secondary Prevention of Small Subcortical Strokes (SPS3) Trial[NCT00059306]Phase 33,020 participants (Actual)Interventional2003-02-28Completed
Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial[NCT00991029]Phase 34,881 participants (Actual)Interventional2010-05-28Terminated (stopped due to The trial was halted by the DSMB.)
Fast Assessment of Stroke and Transient Ischemic Attack to Prevent Early Recurrence (FASTER)[NCT00109382]Phase 2/Phase 3500 participants (Anticipated)Interventional2003-05-31Completed
Antiplatelet Therapy in Acute Mild-Moderate Ischemic Stroke (ATAMIS): a Parallel Randomized, Open-label, Multicenter, Prospective Study[NCT02869009]Phase 33,000 participants (Actual)Interventional2016-11-30Completed
A REAl-life Study on Short-term Dual Antiplatelet Treatment in Patients With Ischemic Stroke or Transient Ischemic Attack[NCT05476081]1,067 participants (Anticipated)Observational [Patient Registry]2021-02-03Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Composite of Ischemic Stroke, Myocardial Infarction, Death From Ischemic Vascular Causes, or Major Hemorrhage

Secondary efficacy outcome: Number of participants with ischemic stroke, myocardial infarction, death from ischemic vascular causes, or major hemorrhage (NCT00991029)
Timeframe: Up to 90 days

InterventionParticipants (Count of Participants)
Clopidogrel141
Placebo167

Composite of Ischemic Stroke, Myocardial Infarction, or Death From Ischemic Vascular Causes

Primary efficacy outcome: Number of Participants with Ischemic Stroke, Myocardial Infarction, or Death From Ischemic Vascular Causes (NCT00991029)
Timeframe: Up to 90 days

InterventionParticipants (Count of Participants)
Clopidogrel121
Placebo160

Death From Any Cause

Other safety outcome: Number of Participants with Death from any cause (NCT00991029)
Timeframe: up to 90 days

InterventionParticipants (Count of Participants)
Clopidogrel18
Placebo12

Death From Ischemic Vascular Causes

Secondary efficacy outcome: Number of participants with Death from ischemic vascular causes (NCT00991029)
Timeframe: Up to 90 days

InterventionParticipants (Count of Participants)
Clopidogrel6
Placebo4

Hemorrhagic Stroke

Other safety outcome: Number of participants with Hemorrhagic stroke (NCT00991029)
Timeframe: up to 90 days

InterventionParticipants (Count of Participants)
Clopidogrel5
Placebo3

Ischemic or Hemorrhagic Stroke

Secondary efficacy outcome: Number of participants with Ischemic or hemorrhagic stroke (NCT00991029)
Timeframe: Up to 90 days

InterventionParticipants (Count of Participants)
Clopidogrel116
Placebo156

Ischemic Stroke

Secondary efficacy outcome:Number of participants with Ischemic stroke (NCT00991029)
Timeframe: Up to 90 days

InterventionParticipants (Count of Participants)
Clopidogrel112
Placebo155

Major Hemorrhage

Primary safety outcome: Number of Participants with major hemorrhage (NCT00991029)
Timeframe: Up to 90 days

InterventionParticipants (Count of Participants)
Clopidogrel23
Placebo10

Major Hemorrhage Other Than Intracranial Hemorrhage

Other safety outcome: Number of Participants with Major hemorrhage other than intracranial hemorrhage (NCT00991029)
Timeframe: up to 90 days

InterventionParticipants (Count of Participants)
Clopidogrel17
Placebo7

Minor Hemorrhage

Other safety outcome:Number of Participants with Minor hemorrhage (NCT00991029)
Timeframe: up to 90 days

InterventionParticipants (Count of Participants)
Clopidogrel40
Placebo13

Myocardial Infarction

Secondary efficacy outcome: Number of participants with Myocardial infarction (NCT00991029)
Timeframe: Up to 90 days

