ticlopidine and Blood Loss, Postoperative studies

Ticlopidine: An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
ticlopidine : A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.

Research Excerpts

Excerpt	Relevance	Reference
"Ticagrelor reduces thrombotic events compared with clopidogrel in patients with acute coronary syndrome, but may also increase bleeding complications."	9.19	Coronary artery bypass grafting-related bleeding complications in real-life acute coronary syndrome patients treated with clopidogrel or ticagrelor. ( Albertsson, P; Dellborg, M; Hansson, EC; Jeppsson, A; Rexius, H, 2014)
"Rectal indomethacin has been proven to be effective for prevention of post-ERCP pancreatitis (PEP) but its impact on bleeding after biliary sphincterotomy (BABES) and cardiovascular mortality has not been extensively studied."	9.19	Does rectal indomethacin given for prevention of post-ERCP pancreatitis increase bleeding after biliary endoscopic sphincterotomy or cardiovascular mortality?: Post hoc analysis using prospective clinical trial data. ( Patai, Á; Patai, ÁV; Solymosi, N, 2014)
"Patients with a recently diagnosed ST-elevation myocardial infarction (STEMI) and implanted coronary drug-eluting stent (DES) who need urgent surgery are at increased risk of surgical bleeding unless aspirin and clopidogrel are discontinued beforehand."	9.17	Short-term follow-up of tirofiban as alternative therapy for urgent surgery patients with an implanted coronary drug-eluting stent after ST-elevation myocardial infarction. ( Liu, XH; Qu, Y; Shen, H; Xia, JG, 2013)
"Patients presenting with acute coronary syndrome (ACS) are treated with dual antiplatelet agents, including aspirin and clopidogrel, to prevent mortality and recurrent ischemia."	8.90	Should clopidogrel be discontinued before coronary artery bypass grafting for patients with acute coronary syndrome? A systematic review and meta-analysis. ( Ang, SC; Bannon, PG; Cao, C; Indraratna, P; Manganas, C; Park, J; Yan, TD, 2014)
"This study aimed to analyze the impact of body mass index (BMI) and the metabolic syndrome (MS) on responses to clopidogrel or prasugrel and bleeding risk after acute coronary syndrome."	7.80	Impact of obesity and the metabolic syndrome on response to clopidogrel or prasugrel and bleeding risk in patients treated after coronary stenting. ( Alessi, MC; Bonnet, G; Bonnet, JL; Cuisset, T; Deharo, P; Dutour, A; Gaborit, B; Lambert, M; Loundou, AD; Morange, PE; Pankert, M; Quilici, J; Valéro, R; Verdier, V, 2014)
" the pharmacokinetics of clopidogrel do not allow for bleeding time to return to normal until the drug has been discontinued for five days."	7.78	Operative treatment of hip fractures in patients on clopidogrel: a case-control study. ( Chaput, CD; Patel, KV; Probe, RA; Wallace, HC, 2012)
" In the PLATO (Platelet Inhibition and Patient Outcomes) trial, which randomized 18,624 patients with acute coronary syndromes, ticagrelor compared with clopidogrel significantly reduced the risk of the primary composite end point of cardiovascular (CV) death, myocardial infarction, or stroke (hazard ratio [HR]: 0."	7.77	Ticagrelor versus clopidogrel in patients with acute coronary syndromes undergoing coronary artery bypass surgery: results from the PLATO (Platelet Inhibition and Patient Outcomes) trial. ( Asenblad, N; Bassand, JP; Becker, RC; Cannon, CP; Claeys, MJ; Harrington, RA; Held, C; Horrow, J; Husted, S; James, SK; Mahaffey, KW; Nicolau, JC; Scirica, BM; Storey, RF; Vintila, M; Wallentin, L; Ycas, J, 2011)
"The purpose of our multicenter study was to examine the impact of pre-operative administration of clopidogrel on reoperation rates, incidence of life-threatening bleeding, inpatient length of stay, and other bleeding-related outcomes in acute coronary syndrome (ACS) patients requiring cardiopulmonary bypass (coronary artery bypass graft surgery [CABG]) in a broad cross section of U."	7.74	Impact of clopidogrel in patients with acute coronary syndromes requiring coronary artery bypass surgery: a multicenter analysis. ( Becker, RC; Berger, JS; Edwards, FH; Frye, CB; Harshaw, Q; Steinhubl, SR, 2008)
"Preoperative continuous administration of clopidogrel did not increase the risk of hemorrhagic complications in patients with acute coronary syndrome undergoing isolated off-pump coronary artery bypass surgery."	7.74	Effects of continuous administration of clopidogrel before off-pump coronary artery bypass grafting in patients with acute coronary syndrome. ( Lee, S; Song, SW; Yi, G; Yoo, KJ; Youn, YN, 2008)
"In the Antagonize P2Y12 Treatment Inhibitors by Transfusion of Platelets in an Urgent or Delayed Timing After Acute Coronary Syndrome or Percutaneous Coronary Intervention Presentation-Acute Coronary Syndrome (APTITUDE-ACS) study, patients presenting with acute coronary syndrome or for elective percutaneous coronary intervention, receiving loading doses of clopidogrel (600 mg, n=13 or 900 mg, n=12), prasugrel 60 mg (n=10), or ticagrelor 180 mg (n=10) were included."	5.20	Efficacy of ex vivo autologous and in vivo platelet transfusion in the reversal of P2Y12 inhibition by clopidogrel, prasugrel, and ticagrelor: the APTITUDE study. ( Abtan, J; Amour, J; Barthélémy, O; Brugier, D; Collet, JP; Kerneis, M; Leprince, P; Martin, R; Mercadier, A; Montalescot, G; O'Connor, SA; Silvain, J, 2015)
"Ticagrelor reduces thrombotic events compared with clopidogrel in patients with acute coronary syndrome, but may also increase bleeding complications."	5.19	Coronary artery bypass grafting-related bleeding complications in real-life acute coronary syndrome patients treated with clopidogrel or ticagrelor. ( Albertsson, P; Dellborg, M; Hansson, EC; Jeppsson, A; Rexius, H, 2014)
"Rectal indomethacin has been proven to be effective for prevention of post-ERCP pancreatitis (PEP) but its impact on bleeding after biliary sphincterotomy (BABES) and cardiovascular mortality has not been extensively studied."	5.19	Does rectal indomethacin given for prevention of post-ERCP pancreatitis increase bleeding after biliary endoscopic sphincterotomy or cardiovascular mortality?: Post hoc analysis using prospective clinical trial data. ( Patai, Á; Patai, ÁV; Solymosi, N, 2014)
"Patients with a recently diagnosed ST-elevation myocardial infarction (STEMI) and implanted coronary drug-eluting stent (DES) who need urgent surgery are at increased risk of surgical bleeding unless aspirin and clopidogrel are discontinued beforehand."	5.17	Short-term follow-up of tirofiban as alternative therapy for urgent surgery patients with an implanted coronary drug-eluting stent after ST-elevation myocardial infarction. ( Liu, XH; Qu, Y; Shen, H; Xia, JG, 2013)
"Patients presenting with acute coronary syndrome (ACS) are treated with dual antiplatelet agents, including aspirin and clopidogrel, to prevent mortality and recurrent ischemia."	4.90	Should clopidogrel be discontinued before coronary artery bypass grafting for patients with acute coronary syndrome? A systematic review and meta-analysis. ( Ang, SC; Bannon, PG; Cao, C; Indraratna, P; Manganas, C; Park, J; Yan, TD, 2014)
"Clopidogrel is one of the most commonly prescribed medications and is currently recommended along with aspirin as treatment to be used for 1 year in all patients without contraindications following an acute coronary syndrome."	4.89	Dual antiplatelet therapy with aspirin and clopidogrel: what is the risk in noncardiac surgery? A narrative review. ( Finkel, JB; Marhefka, GD; Weitz, HH, 2013)
" Premature withdrawal of dual antiplatelet therapy carries a substantial risk of stent thrombosis but perioperative continuation of dual antiplatelet therapy is associated with an increased risk of bleeding, particularly in patients treated with the new potent drugs prasugrel and ticagrelor."	4.88	[Platelet function: new drugs, new assays : possible impacts on operative medicine?]. ( Freynhofer, MK; Höchtl, T; Huber, K; Mahla, E; Prüller, F, 2012)
"The patients at greatest risk, when discontinuing clopidogrel therapy, are those with drug eluting stents who may be at risk of stent thrombosis."	4.87	Clopidogrel dilemma for orthopaedic surgeons. ( Bell, G; Fletcher, JP; Fox, JS; Grigg, LE; Steele, MJ, 2011)
" Vorapaxar, a novel platelet thrombin receptor (PAR-1/4) blocker, is currently approved for post-myocardial infarction and peripheral artery disease indications on top of clopidogrel or/and aspirin."	3.83	Continued vorapaxar versus withdrawed clopidogrel both on top of low dose aspirin in patients undergoing heart surgery: A call for randomized trial. ( Bekbossynova, M; Cattaneo, M; Golukhova, E; Kim, MH; Marciniak, TA; Pya, Y; Serebruany, VL, 2016)
"This study aimed to analyze the impact of body mass index (BMI) and the metabolic syndrome (MS) on responses to clopidogrel or prasugrel and bleeding risk after acute coronary syndrome."	3.80	Impact of obesity and the metabolic syndrome on response to clopidogrel or prasugrel and bleeding risk in patients treated after coronary stenting. ( Alessi, MC; Bonnet, G; Bonnet, JL; Cuisset, T; Deharo, P; Dutour, A; Gaborit, B; Lambert, M; Loundou, AD; Morange, PE; Pankert, M; Quilici, J; Valéro, R; Verdier, V, 2014)
"To investigate the association between adenosine diphosphate (ADP)-induced platelet aggregation measured by single-platelet count testing and postoperative blood loss in clopidogrel-treated patients with acute coronary syndromes undergoing coronary artery bypass grafting (CABG)."	3.80	Adenosine diphosphate-induced single-platelet count aggregation and bleeding in clopidogrel-treated patients undergoing coronary artery bypass grafting. ( Dalén, M; Holm, M; Ivert, T; Lindvall, G; van der Linden, J, 2014)
