Page last updated: 2024-11-05

ticlopidine and Blood Loss, Surgical

ticlopidine has been researched along with Blood Loss, Surgical in 116 studies

Ticlopidine: An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
ticlopidine : A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.

Blood Loss, Surgical: Loss of blood during a surgical procedure.

Research Excerpts

ExcerptRelevanceReference
" the pharmacokinetics of clopidogrel do not allow for bleeding time to return to normal until the drug has been discontinued for five days."7.78Operative treatment of hip fractures in patients on clopidogrel: a case-control study. ( Chaput, CD; Patel, KV; Probe, RA; Wallace, HC, 2012)
"Aspirin-treated patients with coronary artery disease were randomly assigned to either prasugrel 10 mg or clopidogrel 75 mg daily for 7 days."6.77Recovery of platelet function after discontinuation of prasugrel or clopidogrel maintenance dosing in aspirin-treated patients with stable coronary disease: the recovery trial. ( Angiolillo, DJ; Baker, BA; Heiselman, DE; Jakubowski, JA; Li, W; Logan, DK; Price, MJ; Walder, JS; Winters, KJ, 2012)
"Femoral neck fractures are an increasingly common injury in the elderly."5.37Femoral neck fractures in patients on Clopidogrel. The effect of delaying surgery and the introduction of the new SIGN guidelines. ( Cam, NB; Chambers, IR; Leonidou, A, 2011)
" Perioperative bleeding and composite of morbidity endpoints including myocardial infarction were compared in relation to the tertile distribution of the fibrinogen concentration."5.19Impact of preoperative fibrinogen concentration on postoperative outcome in patients who received dual antiplatelet therapy in proximity to off-pump coronary bypass surgery. ( Kim, EK; Kim, NY; Kwak, YL; Shim, JK; Song, JW, 2014)
"A subset of the TRITON-TIMI 38 study (Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition with Prasugrel-Thrombolysis In Myocardial Infarction 38), in which patients with acute coronary syndrome were randomized to treatment with aspirin and either clopidogrel or prasugrel, underwent isolated CABG (N = 346)."5.16Mortality benefit with prasugrel in the TRITON-TIMI 38 coronary artery bypass grafting cohort: risk-adjusted retrospective data analysis. ( Goodnough, LT; Lenarz, LA; Levy, JH; Poston, RS; Short, MA; Smith, PK; Weerakkody, GJ, 2012)
" As the indications for clopidogrel expand, an increasing number of patients undergoing off-pump coronary artery bypass surgery (OPCAB) are also undergoing dual antiplatelet therapy (DAPT), with its higher risk of bleeding complications."5.15Effect of hydroxyethyl starch 130/0.4 on blood loss and coagulation in patients with recent exposure to dual antiplatelet therapy undergoing off-pump coronary artery bypass graft surgery. ( Ahn, SW; Kwak, YL; Lee, JS; Shim, JK; Song, JW; Yoo, KJ, 2011)
"The patients at greatest risk, when discontinuing clopidogrel therapy, are those with drug eluting stents who may be at risk of stent thrombosis."4.87Clopidogrel dilemma for orthopaedic surgeons. ( Bell, G; Fletcher, JP; Fox, JS; Grigg, LE; Steele, MJ, 2011)
" the pharmacokinetics of clopidogrel do not allow for bleeding time to return to normal until the drug has been discontinued for five days."3.78Operative treatment of hip fractures in patients on clopidogrel: a case-control study. ( Chaput, CD; Patel, KV; Probe, RA; Wallace, HC, 2012)
"Dual antiplatelet therapy with combined aspirin and clopidogrel as well as clopidogrel is associated with an increased incidence of perioperative wound hematoma compared to aspirin but on an acceptable low level of incidence."3.78Risk of wound hematoma at carotid endarterectomy under dual antiplatelet therapy. ( Goertler, M; Halloul, Z; Heinze, HJ; Meyer, F; Oldag, A; Schreiber, S; Weber, M, 2012)
"An increasing number of patients suffering from cardiovascular disease, especially coronary artery disease (CAD), are treated with aspirin and/or clopidogrel for the prevention of major adverse events."3.77Peri-operative management of antiplatelet therapy in patients with coronary artery disease: joint position paper by members of the working group on Perioperative Haemostasis of the Society on Thrombosis and Haemostasis Research (GTH), the working group on ( Cattaneo, M; Chassot, PG; Eichinger, S; Hofmann, N; Huber, K; Korte, W; Rickli, H; Spannagl, M; Verheugt, F; von Heymann, C; Ziegler, B, 2011)
"Aspirin-treated patients with coronary artery disease were randomly assigned to either prasugrel 10 mg or clopidogrel 75 mg daily for 7 days."2.77Recovery of platelet function after discontinuation of prasugrel or clopidogrel maintenance dosing in aspirin-treated patients with stable coronary disease: the recovery trial. ( Angiolillo, DJ; Baker, BA; Heiselman, DE; Jakubowski, JA; Li, W; Logan, DK; Price, MJ; Walder, JS; Winters, KJ, 2012)
"tirofiban may allow temporary withdrawal of oral clopidogrel without increasing the risk of bleeding."2.75Urgent surgery in patients with a recently implanted coronary drug-eluting stent: a phase II study of 'bridging' antiplatelet therapy with tirofiban during temporary withdrawal of clopidogrel. ( Barlocco, F; Caracciolo, M; D'Urbano, M; De Servi, S; Klugmann, S; Mariani, G; Nichelatti, M; Savonitto, S, 2010)
" Operating early on patients on clopidogrel is safe and does not appear to confer any clinically significant bleeding risk."2.53Clopidogrel and hip fractures, is it safe? A systematic review and meta-analysis. ( Della Torre, PK; Shatwell, MA; Soo, CG; Yolland, TJ, 2016)
"Postoperative complications were similar in the 2 groups."1.46Poor prognosis after surgery for intertrochanteric fracture in elderly patients with clopidogrel treatment: A cohort study. ( Chen, X; Liu, Z; Ren, J; Sun, T; Wang, J; Wang, X; Zhang, J, 2017)
" The purpose of this study was to compare the efficacy and safety of clopidogrel combined with aspirin (CA) versus sarpogrelate combined with aspirin (SA) treatment in carotid endarterectomy (CEA) patients."1.43Effects of Sarpogrelate Combined with Aspirin in Patients Undergoing Carotid Endarterectomy in China: A Single-Center Retrospective Study. ( Gu, Y; Guo, J; Guo, L; Qi, L; Tong, Z; Wang, Z; Yu, H; Zhang, J, 2016)
"Clopidogrel and ticlopidine, sometimes in combination with ASA, are associated with a low risk of bleeding during renal transplantation and does not seem to be a contraindication for renal transplant surgery."1.40Ticlopidine and clopidogrel, sometimes combined with aspirin, only minimally increase the surgical risk in renal transplantation: a case-control study. ( Abramowicz, D; Benahmed, A; Broeders, N; Donckier, V; Ghisdal, L; Hoang, AD; Kianda, M; Le Moine, A; Lemy, A; Madhoun, P; Massart, A; Mikhalski, D; Racapé, J; Sadis, C; Wissing, M, 2014)
"Femoral neck fractures are an increasingly common injury in the elderly."1.37Femoral neck fractures in patients on Clopidogrel. The effect of delaying surgery and the introduction of the new SIGN guidelines. ( Cam, NB; Chambers, IR; Leonidou, A, 2011)
"Surgical blood loss was measured, and the groups were compared for statistically significant differences in blood loss."1.35The effect of platelet-altering medications on bleeding from minor oral surgery procedures. ( Alvarado, F; Campbell, JH; Partridge, CG, 2008)