InterventionParticipants (Count of Participants)
Clopidogrel10
Placebo7

Other Symptomatic Intracranial Hemorrhage

Other safety outcome: Number of participants with other symptomatic intracranial hemorrhage (NCT00991029)
Timeframe: up to 90 days

InterventionParticipants (Count of Participants)
Clopidogrel2
Placebo0

Symptomatic Intracerebral Hemorrhage

Other safety outcome: Number of participants with Symptomatic intracerebral hemorrhage (NCT00991029)
Timeframe: up to 90 days

InterventionParticipants (Count of Participants)
Clopidogrel2
Placebo2

Reviews

8 reviews available for ticlopidine and Cerebral Hemorrhage

ArticleYear
Antiplatelet treatment for prevention of cerebrovascular events in patients with vascular diseases: a systematic review and meta-analysis.
    Stroke, 2014, Volume: 45, Issue:2

    Topics: Adenosine; Aged; Aspirin; Cerebral Hemorrhage; Cerebrovascular Disorders; Clopidogrel; Cohort Studie

2014
Intracerebral hemorrhage after pipeline embolization: Management of antiplatelet agents and the case for point-of-care testing--case reports and review of literature.
    Clinical neurology and neurosurgery, 2014, Volume: 124

    Topics: Aspirin; Cerebral Hemorrhage; Clinical Protocols; Clopidogrel; Drug Administration Schedule; Emboliz

2014
Edoxaban versus placebo, aspirin, or aspirin plus clopidogrel for stroke prevention in atrial fibrillation. An indirect comparison analysis.
    Thrombosis and haemostasis, 2015, Volume: 114, Issue:2

    Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Brain Ischemia; Cerebral Hemorrhage; Clopidogrel; Drug

2015
Optimal pediatric dosing of anti-platelet agents for pipeline stent embolization -a case report and review of the literature.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2017, Volume: 33, Issue:4

    Topics: Adolescent; Aspirin; Bone Neoplasms; Cerebral Hemorrhage; Clopidogrel; Embolization, Therapeutic; Fe

2017
P2X(1) receptor inhibition and soluble CD39 administration as novel approaches to widen the cardiovascular therapeutic window.
    Trends in cardiovascular medicine, 2009, Volume: 19, Issue:1

    Topics: Adenosine Triphosphate; Antigens, CD; Apyrase; Aspirin; Biomedical Research; Cardiovascular Diseases

2009
Effect of addition of clopidogrel to aspirin on mortality: systematic review of randomized trials.
    Stroke, 2012, Volume: 43, Issue:8

    Topics: Adult; Aged; Aspirin; Cause of Death; Cerebral Hemorrhage; Clopidogrel; Data Interpretation, Statist

2012
Avoiding central nervous system bleeding during antithrombotic therapy: recent data and ideas.
    Stroke, 2005, Volume: 36, Issue:7

    Topics: Administration, Oral; Age Factors; Aged; Anticoagulants; Aspirin; Atrial Fibrillation; Blood Pressur

2005
[Secondary prevention following cerebral ischemia: is monotherapy with acetylsalicylic acid still first choice?].
    Nederlands tijdschrift voor geneeskunde, 1998, Feb-07, Volume: 142, Issue:6

    Topics: Anticoagulants; Aspirin; Brain Ischemia; Cerebral Hemorrhage; Cerebrovascular Disorders; Clopidogrel

1998

Trials

10 trials available for ticlopidine and Cerebral Hemorrhage

ArticleYear
Microbleeds in the Secondary Prevention of Small Subcortical Strokes Trial: Stroke, mortality, and treatment interactions.
    Annals of neurology, 2017, Volume: 82, Issue:2

    Topics: Aspirin; Cerebral Hemorrhage; Clopidogrel; Double-Blind Method; Female; Humans; Magnetic Resonance I

