ticlopidine and Brain Vascular Disorders studies

Ticlopidine: An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
ticlopidine : A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.

Research Excerpts

Excerpt	Relevance	Reference
"The Swedish Ticlopidine Multicentre Study (STIMS) was a double-blind placebo-controlled trial designed to determine whether ticlopidine, a platelet antiaggregatory agent, reduces the incidence of myocardial infarction, stroke and transitory ischaemic attacks in patients with intermittent claudication."	9.06	Prevention of myocardial infarction and stroke in patients with intermittent claudication; effects of ticlopidine. Results from STIMS, the Swedish Ticlopidine Multicentre Study. ( Almgren, B; Bergqvist, D; Boberg, J; Boberg, M; Eriksson, I; Fagher, B; Janzon, L; Kjellström, T; Lindgärde, F; Persson, G, 1990)
"The role of concomitant aspirin (ASA) therapy in patients with atrial fibrillation (AF) receiving oral anticoagulation (OAC) is unclear."	7.79	Use and associated risks of concomitant aspirin therapy with oral anticoagulation in patients with atrial fibrillation: insights from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) Registry. ( Ansell, J; Chang, P; Ezekowitz, MD; Fonarow, GC; Gersh, B; Go, AS; Hylek, E; Kim, S; Kowey, P; Lopes, RD; Mahaffey, KW; Peterson, ED; Piccini, JP; Singer, DE; Steinberg, BA; Thomas, L, 2013)
"Ticlopidine (TCP) is a drug that inhibits platelet aggregation."	5.29	[Ticlopidine-induced neutropenia]. ( Atias, D; Balbir, A; Odeh, M; Oliven, A, 1996)
"Between 2009 and 2012, 2286 patients invasively managed for ACS were enrolled in the multicentre Swiss ACS Bleeding Cohort, among whom 2148 patients received either prasugrel or clopidogrel according to current guidelines."	5.20	Safety profile of prasugrel and clopidogrel in patients with acute coronary syndromes in Switzerland. ( Auer, R; Carballo, D; Gencer, B; Heg, D; Jaguszewski, M; Jakob, P; Jüni, P; Klingenberg, R; Landmesser, U; Lüscher, TF; Mach, F; Maier, W; Matter, CM; Meier, B; Nanchen, D; Räber, L; Rodondi, N; Roffi, M; Stähli, BE; Stefanini, GG; Templin, C; Vogt, P; Windecker, S, 2015)
"Compared with aspirin, clopidogrel reduced the combined risk of ischaemic stroke, myocardial infarction or vascular death by 8."	5.09	Comparative safety and tolerability of clopidogrel and aspirin: results from CAPRIE. CAPRIE Steering Committee and Investigators. Clopidogrel versus aspirin in patients at risk of ischaemic events. ( Boissel, JP; Gent, M; Harker, LA; Pilgrim, AJ, 1999)
"The mortality in patients with intermittent claudication can be reduced by treatment with ticlopidine."	5.08	The STIMS trial: the ticlopidine experience and its clinical applications. Swedish Ticlopidine Multicenter Study. ( Janzon, L, 1996)
"The Swedish Ticlopidine Multicentre Study (STIMS) was a double-blind placebo-controlled trial designed to determine whether ticlopidine, a platelet antiaggregatory agent, reduces the incidence of myocardial infarction, stroke and transitory ischaemic attacks in patients with intermittent claudication."	5.06	Prevention of myocardial infarction and stroke in patients with intermittent claudication; effects of ticlopidine. Results from STIMS, the Swedish Ticlopidine Multicentre Study. ( Almgren, B; Bergqvist, D; Boberg, J; Boberg, M; Eriksson, I; Fagher, B; Janzon, L; Kjellström, T; Lindgärde, F; Persson, G, 1990)
"The Canadian American Ticlopidine Study (CATS) is a randomised, double-blind, placebo-controlled trial to assess the effect of ticlopidine (250 mg twice daily) in reducing the rate of subsequent occurrence of stroke, myocardial infarction, or vascular death in patients who have had a recent thromboembolic stroke."	5.06	The Canadian American Ticlopidine Study (CATS) in thromboembolic stroke. ( Blakely, JA; Easton, JD; Ellis, DJ; Gent, M; Hachinski, VC; Harbison, JW; Panak, E; Roberts, RS; Sicurella, J; Turpie, AG, 1989)
"The purpose of this review is to update our current knowledge and understanding of the pharmacogenetic basis for poor clopidogrel responsiveness in patients undergoing CAS and endovascular interventions as well as to explore usefulness of genotyping to reduce the rate of procedure-related thrombosis that results in ischemic complications."	4.95	Potential Usefulness of Clopidogrel Pharmacogenetics in Cerebral Endovascular Procedures and Carotid Artery Stenting. ( Duconge, J; Hernandez-Suarez, DF, 2017)
"In the overall population, dual antiplatelet therapy (DAPT) with aspirin and clopidogrel in comparison to aspirin monotherapy reduced the relative risk of total stroke by 20% (risk ratio [RR], 0."	4.90	Antiplatelet treatment for prevention of cerebrovascular events in patients with vascular diseases: a systematic review and meta-analysis. ( Arrich, J; Gouya, G; Gurbel, PA; Huber, K; Pirker-Kees, A; Siller-Matula, JM; Verheugt, FW; Wolzt, M, 2014)
"Using the key terms acute coronary syndrome, atherothrombosis, ischemic stroke, myocardial infarction, MI, peripheral arterial disease, TIA, transient ischemic attack, unstable angina,aspirin,ticlopidine,dipyridamole, and clopidogrel, we searched the MEDLINE database as well as the trial register of the Cochrane Groups to identify studies published from 1960 to August 2004."	4.82	Oral antiplatelet therapy in cerebrovascular disease, coronary artery disease, and peripheral arterial disease. ( Anand, SS; Tran, H, 2004)
" The gastrointestinal bleeding risk was significantly lower with ticlopidine and clopidogrel, which were both somewhat more effective than aspirin in the prevention of vascular events."	4.80	Bleeding complications in secondary stroke prevention by antiplatelet therapy: a benefit-risk analysis. ( Boysen, G, 1999)
"We present the case of a 77 year old man who had been treated for twenty years with phenytoin for partial crises secondary to a left frontal hematoma."	4.80	[Acute phenytoin poisoning secondary to an interaction with ticlopidine]. ( López-Ariztegui, N; Martín, M; Nevado, C; Ochoà, M; Sánchez-Migallón, MJ, 1998)
"In patients with nonvalvular atrial fibrillation, warfarin is highly effective in reducing stroke and death but may result in more complications."	4.79	Medical treatment for stroke prevention. ( Barnett, HJ; Feussner, JR; Matchar, DB; McCrory, DC, 1994)
"A retrospective review of all patients with stroke and transient ischemic attack (TIA) tested for the clopidogrel CYP2C19 genotype was performed, with a collection of data including race/ethnicity, CYP2C19 status, and the presence of recurrent vascular events."	3.80	Reduced clopidogrel metabolism in a multiethnic population: prevalence and rates of recurrent cerebrovascular events. ( Barazangi, N; Chen, C; Jaramillo, V; Rose, J; Spokoyny, I; Tong, D; Wong, C, 2014)
"The role of concomitant aspirin (ASA) therapy in patients with atrial fibrillation (AF) receiving oral anticoagulation (OAC) is unclear."	3.79	Use and associated risks of concomitant aspirin therapy with oral anticoagulation in patients with atrial fibrillation: insights from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) Registry. ( Ansell, J; Chang, P; Ezekowitz, MD; Fonarow, GC; Gersh, B; Go, AS; Hylek, E; Kim, S; Kowey, P; Lopes, RD; Mahaffey, KW; Peterson, ED; Piccini, JP; Singer, DE; Steinberg, BA; Thomas, L, 2013)
" These results indicate that clopidogrel is more effective and safer than aspirin in reducing adverse cardiovascular events in patients with atherosclerosis."	3.79	Results of the CAPRIE trial: efficacy and safety of clopidogrel. Clopidogrel versus aspirin in patients at risk of ischaemic events. ( Creager, MA, 1998)
"The CYP2C19 genotype is a predictor of adverse cardiovascular events in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI) treated with clopidogrel."	3.79	Genetic testing in patients with acute coronary syndrome undergoing percutaneous coronary intervention: a cost-effectiveness analysis. ( Berger, JS; Hochman, JS; Ladapo, JA; Lala, A; Scott Braithwaite, R; Sharma, G, 2013)
"Patients who have had a recent transient ischemic attack (TIA) are at high risk for subsequent stroke."	3.77	Epidemiology of and stroke-preventive strategies for atherothromboembolic brain infarction in the elderly. ( Adams, HP; Gordon, DL, 1991)
"Among patients receiving clopidogrel for coronary artery disease, concomitant therapy with proton pump inhibitors (PPIs) has been associated with an increased risk for recurrent coronary events."	3.77	Concomitant use of proton pump inhibitors and clopidogrel in patients with coronary, cerebrovascular, or peripheral artery disease in the factores de Riesgo y ENfermedad Arterial (FRENA) registry. ( Escudero, D; Monreal, M; Muñoz-Torrero, JF; Pascual, MT; Sanclemente, C; Suárez, C; Trujillo-Santos, J; Zamorano, J, 2011)
"Data obtained in this study suggest a suboptimal clopidogrel response in patients with greater body weight and body mass index."	3.77	Body weight: a risk factor for subtherapeutic antithrombotic therapy in neurovascular stenting. ( Alexander, MJ; Choulakian, A; Drazin, D; Kornbluth, P; Nuño, M, 2011)
"One possible cause of stent thrombosis is an insufficient effect of clopidogrel."	3.77	Optimizing of thienopyridine therapy by multiple electrode platelet aggregometry in clopidogrel low responders undergoing PCI. ( Behr, T; Behr, W; Kuch, B; von Scheidt, W, 2011)