Research

Studies (116)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (2.59)18.2507
2000's32 (27.59)29.6817
2010's81 (69.83)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Columbo, JA1
Lambour, AJ1
Sundling, RA1
Chauhan, NB1
Bessen, SY1
Linshaw, DL1
Kang, R1
Riblet, NBV1
Goodney, PP2
Stone, DH2
Buhatem Medeiros, F1
Pepe Medeiros de Rezende, N1
Bertoldi Franco, J1
Porrio de Andrade, AC1
Timerman, L1
Gallottini, M1
Itagiba Neves, IL1
Ortega, KL1
Zhang, J2
Chen, X1
Wang, J1
Liu, Z1
Wang, X1
Ren, J1
Sun, T1
Pearcy, C1
Almahmoud, K1
Jackson, T1
Hartline, C1
Cahill, A1
Spence, L1
Kim, D1
Olatubosun, O1
Todd, SR1
Campion, EM1
Burlew, CC1
Regner, J1
Frazee, R1
Michaels, D1
Dissanaike, S1
Stewart, C1
Foley, N1
Nelson, P1
Agrawal, V1
Truitt, MS1
Prader, R1
De Broca, B1
Chevallier, D1
Amiel, J1
Durand, M1
Shi, J2
Ji, H2
Ren, F1
Wang, G2
Xu, M1
Xue, Y1
Chen, M1
Qi, J1
Li, L2
Faraday, N1
Fujikawa, T1
Noda, T1
Tada, S1
Tanaka, A1
Wallace, HC1
Probe, RA1
Chaput, CD1
Patel, KV1
McKenzie, JL1
Douglas, G1
Bazargan, A1
Fitchett, D1
Mazer, CD1
Eikelboom, J1
Verma, S1
Rouine-Rapp, K1
McDermott, MW1
Song, Y2
Song, JW3
Shim, JK5
Kwak, YL5
Al Khudairy, A1
Al-Hadeedi, O1
Sayana, MK1
Galvin, R1
Quinlan, JF1
Girotra, C1
Padhye, M1
Mandlik, G1
Dabir, A1
Gite, M1
Dhonnar, R1
Pandhi, V1
Vandekar, M1
Abouzgheib, W1
Meena, N1
Jagtap, P1
Schorr, C1
Boujaoude, Z1
Bartter, T1
Benahmed, A1
Kianda, M1
Ghisdal, L1
Broeders, N1
Massart, A1
Lemy, A1
Mikhalski, D1
Hoang, AD1
Donckier, V1
Sadis, C1
Le Moine, A1
Madhoun, P1
Racapé, J1
Wissing, M1
Abramowicz, D1
Zheng, Z1
Liu, JH1
Huang, FJ1
Yu, JB1
Kim, NY1
Kim, EK1
Capodanno, D1
Anderson, K1
Jupiter, DC1
Abernathy, SW1
Frazee, RC1
Plicner, D1
Mazur, P1
Hymczak, H1
Stoliński, J1
Litwinowicz, R1
Drwiła, R1
Undas, A1
Gielen, CL1
Bruggemans, EF1
Stijnen, T1
Eikenboom, J1
Tavilla, G1
Brand, A1
Klautz, RJ1
Batchelder, A1
Hunter, J1
Cairns, V1
Sandford, R1
Munshi, A1
Naylor, AR1
Althaus, AB1
Dovirak, O1
Chang, P1
Taylor, KN1
O'Halloran, TD1
Wagner, AA1
Kuliczkowski, W1
Sliwka, J1
Kaczmarski, J1
Zysko, D1
Zembala, M2
Steter, D1
Fortmann, S1
Serebruany, V1
Hunter, JB1
Carlson, ML1
Sweeney, AD1
Tombers, NM1
Wanna, GB1
Driscoll, CL1
Haynes, DS1
Lu, SY1
Tsai, CY1
Lin, LH1
Lu, SN1
Chu, EW2
Chernoguz, A3
Divino, CM4
Soo, CG1
Della Torre, PK1
Yolland, TJ1
Shatwell, MA1
Guo, J1
Gu, Y1
Guo, L1
Yu, H1
Qi, L1
Tong, Z1
Wang, Z1
Moon, K1
Nanaszko, M1
Levitt, MR1
Gross, BA1
Zabramski, JM1
Spetzler, RF2
Nakaji, P2
Strosberg, DS1
Corbey, T1
Henry, JC1
Starr, JE1
Mattesi, L1
Noailles, T1
Rosencher, N1
Rouvillain, JL1
Jones, DW1
Schermerhorn, ML1
Brooke, BS1
Conrad, MF1
Wyers, MC1
Ghanem, ES1
Richard, RD1
Wingert, NCH1
Gotoff, JR1
Graham, JH1
Bowen, TR1
Newsome, LT1
Weller, RS1
Gerancher, JC1
Kutcher, MA1
Royster, RL1
Johansen, A1
White, J1
Turk, A1
Ozao-Choy, J2
Tammaro, Y2
Fradis, M1
Weber, K1
Vaccarino, GN1
Thierer, J1
Albertal, M1
Vrancic, M1
Piccinini, F1
Benzadón, M1
Raich, H1
Navia, DO1
Jensen, MK1
Hüttel, M1
Kuczkowski, KM1
Velik-Salchner, C1
Maier, S1
Innerhofer, P1
Kolbitsch, C1
Streif, W1
Mittermayr, M1
Praxmarer, M1
Fries, D1
Metzler, H1
Prüller, F1
Münch, A1
Primus, G1
Kainz, J1
Hödl, R1
Rehak, P1
Duggan, ST1
Keating, GM1
Stewart, LC1
Langtry, JA1
Colombo, A1
Gerber, RT1
Savonitto, S1
D'Urbano, M1
Caracciolo, M1
Barlocco, F1
Mariani, G1
Nichelatti, M1
Klugmann, S1
De Servi, S1
Wait, SD1
Abla, AA1
Killory, BD1
Starke, RM1
García-Bracamonte, B1
Vanaclocha, F1
Johansen, M1
Afshari, A1
Kristensen, BB1
Nydick, JA1
Farrell, ED1
Marcantonio, AJ1
Hume, EL1
Marburger, R1
Ostrum, RF1
Möllmann, H1
Nef, HM1
Hamm, CW1
Wessely, R1
Cerfolio, RJ1
Minnich, DJ1
Bryant, AS1
Telem, DA2
Llau, JV1
Ferrandis, R1
Sierra, P1
Gómez-Luque, A1
Kim, JC1
Choi, YS2
Yoo, KJ3
Hussaini, BE1
Thatte, HS1
Rhodes, BA1
Treanor, PR1
Birjiniuk, V1
Chechik, O2
Thein, R1
Fichman, G1
Haim, A1
Tov, TB1
Steinberg, EL1
Chu, E1
Korte, W1
Cattaneo, M1
Chassot, PG2
Eichinger, S1
von Heymann, C1
Hofmann, N1
Rickli, H1
Spannagl, M1
Ziegler, B1
Verheugt, F1
Huber, K1
Bracey, AW1
Reyes, MA1
Chen, AJ1
Bayat, M1
Allison, PM1
Barequet, IS1
Sachs, D1
Shenkman, B1
Priel, A1
Wasserzug, Y1
Budnik, I1
Moisseiev, J1
Salomon, O1
Lee, JS1
Ahn, SW1
Duggie, AJ1
Dimech, J1
Zagórski, M1
Goch, A1
Nwachuku, IC1
Jones, M1
Clough, TM1
Mariscalco, G1
Bruno, VD1
Cottini, M1
Borsani, P1
Banach, M1
Piffaretti, G1
Dominici, C1
Beghi, C1
Sala, A1
Leonidou, A1
Cam, NB1
Chambers, IR1
Douketis, JD1
Edry, R1
Katz, Y1
Sylvester, DC1
Coatesworth, AP1
Bittner, HB1
Lehmann, S1
Rastan, A1
Mohr, FW1
Brizzio, ME1
Shaw, RE1
Bosticco, B1
Collins, M1
Grau, JB1
Mak, AW1
Zapolanski, A1
Nathan, S1
Steele, MJ1
Fox, JS1
Fletcher, JP2
Grigg, LE1
Bell, G1
Thiele, T1
Sümnig, A1
Hron, G1
Müller, C1
Althaus, K1
Schroeder, HW1
Greinacher, A1
Collinge, CA1
Kelly, KC1
Little, B1
Weaver, T1
Schuster, RD1
Goldstein, Y1
Behrbalk, E1
Kaufman, E1
Rabinovich, Y1
Vetter, TR1
Boudreaux, AM1
Papapietro, SE1
Smith, PW1
Taylor, BB1
Porterfield, JR1
Smith, PK1
Goodnough, LT1
Levy, JH1
Poston, RS1
Short, MA1
Weerakkody, GJ1
Lenarz, LA1
Oldag, A1
Schreiber, S2
Heinze, HJ1
Meyer, F1
Weber, M1
Halloul, Z1
Goertler, M1
Radovanovic, I1
Queally, J1
Bahari, S1
Sproule, J1
McElwain, J1
Price, MJ1
Walder, JS1
Baker, BA1
Heiselman, DE1
Jakubowski, JA1
Logan, DK1
Winters, KJ1
Li, W1
Angiolillo, DJ1
Savage, JR1
Parmar, A1
Robinson, PJ1
Lv, H1
Yuan, S1
Wang, Y1
Paul, S1
Stock, C1
Chiu, YL1
Kansler, A1
Port, JL1
Lee, PC1
Stiles, BM1
Nasar, A1
Sedrakyan, A1
Altorki, NK1
Wordsworth, DR1
Halsey, T1
Griffiths, R1
Parker, MJ1
Feely, MA1
Mabry, TM1
Lohse, CM1
Sems, SA1
Mauck, KF1
Akowuah, E1
Shrivastava, V1
Cooper, G1
Pivalizza, EG1
Warters, RD1
Gottschalk, LI1
Luehr, SL1
Hartwell, EA1
Schieber, M1
Sechtem, U1
Chu, MW1
Wilson, SR1
Novick, RJ1
Stitt, LW1
Quantz, MA1
Kapetanakis, EI1
Medlam, DA1
Boyce, SW1
Haile, E1
Hill, PC1
Dullum, MK1
Bafi, AS1
Petro, KR1
Corso, PJ1
Ascione, R1
Ghosh, A1
Rogers, CA1
Cohen, A1
Monk, C1
Angelini, GD1
Madi-Jebara, S1
Rkeiby-Kassabian, N1
Yazigi, A1
Lindvall, G1
Sartipy, U1
van der Linden, J1
Hitos, K1
Purkayastha, S1
Athanasiou, T1
Malinovski, V1
Tekkis, P1
Foale, R1
Casula, R1
Glenville, B1
Darzi, A1
Hirose, H1
Delabays, A1
Ravussin, P1
Spahn, DR1
Oh, YJ1
Bang, SO1
Iwahashi, H1
Tashiro, T1
Morishige, N1
Hayashida, Y1
Ito, N1
Takeuchi, K1
Teshima, H1
Kuwahara, G1
Partridge, CG1
Campbell, JH1
Alvarado, F1
Reichert, MG1
Robinson, AH1
Travis, JA1
Hammon, JW1
Kon, ND1
Kincaid, EH1
Benzimra, JD1
Johnston, RL1
Jaycock, P1
Galloway, PH1
Lambert, G1
Chung, AK1
Eke, T1
Sparrow, JM1
Price, J1
Tadbiri, S1
Pickard, AS1
Becker, RC1
Schumock, GT1
Frye, CB1
Rodin, IuV1
Widimsky, P1
Motovská, Z1
Simek, S1
Kala, P1
Pudil, R1
Holm, F1
Petr, R1
Bílková, D1
Skalická, H1
Kuchynka, P1
Poloczek, M1
Miklík, R1
Maly, M1
Aschermann, M1
Maltais, S1
Perrault, LP1
Do, QB1
Alvarez, JM1
Harper, RW1
Peverill, RE1
Aylward, P1
Ley, SJ1
Nevelsteen, A1
Mortelmans, L1
Van de Cruys, A1
Merckx, E1
Verhaeghe, R1