2017
Combined clopidogrel-aspirin treatment for high risk TIA or minor stroke does not increase cerebral microbleeds.
    Neurological research, 2015, Volume: 37, Issue:11

    Topics: Aged; Aspirin; Cerebral Cortex; Cerebral Hemorrhage; Clopidogrel; Drug Therapy, Combination; Female;

2015
Protocol for the comparison of triflusal and clopidogrel in secondary prevention of stroke based on cytochrome P450 2C19 genotyping (MASETRO study): A multicenter, randomized, open-label, parallel-group trial.
    International journal of stroke : official journal of the International Stroke Society, 2016, Volume: 11, Issue:4

    Topics: Brain Ischemia; Cerebral Hemorrhage; Chemoprevention; Clopidogrel; Cytochrome P-450 CYP2C19; Follow-

2016
Effect of Estimated Glomerular Filtration Rate Decline on the Efficacy and Safety of Clopidogrel With Aspirin in Minor Stroke or Transient Ischemic Attack: CHANCE Substudy (Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events).
    Stroke, 2016, Volume: 47, Issue:11

    Topics: Aged; Aged, 80 and over; Aspirin; Cerebral Hemorrhage; Clopidogrel; Comorbidity; Drug Therapy, Combi

2016
Predicting the risk of symptomatic intracerebral hemorrhage in ischemic stroke treated with intravenous alteplase: safe Implementation of Treatments in Stroke (SITS) symptomatic intracerebral hemorrhage risk score.
    Stroke, 2012, Volume: 43, Issue:6

    Topics: Age Factors; Aged; Aspirin; Body Weight; Brain Ischemia; Cerebral Hemorrhage; Clopidogrel; Female; F

2012
Risk of intracerebral hemorrhage in patients with cerebral microbleeds undergoing endovascular intervention.
    Stroke, 2012, Volume: 43, Issue:6

    Topics: Aged; Aged, 80 and over; Aspirin; Atherosclerosis; Brain Ischemia; Cerebral Hemorrhage; Clopidogrel;

2012
Clopidogrel hyper-response and bleeding risk in neurointerventional procedures.
    AJNR. American journal of neuroradiology, 2013, Volume: 34, Issue:4

    Topics: Adult; Aged; Anticoagulants; Blood Platelets; Cerebral Arteries; Cerebral Hemorrhage; Clopidogrel; D

2013
Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial.
    The Lancet. Neurology, 2007, Volume: 6, Issue:11

    Topics: Aged; Aged, 80 and over; Aspirin; Cerebral Hemorrhage; Clopidogrel; Drug Therapy, Combination; Femal

2007
Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial.
    The Lancet. Neurology, 2007, Volume: 6, Issue:11

    Topics: Aged; Aged, 80 and over; Aspirin; Cerebral Hemorrhage; Clopidogrel; Drug Therapy, Combination; Femal

2007
Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial.
    The Lancet. Neurology, 2007, Volume: 6, Issue:11

    Topics: Aged; Aged, 80 and over; Aspirin; Cerebral Hemorrhage; Clopidogrel; Drug Therapy, Combination; Femal

2007
Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial.
    The Lancet. Neurology, 2007, Volume: 6, Issue:11

    Topics: Aged; Aged, 80 and over; Aspirin; Cerebral Hemorrhage; Clopidogrel; Drug Therapy, Combination; Femal

2007
Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial.
    The Lancet. Neurology, 2007, Volume: 6, Issue:11

    Topics: Aged; Aged, 80 and over; Aspirin; Cerebral Hemorrhage; Clopidogrel; Drug Therapy, Combination; Femal

2007
Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial.
    The Lancet. Neurology, 2007, Volume: 6, Issue:11

    Topics: Aged; Aged, 80 and over; Aspirin; Cerebral Hemorrhage; Clopidogrel; Drug Therapy, Combination; Femal

2007
Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial.
    The Lancet. Neurology, 2007, Volume: 6, Issue:11