"We sought to assess the effect of clopidogrel on in-hospital events in unselected patients with acute ST elevation myocardial infarction (STEMI)."	3.74	Clopidogrel in addition to aspirin reduces in-hospital major cardiac and cerebrovascular events in unselected patients with acute ST segment elevation myocardial. ( Bauer, T; Gitt, A; Gottwik, M; Heer, T; Jünger, C; Koeth, O; Mark, B; Senges, J; Zahn, R; Zeymer, U, 2008)
"The rapid and significant decline of MES in our stroke and TIA patients suggests the possible efficacy of dual antiplatelet therapy with aspirin and clopidogrel in patients with MES and symptomatic large-artery occlusive disease."	3.73	Efficacy of dual antiplatelet therapy in cerebrovascular disease as demonstrated by a decline in microembolic signals. A report of eight cases. ( Chang, HM; Chen, CL; Esagunde, RU; Gan, HY; Lee, MP; Wong, KS; Wong, MC, 2006)
"Elevated levels of plasma fibrinogen are a risk factor for cerebral infarction."	3.69	Effect of plasma fibrinogen concentration on the inhibition of platelet aggregation after ticlopidine compared with aspirin. ( Kashiwaya, M; Takahashi, H; Tohgi, H; Watanabe, K, 1994)
" A low postoperative dose of aprotinin in patients receiving clopidogrel is safe and has comparable effects regarding postoperative bleeding complications as a high dose."	2.75	Low postoperative dose of aprotinin reduces bleeding and is safe in patients receiving clopidogrel before coronary artery bypass surgery. A prospective randomized study. ( Istad, R; Ringdal, MA; Tangen, G; Tølløfsrud, S; Øvrum, E; Øystese, R, 2010)
"To investigate the effect of removing phlegm and dispelling stasis method (RPDSM) combined with Western medicine for treatment of cerebrovascular stenosis."	2.73	[Removing phlegm and dispelling stasis method combined with Western medicine for treatment of cerebrovascular stenosis]. ( Gao, L; Liu, Q; Wang, PP, 2008)
" For aspirin, the median dosage per week was 1300 mg and median ARU was 410."	2.73	Prevalence and risk factors for aspirin and clopidogrel resistance in cerebrovascular stenting. ( Flaherty, CA; Lee, VH; Lopes, DK; Prabhakaran, S; Wells, KR, 2008)
"Only aspirin has been evaluated in the setting of primary prevention and it seems to be ineffective in preventing cerebral infarction."	2.68	[Primary and secondary prevention of ischemic cerebrovascular accidents of arteriosclerosis by platelet inhibitors]. ( Canaple, S; Rosa, A, 1996)
" Twenty-six patients were dosed for 2 weeks, 300 mg aspirin once daily and then for 2 weeks, 250 mg ticlopidine twice daily."	2.68	Asymptomatic circulating cerebral emboli and cerebral blood flow velocity under aspirin and ticlopidine in patients with cerebrovascular disease. ( Droste, DW; Kaps, M; Siemens, HJ; Sonne, M, 1996)
"048), and the frequency of adverse events was not significantly different between the two treatment groups."	2.67	The efficacy and safety of ticlopidine and aspirin in non-whites: analysis of a patient subgroup from the Ticlopidine Aspirin Stroke Study. ( Weisberg, LA, 1993)
"Ticlopidine has not been formally compared with aspirin in patients with a completed stroke."	2.67	Ticlopidine versus aspirin for the prevention of recurrent stroke. Analysis of patients with minor stroke from the Ticlopidine Aspirin Stroke Study. ( Harbison, JW, 1992)
"Ticlopidine was more effective than aspirin in both sexes."	2.66	A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients. Ticlopidine Aspirin Stroke Study Group. ( Adams, HP; Anderson, S; Easton, JD; Hass, WK; Kamm, B; Molony, BA; Pryse-Phillips, W, 1989)
"Aspirin treatment appears to be strongly indicated."	2.41	Update on clinical trials of antiplatelet therapy for cerebrovascular diseases. ( Bhatt, DL; Kapadia, SR; Topol, EJ; Yadav, JS, 2000)
"Ticlopidine is an antiplatelet agent that is used to reduce the occurrence of atherothrombotic arterial events."	2.40	Adverse haematological effects of ticlopidine. Prevention, recognition and management. ( Biller, J; Gent, M; Love, BB, 1998)
"Aspirin has remained the pharmacologic foundation of stroke prevention, primarily because of its low cost."	2.40	Clinical considerations in selecting antiplatelet therapy in cerebrovascular disease. ( Harbison, JW, 1998)
" This review article examines research on both monotherapy and combination antiplatelet therapy for secondary stroke prevention, with an emphasis on lessons learned about dosage schedules, treatment protocols, and side-effect profiles."	2.40	Antiplatelet therapy for secondary stroke prevention. ( Forbes, CD, 1999)
"Ticlopidine is a thienopyridine derivative which reduces the risk of reversible ischaemia and stroke in patients who have previously experienced a cerebral ischaemic episode."	2.39	Ticlopidine. A review of its pharmacology, clinical efficacy and tolerability in the prevention of cerebral ischaemia and stroke. ( Goa, KL; Noble, S, 1996)
"Ticlopidine is a new antiplatelet agent with a distinct mechanism of action."	2.38	Ticlopidine and antiplatelet therapy. ( Flores-Runk, P; Raasch, RH, 1993)
"Strokes due to carotid artery stenosis differ in outcome from those due to cardiac embolism; the most benign group is that of lacunar strokes."	2.38	Outcome of transient ischaemic attacks and stroke. ( Norris, JW, 1991)
"Ticlopidine has been well tolerated in preliminary studies, with the most commonly described adverse effects being rash and gastrointestinal complaints."	2.38	Ticlopidine: a new antiplatelet agent for cerebrovascular disease. ( Fagan, SC; Miller, AJ; Robert, S, 1991)
"Ticlopidine was more effective than aspirin in reducing stroke in both males and females."	2.38	Antiplatelet therapy in the prevention of stroke. ( Easton, JD, 1991)
"Measuring platelet thrombus formation (PTF) for evaluating antiplatelet effects was assessed."	1.43	Measurement of residual platelet thrombogenicity under arterial shear conditions in cerebrovascular disease patients receiving antiplatelet therapy. ( Hosokawa, K; Kawashima, A; Kitagawa, K; Ohnishi, T; Okada, Y; Uchiyama, S; Yamaguchi, K; Yamazaki, M; Yoneyama, T, 2016)
"A fibrinogen level>4."	1.42	Predictors of high on-aspirin platelet reactivity in high-risk vascular patients treated with single or dual antiplatelet therapy. ( Amsallem, M; Bal dit Sollier, C; Dillinger, JG; Drouet, L; Henry, P; Manzo-Silberman, S; Sideris, G; Voicu, S, 2015)
" All of our patients showed immediate platelet inhibition after a loading dose of 180 mg of ticagrelor, with no adverse effects."	1.40	Safety and efficacy of ticagrelor for neuroendovascular procedures. A single center initial experience. ( Dixon, T; Freeman, WD; Hanel, RA; Johns, G; Miller, DA; Navarro, R; Nordeen, JD; Sapin, M; Taussky, P; Tawk, RG, 2014)
"In this large real-world PCI population, CR was as effective and as safe as CB in preventing adverse clinical outcomes."	1.39	Comparison of clinical efficacy and safety of clopidogrel resinate with clopidogrel bisulfate in patients undergoing percutaneous coronary intervention. ( Chang, K; Cho, JS; Chung, WS; Her, SH; Jeong, SH; Kim, CJ; Kim, PJ; Park, MW; Seung, KB; Yim, HW, 2013)
"Instances of ticlopidine-associated thrombotic thrombocytopenic purpura were identified."	1.30	Thrombotic thrombocytopenic purpura associated with ticlopidine. A review of 60 cases. ( Bennett, CL; Green, D; Kwaan, HC; Rozenberg-Ben-Dror, K; Weinberg, PD; Yarnold, PR, 1998)
"Ticlopidine (TCP) is a drug that inhibits platelet aggregation."	1.29	[Ticlopidine-induced neutropenia]. ( Atias, D; Balbir, A; Odeh, M; Oliven, A, 1996)
"To report a case of aplastic anemia that developed during ticlopidine treatment."	1.29	Ticlopidine and fatal aplastic anemia in an elderly woman. ( Mallet, J; Mallet, L, 1994)
"However, their effects on thrombus formation have rarely been evaluated in experimental animals in vivo."	1.29	In vivo evaluation of antiplatelet agents in gerbil model of carotid artery thrombosis. ( Iwamoto, Y; Naritomi, H; Nishimura, H; Sugita, M; Tachibana, H, 1996)
"Ticlopidine hydrochloride is an antiplatelet agent of proven antithrombotic efficacy that in December 1991 became available for general clinical use in the United States."	1.29	Ticlopidine hydrochloride use and threatened stroke. ( Hart, RG; Rothrock, JF, 1994)
"In the AA-induced sudden death model, 30 min after beraprost administration (1 or 3 mg/kg, po), AA was injected into the rabbit internal carotid artery, and incidence of convulsion and sudden death were assessed."	1.28	The effects of beraprost Na, a stable prostacyclin analog, on animal models of stroke. ( Hirano, T; Kanai, N; Nishio, S; Umetsu, T; Yamori, Y, 1992)
"Ticlopidine was more effective in patients without carotid stenosis."	1.28	Prevention of stroke with ticlopidine: who benefits most? TASS Baseline and Angiographic Data Subgroup. ( Grotta, JC; Kamm, B; Norris, JW, 1992)
"A trial was performed on thirty-two patients with cerebrovascular disease (transient ischaemic attack and stroke) to assess the effect of ticlopidine, a new inhibitor of platelet aggregation, on some platelet functions and coagulation, and its safety in long-term use (6 months)."	1.27	Effects of long-term ticlopidine treatment on platelet function and its tolerability in cerebrovascular disease. ( Carfagna, S; Carrieri, P; Fioretti, A; Indaco, A; Orefice, G, 1984)

Timeframe	Studies, this research(%)	All Research%
pre-1990	15 (8.47)	18.7374
1990's	109 (61.58)	18.2507
2000's	18 (10.17)	29.6817
2010's	33 (18.64)	24.3611
2020's	2 (1.13)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF)[NCT01165710]		10,179 participants (Actual)	Observational	2010-06-30	Completed