Clinical Trials (10)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of Antifibrinolytics on Bleeding and Transfusion Outcomes in Patients Receiving Coronary Artery Bypass Surgery With Preoperative Clopidogrel Exposure[NCT01060163]552 participants (Actual)Interventional2010-01-31Completed
Evaluation of Clopidogrel Use in Peri-Operative General Surgery Patients: A Prospective Study[NCT01960296]Phase 248 participants (Actual)Interventional2012-01-31Completed
Alignment of Treatment Preferences and Repair Type for Veterans With AAA[NCT03115346]238 participants (Anticipated)Interventional2017-04-15Active, not recruiting
Influence of Extracorporeal Circulation on Platelet Function of Patients Undergoing Cardiac Surgery - a Prospective Observational Study[NCT01354847]25 participants (Actual)Observational2011-06-30Completed
Management of Antiplatelet Regimen During Surgical Procedures (MARS Registry)[NCT03981835]1,492 participants (Anticipated)Observational [Patient Registry]2019-08-01Recruiting
A Prospective, Nonrandomized, Study Comparing the Use of Aspirin and Intraoperative Blood Loss and Postoperative Complications Following Open Inguinal Hernia Repair.[NCT02084615]300 participants (Anticipated)Interventional2014-08-31Enrolling by invitation
A Comparison of CS-747 and Clopidogrel in Acute Coronary Syndrome Subjects Who Are to Undergo Percutaneous Coronary Intervention[NCT00097591]Phase 313,619 participants (Actual)Interventional2004-11-30Completed
Platelet Aggregometry to Drive the Surgical Timing in Elderlies With Hip Fracture and Receiving Clopidogrel.[NCT04642209]9 participants (Anticipated)Observational2020-12-01Not yet recruiting
Recovery of Platelet Function Following Discontinuation of Prasugrel or Clopidogrel Maintenance Dosing in Aspirin-Treated Subjects With Stable Coronary Disease[NCT01014624]Phase 456 participants (Actual)Interventional2010-02-28Completed
Maintenance Of aNtiplatElet Therapy in Patients With Coronary Stenting Undergoing Surgery[NCT03445273]1,800 participants (Anticipated)Observational [Patient Registry]2018-11-21Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Average Change in Hematocrit

hematocrit levels change from preoperative to postoperative (NCT01960296)
Timeframe: baseline and Day 1

Interventionpercent change (Mean)
Clopidogrel-3
Discontinue-1

Average Length of Hospital Stay

(NCT01960296)
Timeframe: up to 90 days

Interventiondays (Mean)
Clopidogrel2.2
Discontinue2.4

Bleeding-related Re-hospitalization

Perioperative Bleeding Complications as indicated by bleeding requiring re-admission. (NCT01960296)
Timeframe: up to 90 days post op

Interventionparticipants (Number)
Clopidogrel1
Discontinue1

Development of Myocardial Infarction or Thrombosis

(NCT01960296)
Timeframe: up to 90 days

Interventionparticipants (Number)
Clopidogrel0
Discontinue0

Perioperative Bleeding Complications

Development of perioperative bleeding complications as indicated for need for blood transfusions, hematoma, and bleeding requiring re-operation. (NCT01960296)
Timeframe: up to 90 days postop

Interventionparticipants (Number)
Clopidogrel0
Discontinue0

Procedure Estimated Blood Loss

(NCT01960296)
Timeframe: up to 90 days postop

InterventionmL (Mean)
Clopidogrel73.6
Discontinue52.1

Procedure Time

(NCT01960296)
Timeframe: Day 1

Interventionminutes (Mean)
Clopidogrel114.3
Discontinue100.4

Same Day Discharged

Number of patients discharged on the day of surgery (NCT01960296)
Timeframe: up to 90 days

,
Interventionparticipants (Number)
same day dischargedhospital admission
Clopidogrel813
Discontinue1210

Number of Subjects Reaching the Composite Endpoint of All-Cause Death, Nonfatal Myocardial Infarction (MI), or Nonfatal Stroke

The endpoint in this measure is a combination of all-cause death, nonfatal MI, or nonfatal stroke. Results are reported for the All ACS population. (NCT00097591)
Timeframe: Randomization up to 15 months

InterventionParticipants (Number)
Prasugrel692
Clopidogrel822

Number of Subjects Reaching the Composite Endpoint of Cardiovascular (CV) Death, Nonfatal Myocardial Infarction (MI), Nonfatal Stroke, or Rehospitalization for Cardiac Ischemic Events

The endpoint in this measure is a combination of CV death, nonfatal MI, nonfatal stroke, or rehospitalization for cardiac ischemic events. Results are reported for the All ACS population. (NCT00097591)
Timeframe: Randomization up to 15 months

InterventionParticipants (Number)
Prasugrel797
Clopidogrel938

Number of Subjects Reaching the Composite Endpoint of Cardiovascular (CV) Death, Nonfatal Myocardial Infarction (MI), or Nonfatal Stroke

The endpoint in this measure is a combination of CV death, nonfatal MI, or nonfatal stroke. Results are reported for the All ACS population for the 30 and 90 day periods. (NCT00097591)
Timeframe: Randomization to 30 days; randomization to 90 days

,
InterventionParticipants (Number)
All ACS (Through 30 days)All ACS (Through 90 days)
Clopidogrel502573
Prasugrel389462

Number of Subjects Reaching the Composite Endpoint of Cardiovascular (CV) Death, Nonfatal Myocardial Infarction (MI), or Nonfatal Stroke

The endpoint in this measure is a combination of CV death, nonfatal MI, or nonfatal stroke. The data is presented by the study population, which is represented as follows: 1) subjects who presented with unstable angina and non-ST-segment elevation myocardial infarction (UA/NSTEMI), 2) subjects who presented with ST segment elevation myocardial infarction (STEMI), and 3) all subjects with acute coronary syndromes (ACS) (i.e. all subjects with UA/NSTEMI or STEMI). (NCT00097591)
Timeframe: Randomization up to 15 months

,
InterventionParticipants (Number)
UA/NSTEMI (n=5044, n=5030)STEMI (n=1769, n=1765)All ACS (n=6813, n=6795)
Clopidogrel565216781
Prasugrel469174643

Number of Subjects Reaching the Composite Endpoint of Cardiovascular (CV) Death, Nonfatal Myocardial Infarction (MI), or Urgent Target Vessel Revascularization (UTVR)

The endpoint in this measure is a combination of CV death, nonfatal MI, or UTVR. Results are reported for the All ACS subject population for the 30 and 90 day periods. (NCT00097591)
Timeframe: Randomization to 30 days; randomization to 90 days

,
InterventionParticipants (Number)
All ACS (Through 30 days)All ACS (Through 90 days)
Clopidogrel504588
Prasugrel399472