" Many medications (warfarin, heparin, clopidogrel) or physiological factors (elevated International Normalized Ratio [INR], thrombocytopenia, uremia) increase the risk for bleeding."	3.79	The safety of thoracentesis in patients with uncorrected bleeding risk. ( Araujo, KL; Argento, AC; Murphy, TE; Pisani, MA; Puchalski, JT, 2013)
" the pharmacokinetics of clopidogrel do not allow for bleeding time to return to normal until the drug has been discontinued for five days."	3.78	Operative treatment of hip fractures in patients on clopidogrel: a case-control study. ( Chaput, CD; Patel, KV; Probe, RA; Wallace, HC, 2012)
"In this study, clopidogrel use during CEA resulted in a significant risk for developing a neck hematoma, particularly when using a Dacron-patch."	3.77	Outcomes related to antiplatelet or anticoagulation use in patients undergoing carotid endarterectomy. ( Alden, PB; Goldman, JA; Graber, JN; Rizvi, AZ; Rosenbaum, A; Sullivan, TM; Tretinyak, AS, 2011)
" In the PLATO (Platelet Inhibition and Patient Outcomes) trial, which randomized 18,624 patients with acute coronary syndromes, ticagrelor compared with clopidogrel significantly reduced the risk of the primary composite end point of cardiovascular (CV) death, myocardial infarction, or stroke (hazard ratio [HR]: 0."	3.77	Ticagrelor versus clopidogrel in patients with acute coronary syndromes undergoing coronary artery bypass surgery: results from the PLATO (Platelet Inhibition and Patient Outcomes) trial. ( Asenblad, N; Bassand, JP; Becker, RC; Cannon, CP; Claeys, MJ; Harrington, RA; Held, C; Horrow, J; Husted, S; James, SK; Mahaffey, KW; Nicolau, JC; Scirica, BM; Storey, RF; Vintila, M; Wallentin, L; Ycas, J, 2011)
" Preoperative treatment with clopidogrel, particularly when it is continued to the day before surgery, and postoperative arterial hypertension seem to be associated with a higher risk of neck bleeding after CEA, requiring re-exploration in most cases."	3.77	Predictors of neck bleeding after eversion carotid endarterectomy. ( Ballotta, E; Baracchini, C; Gruppo, M; Lorenzetti, R; Mazzalai, F; Meneghetti, G, 2011)
" clopidogrel) is known to be essential in patients in whom percutaneous coronary intervention with stent implantation has been performed in order to prevent stent thrombosis and its fatal consequences."	3.77	[Diagnostic laparoscopy under dual antiplatelet therapy with clopidogrel and aspirin]. ( Buerke, M; Mannes, F; Plehn, A; Schlitt, A; Vogt, A; Werdan, K; Wolf, HH, 2011)
"Studies suggest that extended clopidogrel use after drug-eluting stent (DES) implantation may decrease the risk of myocardial infarction (MI) and death."	3.76	Increased risk of bleeding in patients on clopidogrel therapy after drug-eluting stents implantation: insights from the HMO Research Network-Stent Registry (HMORN-stent). ( Carroll, NM; Go, AS; Ho, PM; Maddox, TM; Magid, DJ; Margolis, K; Powers, JD; Rumsfeld, JS; Shetterly, SM; Tsai, TT; Xu, S, 2010)
"The purpose of our multicenter study was to examine the impact of pre-operative administration of clopidogrel on reoperation rates, incidence of life-threatening bleeding, inpatient length of stay, and other bleeding-related outcomes in acute coronary syndrome (ACS) patients requiring cardiopulmonary bypass (coronary artery bypass graft surgery [CABG]) in a broad cross section of U."	3.74	Impact of clopidogrel in patients with acute coronary syndromes requiring coronary artery bypass surgery: a multicenter analysis. ( Becker, RC; Berger, JS; Edwards, FH; Frye, CB; Harshaw, Q; Steinhubl, SR, 2008)
"There is wide variation in practice regarding the discontinuation of clopidogrel preoperatively in patients due to undergo surgery for femoral neck fractures."	3.74	Is clopidogrel stopped prior to hip fracture surgery--A survey of current practice in the United Kingdom. ( Odutola, A; Palan, J; White, SP, 2007)
"Preoperative continuous administration of clopidogrel did not increase the risk of hemorrhagic complications in patients with acute coronary syndrome undergoing isolated off-pump coronary artery bypass surgery."	3.74	Effects of continuous administration of clopidogrel before off-pump coronary artery bypass grafting in patients with acute coronary syndrome. ( Lee, S; Song, SW; Yi, G; Yoo, KJ; Youn, YN, 2008)
"Among 3,602 patients with STEMI who were enrolled in the HORIZONS-AMI (Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction) trial, all ischemic and bleeding events, including recurrent events, were classified according to the timing of their occurrence as acute (≤24 h after PCI), subacute (1 day to 30 days), and late (30 days to 1 year)."	2.84	Characterization of the Average Daily Ischemic and Bleeding Risk After Primary PCI for STEMI. ( Brener, SJ; Dangas, GD; Deliargyris, EN; Généreux, P; Giustino, G; Kirtane, AJ; Mehran, R; Pocock, SJ; Prats, J; Redfors, B; Stone, GW, 2017)
"Major bleeding was associated with higher short-term mortality (adjusted hazard ratio [HR] 9."	2.80	Association of spontaneous and procedure-related bleeds with short- and long-term mortality after acute coronary syndromes: an analysis from the PLATO trial. ( Becker, RC; Cannon, CP; Ducrocq, G; Harrington, RA; Held, C; Himmelmann, A; Lassila, R; Schulte, PJ; Sorbets, E; Steg, PG; Storey, RF; Wallentin, L, 2015)
"The tranexamic acid regimen was a bolus of 10 mg/kg followed by a maintenance of 10 mg·kg(-1)·h(-1) throughout the surgery."	2.78	[Effectiveness and safety of tranexamic acid in patients receiving on-pump coronary artery bypass grafting without clopidogrel and aspirin cessation]. ( Li, LH; Shi, J; Wang, GY; Wang, YF; Xue, QH; Yuan, S, 2013)
" A low postoperative dose of aprotinin in patients receiving clopidogrel is safe and has comparable effects regarding postoperative bleeding complications as a high dose."	2.75	Low postoperative dose of aprotinin reduces bleeding and is safe in patients receiving clopidogrel before coronary artery bypass surgery. A prospective randomized study. ( Istad, R; Ringdal, MA; Tangen, G; Tølløfsrud, S; Øvrum, E; Øystese, R, 2010)
"Significantly more postoperative blood loss was observed in group 3 compared to group 1 (929+/-472 ml vs 664+/-312 ml; p=0."	2.74	Postoperative blood loss in patients undergoing coronary artery bypass surgery after preoperative treatment with clopidogrel. A prospective randomised controlled study. ( Firanescu, CE; Martens, EJ; Schönberger, JP; Soliman Hamad, MA; van Straten, AH, 2009)
"Clopidogrel in combination with aspirin before CABG is associated with higher postoperative bleeding and morbidity."	2.70	The effect of clopidogrel in combination with aspirin when given before coronary artery bypass grafting. ( Dick, SE; Hongo, RH; Ley, J; Yee, RR, 2002)
"Early surgery appears safe for patients with hip fracture though there may be a small increase in the rate of blood transfusion."	2.52	Is early hip fracture surgery safe for patients on clopidogrel? Systematic review, meta-analysis and meta-regression. ( Doleman, B; Moppett, IK, 2015)
"All the patients presented with carotid artery stenosis >70% (North American Symptomatic Carotid Endarterectomy Trial [NASCET] criteria), which was symptomatic in 42 patients (transient ischemic attack, n = 32; minor stroke, n = 10) and asymptomatic in 146."	1.46	Dual Antiplatelet Therapy Does Not Increase the Risk of Bleeding After Carotid Endarterectomy: Results of a Prospective Study. ( Calio', FG; Illuminati, G; Masci, F; Pizzardi, G; Ricco, JB; Schneider, F, 2017)
"Postoperative hemorrhage was treated successfully in all cases with local measures."	1.42	Postoperative bleeding risk for oral surgery under continued clopidogrel antiplatelet therapy. ( Al-Dam, A; Eichhorn, W; Fraederich, M; Gröbe, A; Haase, M; Hanken, H; Heiland, M; Kluwe, L; Semmusch, J; Smeets, R; Wikner, J; Zeuch, J, 2015)
"The risk of postoperative hemorrhage following gastric ESD was higher in patients with antithrombotic therapy than in those without that therapy."	1.39	The postoperative bleeding rate and its risk factors in patients on antithrombotic therapy who undergo gastric endoscopic submucosal dissection. ( Edogawa, S; Harada, S; Higuchi, K; Kojima, Y; Ota, K; Takeuchi, T; Tokioka, S; Umegaki, E, 2013)
"OH 44195: The insertion of small-bore chest tube in patients receiving clopidogrel can be safe if performed by experienced operators and by using US guidance along with lateral insertion site, which has the lowest risk of lacerating the intercostal arteries."	1.39	Safety of ultrasound-guided small-bore chest tube insertion in patients on clopidogrel. ( Boujaoude, Z; Dammert, P; Pratter, M, 2013)
"Surgical blood loss was measured, and the groups were compared for statistically significant differences in blood loss."	1.35	The effect of platelet-altering medications on bleeding from minor oral surgery procedures. ( Alvarado, F; Campbell, JH; Partridge, CG, 2008)
"Early administration of a combined regimen of clopidogrel and aspirin following off-pump CABG is safe and is associated with a relatively low incidence of major adverse cardiac events, bleeding, PE, and DVT."	1.32	A feasibility study of the safety and efficacy of a combined clopidogrel and aspirin regimen following off-pump coronary artery bypass grafting. ( Benhameid, O; Endo, M; Shennib, H, 2003)