Comparison of Biolimus Eluted From an Erodable Stent Coating With Bare-Metal Stents in Acute ST-Elevation Myocardial Infarction and In Vivo 3-Vessel Assessment of Time-Related Changes of Culprit and Non-Culprit Lesions by IVUS/OCT in AMI[NCT00962416]	Phase 4	1,161 participants (Actual)	Interventional	2009-09-30	Completed
Inflammation and Acute Coronary Syndromes (ACS) - Novel Strategies for Prevention and Clinical Management[NCT01000701]		4,000 participants (Anticipated)	Observational	2009-10-31	Recruiting
MONET BRIDGE(Maintenance Of aNtiplatElet Therapy in Patients With Coronary Stenting Undergoing Surgery) - (Mantenimento Della Terapia Antiaggregante Nei Pazienti Portatori di Stent Coronarico Candidati a Chirurgia)[NCT03862651]	Phase 2	140 participants (Anticipated)	Interventional	2019-06-01	Not yet recruiting
Multicenter, Prospective Cohort of Patient With Coronary Stents Undergoing Non Cardiac Surgery or Invasive Procedures.[NCT01045850]		1,312 participants (Actual)	Observational	2006-02-28	Completed
[NCT01584791]	Phase 4	148 participants (Actual)	Interventional	2010-10-31	Completed
Improvements of Hand Function in Chronic Stroke Related to Upper Arm Anesthesia[NCT00006414]		12 participants	Observational	2000-10-31	Completed
Induction of Mucosal Tolerance to E-Selectin for the Secondary Prevention of Stroke[NCT00012454]	Phase 2	60 participants	Interventional	2001-03-31	Terminated
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
A Systematic Review of Clopidogrel Resistance in Vascular Surgery: Current Perspectives and Future Directions. Annals of vascular surgery, 2023, Volume: 91 Topics: Cerebrovascular Disorders; Clopidogrel; Humans; Peripheral Arterial Disease; Platelet Aggregation In	2023
Monotherapy with a P2Y Lancet (London, England), 2020, 05-09, Volume: 395, Issue:10235 Topics: Aged; Aspirin; Atherosclerosis; Cerebrovascular Disorders; Clopidogrel; Coronary Disease; Female; He	2020
Clinical consequences of aspirin and clopidogrel resistance: an overview. Acta neurologica Scandinavica, 2013, Volume: 128, Issue:4 Topics: Aryl Hydrocarbon Hydroxylases; Aspirin; Cerebrovascular Disorders; Clopidogrel; Cytochrome P-450 CYP	2013
Antiplatelet treatment for prevention of cerebrovascular events in patients with vascular diseases: a systematic review and meta-analysis. Stroke, 2014, Volume: 45, Issue:2 Topics: Adenosine; Aged; Aspirin; Cerebral Hemorrhage; Cerebrovascular Disorders; Clopidogrel; Cohort Studie	2014
Aspirin, clopidogrel, and the surgeon. Advances in surgery, 2014, Volume: 48 Topics: Aspirin; Cardiovascular Diseases; Cerebrovascular Disorders; Clopidogrel; Humans; Platelet Aggregati	2014
High maintenance dose of clopidogrel in patients with high on-treatment platelet reactivity after a percutaneous coronary intervention: a meta-analysis. Coronary artery disease, 2015, Volume: 26, Issue:5 Topics: Cerebrovascular Disorders; Chi-Square Distribution; Clopidogrel; Drug Resistance; Heart Diseases; He	2015
Potential Usefulness of Clopidogrel Pharmacogenetics in Cerebral Endovascular Procedures and Carotid Artery Stenting. Current clinical pharmacology, 2017, Volume: 12, Issue:1 Topics: Carotid Artery Diseases; Cerebrovascular Disorders; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resi	2017
Heterogeneity of efficacy and safety of antiplatelet therapy in cardiovascular and cerebrovascular disease. American journal of cardiovascular drugs : drugs, devices, and other interventions, 2010, Volume: 10, Issue:2 Topics: Acute Coronary Syndrome; Aspirin; Cardiovascular Diseases; Cerebrovascular Disorders; Clinical Trial	2010
[Efficacy and safety of various doses of acetylsalicylic Acid in prevention of complications of atherothrombosis]. Kardiologiia, 2010, Volume: 50, Issue:10 Topics: Aspirin; Blood Platelets; Blood Vessels; Cardiovascular Diseases; Cerebrovascular Disorders; Clinica	2010
[Strategy to manage low dose aspirin-induced gastrointestinal injury]. Nihon rinsho. Japanese journal of clinical medicine, 2011, Volume: 69, Issue:2 Topics: Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Cerebrovascular Disorders; Clopidogrel; Famotid	2011
Antiplatelet therapy in cerebrovascular disorders. Handbook of experimental pharmacology, 2012, Issue:210 Topics: Anticoagulants; Aspirin; Cerebrovascular Disorders; Clopidogrel; Dipyridamole; Humans; Platelet Aggr	2012
Oral antiplatelet therapy in cerebrovascular disease, coronary artery disease, and peripheral arterial disease. JAMA, 2004, Oct-20, Volume: 292, Issue:15 Topics: Administration, Oral; Angina Pectoris; Arteriosclerosis; Aspirin; Cerebrovascular Disorders; Clopido	2004
Prevention of vascular events in patients with cerebrovascular disease: efficacy and appropriate duration of antiplatelet therapy. Clinical cardiology, 2006, Volume: 29, Issue:6 Topics: Aspirin; Cerebrovascular Disorders; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Humans; Pl	2006
[Brain nerve symptoms due to thrombotic microangiopathy]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2007, Feb-10, Volume: 96, Issue:2 Topics: ADAM Proteins; ADAMTS13 Protein; Adult; Aged; Aged, 80 and over; Cerebrovascular Disorders; Clopidog	2007
Antiplatelet therapy with clopidogrel and aspirin in vascular diseases: clinical evidence for and against the combination. Expert opinion on pharmacotherapy, 2008, Volume: 9, Issue:3 Topics: Aspirin; Cardiovascular Diseases; Cerebrovascular Disorders; Clopidogrel; Coronary Disease; Drug The	2008
[Role of antiaggregant platelet drugs in thromboembolism]. Giornale italiano di cardiologia, 1981, Volume: 11, Issue:8 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anti-Bacterial Agents; Aspirin; Cerebrova	1981
Overview: clinical experiences with ticlopidine. Agents and actions. Supplements, 1984, Volume: 15 Topics: Anemia, Sickle Cell; Anticoagulants; Arterial Occlusive Diseases; Cerebrovascular Disorders; Clinica	1984
Medical treatment for stroke prevention. Annals of internal medicine, 1994, Jul-01, Volume: 121, Issue:1 Topics: Aspirin; Atrial Fibrillation; Cerebrovascular Disorders; Humans; Ischemic Attack, Transient; Myocard	1994
Ticlopidine: a new antiplatelet agent for the secondary prevention of stroke. Clinical neuropharmacology, 1994, Volume: 17, Issue:1 Topics: Cerebrovascular Disorders; Clinical Trials as Topic; Drug Interactions; Female; Humans; Ticlopidine	1994
Antithrombotic therapies for stroke prevention. Current opinion in neurology, 1994, Volume: 7, Issue:1 Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Brain Ischemia; Cerebrovascular Disorders; Fibrinolyti	1994
Ticlopidine and antiplatelet therapy. The Annals of pharmacotherapy, 1993, Volume: 27, Issue:9 Topics: Cardiovascular Diseases; Cerebrovascular Disorders; Clinical Trials as Topic; Drug Interactions; Hum	1993
Antiplatelet therapy in the treatment of cerebrovascular disease. Clinical cardiology, 1993, Volume: 16, Issue:10 Topics: Adult; Aged; Aspirin; Cardiovascular Diseases; Cerebrovascular Disorders; Female; Humans; Male; Midd	1993
Prophylactic drug therapy in cerebrovascular disease. American family physician, 1993, Volume: 48, Issue:1 Topics: Aspirin; Cerebrovascular Disorders; Humans; Ticlopidine; Warfarin	1993
Strategies for preventing stroke. Current opinion in neurology and neurosurgery, 1993, Volume: 6, Issue:1 Topics: Adult; Aged; Aspirin; Blood Pressure; Cerebrovascular Disorders; Endarterectomy, Carotid; Female; Hu	1993
[Current status of primary and secondary prevention of cerebral apoplexy]. Wiener medizinische Wochenschrift (1946), 1995, Volume: 145, Issue:19-20 Topics: Aspirin; Cerebrovascular Disorders; Humans; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidi	1995
Ticlopidine. A review of its pharmacology, clinical efficacy and tolerability in the prevention of cerebral ischaemia and stroke. Drugs & aging, 1996, Volume: 8, Issue:3 Topics: Brain Ischemia; Cerebrovascular Disorders; Drug Interactions; Humans; Platelet Aggregation Inhibitor	1996
[Antithrombotic agents and prevention of cerebrovascular accidents]. Revue medicale de la Suisse romande, 1996, Volume: 116, Issue:8 Topics: Aspirin; Atrial Fibrillation; Cerebrovascular Disorders; Clopidogrel; Echocardiography; Humans; Intr	1996
Ticlopidine or clopidogrel as alternatives to aspirin in prevention of ischemic stroke. European neurology, 1996, Volume: 36, Issue:5 Topics: Aspirin; Brain Ischemia; Cerebrovascular Disorders; Clopidogrel; Humans; Platelet Aggregation Inhibi	1996
Confusion in reperfusion. Problems in the clinical development of antithrombotic drugs. Circulation, 1997, Feb-18, Volume: 95, Issue:4 Topics: Abciximab; Antibodies, Monoclonal; Aspirin; Cerebrovascular Disorders; Drug Therapy, Combination; Fi	1997
Ticlopidine induced cholestatic jaundice. Singapore medical journal, 1997, Volume: 38, Issue:3 Topics: Aged; Cerebrovascular Disorders; Cholestasis; Fatal Outcome; Female; Humans; Platelet Aggregation In	1997
[Pharmacology of ticlopidine and clopidogrel in comparison with acetylsalicylic acid]. Der Internist, 1997, Volume: 38, Issue:11 Topics: Aspirin; Cerebrovascular Disorders; Clopidogrel; Coronary Thrombosis; Death, Sudden, Cardiac; Humans	1997
[Secondary prevention following cerebral ischemia: is monotherapy with acetylsalicylic acid still first choice?]. Nederlands tijdschrift voor geneeskunde, 1998, Feb-07, Volume: 142, Issue:6 Topics: Anticoagulants; Aspirin; Brain Ischemia; Cerebral Hemorrhage; Cerebrovascular Disorders; Clopidogrel	1998