Number of Treated Subjects With Non-Coronary Artery Bypass Graft (CABG) Related Thrombolysis In Myocardial Infarction (TIMI) Study Group Major and Minor Bleeding Events

TIMI classification for major and minor bleeding in the subset of subjects who did not undergo a coronary artery bypass operation (CABG) were defined as follows: Major bleeding: any intracranial hemorrhage (ICH) OR any clinically overt bleeding (including bleeding evident on imaging studies) associated with a fall in hemoglobin (Hgb) of ≥5 grams/deciliter (gm/dL)from baseline. Minor Bleeding: any clinically overt bleeding associated with a fall in Hgb of ≥3 gm/dL but <5 gm/dL from baseline. Major bleeding events were further examined as events that were deemed life threatening and/or fatal. (NCT00097591)
Timeframe: First dose of study drug up to 15 months (while at risk)

,
InterventionParticipants (Number)
TIMI Major or Minor BleedingTIMI Major BleedingTIMI Major Bleeding - Life-threatening (LT)LT - FatalLT - Symptomatic intracranial hemorrage (ICH)LT - Requiring inotropesLT - Requiring surgical interventionLT - Requiring transfusion (>=4 units)TIMI Minor Bleeding
Clopidogrel2311115651781930125
Prasugrel303146852119211945164

Percentage of Inhibition of Platelet Aggregation on Washout Day 1

Inhibition of platelet aggregation was assessed by Accumetrics VerifyNow® P2Y12 reaction units (PRU). On the first day of the Washout Period (Visit 3), the blood draw for platelet function testing was obtained 24 hour (+/- 6 hours) after the last dose of study medication. Following Visit 3, platelet function testing was performed during each visit of the Washout Period until the participant met the following exit criteria: (Baseline PRU-PRU) less than or equal to 60 units and (Baseline PRU-PRU)/(Baseline PRU) less than or equal to 20%. (NCT01014624)
Timeframe: Washout Day 1

Interventionpercentage (Mean)
Prasugrel72.3
Clopidogrel35.4

Time to Return to Baseline PRU for the Primary Population Using the Primary Definition of Return to Baseline in Relation to the Inhibition of Platelet Aggregation 24 Hours Following the Last Maintenance Dose

Time to return to baseline PRU (<= 60 units of baseline) dependent upon baseline PRU and platelet % inhibition on Washout Period Day 1 but independent of treatment. The following regression model was derived for predicting number of days to return to baseline PRU where PI(1) represents platelet percentage inhibition on Washout Day 1. Number days to return to baseline PRU derived from: Number days to return to baseline PRU=-3.350+0.079*PI(1)+0.014*baseline PRU. The predicted number of days to return to baseline based on device-derived platelet percentage inhibition is reported for each treatment group. (NCT01014624)
Timeframe: up to 12 days after the last dose

Interventiondays (Number)
Prasugrel6.2
Clopidogrel3.7

Day at Which 50%, 75%, and 90% of Participants Returned to Baseline Platelet Function Based on Primary Definition of Return to Baseline Using the Primary Population

On the first day of the Washout Period (Visit 3), the blood draw for platelet function testing was obtained 24 hours (+/-6 hours) after the last dose of study medication. Following Visit 3, platelet function testing was performed during each visit of the Washout Period until the participants met the following exit criteria: (Baseline PRU-PRU) less than or equal to 60 units and (Baseline PRU-PRU)/Baseline PRU less than or equal to 20%. (NCT01014624)
Timeframe: up to 12 days after last dose

,
Interventiondays (Number)
Washout day 50% returned to baseline PRUWashout day 75% returned to baseline PRUWashout day 90% returned to baseline PRU
Clopidogrel356
Prasugrel679

Day at Which 50%, 75%, and 90% of Participants Returned to Baseline Platelet Function Based on Secondary Definition of Return to Baseline Using the Primary Population

On the first day of the Washout Period (Visit 3), the blood draw for platelet function testing was obtained 24 hours (+/-6 hours) after the last dose of study medication. Following Visit 3, platelet function testing was performed during each visit of the Washout Period until the participant met the following exit criteria: (Baseline PRU-PRU) less than or equal to 60 units and (Baseline PRU-PRU)/Baseline PRU less than or equal to 20%. (NCT01014624)
Timeframe: up to 12 days after last dose

,
Interventiondays (Number)
Washout day 50% returned to baseline PRUWashout day 75% returned to baseline PRUWashout day 90% returned to baseline PRU
Clopidogrel357
Prasugrel679

Day at Which 50%, 75%, and 90% of Participants Returned to Baseline Platelet Function Based on the Primary Definition of Return to Baseline Using the Responder Population

On the first day of the Washout Period (Visit 3), the blood draw for platelet function testing was obtained 24 hours (+/-6 hours) after the last dose of study medication. Following Visit 3, platelet function testing was performed during each visit of the Washout Period until the participant met the following exit criteria: (Baseline PRU-PRU) less than or equal to 60 units and (Baseline PRU-PRU)/Baseline PRU less than or equal to 20%. (NCT01014624)
Timeframe: up to 12 days after last dose

,
Interventiondays (Number)
Washout day 50% returned to baseline PRUWashout day 75% returned to baseline PRUWashout day 90% returned to baseline PRU
Clopidogrel556
Prasugrel679

Day at Which 50%, 75%, and 90% of Participants Returned to Baseline Platelet Function Based on the Secondary Definition of Return to Baseline Using the Responder Population

On the first day of the Washout Period (Visit 3), the blood draw for platelet function testing was obtained 24 hour (+/- 6 hours) after the last dose of study medication. Following Visit 3, platelet function testing was performed during each visit of the Washout Period until the participant met the following exit criteria: (Baseline PRU-PRU) less than or equal to 60 units and (Baseline PRU-PRU)/(Baseline PRU) less than or equal to (<=) 20%. (NCT01014624)
Timeframe: up to 12 days after the last dose

,
Interventiondays (Number)
Washout day 50% returned to baseline PRUWashout day 75% returned to baseline PRUWashout day 90% returned to baseline PRU
Clopidogrel567
Prasugrel679

The Time to Return to Baseline Platelet Function as Assessed by P2Y12 Reaction Units (PRU) Using the Accumetrics VerifyNOW P2Y12 Device Based on the Primary Definition of Return to Baseline

On the first day of the Washout Period (Visit 3), the blood draw for platelet function testing was obtained 24 hours (+/- 6 hours) after the last dose of study medication. Following Visit 3, platelet function testing was performed during each visit of the Washout Period until the participant met the following exit criteria: (Baseline PRU-PRU) less than or equal to 60 units and (Baseline PRU-PRU)/(Baseline PRU) less than or equal to 20%. The results are expressed as cumulative percentage of participants. (NCT01014624)
Timeframe: up to 12 days after last dose

,
Interventioncumulative percentage of participants (Number)
return to baseline PRU by washout day 1return to baseline PRU by washout day 3return to baseline PRU by washout day 5return to baseline PRU by washout day 6return to baseline PRU by washout day 7return to baseline PRU by washout day 9
Clopidogrel30.853.984.696.296.2100.0
Prasugrel03.637.062.977.8100.0

The Time to Return to Baseline Platelet Function as Assessed by P2Y12 Reaction Units (PRU) Using the Accumetrics VerifyNOW P2Y12 Device Based on the Secondary Definition of Return to Baseline

On the first day of the Washout Period (visit 3), the blood draw for platelet function testing was obtained 24 hours (+/- 6 hours) after the last dose of study medication. Following Visit 3, platelet function testing was performed during each visit of the Washout Period until the participant met the following exit criteria: (Baseline PRU-PRU) less than or equal to 60 units and (Baseline PRU-PRU)/(Baseline PRU) less than or equal to 20%. (NCT01014624)
Timeframe: up to 12 days after last dose

,
Interventioncumulative percentage of participants (Number)
returned to baseline PRU by washout day 1returned to baseline PRU by washout day 3returned to baseline PRU by washout day 5returned to baseline PRU by washout day 6returned to baseline PRU by washout day 7returned to baseline PRU by washout day 9
Clopidogrel30.853.980.888.596.2100.0
Prasugrel0.00.037.055.677.8100.0

Reviews

15 reviews available for ticlopidine and Blood Loss, Surgical

ArticleYear
A Meta-analysis of the Impact of Aspirin, Clopidogrel, and Dual Antiplatelet Therapy on Bleeding Complications in Noncardiac Surgery.
    Annals of surgery, 2018, Volume: 267, Issue:1

    Topics: Aspirin; Blood Loss, Surgical; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation

2018
Perioperative management of anticoagulation in elective surgery.
    ANZ journal of surgery, 2013, Volume: 83, Issue:11

    Topics: Anticoagulants; Antithrombins; Benzimidazoles; beta-Alanine; Blood Loss, Surgical; Cardiovascular Di