    Topics: Aged; Aged, 80 and over; Aspirin; Cerebral Hemorrhage; Clopidogrel; Drug Therapy, Combination; Femal

2007
Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial.
    The Lancet. Neurology, 2007, Volume: 6, Issue:11

    Topics: Aged; Aged, 80 and over; Aspirin; Cerebral Hemorrhage; Clopidogrel; Drug Therapy, Combination; Femal

2007
Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial.
    The Lancet. Neurology, 2007, Volume: 6, Issue:11

    Topics: Aged; Aged, 80 and over; Aspirin; Cerebral Hemorrhage; Clopidogrel; Drug Therapy, Combination; Femal

2007
Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial.
    The Lancet. Neurology, 2007, Volume: 6, Issue:11

    Topics: Aged; Aged, 80 and over; Aspirin; Cerebral Hemorrhage; Clopidogrel; Drug Therapy, Combination; Femal

2007
Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial.
    The Lancet. Neurology, 2007, Volume: 6, Issue:11

    Topics: Aged; Aged, 80 and over; Aspirin; Cerebral Hemorrhage; Clopidogrel; Drug Therapy, Combination; Femal

2007
Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial.
    The Lancet. Neurology, 2007, Volume: 6, Issue:11

    Topics: Aged; Aged, 80 and over; Aspirin; Cerebral Hemorrhage; Clopidogrel; Drug Therapy, Combination; Femal

2007
Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial.
    The Lancet. Neurology, 2007, Volume: 6, Issue:11

    Topics: Aged; Aged, 80 and over; Aspirin; Cerebral Hemorrhage; Clopidogrel; Drug Therapy, Combination; Femal

2007
Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial.
    The Lancet. Neurology, 2007, Volume: 6, Issue:11

    Topics: Aged; Aged, 80 and over; Aspirin; Cerebral Hemorrhage; Clopidogrel; Drug Therapy, Combination; Femal

2007
Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial.
    The Lancet. Neurology, 2007, Volume: 6, Issue:11

    Topics: Aged; Aged, 80 and over; Aspirin; Cerebral Hemorrhage; Clopidogrel; Drug Therapy, Combination; Femal

2007
Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial.
    The Lancet. Neurology, 2007, Volume: 6, Issue:11

    Topics: Aged; Aged, 80 and over; Aspirin; Cerebral Hemorrhage; Clopidogrel; Drug Therapy, Combination; Femal

2007
Risks and benefits of oral anticoagulation compared with clopidogrel plus aspirin in patients with atrial fibrillation according to stroke risk: the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events (ACTIVE-W).
    Stroke, 2008, Volume: 39, Issue:5

    Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Anticoagulants; Aspirin; Atrial Fibrillation; Bipheny

2008
Oral anticoagulant therapy during and after coronary angioplasty the intensity and duration of anticoagulation are essential to reduce thrombotic complications.
    Circulation, 2001, Apr-24, Volume: 103, Issue:16

    Topics: Administration, Oral; Aneurysm, False; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Cere

2001

Other Studies

38 other studies available for ticlopidine and Cerebral Hemorrhage

ArticleYear
STARTING-SICH Nomogram to Predict Symptomatic Intracerebral Hemorrhage After Intravenous Thrombolysis for Stroke.
    Stroke, 2018, Volume: 49, Issue:2

    Topics: Aged; Aged, 80 and over; Aspirin; Brain Ischemia; Cerebral Hemorrhage; Clopidogrel; Female; Fibrinol

2018
Multiple electrode aggregometry in antiplatelet-related intracerebral haemorrhage.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2013, Volume: 20, Issue:12

    Topics: Adult; Aspirin; Blood Platelets; Brain Ischemia; Cerebral Hemorrhage; Clopidogrel; Humans; Male; Pla

2013
Clopidogrel use is associated with an increased prevalence of cerebral microbleeds in a stroke-free population: the Rotterdam study.
    Journal of the American Heart Association, 2013, Sep-26, Volume: 2, Issue:5