Anticoagulants and antiplatelet agents in acute ischemic stroke. Virginia medical quarterly : VMQ, 1998,Spring, Volume: 125, Issue:2 Topics: Acute Disease; Anticoagulants; Aspirin; Brain Ischemia; Cerebrovascular Disorders; Clinical Trials a	1998
Antiplatelet drugs in secondary prevention of stroke. International journal of clinical practice, 1998, Volume: 52, Issue:2 Topics: Aged; Aspirin; Cerebrovascular Disorders; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Huma	1998
[Acute phenytoin poisoning secondary to an interaction with ticlopidine]. Revista de neurologia, 1998, Volume: 26, Issue:154 Topics: Acute Disease; Aged; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Ataxia; Cerebrovascular Disorde	1998
Adverse haematological effects of ticlopidine. Prevention, recognition and management. Drug safety, 1998, Volume: 19, Issue:2 Topics: Anemia, Aplastic; Cerebrovascular Disorders; Female; Humans; Male; Neutropenia; Platelet Aggregation	1998
The results of CAPRIE, IST and CAST. Clopidogrel vs. Aspirin in Patients at Risk of Ischaemic Events. International Stroke Trial. Chinese Acute Stroke Trial. Thrombosis research, 1998, Sep-15, Volume: 92, Issue:1 Suppl 1 Topics: Aspirin; Cerebrovascular Disorders; Clopidogrel; Double-Blind Method; Humans; Ischemia; Myocardial I	1998
Clinical considerations in selecting antiplatelet therapy in cerebrovascular disease. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1998, Oct-01, Volume: 55, Issue:19 Suppl 1 Topics: Aspirin; Cerebrovascular Disorders; Clopidogrel; Dipyridamole; Humans; Platelet Aggregation Inhibito	1998
Ticlopidine-induced cholestatic hepatitis: report of three cases and review of the literature. Digestive diseases and sciences, 1998, Volume: 43, Issue:10 Topics: Aged; Aged, 80 and over; Cerebrovascular Disorders; Chemical and Drug Induced Liver Injury; Cholesta	1998
Results of the CAPRIE trial: efficacy and safety of clopidogrel. Clopidogrel versus aspirin in patients at risk of ischaemic events. Vascular medicine (London, England), 1998, Volume: 3, Issue:3 Topics: Arteriosclerosis; Aspirin; Cerebrovascular Disorders; Clopidogrel; Follow-Up Studies; Humans; Myocar	1998
Antiplatelet agents and stroke prevention. Seminars in neurology, 1998, Volume: 18, Issue:4 Topics: Aspirin; Atrial Fibrillation; Cerebrovascular Disorders; Clinical Trials as Topic; Clopidogrel; Dipy	1998
Stroke: part I. A clinical update on prevention. American family physician, 1999, May-01, Volume: 59, Issue:9 Topics: Aspirin; Atrial Fibrillation; Carotid Stenosis; Cerebrovascular Disorders; Clinical Trials as Topic;	1999
Antiplatelet therapy for secondary stroke prevention. Scottish medical journal, 1999, Volume: 44, Issue:2 Topics: Aspirin; Cerebrovascular Disorders; Clinical Trials as Topic; Clopidogrel; Dipyridamole; Drug Therap	1999
Bleeding complications in secondary stroke prevention by antiplatelet therapy: a benefit-risk analysis. Journal of internal medicine, 1999, Volume: 246, Issue:3 Topics: Aspirin; Cerebrovascular Disorders; Clopidogrel; Hemorrhage; Humans; Platelet Aggregation Inhibitors	1999
Update on clinical trials of antiplatelet therapy for cerebrovascular diseases. Cerebrovascular diseases (Basel, Switzerland), 2000, Volume: 10 Suppl 5 Topics: Aspirin; Cerebrovascular Disorders; Clinical Trials as Topic; Clopidogrel; Dipyridamole; Humans; Pla	2000
Aspirin and other platelet-active drugs. The relationship between dose, effectiveness, and side effects. Chest, 1992, Volume: 102, Issue:4 Suppl Topics: Anticoagulants; Aspirin; Cerebrovascular Disorders; Dipyridamole; Dose-Response Relationship, Drug;	1992
Ticlopidine hydrochloride. The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses, 1992, Volume: 24, Issue:5 Topics: Blood Platelets; Cerebrovascular Disorders; Humans; Intracranial Arteriosclerosis; Intracranial Embo	1992
Role of ticlopidine for prevention of stroke. Stroke, 1992, Volume: 23, Issue:6 Topics: Cerebrovascular Disorders; Drug Combinations; Humans; Risk Factors; Ticlopidine; Vascular Diseases	1992
Outcome of transient ischaemic attacks and stroke. Drugs, 1991, Volume: 42 Suppl 5 Topics: Aged; Carotid Stenosis; Cerebrovascular Disorders; Humans; Ischemic Attack, Transient; Middle Aged;	1991
Antiplatelet therapy in the prevention of stroke. Drugs, 1991, Volume: 42 Suppl 5 Topics: Aspirin; Cerebrovascular Disorders; Dipyridamole; Humans; Platelet Aggregation Inhibitors; Randomize	1991
Stroke prevention in women: role of aspirin versus ticlopidine. The American journal of medicine, 1991, Volume: 91, Issue:3 Topics: Aspirin; Cerebrovascular Disorders; Female; Humans; Meta-Analysis as Topic; Recurrence; Sex Factors;	1991
Epidemiology of and stroke-preventive strategies for atherothromboembolic brain infarction in the elderly. Clinics in geriatric medicine, 1991, Volume: 7, Issue:3 Topics: Aged; Anticoagulants; Arteriosclerosis; Aspirin; Cerebral Infarction; Cerebrovascular Disorders; Fem	1991
Ticlopidine: a new antiplatelet agent for cerebrovascular disease. Pharmacotherapy, 1991, Volume: 11, Issue:4 Topics: Cerebrovascular Disorders; Clinical Trials as Topic; Drug Interactions; Female; Humans; Ischemic Att	1991
Ticlopidine, a new antithrombotic drug: but is it better than aspirin for longterm use? Journal of neurology, neurosurgery, and psychiatry, 1990, Volume: 53, Issue:3 Topics: Aspirin; Cerebrovascular Disorders; Humans; Ischemic Attack, Transient; Myocardial Infarction; Rando	1990
Ticlopidine. An updated review of its pharmacology and therapeutic use in platelet-dependent disorders. Drugs, 1990, Volume: 40, Issue:2 Topics: Adult; Aged; Blood Platelets; Cerebrovascular Disorders; Coronary Disease; Drug Interactions; Humans	1990
Current use of antiplatelet drugs in stroke syndromes in the USA. Annals of the New York Academy of Sciences, 1990, Volume: 598 Topics: Aspirin; Cerebrovascular Disorders; Female; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidi	1990
Issues in planning and interpreting active control equivalence studies. Journal of clinical epidemiology, 1989, Volume: 42, Issue:6 Topics: Adult; Aspirin; Cerebrovascular Disorders; Clinical Trials as Topic; Humans; Random Allocation; Rese	1989
Antiplatelet drugs in the management of patients with thrombotic disorders. Seminars in thrombosis and hemostasis, 1986, Volume: 12, Issue:2 Topics: Arterial Occlusive Diseases; Arteriosclerosis; Aspirin; Blood Coagulation Disorders; Blood Platelets	1986
Transient ischemic attacks and stroke. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1988, Jun-15, Volume: 138, Issue:12 Topics: Aspirin; Cerebrovascular Disorders; Humans; Ischemic Attack, Transient; Risk Factors; Ticlopidine	1988

Article	Year
Safety profile of prasugrel and clopidogrel in patients with acute coronary syndromes in Switzerland. Heart (British Cardiac Society), 2015, Volume: 101, Issue:11 Topics: Adolescent; Adult; Aged; Cerebrovascular Disorders; Clopidogrel; Drug-Eluting Stents; Female; Guidel	2015
Safety profile of prasugrel and clopidogrel in patients with acute coronary syndromes in Switzerland. Heart (British Cardiac Society), 2015, Volume: 101, Issue:11 Topics: Adolescent; Adult; Aged; Cerebrovascular Disorders; Clopidogrel; Drug-Eluting Stents; Female; Guidel	2015
Safety profile of prasugrel and clopidogrel in patients with acute coronary syndromes in Switzerland. Heart (British Cardiac Society), 2015, Volume: 101, Issue:11 Topics: Adolescent; Adult; Aged; Cerebrovascular Disorders; Clopidogrel; Drug-Eluting Stents; Female; Guidel	2015
Safety profile of prasugrel and clopidogrel in patients with acute coronary syndromes in Switzerland. Heart (British Cardiac Society), 2015, Volume: 101, Issue:11 Topics: Adolescent; Adult; Aged; Cerebrovascular Disorders; Clopidogrel; Drug-Eluting Stents; Female; Guidel	2015
Low postoperative dose of aprotinin reduces bleeding and is safe in patients receiving clopidogrel before coronary artery bypass surgery. A prospective randomized study. Interactive cardiovascular and thoracic surgery, 2010, Volume: 10, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Aprotinin; Blood Transfusion; Cerebrovascular Disorders; Clopidogrel	2010
Effects of cilostazol on cognition and regional cerebral blood flow in patients with Alzheimer's disease and cerebrovascular disease: a pilot study. Geriatrics & gerontology international, 2013, Volume: 13, Issue:1 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspirin; Cerebrovascular Circulati	2013
The effectiveness of dual antiplatelet treatment in acute ischemic stroke patients with intracranial arterial stenosis: a subgroup analysis of CLAIR study. International journal of stroke : official journal of the International Stroke Society, 2013, Volume: 8, Issue:8 Topics: Aspirin; Cerebrovascular Disorders; Clopidogrel; Constriction, Pathologic; Drug Therapy, Combination	2013
Comparing ticagrelor versus clopidogrel in patients with a history of cerebrovascular disease: a net clinical harm? Stroke, 2012, Volume: 43, Issue:12 Topics: Adenosine; Cerebrovascular Disorders; Clopidogrel; Humans; Purinergic P2Y Receptor Antagonists; Risk	2012
Comparison of antiplatelet efficacy and tolerability of clopidogrel napadisilate with clopidogrel bisulfate in coronary artery disease patients after percutaneous coronary intervention: a prospective, multicenter, randomized, open-label, phase IV, noninfe Clinical therapeutics, 2013, Volume: 35, Issue:1 Topics: Aged; Blood Platelets; Cerebrovascular Disorders; Chi-Square Distribution; Clopidogrel; Coronary Art	2013