2013
Antiplatelet therapy and cardiac surgery: review of recent evidence and clinical implications.
    The Canadian journal of cardiology, 2013, Volume: 29, Issue:9

    Topics: Adenosine; Blood Loss, Surgical; Clopidogrel; Combined Modality Therapy; Coronary Artery Bypass; Dru

2013
Clopidogrel and hip fractures, is it safe? A systematic review and meta-analysis.
    BMC musculoskeletal disorders, 2016, Mar-22, Volume: 17

    Topics: Blood Loss, Surgical; Chi-Square Distribution; Clopidogrel; Drug Administration Schedule; Femoral Ne

2016
Discontinuation of Plavix
    Orthopaedics & traumatology, surgery & research : OTSR, 2016, Volume: 102, Issue:8

    Topics: Blood Loss, Surgical; Clopidogrel; Hip Fractures; Humans; Platelet Aggregation Inhibitors; Postopera

2016
Coronary artery stents: II. Perioperative considerations and management.
    Anesthesia and analgesia, 2008, Volume: 107, Issue:2

    Topics: Anesthesia, Conduction; Angioplasty, Balloon, Coronary; Aspirin; Blood Loss, Surgical; Clopidogrel;

2008
Prasugrel: a review of its use in patients with acute coronary syndromes undergoing percutaneous coronary intervention.
    Drugs, 2009, Aug-20, Volume: 69, Issue:12

    Topics: Acute Coronary Syndrome; Adult; Aged; Angioplasty, Balloon, Coronary; Blood Loss, Surgical; Clopidog

2009
Clopidogrel: mechanisms of action and review of the evidence relating to use during skin surgery procedures.
    Clinical and experimental dermatology, 2010, Volume: 35, Issue:4

    Topics: Aspirin; Blood Loss, Surgical; Clopidogrel; Dermatologic Surgical Procedures; Drug Therapy, Combinat

2010
[Discontinuation of treatment with platelet aggregation inhibitors in surgical patients with cardiac stents].
    Ugeskrift for laeger, 2010, Mar-15, Volume: 172, Issue:11

    Topics: Angioplasty, Balloon, Coronary; Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Thrombosis; Dru

2010
Prevention of the renarrowing of coronary arteries using drug-eluting stents in the perioperative period: an update.
    Vascular health and risk management, 2010, Oct-05, Volume: 6

    Topics: Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Thrombosis; Coronary Vessels; Drug-Eluting Sten

2010
Antiplatelet therapy in ENT surgery: a review.
    The Journal of laryngology and otology, 2012, Volume: 126, Issue:4

    Topics: Aspirin; Blood Loss, Surgical; Clopidogrel; Decision Making; Drug-Eluting Stents; Humans; Otorhinola

2012
Clopidogrel dilemma for orthopaedic surgeons.
    ANZ journal of surgery, 2011, Volume: 81, Issue:11

    Topics: Attitude of Health Personnel; Blood Loss, Surgical; Clopidogrel; Decision Making; Dose-Response Rela

2011
Does clopidogrel affect outcome after coronary artery bypass grafting? A meta-analysis.
    Heart (British Cardiac Society), 2006, Volume: 92, Issue:4

    Topics: Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Humans; Length of Stay

2006
[Antiplatelet drugs and intraoperative hemorrhage].
    Revue medicale suisse, 2006, Nov-22, Volume: 2, Issue:88

    Topics: Algorithms; Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combinati

2006
Clopidogrel-associated bleeding and related complications in patients undergoing coronary artery bypass grafting.
    Pharmacotherapy, 2008, Volume: 28, Issue:3

    Topics: Blood Loss, Surgical; Blood Transfusion; Clinical Trials as Topic; Clopidogrel; Coronary Artery Bypa

2008

Trials

20 trials available for ticlopidine and Blood Loss, Surgical

ArticleYear
Protective effects of tranexamic acid on clopidogrel before coronary artery bypass grafting: a multicenter randomized trial.
    JAMA surgery, 2013, Volume: 148, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antifibrinolytic Agents; Blood Loss, Surgical; Clopidogr

2013
Assessment of the risk of haemorrhage and its control following minor oral surgical procedures in patients on anti-platelet therapy: a prospective study.
    International journal of oral and maxillofacial surgery, 2014, Volume: 43, Issue:1

    Topics: Adult; Aged; Aspirin; Blood Loss, Surgical; Clopidogrel; Female; Hemostasis, Surgical; Humans; Male;

2014
[Effects of preoperative uses of aspirin and clopidogrel on patients undergoing coronary artery bypass graft surgery].
    Zhonghua yi xue za zhi, 2013, Oct-15, Volume: 93, Issue:38

    Topics: Aged; Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass, Off-Pump; Female; Humans;

2013
Impact of preoperative fibrinogen concentration on postoperative outcome in patients who received dual antiplatelet therapy in proximity to off-pump coronary bypass surgery.
    Circulation journal : official journal of the Japanese Circulation Society, 2014, Volume: 78, Issue:7

    Topics: Aged; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass, Off-Pump; Female; Fibrinogen; Human

2014
Preoperative platelet aggregation predicts perioperative blood loss and rethoracotomy for bleeding in patients receiving dual antiplatelet treatment prior to coronary surgery.
    Thrombosis research, 2015, Volume: 136, Issue:3

    Topics: Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass; Drug Combinations; Female; Human

2015
Stopping antiplatelet medication before coronary artery bypass graft surgery: is there an optimal timing to minimize bleeding?
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2015, Volume: 48, Issue:4

    Topics: Aged; Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; D

2015
The evaluation of clopidogrel use in perioperative general surgery patients: a prospective randomized controlled trial.
    American journal of surgery, 2016, Volume: 211, Issue:6

    Topics: Aged; Blood Loss, Surgical; Clopidogrel; Elective Surgical Procedures; Female; General Surgery; Hosp

2016
Carotid Endarterectomy on Antiplatelet Agents in the Era of Point-of-Care Testing.
    World neurosurgery, 2016, Volume: 93

    Topics: Aged; Arizona; Blood Loss, Surgical; Carotid Stenosis; Clopidogrel; Endarterectomy, Carotid; Female;

2016
Urgent surgery in patients with a recently implanted coronary drug-eluting stent: a phase II study of 'bridging' antiplatelet therapy with tirofiban during temporary withdrawal of clopidogrel.
    British journal of anaesthesia, 2010, Volume: 104, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Blood Loss, Surgical; Clopidogrel; C

2010
Clopidogrel responsiveness regardless of the discontinuation date predicts increased blood loss and transfusion requirement after off-pump coronary artery bypass graft surgery.
    Journal of the American College of Cardiology, 2010, Dec-07, Volume: 56, Issue:24

    Topics: Aged; Blood Loss, Surgical; Blood Platelets; Blood Transfusion; Clopidogrel; Coronary Artery Bypass,

2010
Effect of hydroxyethyl starch 130/0.4 on blood loss and coagulation in patients with recent exposure to dual antiplatelet therapy undergoing off-pump coronary artery bypass graft surgery.
    Circulation journal : official journal of the Japanese Circulation Society, 2011, Volume: 75, Issue:10

    Topics: Aged; Aspirin; Blood Coagulation; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass, Off-Pum

2011
Optimal timing of discontinuation of clopidogrel and risk of blood transfusion after coronary surgery. Propensity score analysis.
    Circulation journal : official journal of the Japanese Circulation Society, 2011, Volume: 75, Issue:12

    Topics: Aged; Aspirin; Blood Loss, Surgical; Blood Transfusion; Cardiac Surgical Procedures; Clopidogrel; Fe

2011
Mortality benefit with prasugrel in the TRITON-TIMI 38 coronary artery bypass grafting cohort: risk-adjusted retrospective data analysis.
    Journal of the American College of Cardiology, 2012, Jul-31, Volume: 60, Issue:5

    Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Aspirin; Blood Loss, Surgical; Cause

2012
Recovery of platelet function after discontinuation of prasugrel or clopidogrel maintenance dosing in aspirin-treated patients with stable coronary disease: the recovery trial.
    Journal of the American College of Cardiology, 2012, Jun-19, Volume: 59, Issue:25

    Topics: Adult; Aged; Aspirin; Blood Loss, Surgical; Blood Platelets; Clopidogrel; Confounding Factors, Epide

2012
Recovery of platelet function after discontinuation of prasugrel or clopidogrel maintenance dosing in aspirin-treated patients with stable coronary disease: the recovery trial.
    Journal of the American College of Cardiology, 2012, Jun-19, Volume: 59, Issue:25

    Topics: Adult; Aged; Aspirin; Blood Loss, Surgical; Blood Platelets; Clopidogrel; Confounding Factors, Epide