Research

Studies (205)

Authors

Clinical Trials (14)

Trial Overview

Trial Outcomes

Number of Patients Who Had an Early Termination of Procedure

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (0.49)	18.2507
2000's	56 (27.32)	29.6817
2010's	147 (71.71)	24.3611
2020's	1 (0.49)	2.80

Authors	Studies
Manunga, J	1
Pedersen, C	1
Stanberry, L	1
Pai, A	1
Skeik, N	1
Sullivan, TM	2
Oimatsu, Y	1
Kaikita, K	1
Ishii, M	1
Mitsuse, T	1
Ito, M	1
Arima, Y	1
Sueta, D	2
Takahashi, A	1
Iwashita, S	1
Yamamoto, E	1
Kojima, S	1
Hokimoto, S	2
Tsujita, K	1
Cvjetko, I	1
Dovžak Bajs, I	1
Bezjak, M	1
Giustino, G	1
Mehran, R	1
Dangas, GD	1
Kirtane, AJ	1
Redfors, B	1
Généreux, P	1
Brener, SJ	1
Prats, J	1
Pocock, SJ	1
Deliargyris, EN	1
Stone, GW	1
Lin, D	1
Soetikno, RM	1
McQuaid, K	1
Pham, C	1
Doan, G	1
Mou, S	1
Shergill, AK	1
Somsouk, M	1
Rouse, RV	1
Kaltenbach, T	1
Straus, S	1
Haxhibeqiri-Karabdic, I	1
Grabovica, SG	1
Granov, N	1
Wang, Z	1
Xia, LM	1
Song, K	1
Li, XY	1
Lyu, QZ	1
Shen, JQ	1
Finkel, JB	1
Marhefka, GD	1
Weitz, HH	1
Deo, SV	1
Dunlay, SM	1
Shah, IK	1
Altarabsheh, SE	1
Erwin, PJ	1
Boilson, BA	1
Park, SJ	1
Joyce, LD	1
Gandhi, S	1
Narula, N	1
Mosleh, W	1
Marshall, JK	1
Farkouh, M	1
Xie, X	1
Ma, YT	1
Yang, YN	1
Li, XM	1
Ma, X	1
Fu, ZY	1
Zheng, YY	1
Chen, BD	1
Liu, F	1
Wallace, HC	1
Probe, RA	1
Chaput, CD	1
Patel, KV	1
Blais, DM	1
Zukkoor, SM	1
Hayes, C	1
Pickworth, KK	1
Porter, K	1
Firstenberg, MS	1
Kremke, M	1
Tang, M	1
Bak, M	1
Kristensen, KL	1
Hindsholm, K	1
Andreasen, JJ	1
Hjortdal, V	1
Jakobsen, CJ	1
Lee, T	1
Lee, R	1
Xia, JG	1
Qu, Y	1
Shen, H	1
Liu, XH	1
Rubboli, A	1
Limbruno, U	1
Francis, DO	1
Dang, JH	1
Fritz, MA	1
Garrett, CG	1
Puchalski, JT	1
Argento, AC	1
Murphy, TE	1
Araujo, KL	1
Pisani, MA	1
Rosengart, TK	1
Romeiser, JL	1
White, LJ	1
Fratello, A	1
Fallon, E	1
Senzel, L	1
Shroyer, AL	1
Takeuchi, T	1
Ota, K	1
Harada, S	1
Edogawa, S	1
Kojima, Y	1
Tokioka, S	1
Umegaki, E	1
Higuchi, K	1
Girotra, C	1
Padhye, M	1
Mandlik, G	1
Dabir, A	1
Gite, M	1
Dhonnar, R	1
Pandhi, V	1
Vandekar, M	1
Shi, J	1
Wang, YF	1
Xue, QH	1
Yuan, S	1
Wang, GY	1
Li, LH	1
Fischer, C	1
Lümmen, G	1
Pankert, M	1
Quilici, J	1
Loundou, AD	1
Verdier, V	1
Lambert, M	1
Deharo, P	1
Bonnet, G	1
Gaborit, B	1
Morange, PE	1
Valéro, R	1
Dutour, A	1
Bonnet, JL	1
Alessi, MC	1
Cuisset, T	1
Vainrub, S	1
Patanwala, AE	1
Cosgrove, R	1
Poston, R	1
Nolan, PE	1
Dalén, M	3
van der Linden, J	3
Holm, M	2
Lindvall, G	4
Ivert, T	4
Hansson, EC	2
Rexius, H	1
Dellborg, M	1
Albertsson, P	1
Jeppsson, A	2
Mannacio, V	2
Meier, P	2
Antignano, A	2
Di Tommaso, L	2
De Amicis, V	2
Vosa, C	2
Chowdhury, M	1
Shore-Lesserson, L	2
Mais, AM	1
Leyvi, G	1
Manaqibwala, MI	1
Butler, KA	1
Sagebien, CA	1
Daniel, WT	1
Liberman, HA	1
Kilgo, P	1
Puskas, JD	1
Vassiliades, TA	1
Devireddy, C	1
Jaber, W	1
Guyton, RA	1
Halkos, ME	1
Sharma, AD	1
Al-Achi, A	1
Seccombe, JF	1
Hummel, R	1
Preston, M	1
Behrend, D	1
Drews, S	1
Bolliger, D	1
Kaiser, C	1
Grapow, M	1
Reuthebuch, O	1
Eckstein, F	1
Matt, P	1
Cao, C	1
Indraratna, P	1
Ang, SC	1
Manganas, C	1
Park, J	1
Bannon, PG	1
Yan, TD	1
Komiya, R	1
Kamintani, K	1
Kubo, E	1
Hattori, M	1
Kataoka, H	1
Iwase, Y	1
Miyoshi, H	1
Minami, M	1
Kato, S	1
Arai, R	1
Yoshida, H	1
Kasivisvanathan, R	1
Abbassi-Ghadi, N	1
Kumar, S	1
Mackenzie, H	1
Thompson, K	1
James, K	1
Mallett, SV	1
Daels, FP	1
Gaizauskas, A	1
Rioja, J	1
Varshney, AK	1
Erkan, E	1
Ozgok, Y	1
Melekos, M	1
de la Rosette, JJ	1
Sood, A	1
Trinh, QD	1
Ducrocq, G	1
Schulte, PJ	1
Becker, RC	4
Cannon, CP	3
Harrington, RA	2
Held, C	2
Himmelmann, A	1
Lassila, R	1
Storey, RF	2
Sorbets, E	1
Wallentin, L	2
Steg, PG	1
Burcar, I	1
Biocina, B	3
Bulum, J	1
Petricevic, M	3
Zrno Mihaljevic, M	1
Kolic, K	1
van derLinden, J	1
Patel, PA	1
Fleisher, LA	1
Bajkin, BV	1
Urosevic, IM	1
Stankov, KM	1
Petrovic, BB	1
Bajkin, IA	1
Wan, S	1
Patai, Á	1
Solymosi, N	1
Patai, ÁV	1
Gröbe, A	2
Fraederich, M	1
Smeets, R	2
Heiland, M	2
Kluwe, L	2
Zeuch, J	2
Haase, M	2
Wikner, J	1
Hanken, H	2
Semmusch, J	1
Al-Dam, A	1
Eichhorn, W	2
Doleman, B	1
Moppett, IK	1
Omar, HR	1
Socias, SM	1
Powless, RA	1
Sprenker, C	1
Karlnoski, R	1
Mangar, D	1
Camporesi, EM	1
Plicner, D	1
Mazur, P	1
Hymczak, H	1
Stoliński, J	1
Litwinowicz, R	1
Drwiła, R	1
Undas, A	1
Akpinar, MB	1
Atalay, A	1
Atalay, H	1
Dogan, OF	1
Ogawa, H	1
Gielen, CL	1
Bruggemans, EF	1
Stijnen, T	1