Extracardiac vascular disease and effectiveness of sustained clopidogrel treatment. Heart (British Cardiac Society), 2006, Volume: 92, Issue:1 Topics: Aged; Cerebrovascular Disorders; Clopidogrel; Epidemiologic Methods; Female; Humans; Male; Periphera	2006
Antiplatelets in stroke prevention: the MATCH trial. Some answers, many questions and countless perspectives. Cerebrovascular diseases (Basel, Switzerland), 2005, Volume: 20 Suppl 2 Topics: Age Factors; Aged; Aspirin; Cerebrovascular Disorders; Clopidogrel; Drug Therapy, Combination; Femal	2005
Prevalence and risk factors for aspirin and clopidogrel resistance in cerebrovascular stenting. AJNR. American journal of neuroradiology, 2008, Volume: 29, Issue:2 Topics: Aged; Aged, 80 and over; Aspirin; Blood Vessel Prosthesis; Cerebrovascular Disorders; Clopidogrel; C	2008
[Removing phlegm and dispelling stasis method combined with Western medicine for treatment of cerebrovascular stenosis]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2008, Volume: 28, Issue:1 Topics: Adult; Aged; Aspirin; C-Reactive Protein; Carotid Stenosis; Cerebrovascular Disorders; Clopidogrel;	2008
The North American ticlopidine aspirin stroke study: structure, stratification variables, and patient characteristics. Agents and actions. Supplements, 1984, Volume: 15 Topics: Age Factors; Aged; Anticoagulants; Aspirin; Cerebrovascular Disorders; Clinical Trials as Topic; Fem	1984
Overview: clinical experiences with ticlopidine. Agents and actions. Supplements, 1984, Volume: 15 Topics: Anemia, Sickle Cell; Anticoagulants; Arterial Occlusive Diseases; Cerebrovascular Disorders; Clinica	1984
[Antiplatelet therapy in patients with cerebral thrombosis at the chronic phase--assessment of its effect on coagulation and fibrinolytic parameters]. Rinsho shinkeigaku = Clinical neurology, 1994, Volume: 34, Issue:8 Topics: Aged; Aspirin; Blood Coagulation; Cerebrovascular Disorders; Chronic Disease; Fibrinolysis; Humans;	1994
Efficacy of ticlopidine and aspirin for prevention of reversible cerebrovascular ischemic events. The Ticlopidine Aspirin Stroke Study. Stroke, 1993, Volume: 24, Issue:10 Topics: Adult; Aged; Aged, 80 and over; Aspirin; Cerebrovascular Disorders; Double-Blind Method; Female; Fol	1993
The efficacy and safety of ticlopidine and aspirin in non-whites: analysis of a patient subgroup from the Ticlopidine Aspirin Stroke Study. Neurology, 1993, Volume: 43, Issue:1 Topics: Aged; Aspirin; Brain Ischemia; Cerebrovascular Disorders; Double-Blind Method; Female; Follow-Up Stu	1993
Hemostaseologic and hematologic parameters with aspirin and ticlopidine treatment in patients with cerebrovascular disease: a cross-over study. Journal of cardiovascular pharmacology, 1996, Volume: 28, Issue:4 Topics: Adenosine Diphosphate; Aged; Aspirin; Cerebrovascular Disorders; Collagen; Cross-Over Studies; Epine	1996
Asymptomatic circulating cerebral emboli and cerebral blood flow velocity under aspirin and ticlopidine in patients with cerebrovascular disease. Neurological research, 1996, Volume: 18, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Flow Velocity; Carotid Stenosis; Cell Survival; Cereb	1996
[Primary and secondary prevention of ischemic cerebrovascular accidents of arteriosclerosis by platelet inhibitors]. Archives des maladies du coeur et des vaisseaux, 1996, Volume: 89, Issue:11 Suppl Topics: Arteriosclerosis; Aspirin; Brain Ischemia; Cerebrovascular Disorders; Dipyridamole; Dose-Response Re	1996
The STIMS trial: the ticlopidine experience and its clinical applications. Swedish Ticlopidine Multicenter Study. Vascular medicine (London, England), 1996, Volume: 1, Issue:2 Topics: Cerebrovascular Disorders; Female; Humans; Intermittent Claudication; Male; Myocardial Infarction; P	1996
The results of CAPRIE, IST and CAST. Clopidogrel vs. Aspirin in Patients at Risk of Ischaemic Events. International Stroke Trial. Chinese Acute Stroke Trial. Thrombosis research, 1998, Sep-15, Volume: 92, Issue:1 Suppl 1 Topics: Aspirin; Cerebrovascular Disorders; Clopidogrel; Double-Blind Method; Humans; Ischemia; Myocardial I	1998
Results of the CAPRIE trial: efficacy and safety of clopidogrel. Clopidogrel versus aspirin in patients at risk of ischaemic events. Vascular medicine (London, England), 1998, Volume: 3, Issue:3 Topics: Arteriosclerosis; Aspirin; Cerebrovascular Disorders; Clopidogrel; Follow-Up Studies; Humans; Myocar	1998
Comparative safety and tolerability of clopidogrel and aspirin: results from CAPRIE. CAPRIE Steering Committee and Investigators. Clopidogrel versus aspirin in patients at risk of ischaemic events. Drug safety, 1999, Volume: 21, Issue:4 Topics: Arteriosclerosis; Aspirin; Cerebrovascular Disorders; Clopidogrel; Double-Blind Method; Gastrointest	1999
Ticlopidine versus aspirin for the prevention of recurrent stroke. Analysis of patients with minor stroke from the Ticlopidine Aspirin Stroke Study. Stroke, 1992, Volume: 23, Issue:12 Topics: Adult; Aspirin; Cerebrovascular Disorders; Diarrhea; Double-Blind Method; Female; Humans; Male; Midd	1992
Efficacy of ticlopidine in the prevention of thromboembolic events in patients with VVI pacemakers. Pacing and clinical electrophysiology : PACE, 1991, Volume: 14, Issue:2 Pt 1 Topics: Aged; Cerebrovascular Disorders; Extremities; Female; Follow-Up Studies; Humans; Incidence; Italy; M	1991
Clinical study on antithrombotic effects of ticlopidine in ischemic stroke. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1991, Volume: 74, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Blood Cell Count; Brain Ischemia; Cerebrovascular Disorders; Epopros	1991
Epidemiology of and stroke-preventive strategies for atherothromboembolic brain infarction in the elderly. Clinics in geriatric medicine, 1991, Volume: 7, Issue:3 Topics: Aged; Anticoagulants; Arteriosclerosis; Aspirin; Cerebral Infarction; Cerebrovascular Disorders; Fem	1991
Ticlopidine, a new antithrombotic drug: but is it better than aspirin for longterm use? Journal of neurology, neurosurgery, and psychiatry, 1990, Volume: 53, Issue:3 Topics: Aspirin; Cerebrovascular Disorders; Humans; Ischemic Attack, Transient; Myocardial Infarction; Rando	1990
Prevention of myocardial infarction and stroke in patients with intermittent claudication; effects of ticlopidine. Results from STIMS, the Swedish Ticlopidine Multicentre Study. Journal of internal medicine, 1990, Volume: 227, Issue:5 Topics: Aged; Cerebrovascular Disorders; Coronary Disease; Female; Humans; Intermittent Claudication; Ischem	1990
The Canadian American Ticlopidine Study (CATS) in thromboembolic stroke. Lancet (London, England), 1989, Jun-03, Volume: 1, Issue:8649 Topics: Aged; Canada; Cause of Death; Cerebrovascular Disorders; Cohort Studies; Drug Administration Schedul	1989
The "trials" of a long-term clinical trial: the Ticlopidine Aspirin Stroke Study and the Canadian-American Ticlopidine Study. Controlled clinical trials, 1989, Volume: 10, Issue:4 Suppl Topics: Aspirin; Canada; Cerebrovascular Disorders; Humans; Legislation, Drug; Multicenter Studies as Topic;	1989
A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients. Ticlopidine Aspirin Stroke Study Group. The New England journal of medicine, 1989, Aug-24, Volume: 321, Issue:8 Topics: Aspirin; Cerebrovascular Disorders; Female; Follow-Up Studies; Humans; Ischemic Attack, Transient; M	1989
The Canadian American Ticlopidine Study (CATS) in thromboembolic stroke. Design, organization, and baseline results. Stroke, 1988, Volume: 19, Issue:10 Topics: Aged; Canada; Cerebrovascular Disorders; Clinical Trials as Topic; Double-Blind Method; Female; Huma	1988

Article	Year
Safety and efficacy of ticagrelor for neuroendovascular procedures. A single center initial experience. Journal of neurointerventional surgery, 2014, Volume: 6, Issue:4 Topics: Adenosine; Adult; Aged; Aged, 80 and over; Blood Vessel Prosthesis; Blood Vessel Prosthesis Implanta	2014
Comparison of clinical efficacy and safety of clopidogrel resinate with clopidogrel bisulfate in patients undergoing percutaneous coronary intervention. Cardiovascular drugs and therapy, 2013, Volume: 27, Issue:5 Topics: Aged; Cardiovascular Diseases; Cerebrovascular Disorders; Clopidogrel; Female; Humans; Male; Middle	2013
Reduced clopidogrel metabolism in a multiethnic population: prevalence and rates of recurrent cerebrovascular events. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2014, Volume: 23, Issue:4 Topics: Aryl Hydrocarbon Hydroxylases; Cerebrovascular Disorders; Clopidogrel; Cytochrome P-450 CYP2C19; Dru	2014
Use and associated risks of concomitant aspirin therapy with oral anticoagulation in patients with atrial fibrillation: insights from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) Registry. Circulation, 2013, Aug-13, Volume: 128, Issue:7 Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Atrial Fibrillation; Benzimidazoles; beta-Alanine;	2013
Predictors of high on-aspirin platelet reactivity in high-risk vascular patients treated with single or dual antiplatelet therapy. The American journal of cardiology, 2015, May-01, Volume: 115, Issue:9 Topics: Adenosine; Aged; Aspirin; Cerebrovascular Disorders; Clopidogrel; Coronary Artery Disease; Drug Ther	2015
Association between CYP2C19 Polymorphisms and Outcomes in Cerebral Endovascular Therapy. AJNR. American journal of neuroradiology, 2016, Volume: 37, Issue:1 Topics: Adult; Aged; Alleles; Brain Ischemia; Cerebrovascular Disorders; Clopidogrel; Cytochrome P-450 CYP2C	2016