2012
Recovery of platelet function after discontinuation of prasugrel or clopidogrel maintenance dosing in aspirin-treated patients with stable coronary disease: the recovery trial.
    Journal of the American College of Cardiology, 2012, Jun-19, Volume: 59, Issue:25

    Topics: Adult; Aged; Aspirin; Blood Loss, Surgical; Blood Platelets; Clopidogrel; Confounding Factors, Epide

2012
Recovery of platelet function after discontinuation of prasugrel or clopidogrel maintenance dosing in aspirin-treated patients with stable coronary disease: the recovery trial.
    Journal of the American College of Cardiology, 2012, Jun-19, Volume: 59, Issue:25

    Topics: Adult; Aged; Aspirin; Blood Loss, Surgical; Blood Platelets; Clopidogrel; Confounding Factors, Epide

2012
Tranexamic Acid in on-pump coronary artery bypass grafting without clopidogrel and aspirin cessation: randomized trial and 1-year follow-up.
    The Annals of thoracic surgery, 2013, Volume: 95, Issue:3

    Topics: Antifibrinolytic Agents; Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass; Coronar

2013
Aprotinin reduces bleeding and blood product use in patients treated with clopidogrel before coronary artery bypass grafting.
    The Annals of thoracic surgery, 2005, Volume: 80, Issue:3

    Topics: Aged; Aprotinin; Blood Loss, Surgical; Blood Transfusion; Blood Volume; Clopidogrel; Coronary Artery

2005
Effects of preoperative aspirin and clopidogrel therapy on perioperative blood loss and blood transfusion requirements in patients undergoing off-pump coronary artery bypass graft surgery.
    The Journal of thoracic and cardiovascular surgery, 2007, Volume: 134, Issue:1

    Topics: Aspirin; Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Drug Administ

2007
[Local hemostasis during the carotid endarterectomy under condition of antithrombocytic therapy].
    Klinichna khirurhiia, 2007, Issue:10

    Topics: Aged; Aprotinin; Blood Coagulation; Blood Loss, Surgical; Blood Volume; Carotid Stenosis; Clopidogre

2007
Clopidogrel pre-treatment in stable angina: for all patients > 6 h before elective coronary angiography or only for angiographically selected patients a few minutes before PCI? A randomized multicentre trial PRAGUE-8.
    European heart journal, 2008, Volume: 29, Issue:12

    Topics: Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Blood Loss, Surgical; Chronic Disease; Clopid

2008
Effect of ticlopidine on blood loss, platelet turnover and platelet deposition on prosthetic surfaces in patients undergoing aorto-femoral bypass grafting.
    Thrombosis research, 1991, Nov-01, Volume: 64, Issue:3

    Topics: Aorta; Blood Loss, Surgical; Blood Platelets; Blood Vessel Prosthesis; Double-Blind Method; Female;

1991

Other Studies

81 other studies available for ticlopidine and Blood Loss, Surgical

ArticleYear
Quantification of bleeding during dental extraction in patients on dual antiplatelet therapy.
    International journal of oral and maxillofacial surgery, 2017, Volume: 46, Issue:9

    Topics: Aspirin; Blood Loss, Surgical; Cardiovascular Diseases; Case-Control Studies; Clopidogrel; Dental Ca

2017
Poor prognosis after surgery for intertrochanteric fracture in elderly patients with clopidogrel treatment: A cohort study.
    Medicine, 2017, Volume: 96, Issue:39

    Topics: Aged; Blood Loss, Surgical; Blood Transfusion; Cardiovascular Diseases; China; Clopidogrel; Cohort S

2017
Risky business? Investigating outcomes of patients undergoing urgent laparoscopic appendectomy on antithrombotic therapy.
    American journal of surgery, 2017, Volume: 214, Issue:6

    Topics: Adult; Appendectomy; Appendicitis; Aspirin; Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Fe

2017
Outcome of Transurethral Resection of Bladder Tumor: Does Antiplatelet Therapy Really Matter? Analysis of a Retrospective Series.
    Journal of endourology, 2017, Volume: 31, Issue:12

    Topics: Aged; Aged, 80 and over; Aspirin; Blood Loss, Surgical; Carcinoma, Transitional Cell; Clopidogrel; C

2017
Balancing thrombotic and bleeding risks related to antiplatelet therapy in coronary bypass surgery: Comment on "Protective effects of tranexamic acid on clopidogrel before coronary artery bypass grafting".
    JAMA surgery, 2013, Volume: 148, Issue:6

    Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass; Female; Humans;

2013
Intractable intraoperative bleeding requiring platelet transfusion during emergent cholecystectomy in a patient with dual antiplatelet therapy after drug-eluting coronary stent implantation (with video).
    BMJ case reports, 2013, Mar-26, Volume: 2013

    Topics: Aged; Aspirin; Blood Loss, Surgical; Cholecystectomy; Coronary Artery Disease; Drug-Eluting Stents;

2013
Operative treatment of hip fractures in patients on clopidogrel: a case-control study.
    The Iowa orthopaedic journal, 2012, Volume: 32

    Topics: Aged; Aged, 80 and over; Blood Loss, Surgical; Blood Transfusion; Case-Control Studies; Clopidogrel;

2012
Perioperative management of a neurosurgical patient with a meningioma and recent coronary artery stent.
    Journal of clinical anesthesia, 2013, Volume: 25, Issue:3

    Topics: Aged; Aspirin; Blood Loss, Surgical; Clopidogrel; Contraindications; Coronary Artery Disease; Drug T

2013
Optimal anticoagulation during off pump coronary artery bypass in patients recently exposed to clopidogrel.
    Yonsei medical journal, 2013, Volume: 54, Issue:5

    Topics: Age Factors; Aged; Anastomosis, Surgical; Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Coro

2013
Withholding clopidogrel for 3 to 6 versus 7 days or more before surgery in hip fracture patients.
    Journal of orthopaedic surgery (Hong Kong), 2013, Volume: 21, Issue:2

    Topics: Aged; Aged, 80 and over; Blood Loss, Surgical; Clopidogrel; Female; Hemorrhage; Hip Fractures; Human

2013
Percutaneous dilational tracheostomy in patients receiving antiplatelet therapy: is it safe?
    Journal of bronchology & interventional pulmonology, 2013, Volume: 20, Issue:4

    Topics: Aged; Blood Loss, Surgical; Case-Control Studies; Clopidogrel; Dilatation; Erythrocyte Indices; Fema

2013
Ticlopidine and clopidogrel, sometimes combined with aspirin, only minimally increase the surgical risk in renal transplantation: a case-control study.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2014, Volume: 29, Issue:2

    Topics: Aspirin; Blood Loss, Surgical; Case-Control Studies; Clopidogrel; Dose-Response Relationship, Drug;

2014
Preoperative fibrinogen and morbidity in patients with residual platelet inhibition undergoing off-pump coronary artery bypass grafting: cause or effect?
    Circulation journal : official journal of the Japanese Circulation Society, 2014, Volume: 78, Issue:7

    Topics: Blood Loss, Surgical; Coronary Artery Bypass, Off-Pump; Female; Fibrinogen; Humans; Male; Platelet A

2014
Should clopidogrel be discontinued before laparoscopic cholecystectomy?
    American journal of surgery, 2014, Volume: 208, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Blood Loss, Surgical; Cholecystectomy, Laparoscopic; Clopidogrel; Fe

2014
Dual Antiplatelet Therapy Prior to Expedited Carotid Surgery Reduces Recurrent Events Prior to Surgery without Significantly Increasing Peri-operative Bleeding Complications.
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2015, Volume: 50, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Loss, Surgical; Carotid Stenosis; Clopidogrel; Drug A

2015
Aspirin and clopidogrel during robotic partial nephrectomy, is it safe?
    The Canadian journal of urology, 2015, Volume: 22, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Loss, Surgical; Clopidogrel; Feasibility Studies; Fem

2015
Predicting Bleeding Risk by Platelet Function Testing in Patients Undergoing Heart Surgery.
    Clinical cardiology, 2015, Volume: 38, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Area Under Curve; Aspirin; Blood Loss, Surgical; Cardiopulmonary Byp

2015
Cochlear Implantation in the Setting of Perioperative Anticoagulation and Antiplatelet Therapy.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2016, Volume: 154, Issue:3

    Topics: Aged; Anticoagulants; Aspirin; Blood Loss, Surgical; Clopidogrel; Cochlear Implantation; Female; Hem

2016
Dental extraction without stopping single or dual antiplatelet therapy: results of a retrospective cohort study.
    International journal of oral and maxillofacial surgery, 2016, Volume: 45, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Loss, Surgical; Female; Humans; Male; Middle Aged; Pl

2016
Effects of Sarpogrelate Combined with Aspirin in Patients Undergoing Carotid Endarterectomy in China: A Single-Center Retrospective Study.
    Annals of vascular surgery, 2016, Volume: 35

    Topics: Aged; Aspirin; Blood Loss, Surgical; Carotid Stenosis; China; Clopidogrel; Drug Therapy, Combination