Eikenboom, J	1
Tavilla, G	1
Brand, A	1
Klautz, RJ	1
Batchelder, A	1
Hunter, J	1
Cairns, V	1
Sandford, R	1
Munshi, A	1
Naylor, AR	1
Takiuchi, H	1
Tanemoto, K	1
Jidéus, L	1
Åberg, B	1
Bjursten, H	1
Dreifaldt, M	1
Holmgren, A	1
Nozohoor, S	1
Barbu, M	1
Svedjeholm, R	1
Wehrmann, M	1
Birkelbach, M	1
Rendenbach, C	1
Althaus, AB	1
Dovirak, O	1
Chang, P	1
Taylor, KN	1
O'Halloran, TD	1
Wagner, AA	1
O'Connor, SA	1
Amour, J	1
Mercadier, A	2
Martin, R	1
Kerneis, M	1
Abtan, J	1
Brugier, D	1
Silvain, J	1
Barthélémy, O	1
Leprince, P	2
Montalescot, G	2
Collet, JP	2
Čolić, MD	1
Čalija, BM	1
Milosavljević, BM	1
Grdinić, AG	1
Angelkov, LG	1
Sagić, DŽ	1
Kruzliak, P	1
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Babić, RM	1
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Park, TK	1
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Hahn, JY	1
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Choi, SH	1
Choi, JH	1
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Tsai, CY	1
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Jupiter, DC	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
Vacuum vs Manual Drainage During Unilateral Thoracentesis: A Randomized Trial[NCT03496987]		100 participants (Actual)	Interventional	2015-12-01	Completed
Efficacy of Local Hemostatic Management in Implant Surgery in Anticoagulated Patients on Warfarin: a Randomized Clinical Study[NCT04846114]		71 participants (Actual)	Interventional	2016-03-31	Completed
The Effect of Remote Ischemic Preconditioning on Myocardial Injury After Noncardiac Surgery in Patients at a High Risk of Cardiac Events[NCT05733208]		766 participants (Anticipated)	Interventional	2023-05-06	Recruiting
Evaluation of Clopidogrel Use in Peri-Operative General Surgery Patients: A Prospective Study[NCT01960296]	Phase 2	48 participants (Actual)	Interventional	2012-01-31	Completed
Alignment of Treatment Preferences and Repair Type for Veterans With AAA[NCT03115346]		238 participants (Anticipated)	Interventional	2017-04-15	Active, not recruiting
Non-randomized, Open-label, Historical Control, Single Group Assignment Trial of a Reduced Dose of Unfractionated Heparin in Patients Undergoing Percutaneous Coronary Interventions[NCT00735280]	Phase 4	2,505 participants (Actual)	Interventional	2008-08-31	Completed
MONET BRIDGE(Maintenance Of aNtiplatElet Therapy in Patients With Coronary Stenting Undergoing Surgery) - (Mantenimento Della Terapia Antiaggregante Nei Pazienti Portatori di Stent Coronarico Candidati a Chirurgia)[NCT03862651]	Phase 2	140 participants (Anticipated)	Interventional	2019-06-01	Not yet recruiting
Multicenter, Prospective Cohort of Patient With Coronary Stents Undergoing Non Cardiac Surgery or Invasive Procedures.[NCT01045850]		1,312 participants (Actual)	Observational	2006-02-28	Completed
[NCT00857155]		200 participants (Anticipated)	Interventional	2009-01-31	Recruiting
A Prospective, Nonrandomized, Study Comparing the Use of Aspirin and Intraoperative Blood Loss and Postoperative Complications Following Open Inguinal Hernia Repair.[NCT02084615]		300 participants (Anticipated)	Interventional	2014-08-31	Enrolling by invitation
Maintenance Of aNtiplatElet Therapy in Patients With Coronary Stenting Undergoing Surgery[NCT03445273]		1,800 participants (Anticipated)	Observational [Patient Registry]	2018-11-21	Not yet recruiting
A Multicentre, Open-label, Single-arm Phase II Trial on the Efficacy and Safety of Sclerotherapy Using 3% Polidocanol Foam to Treat Second-degree Hemorrhoidal Disease[NCT03791775]	Phase 2	183 participants (Actual)	Interventional	2019-01-02	Completed
PHASE IV Study of Dual Antiplatelet Therapy Versus Oral Anticoagulation for a Short Time to Prevent Cerebral Embolism After Percutaneous Aortic Valve Implantation. Multicenter Randomized Clinical Trial[NCT01642134]	Phase 4	124 participants (Actual)	Interventional	2013-04-30	Completed
Observatory of Anticoagulation After Bioprosthetic Aortic Valve Replacement[NCT01293188]		434 participants (Actual)	Observational	2011-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Patients who had procedure termination prior to complete evacuation of the pleural contents (usually as a result of refractory pain or another symptom that the patient perceived). (NCT03496987)
Timeframe: 5-20 minutes