    Topics: Aged; Aged, 80 and over; Cerebral Hemorrhage; Clopidogrel; Cross-Sectional Studies; Female; Humans;

2013
Progressive hemorrhagic transformation following dual antiplatelet therapy.
    CNS neuroscience & therapeutics, 2014, Volume: 20, Issue:1

    Topics: Angiography, Digital Subtraction; Aspirin; Brain; Cerebral Angiography; Cerebral Hemorrhage; Clopido

2014
Variability in initial response to standard clopidogrel therapy, delayed conversion to clopidogrel hyper-response, and associated thromboembolic and hemorrhagic complications in patients undergoing endovascular treatment of unruptured cerebral aneurysms.
    Journal of neurointerventional surgery, 2014, Volume: 6, Issue:10

    Topics: Cerebral Hemorrhage; Clopidogrel; Endovascular Procedures; Female; Humans; Intracranial Aneurysm; In

2014
Enteric-coated aspirin versus other antiplatelet drugs in acute non-cardioembolic ischemic stroke: post-marketing study in Japan.
    Advances in therapy, 2014, Volume: 31, Issue:1

    Topics: Aged; Aged, 80 and over; Aspirin; Cerebral Hemorrhage; Cerebral Infarction; Cilostazol; Dipyridamole

2014
Thrombelastography detects possible coagulation disturbance in patients with intracerebral hemorrhage with hematoma enlargement.
    Stroke, 2014, Volume: 45, Issue:3

    Topics: Aged; Blood Coagulation Disorders; Cerebral Hemorrhage; Clopidogrel; Data Interpretation, Statistica

2014
Does clopidogrel with aspirin after acute minor stroke or transient ischemic attack increase the risk of cerebral hemorrhage?
    Chinese medical journal, 2014, Volume: 127, Issue:18

    Topics: Aspirin; Cerebral Hemorrhage; Clopidogrel; Humans; Ischemic Attack, Transient; Male; Middle Aged; Ti

2014
How should I treat subacute stent thrombosis in the context of brain haemorrhage with abciximab?
    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2015, Volume: 10, Issue:10

    Topics: Abciximab; Antibodies, Monoclonal; Aspirin; Cerebral Hemorrhage; Clopidogrel; Embolic Protection Dev

2015
Ventriculostomy-Related Hemorrhage After Treatment of Acutely Ruptured Aneurysms: The Influence of Anticoagulation and Antiplatelet Treatment.
    World neurosurgery, 2015, Volume: 84, Issue:6

    Topics: Acute Disease; Adult; Aged; Aneurysm, Ruptured; Anticoagulants; Aspirin; Cerebral Hemorrhage; Clopid

2015
A Novel Use of Direct Platelet Application During Surgery for Clopidogrel-Associated Intracerebral Hemorrhage.
    World neurosurgery, 2015, Volume: 84, Issue:6

    Topics: Aneurysm, False; Aneurysm, Ruptured; Cerebral Angiography; Cerebral Hemorrhage; Clopidogrel; Female;

2015
Accumetrics-based clopidogrel dosing in endovascular neurosurgery.
    Neurological research, 2015, Volume: 37, Issue:11

    Topics: Aged; Aspirin; Cerebral Hemorrhage; Clopidogrel; Drug Therapy, Combination; Endovascular Procedures;

2015
Comparison of antiplatelet regimens in secondary stroke prevention: a nationwide cohort study.
    BMC neurology, 2015, Nov-02, Volume: 15

    Topics: Aged; Aged, 80 and over; Aspirin; Brain Ischemia; Cerebral Hemorrhage; Clopidogrel; Cohort Studies;

2015
Antithrombotic Medication Use and Misuse Among Patients with Intracranial Hemorrhage: A 16-Year, Lebanese, Single-Center Experience.
    World neurosurgery, 2016, Volume: 95