2016
Preoperative antiplatelet use does not increase incidence of bleeding after major operations.
    Surgery, 2016, Volume: 160, Issue:4

    Topics: Adult; Aged; Blood Loss, Surgical; Clopidogrel; Databases, Factual; Elective Surgical Procedures; Fe

2016
Perioperative clopidogrel is associated with increased bleeding and blood transfusion at the time of lower extremity bypass.
    Journal of vascular surgery, 2017, Volume: 65, Issue:6

    Topics: Aged; Blood Loss, Surgical; Blood Transfusion; Chi-Square Distribution; Clopidogrel; Databases, Fact

2017
Preoperative Use of Clopidogrel Does Not Affect Outcomes for Femoral Neck Fractures Treated With Hemiarthroplasty.
    The Journal of arthroplasty, 2017, Volume: 32, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Blood Loss, Surgical; Cerebrovascular Disorders; Clopidogrel; Comorb

2017
Clopidogrel therapy--implications for hip fracture surgery.
    Injury, 2008, Volume: 39, Issue:10

    Topics: Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Drug Administration Schedule; Follow-Up Studie

2008
Clopidogrel and bleeding after general surgery procedures.
    The American surgeon, 2008, Volume: 74, Issue:8

    Topics: Aged; Blood Loss, Surgical; Clopidogrel; Female; Humans; Male; Platelet Aggregation Inhibitors; Post

2008
Impact of preoperative clopidogrel in off pump coronary artery bypass surgery: a propensity score analysis.
    The Journal of thoracic and cardiovascular surgery, 2009, Volume: 137, Issue:2

    Topics: Aged; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass, Off-Pump; Female; Hemostasis, Surgi

2009
[Bleeding or stent thrombosis in combination with drug-eluting stents].
    Ugeskrift for laeger, 2009, Feb-23, Volume: 171, Issue:9

    Topics: Aneurysm, False; Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass; Drug-Eluting St

2009
Clopidogrel and pregnancy: a situation pregnant with danger?
    Archives of gynecology and obstetrics, 2009, Volume: 280, Issue:4

    Topics: Adult; Blood Loss, Surgical; Clopidogrel; Female; Humans; Platelet Aggregation Inhibitors; Pregnancy

2009
An assessment of cardiopulmonary bypass-induced changes in platelet function using whole blood and classical light transmission aggregometry: the results of a pilot study.
    Anesthesia and analgesia, 2009, Volume: 108, Issue:6

    Topics: Aged; Anesthesia; Aspirin; Blood Loss, Surgical; Blood Platelets; Cardiopulmonary Bypass; Clopidogre

2009
Premature preoperative discontinuation of antiplatelet drug therapy in cardiovascular risk patients: a preliminary study on the role of P2Y12 receptor monitoring.
    European journal of anaesthesiology, 2010, Volume: 27, Issue:2

    Topics: Adult; Aged; Aspirin; Blood Loss, Surgical; Cardiovascular Diseases; Case-Control Studies; Cell Adhe

2010
Should dual antiplatelet therapy after drug-eluting stents be continued for more than 1 year?: Dual antiplatelet therapy after drug-eluting stents should not be continued for more than 1 year and preferably indefinitely.
    Circulation. Cardiovascular interventions, 2008, Volume: 1, Issue:3

    Topics: Angioplasty, Balloon, Coronary; Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Restenosis; Cor

2008
Safety of carotid endarterectomy while on clopidogrel (Plavix). Clinical article.
    Journal of neurosurgery, 2010, Volume: 113, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Loss, Surgical; Clopidogrel; Cohort Studies; Edema; E

2010
[Comment about patients with dual antiplatelet therapy].
    Actas dermo-sifiliograficas, 2010, Volume: 101, Issue:2

    Topics: Anticoagulants; Aspirin; Blood Loss, Surgical; Clopidogrel; Contraindications; Drug Therapy, Combina

2010
The use of clopidogrel (Plavix) in patients undergoing nonelective orthopaedic surgery.
    Journal of orthopaedic trauma, 2010, Volume: 24, Issue:6

    Topics: Aged; Aged, 80 and over; Blood Loss, Surgical; Clopidogrel; Cohort Studies; Contraindications; Femal

2010
Clinical pharmacology: antiplatelet therapy during surgery.
    Heart (British Cardiac Society), 2010, Volume: 96, Issue:12

    Topics: Aspirin; Blood Loss, Surgical; Clopidogrel; Humans; Perioperative Care; Platelet Aggregation Inhibit

2010
Initial experience with an institutional bridging protocol for patients with recent coronary stent implantation requiring discontinuation of dual antiplatelet therapy resulting from urgent surgery.
    American journal of therapeutics, 2011, Volume: 18, Issue:6

    Topics: Antithrombins; Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Thrombosis; Drug-Eluting Stents;

2011
General thoracic surgery is safe in patients taking clopidogrel (Plavix).
    The Journal of thoracic and cardiovascular surgery, 2010, Volume: 140, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Alabama; Angioplasty, Balloon, Coronary; Blood Loss, Surgical; Case-

2010
Assessing the risk of clopidogrel-related bleeding complications in patients undergoing inguinal herniorrhaphy.
    Hernia : the journal of hernias and abdominal wall surgery, 2011, Volume: 15, Issue:1

    Topics: Aged; Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Critical Care; Female; Hematoma; Hernia,

2011
Thromboresistant surfaces with low-dose anticoagulation alleviate clopidogrel-related complications in patients undergoing coronary artery bypass grafting.
    The Journal of thoracic and cardiovascular surgery, 2011, Volume: 141, Issue:3

    Topics: Aged; Anticoagulants; Biocompatible Materials; Blood Loss, Surgical; Blood Transfusion; Boston; Ches

2011
The effect of clopidogrel and aspirin on blood loss in hip fracture surgery.
    Injury, 2011, Volume: 42, Issue:11

    Topics: Aged; Aged, 80 and over; Aspirin; Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Drug Therapy

2011
Cessation of clopidogrel before major abdominal procedures.
    Archives of surgery (Chicago, Ill. : 1960), 2011, Volume: 146, Issue:3

    Topics: Abdomen; Aged; Analysis of Variance; Blood Loss, Surgical; Clopidogrel; Cohort Studies; Confidence I

2011
Peri-operative management of antiplatelet therapy in patients with coronary artery disease: joint position paper by members of the working group on Perioperative Haemostasis of the Society on Thrombosis and Haemostasis Research (GTH), the working group on
    Thrombosis and haemostasis, 2011, Volume: 105, Issue:5

    Topics: Aspirin; Blood Loss, Surgical; Cardiovascular Surgical Procedures; Clopidogrel; Contraindications; C

2011
How do we manage patients treated with antithrombotic therapy in the perioperative interval.
    Transfusion, 2011, Volume: 51, Issue:10

    Topics: Anticoagulants; Antifibrinolytic Agents; Antithrombins; Aspirin; Blood Loss, Surgical; Blood Transfu

2011
Risk assessment of simple phacoemulsification in patients on combined anticoagulant and antiplatelet therapy.
    Journal of cataract and refractive surgery, 2011, Volume: 37, Issue:8

    Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Blood Loss, Surgical; Clopidogrel; Drug Therapy, C

2011
Emergency surgery following trancutaneous aortic valve insertion.
    Anaesthesia and intensive care, 2011, Volume: 39, Issue:4

    Topics: Aged, 80 and over; Aortic Valve; Aspirin; Blood Loss, Surgical; Clopidogrel; Emergency Medical Servi

2011
[Application of activated eptacog alfa in cardiac surgery].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2011, Volume: 31, Issue:181

    Topics: Adult; Aged; Blood Loss, Surgical; Cardiac Surgical Procedures; Clopidogrel; Factor VIIa; Female; Hu

2011
Clopidogrel: is a surgical delay necessary in fractured neck of femur?
    Annals of the Royal College of Surgeons of England, 2011, Volume: 93, Issue:4

    Topics: Aged; Aged, 80 and over; Blood Loss, Surgical; Clopidogrel; Dipyridamole; Female; Femoral Neck Fract

2011
Femoral neck fractures in patients on Clopidogrel. The effect of delaying surgery and the introduction of the new SIGN guidelines.
    The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland, 2011, Volume: 9, Issue:6

    Topics: Aged; Aged, 80 and over; Blood Loss, Surgical; Clopidogrel; Female; Femoral Neck Fractures; Humans;

2011
Perioperative management of patients receiving anticoagulant or antiplatelet therapy: a clinician-oriented and practical approach.
    Hospital practice (1995), 2011, Volume: 39, Issue:4

    Topics: Anticoagulants; Aspirin; Blood Loss, Surgical; Clopidogrel; Evidence-Based Medicine; Humans; Periope

2011
[Perioperative anti-platelet therapy management--protocol suggestion].
    Harefuah, 2011, Volume: 150, Issue:4