Pain Change

Intervention	Participants (Count of Participants)
Manual Drainage	1
Vacuum Bottle Drainage	8

"Difference in pain between pre-procedural pain and during drainage pain as measured as the difference between a pre-procedural NPSS pain score (range from 0 (no pain) to 10 (maximum pain)). This was asked again during drainage and the difference between the two was recorded. The values ranged from -10 to 10 (with a more negative number representing a decrease in pain and a more positive number representing an increase in pain)~The scale used is called The Numeric Pain Rating Scale. With ratings from 0-10. Zero is the least amount of pain experienced while 10 is the worst pain possible." (NCT03496987)
Timeframe: 5-20 minutes

Time of Drainage

Intervention	Pre-post NPRS Pain Scale Score (Mean)
Manual Drainage	0.53
Vacuum Bottle Drainage	1.43

Actual time of drainage in seconds for each patient. (NCT03496987)
Timeframe: 5-20 minutes

Volume of Effusion

Etiology of Effusion

Number of Patients Who Had a Complication as a Result of the Procedure

Intervention	seconds (Mean)
Manual Drainage	498.5
Vacuum Bottle Drainage	318.6

Intervention	milliters (Mean)
Manual Drainage	1023
Vacuum Bottle Drainage	1143

Intervention	Participants (Count of Participants)
	Malignant	Paramalignant	Heart Failure	Hepatic Hydrothorax	Post-Cardiothoracic Procedure	Parapneumonic	Unknown
Manual Drainage	13	7	7	3	13	3	3
Vacuum Bottle Drainage	8	2	8	5	17	2	8

Any complications that occur as a direct result of the procedure. We tracked patients for 7 days after the procedure to capture any complications (which is typical clinical practice) (NCT03496987)
Timeframe: <7 days

Average Change in Hematocrit

Intervention	Participants (Count of Participants)
	Pneumothorax	Hemothorax	Clinically Significant Pulmonary Edema
Manual Drainage	0	0	0
Vacuum Bottle Drainage	3	1	1

hematocrit levels change from preoperative to postoperative (NCT01960296)
Timeframe: baseline and Day 1

Average Length of Hospital Stay

Bleeding-related Re-hospitalization

Intervention	percent change (Mean)
Clopidogrel	-3
Discontinue	-1

Intervention	days (Mean)
Clopidogrel	2.2
Discontinue	2.4

Perioperative Bleeding Complications as indicated by bleeding requiring re-admission. (NCT01960296)
Timeframe: up to 90 days post op

Development of Myocardial Infarction or Thrombosis

Perioperative Bleeding Complications

Intervention	participants (Number)
Clopidogrel	1
Discontinue	1

Intervention	participants (Number)
Clopidogrel	0
Discontinue	0

Development of perioperative bleeding complications as indicated for need for blood transfusions, hematoma, and bleeding requiring re-operation. (NCT01960296)
Timeframe: up to 90 days postop

Procedure Estimated Blood Loss

Procedure Time

Same Day Discharged

Intervention	participants (Number)
Clopidogrel	0
Discontinue	0

Intervention	mL (Mean)
Clopidogrel	73.6
Discontinue	52.1

Intervention	minutes (Mean)
Clopidogrel	114.3
Discontinue	100.4

Number of patients discharged on the day of surgery (NCT01960296)
Timeframe: up to 90 days

Article	Year
Dual antiplatelet therapy with aspirin and clopidogrel: what is the risk in noncardiac surgery? A narrative review. Hospital practice (1995), 2013, Volume: 41, Issue:1 Topics: Acute Coronary Syndrome; Clopidogrel; Humans; Perioperative Care; Platelet Aggregation Inhibitors; P	2013
Dual anti-platelet therapy after coronary artery bypass grafting: is there any benefit? A systematic review and meta-analysis. Journal of cardiac surgery, 2013, Volume: 28, Issue:2 Topics: Angina Pectoris; Aspirin; Clopidogrel; Coronary Artery Bypass; Drug Therapy, Combination; Graft Occl	2013
Meta-analysis: colonoscopic post-polypectomy bleeding in patients on continued clopidogrel therapy. Alimentary pharmacology & therapeutics, 2013, Volume: 37, Issue:10 Topics: Clopidogrel; Colonic Polyps; Colonoscopy; Humans; Platelet Aggregation Inhibitors; Postoperative Hem	2013
Should clopidogrel be discontinued before coronary artery bypass grafting for patients with acute coronary syndrome? A systematic review and meta-analysis. The Journal of thoracic and cardiovascular surgery, 2014, Volume: 148, Issue:6 Topics: Acute Coronary Syndrome; Chi-Square Distribution; Clopidogrel; Coronary Artery Bypass; Drug Administ	2014
Aspirin, clopidogrel, and the surgeon. Advances in surgery, 2014, Volume: 48 Topics: Aspirin; Cardiovascular Diseases; Cerebrovascular Disorders; Clopidogrel; Humans; Platelet Aggregati	2014
Is early hip fracture surgery safe for patients on clopidogrel? Systematic review, meta-analysis and meta-regression. Injury, 2015, Volume: 46, Issue:6 Topics: Aged; Aged, 80 and over; Anticoagulants; Blood Transfusion; Clopidogrel; Contraindications; Cross-Se	2015
Perioperative Management to Reduce Cardiovascular Events. Circulation, 2016, Mar-15, Volume: 133, Issue:11 Topics: Adrenergic beta-Antagonists; Aged; Anesthesia; Anticoagulants; Arthroplasty, Replacement, Knee; Aspi	2016
Discontinuation of Plavix Orthopaedics & traumatology, surgery & research : OTSR, 2016, Volume: 102, Issue:8 Topics: Blood Loss, Surgical; Clopidogrel; Hip Fractures; Humans; Platelet Aggregation Inhibitors; Postopera	2016
Oral antiplatelet agents and bleeding risk in relation to major cardiovascular surgery. Current drug safety, 2006, Volume: 1, Issue:3 Topics: Aspirin; Cardiovascular Surgical Procedures; Cilostazol; Clopidogrel; Dipyridamole; Humans; Platelet	2006
Treatment strategies in non-ST-elevation acute coronary syndromes in patients undergoing percutaneous coronary intervention: an evidence-based review of clinical trial results and treatment guidelines: report on a roundtable discussion. Journal of interventional cardiology, 2008, Volume: 21, Issue:4 Topics: Acute Coronary Syndrome; Algorithms; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Cardio	2008
Antiplatelet therapy discontinuation following drug-eluting stent placement: dangers, reasons, and management recommendations. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2009, Dec-01, Volume: 74, Issue:7 Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Administration Schedule; Drug Therapy, Co	2009
Clopidogrel: mechanisms of action and review of the evidence relating to use during skin surgery procedures. Clinical and experimental dermatology, 2010, Volume: 35, Issue:4 Topics: Aspirin; Blood Loss, Surgical; Clopidogrel; Dermatologic Surgical Procedures; Drug Therapy, Combinat	2010
[Discontinuation of treatment with platelet aggregation inhibitors in surgical patients with cardiac stents]. Ugeskrift for laeger, 2010, Mar-15, Volume: 172, Issue:11 Topics: Angioplasty, Balloon, Coronary; Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Thrombosis; Dru	2010
[Current coagulation diagnostics in intensive care medicine]. Medizinische Klinik, Intensivmedizin und Notfallmedizin, 2011, Volume: 106, Issue:3 Topics: Anticoagulants; Aspirin; Blood Coagulation Tests; Clopidogrel; Cost-Benefit Analysis; Early Diagnosi	2011
Clopidogrel dilemma for orthopaedic surgeons. ANZ journal of surgery, 2011, Volume: 81, Issue:11 Topics: Attitude of Health Personnel; Blood Loss, Surgical; Clopidogrel; Decision Making; Dose-Response Rela	2011
[Platelet function: new drugs, new assays : possible impacts on operative medicine?]. Der Anaesthesist, 2012, Volume: 61, Issue:6 Topics: Adenosine; Angioplasty, Balloon, Coronary; Clopidogrel; Humans; Piperazines; Platelet Aggregation; P	2012
Balancing the benefit and risk of oral antiplatelet agents in coronary artery bypass surgery. The Annals of thoracic surgery, 2005, Volume: 80, Issue:2 Topics: Administration, Oral; Aspirin; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Coron	2005
Drug insight: antithrombotic therapy after percutaneous coronary intervention in patients with an indication for anticoagulation. Nature clinical practice. Cardiovascular medicine, 2006, Volume: 3, Issue:12 Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Drug Admi	2006
Low-dose aspirin and clopidogrel: how to act in patients scheduled for day surgery. Current opinion in anaesthesiology, 2007, Volume: 20, Issue:6 Topics: Anesthesia; Aspirin; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Postoperative Hemorrhage;	2007
Guideline on antiplatelet and anticoagulation management in cardiac surgery. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2008, Volume: 34, Issue:1 Topics: Anticoagulants; Aprotinin; Aspirin; Cardiac Surgical Procedures; Clopidogrel; Contraindications; Evi	2008
Guideline on antiplatelet and anticoagulation management in cardiac surgery. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2008, Volume: 34, Issue:1 Topics: Anticoagulants; Aprotinin; Aspirin; Cardiac Surgical Procedures; Clopidogrel; Contraindications; Evi	2008
Guideline on antiplatelet and anticoagulation management in cardiac surgery. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2008, Volume: 34, Issue:1 Topics: Anticoagulants; Aprotinin; Aspirin; Cardiac Surgical Procedures; Clopidogrel; Contraindications; Evi	2008
Guideline on antiplatelet and anticoagulation management in cardiac surgery. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2008, Volume: 34, Issue:1 Topics: Anticoagulants; Aprotinin; Aspirin; Cardiac Surgical Procedures; Clopidogrel; Contraindications; Evi	2008