    Topics: Acenocoumarol; Adult; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Atrial Fibrillation; Cerebra

2016
Risk of bleeding after hospitalization for a serious coronary event: a retrospective cohort study with nested case-control analyses.
    BMC cardiovascular disorders, 2016, 08-30, Volume: 16, Issue:1

    Topics: Aged; Aged, 80 and over; Aspirin; Cerebral Hemorrhage; Clopidogrel; Confidence Intervals; Coronary A

2016
Impact of an Interaction Between Clopidogrel and Selective Serotonin Reuptake Inhibitors.
    The American journal of cardiology, 2017, 02-15, Volume: 119, Issue:4

    Topics: Aged; Cerebral Hemorrhage; Clopidogrel; Cohort Studies; Cytochrome P-450 CYP2C19 Inhibitors; Databas

2017
Antiplatelets for stroke prevention: implications of the PRoFESS trial.
    Stroke, 2009, Volume: 40, Issue:5

    Topics: Aspirin; Cerebral Hemorrhage; Clopidogrel; Delayed-Action Preparations; Dipyridamole; Drug Therapy,

2009
Platelet activity and outcome after intracerebral hemorrhage.
    Annals of neurology, 2009, Volume: 65, Issue:3

    Topics: Aged; Aged, 80 and over; Aspirin; Blood Platelets; Cerebral Hemorrhage; Clopidogrel; Female; Glasgow

2009
Reduced platelet activity is more common than reported anti-platelet medication use in patients with intracerebral hemorrhage.
    Neurocritical care, 2009, Volume: 11, Issue:3

    Topics: Aged; Aspirin; Blood Platelets; Cerebral Hemorrhage; Clopidogrel; Drug Therapy, Combination; Female;

2009
Combined anti-platelet therapy with aspirin and clopidogrel: risk factor for thrombolysis-related intracerebral hemorrhage in acute ischemic stroke?
    Journal of the neurological sciences, 2009, Sep-15, Volume: 284, Issue:1-2

    Topics: Aged; Aged, 80 and over; Aspirin; Brain Ischemia; Cerebral Hemorrhage; Clopidogrel; Female; Fibrinol

2009
Reduced platelet activity is associated with more intraventricular hemorrhage.
    Neurosurgery, 2009, Volume: 65, Issue:4

    Topics: Adult; Aged; Aspirin; Blood Platelet Disorders; Blood Platelets; Cerebral Hemorrhage; Clopidogrel; C

2009
Antiplatelet therapy after coronary intervention in Asia and Japan: the Asian perspective of antiplatelet intervention.
    Hamostaseologie, 2009, Volume: 29, Issue:4

    Topics: Asia; Cerebral Hemorrhage; Cerebrovascular Disorders; Cilostazol; Clopidogrel; Coronary Disease; Eur

2009
Safety of intravenous thrombolysis for acute ischemic stroke in patients receiving antiplatelet therapy at stroke onset.
    Stroke, 2010, Volume: 41, Issue:2

    Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Brain Ischemia; Cerebral Hemorrh

2010
Impact of platelet transfusion on hematoma expansion in patients receiving antiplatelet agents before intracerebral hemorrhage.
    Neurological research, 2010, Volume: 32, Issue:7

    Topics: Aged; Aged, 80 and over; Aspirin; Cerebral Hemorrhage; Clopidogrel; Databases, Factual; Female; Hema

2010
[Between thrombosis and bleeding - a case of paroxysmal nocturnal hemoglobinuria].
    Therapeutische Umschau. Revue therapeutique, 2010, Volume: 67, Issue:12

    Topics: Aged; Anticoagulants; Aspirin; Cerebral Hemorrhage; Clopidogrel; Coronary Thrombosis; Drug Therapy,

2010
Delayed intracranial hemorrhage associated with antiplatelet therapy in stent-assisted coil embolized cerebral aneurysms.
    Acta neurochirurgica. Supplement, 2011, Volume: 110, Issue:Pt 2