    Topics: Aspirin; Blood Loss, Surgical; Clinical Protocols; Clopidogrel; Drug Therapy, Combination; Humans; P

2011
Impact of clopidogrel on bleeding complications and survival in off-pump coronary artery bypass grafting.
    Interactive cardiovascular and thoracic surgery, 2012, Volume: 14, Issue:3

    Topics: Aged; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass, Off-Pump; Coronary Restenosis; Dose

2012
Use of an objective tool to assess platelet inhibition prior to off-pump coronary surgery to reduce blood usage.
    The Journal of invasive cardiology, 2012, Volume: 24, Issue:2

    Topics: Adenosine Diphosphate; Aged; Blood Coagulation Tests; Blood Loss, Surgical; Blood Transfusion; Clopi

2012
Coronary artery bypass graft surgery in patients receiving antiplatelet therapy: can we "fine-tune" the balance of safety and efficacy?
    The Journal of invasive cardiology, 2012, Volume: 24, Issue:2

    Topics: Blood Coagulation Tests; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass, Off-Pump; Female

2012
Platelet transfusion for reversal of dual antiplatelet therapy in patients requiring urgent surgery: a pilot study.
    Journal of thrombosis and haemostasis : JTH, 2012, Volume: 10, Issue:5

    Topics: Aged; Aged, 80 and over; Aspirin; Blood Loss, Surgical; Clopidogrel; Drug Administration Schedule; D

2012
The effects of clopidogrel (Plavix) and other oral anticoagulants on early hip fracture surgery.
    Journal of orthopaedic trauma, 2012, Volume: 26, Issue:10

    Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Blood Loss, Surgical; Clopidogrel; Cohort Studies;

2012
Blood loss and complications following carotid endarterectomy in patients treated with clopidogrel.
    Vascular, 2012, Volume: 20, Issue:4

    Topics: Aged; Aged, 80 and over; Aspirin; Blood Loss, Surgical; Carotid Artery Diseases; Clopidogrel; Drug T

2012
The perioperative management of patients with coronary artery stents: surveying the clinical stakeholders and arriving at a consensus regarding optimal care.
    American journal of surgery, 2012, Volume: 204, Issue:4

    Topics: Adult; Advisory Committees; Alabama; Anesthesiology; Aspirin; Blood Loss, Surgical; Cardiac Catheter

2012
Risk of wound hematoma at carotid endarterectomy under dual antiplatelet therapy.
    Langenbeck's archives of surgery, 2012, Volume: 397, Issue:8

    Topics: Aged; Aspirin; Blood Loss, Surgical; Clopidogrel; Drug Therapy, Combination; Endarterectomy, Carotid

2012
Anticoagulant use and its effect on bleeding and complications in total knee arthroplasty.
    Acta orthopaedica Belgica, 2012, Volume: 78, Issue:2

    Topics: Aged; Anticoagulants; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Clopidogrel; Elective S

2012
Antiplatelet drugs in elective ENT surgery.
    The Journal of laryngology and otology, 2012, Volume: 126, Issue:9

    Topics: Aspirin; Blood Loss, Surgical; Clinical Protocols; Clopidogrel; Data Collection; Elective Surgical P

2012
Management and outcomes of patients on preoperative plavix (clopidogrel) undergoing general thoracic surgery.
    The Thoracic and cardiovascular surgeon, 2013, Volume: 61, Issue:6

    Topics: Aged; Aged, 80 and over; Blood Loss, Surgical; Blood Transfusion; Cardiovascular Diseases; Clopidogr

2013
Clopidogrel has no effect on mortality from hip fracture.
    Injury, 2013, Volume: 44, Issue:6

    Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Arthroplasty, Replacement, Hip; Aspirin; Bl

2013
Safety of clopidogrel in hip fracture surgery.
    Mayo Clinic proceedings, 2013, Volume: 88, Issue:2

    Topics: Aged; Aged, 80 and over; Blood Loss, Surgical; Case-Control Studies; Clopidogrel; Cohort Studies; Fe

2013
Coronary artery bypass graft surgery in patients with recent exposure to clopidogrel and aspirin therapy.
    Journal of the American College of Cardiology, 2003, Apr-16, Volume: 41, Issue:8

    Topics: Aspirin; Blood Component Transfusion; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass; Hum

2003
Clopidogrel and platelet transfusion in patients undergoing coronary artery bypass graft surgery.
    Anaesthesia, 2003, Volume: 58, Issue:6

    Topics: Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass; Humans; Platelet Aggregation Inhibitors;

2003
[Must platelet aggregation inhibitors be discontinued before surgery?].
    Deutsche medizinische Wochenschrift (1946), 2004, Feb-06, Volume: 129, Issue:6

    Topics: Angiography; Aspirin; Blood Loss, Surgical; Clopidogrel; Humans; Pacemaker, Artificial; Platelet Agg

2004
Does clopidogrel increase blood loss following coronary artery bypass surgery?
    The Annals of thoracic surgery, 2004, Volume: 78, Issue:5

    Topics: Aged; Aspirin; Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Critica

2004
Clopidogrel administration prior to coronary artery bypass grafting surgery: the cardiologist's panacea or the surgeon's headache?
    European heart journal, 2005, Volume: 26, Issue:6

    Topics: Aged; Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Coronary Disease

2005
In-hospital patients exposed to clopidogrel before coronary artery bypass graft surgery: a word of caution.
    The Annals of thoracic surgery, 2005, Volume: 79, Issue:4

    Topics: Aged; Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass; Female; Heparin; Hospital

2005
[Antiplatelet agents and regional anaesthesia: experience in 130 patients].
    Annales francaises d'anesthesie et de reanimation, 2005, Volume: 24, Issue:5

    Topics: Aged; Aspirin; Autonomic Nerve Block; Blood Loss, Surgical; Blood Vessel Prosthesis Implantation; Cl

2005
Venous thromboembolism and fractured neck of femur.
    Thrombosis and haemostasis, 2005, Volume: 94, Issue:5

    Topics: Aged; Aged, 80 and over; Anesthesia; Anticoagulants; Aspirin; Blood Loss, Surgical; Blood Transfusio

2005
Clopidogrel (PLAVIX) increases risk of bleeding in a patient undergoing coronary artery bypass grafting.
    The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi, 2006, Volume: 54, Issue:9

    Topics: Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Humans; Meta-Analysis

2006
[Aprotinin reduces bleeding during off-pump coronary artery bypass grafting in a patient on ticlopidine; report of a case].
    Kyobu geka. The Japanese journal of thoracic surgery, 2007, Volume: 60, Issue:12

    Topics: Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Aprotinin; Blood Loss, Surgical; Coronary Ar

2007
The effect of platelet-altering medications on bleeding from minor oral surgery procedures.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2008, Volume: 66, Issue:1

    Topics: Analysis of Variance; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bl

2008
Effects of a waiting period after clopidogrel treatment before performing coronary artery bypass grafting.
    Pharmacotherapy, 2008, Volume: 28, Issue:2

    Topics: Academic Medical Centers; Blood Loss, Surgical; Blood Volume; Clopidogrel; Coronary Artery Bypass; D

2008
The Cataract National Dataset electronic multicentre audit of 55,567 operations: antiplatelet and anticoagulant medications.
    Eye (London, England), 2009, Volume: 23, Issue:1

    Topics: Aged; Anesthetics, Local; Anticoagulants; Aspirin; Blood Loss, Surgical; Cataract Extraction; Choroi

2009
Aspirin and clopidogrel use in the perioperative period for non-cardiac surgery.
    British journal of hospital medicine (London, England : 2005), 2008, Volume: 69, Issue:1

    Topics: Aspirin; Blood Loss, Surgical; Clopidogrel; Drug-Eluting Stents; Humans; Intraoperative Complication

2008
Effect of clopidogrel on bleeding and transfusions after off-pump coronary artery bypass graft surgery: impact of discontinuation prior to surgery.
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2008, Volume: 34, Issue:1

    Topics: Aged; Analysis of Variance; Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Coronary Artery By

2008
Emergency coronary artery bypass grafting (CABG) after failed coronary artery intervention--caution regarding the combined use of aspirin, ticlopidine and abciximab.
    Australian and New Zealand journal of medicine, 1998, Volume: 28, Issue:4

    Topics: Abciximab; Adult; Angina Pectoris; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin;

1998
Glycoprotein IIb/IIIa inhibitors, surgery and bleeding.
    Australian and New Zealand journal of medicine, 1998, Volume: 28, Issue:5

    Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Blood Loss, Surgical; Co

1998
Quality care outcomes in cardiac surgery: the role of evidence-based practice.
    AACN clinical issues, 2001, Volume: 12, Issue:4

    Topics: Aged; Blood Loss, Surgical; California; Clopidogrel; Coronary Artery Bypass; Evidence-Based Medicine

2001