Article	Year
Characterization of the Average Daily Ischemic and Bleeding Risk After Primary PCI for STEMI. Journal of the American College of Cardiology, 2017, Oct-10, Volume: 70, Issue:15 Topics: Aged; Aspirin; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Percutaneous Cor	2017
Short-term follow-up of tirofiban as alternative therapy for urgent surgery patients with an implanted coronary drug-eluting stent after ST-elevation myocardial infarction. Coronary artery disease, 2013, Volume: 24, Issue:6 Topics: Aged; Aspirin; China; Clopidogrel; Drug Administration Schedule; Drug Substitution; Drug Therapy, Co	2013
Assessment of the risk of haemorrhage and its control following minor oral surgical procedures in patients on anti-platelet therapy: a prospective study. International journal of oral and maxillofacial surgery, 2014, Volume: 43, Issue:1 Topics: Adult; Aged; Aspirin; Blood Loss, Surgical; Clopidogrel; Female; Hemostasis, Surgical; Humans; Male;	2014
[Effectiveness and safety of tranexamic acid in patients receiving on-pump coronary artery bypass grafting without clopidogrel and aspirin cessation]. Zhonghua wai ke za zhi [Chinese journal of surgery], 2013, Jun-01, Volume: 51, Issue:6 Topics: Aged; Aged, 80 and over; Aspirin; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Female; Hu	2013
Coronary artery bypass grafting-related bleeding complications in real-life acute coronary syndrome patients treated with clopidogrel or ticagrelor. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2014, Volume: 46, Issue:4 Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Coronary Artery Bypass; Coronary Thrombosis;	2014
Association of spontaneous and procedure-related bleeds with short- and long-term mortality after acute coronary syndromes: an analysis from the PLATO trial. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2015, Volume: 11, Issue:7 Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Coronary Angiography; Coronary Artery Bypass;	2015
Does rectal indomethacin given for prevention of post-ERCP pancreatitis increase bleeding after biliary endoscopic sphincterotomy or cardiovascular mortality?: Post hoc analysis using prospective clinical trial data. Medicine, 2014, Volume: 93, Issue:26 Topics: Administration, Rectal; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; C	2014
Preoperative platelet aggregation predicts perioperative blood loss and rethoracotomy for bleeding in patients receiving dual antiplatelet treatment prior to coronary surgery. Thrombosis research, 2015, Volume: 136, Issue:3 Topics: Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass; Drug Combinations; Female; Human	2015
Ankaferd blood stopper decreases postoperative bleeding and number of transfusions in patients treated with clopidogrel: a double-blind, placebo-controlled, randomized clinical trial. The heart surgery forum, 2015, Jun-26, Volume: 18, Issue:3 Topics: Aged; Aspirin; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Double-Blind Method; Female;	2015
Stopping antiplatelet medication before coronary artery bypass graft surgery: is there an optimal timing to minimize bleeding? European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2015, Volume: 48, Issue:4 Topics: Aged; Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; D	2015
Efficacy of ex vivo autologous and in vivo platelet transfusion in the reversal of P2Y12 inhibition by clopidogrel, prasugrel, and ticagrelor: the APTITUDE study. Circulation. Cardiovascular interventions, 2015, Volume: 8, Issue:11 Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Female; Humans; Male; Middle Aged; Percutaneo	2015
The evaluation of clopidogrel use in perioperative general surgery patients: a prospective randomized controlled trial. American journal of surgery, 2016, Volume: 211, Issue:6 Topics: Aged; Blood Loss, Surgical; Clopidogrel; Elective Surgical Procedures; Female; General Surgery; Hosp	2016
Carotid Endarterectomy on Antiplatelet Agents in the Era of Point-of-Care Testing. World neurosurgery, 2016, Volume: 93 Topics: Aged; Arizona; Blood Loss, Surgical; Carotid Stenosis; Clopidogrel; Endarterectomy, Carotid; Female;	2016
Aprotinin for patients exposed to clopidogrel before off-pump coronary bypass. Asian cardiovascular & thoracic annals, 2008, Volume: 16, Issue:6 Topics: Adult; Aged; Angina, Unstable; Aprotinin; Blood Transfusion; Chest Tubes; Clopidogrel; Coronary Arte	2008
Postoperative blood loss in patients undergoing coronary artery bypass surgery after preoperative treatment with clopidogrel. A prospective randomised controlled study. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2009, Volume: 36, Issue:5 Topics: Aged; Blood Component Transfusion; Clopidogrel; Coronary Artery Bypass; Drug Administration Schedule	2009
Low postoperative dose of aprotinin reduces bleeding and is safe in patients receiving clopidogrel before coronary artery bypass surgery. A prospective randomized study. Interactive cardiovascular and thoracic surgery, 2010, Volume: 10, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Aprotinin; Blood Transfusion; Cerebrovascular Disorders; Clopidogrel	2010
Modified thromboelastography evaluation of platelet dysfunction in patients undergoing coronary artery surgery. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2010, Volume: 37, Issue:6 Topics: Aged; Aspirin; Blood Platelet Disorders; Clopidogrel; Coronary Artery Bypass; Drug Administration Sc	2010
ISAR-REACT 3A: a study of reduced dose of unfractionated heparin in biomarker negative patients undergoing percutaneous coronary intervention. European heart journal, 2010, Volume: 31, Issue:20 Topics: Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Anticoagulants; Biomarkers; Clopidogrel; Deat	2010
Platelet function measurement-based strategy to reduce bleeding and waiting time in clopidogrel-treated patients undergoing coronary artery bypass graft surgery: the timing based on platelet function strategy to reduce clopidogrel-associated bleeding rela Circulation. Cardiovascular interventions, 2012, Volume: 5, Issue:2 Topics: Aged; Blood Transfusion; Chest Tubes; Clopidogrel; Coronary Artery Bypass; Drainage; Female; Humans;	2012
The effect of preoperative antiplatelet/anticoagulant prophylaxis on postoperative blood loss in cardiac surgery. Anesthesia and analgesia, 2004, Volume: 98, Issue:1 Topics: Adenosine Diphosphate; Aged; Anticoagulants; Body Temperature; Cardiac Surgical Procedures; Clopidog	2004
Clopidogrel does not increase bleeding and allogenic blood transfusion in coronary artery surgery. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2004, Volume: 25, Issue:3 Topics: Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Coronary Disease; Female; Humans; Length of	2004
Clopidogrel and bleeding in patients undergoing elective coronary artery bypass grafting. The Journal of thoracic and cardiovascular surgery, 2004, Volume: 128, Issue:3 Topics: Algorithms; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Elective Surgical Procedures; Fe	2004
Closure devices and vascular complications among percutaneous coronary intervention patients receiving enoxaparin, glycoprotein IIb/IIIa inhibitors, and clopidogrel. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2005, Volume: 64, Issue:3 Topics: Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Clopidogrel; Coronary Angiography; Enoxaparin;	2005
Clopidogrel and bleeding after coronary artery bypass graft surgery. The Annals of thoracic surgery, 2005, Volume: 80, Issue:3 Topics: Aged; Aspirin; Blood Transfusion; Blood Volume; Clopidogrel; Coronary Artery Bypass; Drug Therapy, C	2005
Aprotinin decreases postoperative bleeding and number of transfusions in patients on clopidogrel undergoing coronary artery bypass graft surgery: a double-blind, placebo-controlled, randomized clinical trial. Circulation, 2005, Aug-30, Volume: 112, Issue:9 Suppl Topics: Aged; Angina, Unstable; Anticoagulants; Aprotinin; Blood Transfusion; Clopidogrel; Coronary Artery B	2005
Normalization of platelet reactivity in clopidogrel-treated subjects. Journal of thrombosis and haemostasis : JTH, 2007, Volume: 5, Issue:1 Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Collagen; Cor	2007
Comparison of two antiplatelet regimens (aspirin alone versus aspirin + ticlopidine or clopidogrel) after intracoronary implantation of a carbofilm-coated stent. The American journal of cardiology, 2007, Apr-15, Volume: 99, Issue:8 Topics: Aspirin; Carbon; Cause of Death; Clopidogrel; Coated Materials, Biocompatible; Coronary Disease; Cor	2007
Patients with non-ST-elevation acute coronary syndromes undergoing coronary artery bypass grafting in the modern era of antithrombotic therapy. American heart journal, 2008, Volume: 155, Issue:2 Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Coronary Artery Bypass; Electrocardiography; Enoxaparin;	2008
Antiplatelet activity of clopidogrel in coronary artery bypass graft surgery patients. Thrombosis and haemostasis, 1999, Volume: 82, Issue:5 Topics: Adenosine Diphosphate; Adult; Bleeding Time; Clopidogrel; Coronary Artery Bypass; Female; Humans; Ma	1999
The effect of clopidogrel in combination with aspirin when given before coronary artery bypass grafting. Journal of the American College of Cardiology, 2002, Jul-17, Volume: 40, Issue:2 Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Bypass; Drug Administration Schedule; Female; Humans; In	2002