Measurement of residual platelet thrombogenicity under arterial shear conditions in cerebrovascular disease patients receiving antiplatelet therapy. Journal of thrombosis and haemostasis : JTH, 2016, Volume: 14, Issue:9 Topics: Adult; Aged; Arteries; Aspirin; Blood Coagulation Tests; Blood Platelets; Carotid Arteries; Cell Adh	2016
Atrial Fibrillation and PCI - Do We Still Need Aspirin? The New England journal of medicine, 2016, 12-22, Volume: 375, Issue:25 Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Cerebrovascular Disorders; Humans; Platelet Aggregatio	2016
Preoperative Use of Clopidogrel Does Not Affect Outcomes for Femoral Neck Fractures Treated With Hemiarthroplasty. The Journal of arthroplasty, 2017, Volume: 32, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Blood Loss, Surgical; Cerebrovascular Disorders; Clopidogrel; Comorb	2017
Antiplatelet therapy after coronary intervention in Asia and Japan: the Asian perspective of antiplatelet intervention. Hamostaseologie, 2009, Volume: 29, Issue:4 Topics: Asia; Cerebral Hemorrhage; Cerebrovascular Disorders; Cilostazol; Clopidogrel; Coronary Disease; Eur	2009
Withdrawal of clopidogrel in active gastric bleeding. Annals of internal medicine, 2010, May-18, Volume: 152, Issue:10 Topics: Aspirin; Cardiovascular Diseases; Cerebrovascular Disorders; Clopidogrel; Gastrointestinal Hemorrhag	2010
Concomitant use of proton pump inhibitors and clopidogrel in patients with coronary, cerebrovascular, or peripheral artery disease in the factores de Riesgo y ENfermedad Arterial (FRENA) registry. Journal of cardiovascular pharmacology, 2011, Volume: 57, Issue:1 Topics: Aged; Cerebrovascular Disorders; Clopidogrel; Contraindications; Coronary Artery Disease; Drug Inter	2011
Optimizing of thienopyridine therapy by multiple electrode platelet aggregometry in clopidogrel low responders undergoing PCI. Clinical research in cardiology : official journal of the German Cardiac Society, 2011, Volume: 100, Issue:10 Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Cardiovascular Diseases; Cerebrovascula	2011
Cytochrome P450 2C19 polymorphism is associated with reduced clopidogrel response in cerebrovascular disease. Yonsei medical journal, 2011, Volume: 52, Issue:5 Topics: Aged; Aryl Hydrocarbon Hydroxylases; Cerebrovascular Disorders; Clopidogrel; Cytochrome P-450 CYP2C1	2011
Non-cardiac surgery in patients with coronary stents: the RECO study. Heart (British Cardiac Society), 2011, Volume: 97, Issue:19 Topics: Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Cerebr	2011
Non-cardiac surgery in patients with coronary stents: the RECO study. Heart (British Cardiac Society), 2011, Volume: 97, Issue:19 Topics: Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Cerebr	2011
Non-cardiac surgery in patients with coronary stents: the RECO study. Heart (British Cardiac Society), 2011, Volume: 97, Issue:19 Topics: Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Cerebr	2011
Non-cardiac surgery in patients with coronary stents: the RECO study. Heart (British Cardiac Society), 2011, Volume: 97, Issue:19 Topics: Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Cerebr	2011
Body weight: a risk factor for subtherapeutic antithrombotic therapy in neurovascular stenting. Journal of neurointerventional surgery, 2011, Volume: 3, Issue:2 Topics: Aspirin; Body Mass Index; Body Weight; Carotid Stenosis; Cerebrovascular Disorders; Clopidogrel; Fem	2011
Factors influencing mortality in patients on antiplatelet agents presenting with proximal femoral fractures. Journal of orthopaedic surgery (Hong Kong), 2011, Volume: 19, Issue:3 Topics: Aged; Aged, 80 and over; Arthroplasty, Replacement, Hip; Cerebrovascular Disorders; Clopidogrel; Com	2011
Predictors and time trends in clopidogrel and proton pump inhibitor coprescription with low-dose acetylsalicylic acid. Pharmacoepidemiology and drug safety, 2012, Volume: 21, Issue:5 Topics: Aged; Aged, 80 and over; Aspirin; Cardiovascular Diseases; Cerebrovascular Disorders; Clopidogrel; D	2012
Genetic testing in patients with acute coronary syndrome undergoing percutaneous coronary intervention: a cost-effectiveness analysis. Journal of thrombosis and haemostasis : JTH, 2013, Volume: 11, Issue:1 Topics: Acute Coronary Syndrome; Aryl Hydrocarbon Hydroxylases; Cerebrovascular Disorders; Clopidogrel; Comp	2013
Elective coronary angiography and percutaneous coronary intervention during uninterrupted warfarin therapy. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2003, Volume: 60, Issue:2 Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Anticoagulants; Atrial Fibrillation; Cardia	2003
Oral antiplatelet therapy. JAMA, 2005, Feb-16, Volume: 293, Issue:7 Topics: Cerebrovascular Disorders; Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Humans; P	2005
Oral antiplatelet therapy. JAMA, 2005, Feb-16, Volume: 293, Issue:7 Topics: Aspirin; Cerebrovascular Disorders; Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease;	2005
Efficacy of dual antiplatelet therapy in cerebrovascular disease as demonstrated by a decline in microembolic signals. A report of eight cases. Cerebrovascular diseases (Basel, Switzerland), 2006, Volume: 21, Issue:4 Topics: Aged; Aspirin; Cerebrovascular Disorders; China; Clopidogrel; Drug Therapy, Combination; Embolism; F	2006
Sub-Tenon's anesthesia with aspirin, warfarin, and clopidogrel. Journal of cataract and refractive surgery, 2006, Volume: 32, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Local; Anticoagulants; Aspirin; Cardiovascular Diseases;	2006
The use of clopidogrel in carotid endarterectomy: an audit of current practice. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2007, Volume: 34, Issue:3 Topics: Aspirin; Cerebrovascular Disorders; Clopidogrel; Endarterectomy, Carotid; Hemorrhage; Humans; Medica	2007
Clopidogrel in addition to aspirin reduces in-hospital major cardiac and cerebrovascular events in unselected patients with acute ST segment elevation myocardial. Thrombosis and haemostasis, 2008, Volume: 99, Issue:1 Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Cerebrovascular Disorders; Clopido	2008
Dual antiplatelet therapy monitoring for neurointerventional procedures using a point-of-care platelet function test: a single-center experience. AJNR. American journal of neuroradiology, 2008, Volume: 29, Issue:7 Topics: Adult; Aged; Angioplasty, Balloon; Aspirin; Cerebrovascular Disorders; Clopidogrel; Drug Administrat	2008
Effects of long-term ticlopidine treatment on platelet function and its tolerability in cerebrovascular disease. The Journal of international medical research, 1984, Volume: 12, Issue:5 Topics: Adult; Aged; Anticoagulants; Blood Coagulation Tests; Blood Platelets; Cerebrovascular Disorders; Fe	1984
[Stroke: new perspectives in prevention. Scientific symposium, 24 April 1993, Frankfurt]. Der Nervenarzt, 1993, Volume: 64, Issue:7 Suppl Topics: Cerebrovascular Disorders; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Prog	1993
ACP guideline on drug therapy for stroke prevention. American family physician, 1995, Volume: 52, Issue:1 Topics: Aspirin; Cerebrovascular Disorders; Humans; Practice Guidelines as Topic; Randomized Controlled Tria	1995
Prevention of ischemic stroke. The New England journal of medicine, 1995, Aug-17, Volume: 333, Issue:7 Topics: Aged; Aged, 80 and over; Agranulocytosis; Anemia, Aplastic; Cerebrovascular Disorders; Female; Human	1995
Essential thrombocytemia and ischemic stroke: report of six cases. Italian journal of neurological sciences, 1994, Volume: 15, Issue:7 Topics: Aged; Aspirin; Brain Ischemia; Cerebrovascular Disorders; Female; Humans; Magnetic Resonance Imaging	1994
Acute interstitial nephritis associated with ticlopidine. American journal of kidney diseases : the official journal of the National Kidney Foundation, 1995, Volume: 25, Issue:6 Topics: Acute Kidney Injury; Aged; Biopsy; Cerebrovascular Disorders; Female; Humans; Kidney; Nephritis, Int	1995
Stroking the stroke prevention numbers. Stroke, 1995, Volume: 26, Issue:2 Topics: Aspirin; Cerebrovascular Disorders; Female; Humans; Male; Risk; Ticlopidine	1995
Ticlopidine and fatal aplastic anemia in an elderly woman. The Annals of pharmacotherapy, 1994, Volume: 28, Issue:10 Topics: Aged; Aged, 80 and over; Anemia, Aplastic; Cerebrovascular Disorders; Fatal Outcome; Female; Humans;	1994
Relative benefits of ticlopidine and aspirin. Stroke, 1994, Volume: 25, Issue:11 Topics: Aspirin; Cerebrovascular Disorders; Humans; Randomized Controlled Trials as Topic; Ticlopidine	1994
Ticlopidine, trials, and "torture". Stroke, 1994, Volume: 25, Issue:12 Topics: Cerebrovascular Disorders; Clinical Trials as Topic; Humans; Terminology as Topic; Ticlopidine; Tort	1994
Effect of plasma fibrinogen concentration on the inhibition of platelet aggregation after ticlopidine compared with aspirin. Stroke, 1994, Volume: 25, Issue:10 Topics: Adenosine Diphosphate; Aged; Aspirin; Cerebral Infarction; Cerebrovascular Disorders; Collagen; Fema	1994
Ticlopidine hydrochloride use and threatened stroke. The Western journal of medicine, 1994, Volume: 160, Issue:1 Topics: Aspirin; Cerebrovascular Disorders; Humans; Ticlopidine	1994
Guidelines for medical treatment for stroke prevention. American College of Physicians. Annals of internal medicine, 1994, Jul-01, Volume: 121, Issue:1 Topics: Aspirin; Atrial Fibrillation; Cerebrovascular Disorders; Humans; Ischemic Attack, Transient; Myocard	1994
Ticlopidine, trials, and torture. Stroke, 1994, Volume: 25, Issue:6 Topics: Arterial Occlusive Diseases; Aspirin; Cause of Death; Cerebrovascular Disorders; Clinical Trials as	1994