    Topics: Adult; Aged; Aspirin; Cerebral Hemorrhage; Clopidogrel; Cohort Studies; Embolization, Therapeutic; F

2011
Antiplatelet pretreatment does not increase hematoma volume in experimental intracerebral hemorrhage.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2011, Volume: 31, Issue:8

    Topics: Animals; Aspirin; Blood Coagulation; Cerebral Hemorrhage; Clopidogrel; Hematoma; Mice; Plasma Cells;

2011
Atrial fibrillation, is warfarin the only option for stroke prevention?
    JPMA. The Journal of the Pakistan Medical Association, 2011, Volume: 61, Issue:4

    Topics: Angiotensin II Type 1 Receptor Blockers; Anticoagulants; Aspirin; Atrial Fibrillation; Biphenyl Comp

2011
[Intracerebral hemorrhage in anticoagulated patients: what do we do afterwards?].
    Neurologia (Barcelona, Spain), 2012, Volume: 27, Issue:3

    Topics: Aged; Anticoagulants; Aspirin; Cerebral Hemorrhage; Clopidogrel; Female; Follow-Up Studies; Humans;

2012
Illustration of the impact of antiplatelet drugs on the genesis and management of chronic subdural hematoma.
    Neuro-Chirurgie, 2012, Volume: 58, Issue:1

    Topics: Aged; Aged, 80 and over; Aspirin; Cerebral Hemorrhage; Clopidogrel; Drug Therapy, Combination; Hemat

2012
Clinical outcomes using a platelet function-guided approach for secondary prevention in patients with ischemic stroke or transient ischemic attack.
    Stroke, 2012, Volume: 43, Issue:9

    Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Brain Ischemia; Cerebral Hemorrhage; Clopidogrel; Fem

2012
Platelet-function testing in patients undergoing neurovascular procedures: caught between a rock and a hard place.
    AJNR. American journal of neuroradiology, 2013, Volume: 34, Issue:4

    Topics: Cerebral Hemorrhage; Clopidogrel; Drug Resistance; Endovascular Procedures; Female; Humans; Male; Pl

2013
Adverse reactions to anticoagulants and to antiplatelet drugs recorded by the German spontaneous reporting system.
    Seminars in thrombosis and hemostasis, 2005, Volume: 31, Issue:4

    Topics: Administration, Oral; Adverse Drug Reaction Reporting Systems; Anticoagulants; Aspirin; Association;

2005
Clopidogrel for the prevention of atherothrombotic events.
    The New England journal of medicine, 2006, Jul-27, Volume: 355, Issue:4

    Topics: Aspirin; Cerebral Hemorrhage; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation I

2006
Management of intracranial hemorrhage associated with anticoagulant therapy.
    Surgical neurology, 1995, Volume: 44, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Cerebral Hemorrhage; Child; Fem

1995
[Cost effectiveness of clopidogrel in secondary cardiovascular prevention: a cost-effectiveness analysis based on the Caprie Study].
    Praxis, 2001, Mar-29, Volume: 90, Issue:13

    Topics: Adult; Aged; Arterial Occlusive Diseases; Aspirin; Cerebral Hemorrhage; Cerebral Infarction; Clopido

2001
Intracerebral hemorrhage following possible interaction between celecoxib and clopidogrel.
    The Annals of pharmacotherapy, 2001, Volume: 35, Issue:12

    Topics: Aged; Aged, 80 and over; Celecoxib; Cerebral Hemorrhage; Clopidogrel; Cyclooxygenase Inhibitors; Dru

2001
Cerebral hemorrhage and thrombotic thrombocytopenic purpura during ticlopidine treatment: case report.
    Acta neurologica Belgica, 1992, Volume: 92, Issue:2

    Topics: Adult; Cerebral Hemorrhage; Combined Modality Therapy; Female; Humans; Plasma Exchange; Puerperal Di

1992