Article	Year
Impact of continued clopidogrel use on outcomes of patients undergoing carotid endarterectomy. Journal of vascular surgery, 2023, Volume: 78, Issue:2 Topics: Aged; Aspirin; Carotid Stenosis; Clopidogrel; Endarterectomy, Carotid; Female; Humans; Male; Myocard	2023
Total Thrombus-formation Analysis System Predicts Periprocedural Bleeding Events in Patients With Coronary Artery Disease Undergoing Percutaneous Coronary Intervention. Journal of the American Heart Association, 2017, Apr-24, Volume: 6, Issue:4 Topics: Aged; Aged, 80 and over; Aspirin; Blood Coagulation Tests; Clopidogrel; Coronary Artery Disease; Fem	2017
[Carotid Endarterectomy in Patients with Antiaggregation Therapy]. Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti, 2016, Volume: 70, Issue:2 Topics: Aged; Anticoagulants; Carotid Artery Diseases; Clopidogrel; Croatia; Drug Therapy, Combination; Enda	2016
Risk factors for postpolypectomy bleeding in patients receiving anticoagulation or antiplatelet medications. Gastrointestinal endoscopy, 2018, Volume: 87, Issue:4 Topics: Aged; Anticoagulants; Aspirin; Case-Control Studies; Clopidogrel; Colonic Polyps; Colonoscopy; Color	2018
A Difference in Bleeding and Use of Blood and Blood Products in Patients who Were Preoperatively on Aspirin or Dual Antiplatelet Therapy Before Coronary Artery Bypass Grafting. Medical archives (Sarajevo, Bosnia and Herzegovina), 2018, Volume: 72, Issue:1 Topics: Aged; Aspirin; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Female; Humans; Male; Middle	2018
[Impact of discontinuation of aspirin and clopidogrel before off-pump coronary artery bypass grafting on postoperative bleeding and transfusion requirement]. Zhonghua wai ke za zhi [Chinese journal of surgery], 2019, Mar-01, Volume: 57, Issue:3 Topics: Aged; Aspirin; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Female; Humans; Male; Middle	2019
PCI patients taking oral anticoagulants may not need aspirin. BMJ (Clinical research ed.), 2013, Feb-20, Volume: 346 Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Atrial Flutter; Clopidogrel; Drug Therapy, Combination	2013
CYP2C19 phenotype, stent thrombosis, myocardial infarction, and mortality in patients with coronary stent placement in a Chinese population. PloS one, 2013, Volume: 8, Issue:3 Topics: Aged; Alleles; Aryl Hydrocarbon Hydroxylases; Asian People; Clopidogrel; Cytochrome P-450 CYP2C19; F	2013
Operative treatment of hip fractures in patients on clopidogrel: a case-control study. The Iowa orthopaedic journal, 2012, Volume: 32 Topics: Aged; Aged, 80 and over; Blood Loss, Surgical; Blood Transfusion; Case-Control Studies; Clopidogrel;	2012
Bleeding outcomes associated with coronary artery bypass graft surgery and recent clopidogrel exposure. The heart surgery forum, 2013, Volume: 16, Issue:2 Topics: Causality; Clopidogrel; Comorbidity; Coronary Artery Bypass; Drug-Related Side Effects and Adverse R	2013
Antiplatelet therapy at the time of coronary artery bypass grafting: a multicentre cohort study. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2013, Volume: 44, Issue:2 Topics: Aged; Analysis of Variance; Aspirin; Blood Transfusion; Clopidogrel; Cohort Studies; Coronary Artery	2013
Ask the doctors. I recently had a drug-eluting stent placed in one of my coronary arteries after an episode of severe chest pain. My doctor told me I had to take Plavix every day. Now I feel perfectly fine-except for my right hip. I need a hip replace Harvard heart letter : from Harvard Medical School, 2013, Volume: 23, Issue:6 Topics: Anticoagulants; Clopidogrel; Coronary Disease; Health Behavior; Hip Fractures; Humans; Platelet Aggr	2013
[The WOEST study]. Giornale italiano di cardiologia (2006), 2013, Volume: 14, Issue:9 Topics: Aspirin; Clopidogrel; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; P	2013
Antiplatelet and anticoagulation therapy in microlaryngeal surgery. The Laryngoscope, 2014, Volume: 124, Issue:4 Topics: Adult; Aged; Aspirin; Clopidogrel; Female; Fibrinolytic Agents; Follow-Up Studies; Humans; Incidence	2014
The safety of thoracentesis in patients with uncorrected bleeding risk. Annals of the American Thoracic Society, 2013, Volume: 10, Issue:4 Topics: Aged; Aged, 80 and over; Anticoagulants; Blood Coagulation Disorders; Clopidogrel; Cohort Studies; D	2013
Platelet activity measured by a rapid turnaround assay identifies coronary artery bypass grafting patients at increased risk for bleeding and transfusion complications after clopidogrel administration. The Journal of thoracic and cardiovascular surgery, 2013, Volume: 146, Issue:5 Topics: Aged; Blood Platelets; Chi-Square Distribution; Clopidogrel; Coronary Artery Bypass; Decision Suppor	2013
The postoperative bleeding rate and its risk factors in patients on antithrombotic therapy who undergo gastric endoscopic submucosal dissection. BMC gastroenterology, 2013, Sep-06, Volume: 13 Topics: Adenoma; Aged; Anti-Ulcer Agents; Anticoagulants; Aspirin; Carcinoma; Case-Control Studies; Clopidog	2013
[ASA and clopidogrel for urological operations. Perioperative management]. Der Urologe. Ausg. A, 2013, Volume: 52, Issue:11 Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Humans; Perioperative Care; Platelet Aggregation Inhi	2013
Impact of obesity and the metabolic syndrome on response to clopidogrel or prasugrel and bleeding risk in patients treated after coronary stenting. The American journal of cardiology, 2014, Jan-01, Volume: 113, Issue:1 Topics: Aged; Clopidogrel; Coronary Artery Disease; Female; Humans; Incidence; Male; Metabolic Syndrome; Mid	2014
Bleeding outcomes in patients given clopidogrel within 5 days of robotic coronary artery bypass graft procedure. The Annals of pharmacotherapy, 2014, Volume: 48, Issue:1 Topics: Academic Medical Centers; Aged; Clopidogrel; Coronary Artery Bypass; Female; Humans; Male; Middle Ag	2014
Adenosine diphosphate-induced single-platelet count aggregation and bleeding in clopidogrel-treated patients undergoing coronary artery bypass grafting. Journal of cardiothoracic and vascular anesthesia, 2014, Volume: 28, Issue:2 Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Anesthesia; Aspirin; Blood Transfusion; Chest	2014