Cost-effectiveness of ticlopidine in preventing stroke in high-risk patients. Stroke, 1994, Volume: 25, Issue:6 Topics: Aged; Aspirin; Cerebrovascular Disorders; Cohort Studies; Cost-Benefit Analysis; Decision Support Te	1994
Ticlopidine hydrochloride and prevention of stroke. The Western journal of medicine, 1993, Volume: 159, Issue:2 Topics: Aspirin; Cerebrovascular Disorders; Clinical Trials as Topic; Female; Humans; Ischemic Attack, Trans	1993
[Clinical and blood rheologic effects of ticlid in patients with cerebrovascular diseases]. Terapevticheskii arkhiv, 1993, Volume: 65, Issue:9 Topics: Adult; Blood Coagulation Tests; Blood Viscosity; Cerebrovascular Disorders; Chronic Disease; Drug Ev	1993
Ticlopidine and stroke prevention. Hospital practice (Office ed.), 1993, Sep-30, Volume: 28, Issue:9A Topics: Aspirin; Cerebrovascular Disorders; Clinical Trials as Topic; Cost-Benefit Analysis; Humans; Ticlopi	1993
Criteria for use of ticlopidine in adult inpatients and outpatients. Clinical pharmacy, 1993, Volume: 12, Issue:1 Topics: Adult; Ambulatory Care; Cerebrovascular Disorders; Female; Hospitalization; Humans; Male; Ticlopidin	1993
Is aspirin effective in preventing strokes in diabetic patients? Stroke, 1993, Volume: 24, Issue:5 Topics: Aspirin; Cerebrovascular Disorders; Diabetes Complications; Humans; Ticlopidine	1993
Coagulation-fibrinolysis system in poststroke patients receiving antiplatelet medication. Stroke, 1993, Volume: 24, Issue:6 Topics: Aged; alpha-2-Antiplasmin; Antifibrinolytic Agents; Antithrombin III; Aspirin; Blood Coagulation; Ce	1993
In vivo evaluation of antiplatelet agents in gerbil model of carotid artery thrombosis. Stroke, 1996, Volume: 27, Issue:6 Topics: Animals; Aspirin; Carotid Artery Diseases; Carotid Artery Injuries; Carotid Artery, Common; Cerebrov	1996
[Cholestatic hepatitis and anemia induced by ticlopidine]. Gastroenterologia y hepatologia, 1996, Volume: 19, Issue:4 Topics: Acute Disease; Aged; Anemia; Cerebrovascular Disorders; Chemical and Drug Induced Liver Injury; Chol	1996
Jaundice and extreme hypercholesterolemia after a stroke. Hospital practice (1995), 1996, Sep-15, Volume: 31, Issue:9 Topics: Cerebrovascular Disorders; Female; Humans; Hypercholesterolemia; Jaundice; Middle Aged; Platelet Agg	1996
Critique of two putative therapies in stroke prevention using platelet inhibitors. European neurology, 1996, Volume: 36, Issue:5 Topics: Cerebrovascular Disorders; Dipyridamole; Humans; Platelet Aggregation Inhibitors; Ticlopidine	1996
[Ticlopidine-induced neutropenia]. Harefuah, 1996, Jun-16, Volume: 130, Issue:12 Topics: Aged; Aged, 80 and over; Blood Cell Count; Cerebrovascular Disorders; Female; Humans; Male; Neutrope	1996
CAPRIE trial. Lancet (London, England), 1997, Feb-01, Volume: 349, Issue:9048 Topics: Aspirin; Cerebrovascular Disorders; Clopidogrel; Cost-Benefit Analysis; Dipyridamole; Humans; Platel	1997
[The use of Ticlid in treating cerebrovascular diseases]. Terapevticheskii arkhiv, 1996, Volume: 68, Issue:10 Topics: Aged; Blood Coagulation; Cerebrovascular Disorders; Drug Evaluation; Female; Follow-Up Studies; Hemo	1996
Aspirin versus clopidogrel: the wrong question? Lancet (London, England), 1997, Mar-15, Volume: 349, Issue:9054 Topics: Aspirin; Cerebrovascular Disorders; Clopidogrel; Humans; Ischemia; Myocardial Infarction; Platelet A	1997
[Prevention and therapy of stroke]. Der Nervenarzt, 1994, Volume: 65, Issue:5 Suppl Topics: Carotid Stenosis; Cerebrovascular Disorders; Humans; Platelet Aggregation Inhibitors; Ticlopidine	1994
Clopidogrel: a new safe and effective antiplatelet agent. But unanswered questions remain. The Medical journal of Australia, 1997, Aug-04, Volume: 167, Issue:3 Topics: Arteriosclerosis; Aspirin; Cerebrovascular Disorders; Clopidogrel; Humans; Myocardial Infarction; Pl	1997
The role of antiplatelet therapy in stroke prevention. Tennessee medicine : journal of the Tennessee Medical Association, 1997, Volume: 90, Issue:11 Topics: Aspirin; Cerebrovascular Disorders; Clinical Trials as Topic; Humans; Ischemic Attack, Transient; Pl	1997
[Myocardial infarct, stroke and vascular events reduced by a third]. Zeitschrift fur Kardiologie, 1997, Volume: 86, Issue:11 Suppl M Topics: Aspirin; Cerebrovascular Disorders; Clopidogrel; Humans; Myocardial Infarction; Peripheral Vascular	1997
[Stroke. Earliest possible acute intervention and promising successful secondary prevention. "Newest trends in epidemiology, pathogenesis and therapy of stroke". Symposium in Dresden, 4 October 1997]. Fortschritte der Neurologie-Psychiatrie, 1997, Volume: 65, Issue:12 Suppl S Topics: Aspirin; Cerebrovascular Disorders; Emergencies; Humans; Platelet Aggregation Inhibitors; Secondary	1997
Blocking platelets more: are we skating on thin ice? Heart (British Cardiac Society), 1998, Volume: 79, Issue:1 Topics: Abciximab; Antibodies, Monoclonal; Aspirin; Cerebrovascular Disorders; Clopidogrel; Humans; Immunogl	1998
Thrombotic thrombocytopenic purpura associated with ticlopidine. A review of 60 cases. Annals of internal medicine, 1998, Apr-01, Volume: 128, Issue:7 Topics: Adult; Aged; Cerebrovascular Disorders; Female; Humans; Male; Middle Aged; Plasmapheresis; Platelet	1998
[Cost-effectiveness analysis of drugs]. Der Internist, 1994, Volume: 35, Issue:5 Kosten-n Topics: Cerebrovascular Disorders; Cost-Benefit Analysis; Drug Costs; Drug Prescriptions; Drug Therapy; Huma	1994
Secondary prevention of stroke--new trials. Scottish medical journal, 1998, Volume: 43, Issue:1 Topics: Aged; Aspirin; Cerebrovascular Disorders; Clopidogrel; Delayed-Action Preparations; Dipyridamole; Dr	1998
[Thrombosis prophylaxis after stroke]. Deutsche medizinische Wochenschrift (1946), 1998, Jun-12, Volume: 123, Issue:24 Topics: Anticoagulants; Aspirin; Cerebrovascular Disorders; Clopidogrel; Heparin; Humans; Middle Aged; Plate	1998
[Prevention of thrombosis after ischemic cerebrovascular attack--new possibilities]. Ugeskrift for laeger, 1998, Jul-20, Volume: 160, Issue:30 Topics: Brain Ischemia; Cerebrovascular Disorders; Clopidogrel; Dipyridamole; Humans; Intracranial Embolism	1998
Clopidogrel and its use in stroke patients. Stroke, 1998, Volume: 29, Issue:8 Topics: Cerebrovascular Disorders; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine	1998
[Secondary prevention of ischemic stroke: aspirin or ticlopidine]. Medicina clinica, 1998, Oct-24, Volume: 111, Issue:13 Topics: Aspirin; Cerebrovascular Disorders; Humans; Platelet Aggregation Inhibitors; Risk; Ticlopidine	1998
[Prevention in the 21st century. Athero-thrombosis and ischemic events]. Zeitschrift fur Kardiologie, 1998, Volume: 87, Issue:11 Suppl A Topics: Aspirin; Cardiovascular Diseases; Cerebrovascular Disorders; Clopidogrel; Female; Forecasting; Human	1998
[Ticlopidine and hepatic adverse reactions. Data from the Spanish drug surveillance system]. Medicina clinica, 1999, Apr-24, Volume: 112, Issue:14 Topics: Aged; Aged, 80 and over; Cerebrovascular Disorders; Chemical and Drug Induced Liver Injury; Female;	1999
[Role of antiplatelet in the prevention and treatment of thrombotic diseases]. Zhonghua nei ke za zhi, 1997, Volume: 36, Issue:5 Topics: Aspirin; Cerebrovascular Disorders; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors;	1997
Secondary stroke prevention with drugs: single or combined therapy? Cerebrovascular diseases (Basel, Switzerland), 1999, Volume: 9 Suppl 3 Topics: Anticoagulants; Aspirin; Cerebrovascular Disorders; Clopidogrel; Dipyridamole; Drug Therapy, Combina	1999
Successful use of clopidogrel for cerebrovascular accident in a patient with suspected ticlopidine-induced hepatotoxicity. The Annals of pharmacotherapy, 1999, Volume: 33, Issue:9 Topics: Aged; Cerebrovascular Disorders; Chemical and Drug Induced Liver Injury; Clopidogrel; Female; Humans	1999
The effects of beraprost Na, a stable prostacyclin analog, on animal models of stroke. Molecular and chemical neuropathology, 1992, Volume: 17, Issue:1 Topics: Animals; Arachidonic Acid; Blood Pressure; Body Weight; Cerebrovascular Circulation; Cerebrovascular	1992
The role of ticlopidine involves the role of neurologists in the prevention of stroke. Stroke, 1992, Volume: 23, Issue:10 Topics: Cerebrovascular Disorders; Humans; Physician's Role; Ticlopidine	1992
Ticlopidine for the prevention of thromboembolic stroke. Axone (Dartmouth, N.S.), 1992, Volume: 14, Issue:2 Topics: Aspirin; Cerebrovascular Disorders; Humans; Thromboembolism; Ticlopidine	1992
Vascular event rates in patients with atherosclerotic cerebrovascular disease. Archives of neurology, 1992, Volume: 49, Issue:8 Topics: Age Factors; Aged; Carotid Stenosis; Cerebrovascular Disorders; Epidemiologic Methods; Humans; Intra	1992
Ticlopidine approved for stroke prevention. Clinical pharmacy, 1992, Volume: 11, Issue:2 Topics: Cerebrovascular Disorders; Clinical Trials as Topic; Humans; Ticlopidine; United States; United Stat	1992
[Severe chronic diarrhea caused by ticlopidine]. Medicina clinica, 1992, Mar-14, Volume: 98, Issue:10 Topics: Cerebrovascular Disorders; Chronic Disease; Diarrhea; Humans; Male; Middle Aged; Ticlopidine	1992
A critical appraisal of ticlopidine, a new antiplatelet agent. Effectiveness and clinical indications for prophylaxis of atherosclerotic events. Archives of internal medicine, 1992, Volume: 152, Issue:7 Topics: Arteriosclerosis; Cerebrovascular Disorders; Diarrhea; Female; Humans; Male; Neutropenia; Randomized	1992
Ticlopidine. Lancet (London, England), 1991, Feb-23, Volume: 337, Issue:8739 Topics: Cerebrovascular Disorders; Drug Administration Schedule; Female; Humans; Male; Monitoring, Physiolog	1991
Ticlopidine. Lancet (London, England), 1991, Mar-23, Volume: 337, Issue:8743 Topics: Cerebrovascular Disorders; Humans; Legislation, Drug; Ticlopidine; United States; United States Food	1991
Stroke therapy advances open new era in care. Hospitals, 1990, Sep-20, Volume: 64, Issue:18 Topics: Cerebrovascular Disorders; Heparinoids; Hospitalization; Humans; Nimodipine; Ticlopidine; Time Facto	1990
Prevention of stroke with ticlopidine: who benefits most? TASS Baseline and Angiographic Data Subgroup. Neurology, 1992, Volume: 42, Issue:1 Topics: Aspirin; Carotid Artery Diseases; Cerebral Angiography; Cerebrovascular Disorders; Female; Humans; L	1992
[Ticlopidine Aspirin Stroke Study]. Arquivos brasileiros de cardiologia, 1990, Volume: 54, Issue:3 Topics: Aspirin; Cerebrovascular Disorders; Humans; Ticlopidine	1990
Comparison of ticlopidine and aspirin for the prevention of stroke. The New England journal of medicine, 1990, Feb-08, Volume: 322, Issue:6 Topics: Aspirin; Cerebrovascular Disorders; Cholesterol; Humans; Myocardial Infarction; Research Design; Tic	1990
Aspirin, ticlopidine, and stroke. Lancet (London, England), 1989, Aug-19, Volume: 2, Issue:8660 Topics: Aspirin; Cerebrovascular Disorders; Humans; Ticlopidine	1989
Large trial finds ticlopidine superior to aspirin in preventing stroke. JAMA, 1989, Mar-17, Volume: 261, Issue:11 Topics: Aspirin; Cerebrovascular Disorders; Female; Follow-Up Studies; Humans; Male; Neutropenia; Random All	1989
Autoradiographic observation of platelets in cerebrovascular injuries induced by arachidonic acid and its prevention by ticlopidine. Thrombosis and haemostasis, 1988, Oct-31, Volume: 60, Issue:2 Topics: Animals; Arachidonic Acid; Arachidonic Acids; Autoradiography; Blood Platelets; Cerebral Arteries; C	1988
[Mode of action and clinical evaluation of platelet aggregation inhibitors]. Revue medicale de Liege, 1987, May-15, Volume: 42, Issue:10 Topics: Aspirin; Cerebrovascular Disorders; Dipyridamole; Graft Occlusion, Vascular; Humans; Ketanserin; Myo	1987

ticlopidine and Brain Vascular Disorders

Research Excerpts

Research

Studies (177)

Authors

Clinical Trials (8)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Kim, Y	1
Weissler, EH	1
Pack, N	1
Latz, CA	1
Chiarito, M	1
Sanz-Sánchez, J	1
Cannata, F	1
Cao, D	1
Sturla, M	1
Panico, C	1
Godino, C	1
Regazzoli, D	1
Reimers, B	1
De Caterina, R	1
Condorelli, G	1
Ferrante, G	1
Stefanini, GG	2
Mijajlovic, MD	1
Shulga, O	1
Bloch, S	1
Covickovic-Sternic, N	1
Aleksic, V	1
Bornstein, NM	1
Hanel, RA	1
Taussky, P	1
Dixon, T	1
Miller, DA	1
Sapin, M	1
Nordeen, JD	1
Tawk, RG	1
Navarro, R	1
Johns, G	1
Freeman, WD	1
Park, MW	1
Jeong, SH	1
Her, SH	1
Kim, PJ	1
Cho, JS	1
Kim, CJ	1
Chung, WS	1
Seung, KB	1
Yim, HW	1
Chang, K	1
Spokoyny, I	1
Barazangi, N	1
Jaramillo, V	1
Rose, J	1
Chen, C	2
Wong, C	1
Tong, D	1
Steinberg, BA	1
Kim, S	1
Piccini, JP	1
Fonarow, GC	1
Lopes, RD	1
Thomas, L	1
Ezekowitz, MD	1
Ansell, J	1
Kowey, P	1
Singer, DE	1
Gersh, B	1
Mahaffey, KW	1
Hylek, E	1
Go, AS	1
Chang, P	1
Peterson, ED	1
Gouya, G	1
Arrich, J	1
Wolzt, M	1
Huber, K	1
Verheugt, FW	1
Gurbel, PA	1
Pirker-Kees, A	1
Siller-Matula, JM	1
Patel, PA	1
Fleisher, LA	1
Amsallem, M	1
Manzo-Silberman, S	1
Dillinger, JG	1
Sideris, G	1
Voicu, S	1
Bal dit Sollier, C	1
Drouet, L	1
Henry, P	1
Klingenberg, R	1
Heg, D	1
Räber, L	1
Carballo, D	1
Nanchen, D	1
Gencer, B	1
Auer, R	1
Jaguszewski, M	1
Stähli, BE	1
Jakob, P	1
Templin, C	1
Meier, B	1
Vogt, P	1
Roffi, M	1
Maier, W	1
Landmesser, U	1
Rodondi, N	1
Mach, F	1
Windecker, S	1
Jüni, P	1
Lüscher, TF	1
Matter, CM	1
Lin, L	1
Wang, H	1
Chen, YF	1
Lin, WW	1
Wang, CL	1
Lin, CH	1
Lin, M	1
Todaro, M	1
Chan, J	1
Churilov, L	1
Zhu, WS	1
Ramdave, S	1
Mitchell, PJ	1
Dowling, RJ	1
Kwan, P	1
Yan, B	1
Yamazaki, M	1
Ohnishi, T	1
Hosokawa, K	1
Yamaguchi, K	1
Yoneyama, T	1
Kawashima, A	1
Okada, Y	1
Kitagawa, K	1
Uchiyama, S	1
Jolly, SS	1
Natarajan, MK	1
Duconge, J	1
Hernandez-Suarez, DF	1
Ghanem, ES	1
Richard, RD	1
Wingert, NCH	1
Gotoff, JR	1
Graham, JH	1
Bowen, TR	1
Goto, S	1
Toda, E	1
Øvrum, E	1
Tangen, G	1
Tølløfsrud, S	1
Ringdal, MA	1
Øystese, R	1
Istad, R	1
Gebel, JM	1
Mourad, JJ	1
Komarov, AL	1
Muñoz-Torrero, JF	1
Escudero, D	1
Suárez, C	1
Sanclemente, C	1
Pascual, MT	1
Zamorano, J	1
Trujillo-Santos, J	1
Monreal, M	1
Hiraishi, H	1
Maeda, M	1
Sasai, T	1
Kanke, K	1
Shimada, T	1
Behr, T	1
Kuch, B	1
Behr, W	1
von Scheidt, W	1
Lee, JB	1
Lee, KA	1
Lee, KY	1
Albaladejo, P	1
Marret, E	1
Samama, CM	1
Collet, JP	1
Abhay, K	1
Loutrel, O	1
Charbonneau, H	1
Jaber, S	1
Thoret, S	1
Bosson, JL	1
Piriou, V	1
Drazin, D	1
Choulakian, A	1
Nuño, M	1
Kornbluth, P	1
Alexander, MJ	1
Maheshwari, R	1
Acharya, M	1
Monda, M	1
Pandey, R	1
Cea Soriano, L	1
Bueno, H	1
Johansson, S	1
García Rodríguez, LA	1
Sakurai, H	1
Hanyu, H	1
Sato, T	1
Kume, K	1
Hirao, K	1
Kanetaka, H	1
Iwamoto, T	1
Wang, X	1
Lin, WH	1
Zhao, YD	1
Chen, XY	1
Leung, TW	1
Fu, J	1
Markus, H	1
Hao, Q	1
Wong, KS	2
Weber, R	1
Brenck, J	1
Diener, HC	2
DiNicolantonio, JJ	1
Serebruany, VL	1
Lala, A	1
Berger, JS	1
Sharma, G	1
Hochman, JS	1
Scott Braithwaite, R	1
Ladapo, JA	1
Park, JB	1
Koo, BK	1
Choi, WG	1
Kim, SY	1
Park, J	1
Kwan, J	1
Park, CG	1
Kim, HS	1
Jessup, DB	1
Coletti, AT	1
Muhlestein, JB	1
Barry, WH	1
Shean, FC	1
Whisenant, BK	1
Tran, H	1
Anand, SS	1
Borja, J	1
Bernstein, RA	1
Albers, GW	2
Mukherjee, D	1
Topol, EJ	2
Moliterno, DJ	1
Brennan, DM	1
Ziada, K	1
Cho, L	1
Steinhubl, SR	1
Bezerra, DC	1
Bogousslavsky, J	2
Esagunde, RU	1
Lee, MP	1
Gan, HY	1
Wong, MC	1
Chang, HM	1
Chen, CL	1
Habib, GB	1
Kumar, N	1
Jivan, S	1
Thomas, P	1
McLure, H	1
Yagi, H	1
Matsumoto, M	1
Fujimura, Y	1
Jackson, AJ	1
Teenan, RP	1
Orr, DJ	1
Prabhakaran, S	1
Wells, KR	1
Lee, VH	1
Flaherty, CA	1
Lopes, DK	1
Zeymer, U	1
Gitt, A	1
Jünger, C	1
Bauer, T	1
Heer, T	1
Koeth, O	1
Mark, B	1
Zahn, R	1
Senges, J	1
Gottwik, M	1
Fares, RR	1
Lansing, LS	1
Gallati, CA	1
Mousa, SA	1
Gao, L	1
Wang, PP	1
Liu, Q	1
Lee, DH	1
Arat, A	1
Morsi, H	1
Shaltoni, H	1
Harris, JR	1
Mawad, ME	1
Tullio, D	1
Hass, WK	2
Kamm, B	3
Day, HJ	1
Carrieri, P	1
Orefice, G	1
Fioretti, A	1
Indaco, A	1
Carfagna, S	1
Ganiats, T	1
Shear, NH	1
Appel, C	1
Casto, L	1
Camerlingo, M	1
Finazzi, G	1
Censori, B	1
Barbui, T	1
Mamoli, A	1
Rosen, H	1
el-Hennawy, AS	1
Greenberg, S	1
Chen, CK	1
Nicastri, AD	1
Landau, WM	1
Mallet, L	1
Mallet, J	1
Matchar, DB	1
McCrory, DC	1
Barnett, HJ	2
Feussner, JR	1
Bladin, CF	1
Norris, JW	3
Marcussen, H	1
Kohriyama, T	1
Tanaka, E	1
Katayama, S	1
Yamamura, Y	1
Nakamura, S	1
Tohgi, H	2
Takahashi, H	2
Kashiwaya, M	1
Watanabe, K	1
Rothrock, JF	1
Hart, RG	3
Murray, JC	1
Kelly, MA	1
Gorelick, PB	2
Solomon, DH	1
van Gijn, J	3
Algra, A	3
Oster, G	1
Huse, DM	1
Lacey, MJ	1
Epstein, AM	1
Macko, R	1
Flores-Runk, P	1
Raasch, RH	1
Couch, JR	1
Suslina, ZA	1
Ionova, VG	1
Nikitenko, NIu	1
Maksimova, MIu	1
Unwin, DH	1
Greenlee, RG	1
Bellavance, A	1
Harbison, JW	5
Weisberg, LA	1
Kanter, MC	1
Sherman, DG	1
Hsu, VD	1
Grotta, J	1
Chiba, K	1
Tamura, K	1
Zippel, C	1
Nishimura, H	1
Naritomi, H	1
Iwamoto, Y	1
Tachibana, H	1
Sugita, M	1
Pascual, S	1
Sarrión, JV	1
Jarque, I	1
Argüello, L	1
Berenguer, J	1
Noble, S	1
Goa, KL	2
Fred, HL	1
Hariharan, R	1
Doucet, J	1
Mehta, N	1
Dewarrat, A	1
Bendixen, BH	1
Adams, HP	3
Meldrum, HE	1
Balbir, A	1
Odeh, M	1
Atias, D	1
Oliven, A	1
Droste, DW	2
Siemens, HJ	2
Sonne, M	2
Kaps, M	2
Wagner, T	1
Barer, D	1
Gusev, EI	1
Skvortsova, VI	1
Kolesnikova, TI	1
Kabanov, AA	1
Iasamanova, AN	1
Catella-Lawson, F	1
FitzGerald, GA	1
Born, GV	1
Collins, R	1
Rosa, A	1
Canaple, S	1
Hankey, GJ	1
Yim, HB	1
Lieu, PK	1
Choo, PW	1
Chesney, CM	1
Weber, AA	1
Schrör, K	1
Choussat, R	1
Montalescot, G	1
Bennett, CL	1
Weinberg, PD	1
Rozenberg-Ben-Dror, K	1
Yarnold, PR	1
Kwaan, HC	1
Green, D	1
Forbes, CD	2
Janzon, L	2
Koudstaal, PJ	1
Pellegrino, TR	1
López-Ariztegui, N	1
Ochoà, M	1
Sánchez-Migallón, MJ	1
Nevado, C	1
Martín, M	1
Schneider, D	1
Boysen, G	2
Love, BB	1
Biller, J	1
Gent, M	4
Hanley, DF	1
Dippel, DW	1
Iqbal, M	1
Goenka, P	1
Young, MF	1
Thomas, E	1
Borthwick, TR	1
Zambrana, JL	1
Díez, F	1
Delgado, M	1
Salas, J	1
Creager, MA	1
Dyken, ML	1
Benavente, O	1
Carvajal García-Pando, A	1
García Ortega, P	1
Rueda de Castro, AM	1
García del Pozo, J	1
Chen, F	1
Zeolla, MM	1
Carson, JJ	1
Harker, LA	2
Boissel, JP	1
Pilgrim, AJ	1
Bhatt, DL	1
Kapadia, SR	1
Yadav, JS	1
Hirano, T	1
Yamori, Y	1
Kanai, N	1
Umetsu, T	1
Nishio, S	1
Hirsh, J	1
Dalen, JE	1
Fuster, V	1
Harker, LB	1
Salzman, EW	1
Blissitt, PA	1
Frey, JL	1
Cowan, S	1
Wilterdink, JL	1
Easton, JD	5
Rota Roca, MR	1
Castellote, J	1
Xiol, X	1
Sánchez Gili, M	1
Haynes, RB	1
Sandler, RS	1
Larson, EB	1
Pater, JL	1
Yatsu, FM	1
Roe, RL	1
Moran, EJ	1
Fazio, S	1
Santomauro, M	1
Cittadini, A	1
Ferraro, S	1
Lucariello, A	1
Maddalena, G	1
Sacca, L	1
Grotta, JC	1
Ketsa-Ard, K	1
Poungvarin, N	1
Juengchareon, M	1
Jarerat, S	1
Kittigul, L	1
Hershey, LA	1
Gordon, DL	1
Robert, S	1
Miller, AJ	1
Fagan, SC	1
Warlow, C	1
Bergqvist, D	1
Boberg, J	1
Boberg, M	1
Eriksson, I	1
Lindgärde, F	1
Persson, G	1
Almgren, B	1
Fagher, B	1
Kjellström, T	1
McTavish, D	1
Faulds, D	1
Nelson, E	1
Lima, JM	1
Blakely, JA	2
Ellis, DJ	2
Hachinski, VC	3
Panak, E	2
Roberts, RS	2
Sicurella, J	2
Turpie, AG	2
Carné, X	1
Arnau, JM	1
Laporte, JR	1
Makuch, R	1
Johnson, M	1
Goyan, JE	1
Pryse-Phillips, W	1
Molony, BA	1
Anderson, S	1
Merz, B	1
Fujimoto, T	1
Suzuki, H	1
Tanoue, K	1
Fukushima, Y	1
Yamazaki, H	1
Mirsen, TR	1
David, JL	1