Individualized strategy for clopidogrel suspension in patients undergoing off-pump coronary surgery for acute coronary syndrome: a case-control study. The Journal of thoracic and cardiovascular surgery, 2014, Volume: 148, Issue:4 Topics: Acute Coronary Syndrome; Case-Control Studies; Clopidogrel; Coronary Artery Bypass, Off-Pump; Female	2014
Thromboelastograph with Platelet Mapping(TM) predicts postoperative chest tube drainage in patients undergoing coronary artery bypass grafting. Journal of cardiothoracic and vascular anesthesia, 2014, Volume: 28, Issue:2 Topics: Adenosine Diphosphate; Aged; Algorithms; Blood Transfusion; Body Mass Index; Chest Tubes; Clopidogre	2014
Complications of hip fracture surgery on patients receiving clopidogrel therapy. Archives of orthopaedic and trauma surgery, 2014, Volume: 134, Issue:6 Topics: Aged; Aged, 80 and over; Clopidogrel; Female; Hemiarthroplasty; Hip Fractures; Humans; Male; Platele	2014
The impact of clopidogrel therapy on postoperative bleeding after robotic-assisted coronary artery bypass surgery. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2014, Volume: 46, Issue:1 Topics: Blood Transfusion; Chest Tubes; Clopidogrel; Coronary Artery Bypass; Drainage; Female; Humans; Logis	2014
Does incorporation of thromboelastography improve bleeding prediction following adult cardiac surgery? Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2014, Volume: 25, Issue:6 Topics: Age Factors; Aged; Blood Platelets; Cardiopulmonary Bypass; Chest Tubes; Clopidogrel; Female; Fibrin	2014
Prasugrel increases the need for platelet transfusions and surgical reexploration rates compared with clopidogrel in coronary artery bypass surgery. The Thoracic and cardiovascular surgeon, 2015, Volume: 63, Issue:1 Topics: Anticoagulants; Clopidogrel; Coronary Artery Bypass; Forecasting; Humans; Logistic Models; Piperazin	2015
[Perioperative management and postoperative complication rates of patients on dual antiplatelet therapies after coronary drug eluting stent implantation]. Masui. The Japanese journal of anesthesiology, 2014, Volume: 63, Issue:6 Topics: Aged; Aged, 80 and over; Aspirin; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Percutaneo	2014
Risk of bleeding and adverse outcomes predicted by thromboelastography platelet mapping in patients taking clopidogrel within 7 days of non-cardiac surgery. The British journal of surgery, 2014, Volume: 101, Issue:11 Topics: Aged; Case-Control Studies; Clopidogrel; Erythrocyte Transfusion; Female; Humans; Male; Middle Aged;	2014
Age-related prevalence of diabetes mellitus, cardiovascular disease and anticoagulation therapy use in a urolithiasis population and their effect on outcomes: the Clinical Research Office of the Endourological Society Ureteroscopy Global Study. World journal of urology, 2015, Volume: 33, Issue:6 Topics: Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Cardiovascula	2015
Perioperative aspirin: to give or not to give? BJU international, 2014, Volume: 114, Issue:3 Topics: Aspirin; Blood Transfusion; Coronary Artery Bypass; Coronary Disease; Female; Fibrinolytic Agents; H	2014
How to optimize an individualized strategy for antiplatelet drug administration and discontinuation management using platelet function testing? The Journal of thoracic and cardiovascular surgery, 2014, Volume: 148, Issue:4 Topics: Acute Coronary Syndrome; Clopidogrel; Coronary Artery Bypass, Off-Pump; Female; Humans; Male; Platel	2014
Reply to the editor. The Journal of thoracic and cardiovascular surgery, 2014, Volume: 148, Issue:4 Topics: Acute Coronary Syndrome; Clopidogrel; Coronary Artery Bypass, Off-Pump; Female; Humans; Male; Platel	2014
Association between adenosine diphosphate-induced platelet aggregation and bleeding outcome in coronary artery surgery. Journal of cardiothoracic and vascular anesthesia, 2014, Volume: 28, Issue:6 Topics: Adenosine Diphosphate; Coronary Artery Bypass; Female; Humans; Male; Platelet Aggregation; Platelet	2014
Response to letter by Petricevic et al regarding "Adenosine diphosphate-induced single-platelet count aggregation and bleeding in clopidogrel-treated patients undergoing coronary artery bypass grafting". Journal of cardiothoracic and vascular anesthesia, 2014, Volume: 28, Issue:6 Topics: Adenosine Diphosphate; Coronary Artery Bypass; Female; Humans; Male; Platelet Aggregation; Platelet	2014
Dental extractions and risk of bleeding in patients taking single and dual antiplatelet treatment. The British journal of oral & maxillofacial surgery, 2015, Volume: 53, Issue:1 Topics: Absorbable Implants; Aged; Aspirin; Clopidogrel; Collagen; Ecchymosis; Female; Hematoma; Hemostasis,	2015
Right here waiting...? The Journal of thoracic and cardiovascular surgery, 2014, Volume: 148, Issue:6 Topics: Acute Coronary Syndrome; Clopidogrel; Coronary Artery Bypass; Humans; Platelet Aggregation Inhibitor	2014
Postoperative bleeding risk for oral surgery under continued clopidogrel antiplatelet therapy. BioMed research international, 2015, Volume: 2015 Topics: Aged; Case-Control Studies; Clopidogrel; Female; Humans; Male; Middle Aged; Oral Surgical Procedures	2015
Clopidogrel is not associated with increased bleeding complications after full-mouth extraction: A retrospective study. Journal of the American Dental Association (1939), 2015, Volume: 146, Issue:5 Topics: Aspirin; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperat	2015
Could perioperative bleeding complications be predicted using a platelet aggregation test? Thrombosis research, 2015, Volume: 136, Issue:3 Topics: Aspirin; Coronary Artery Bypass; Female; Humans; Male; Platelet Function Tests; Postoperative Hemorr	2015
Dual Antiplatelet Therapy Prior to Expedited Carotid Surgery Reduces Recurrent Events Prior to Surgery without Significantly Increasing Peri-operative Bleeding Complications. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2015, Volume: 50, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Loss, Surgical; Carotid Stenosis; Clopidogrel; Drug A	2015
Optimal timing of clopidogrel discontinuation in Japanese patients: platelet aggregation test using the VerifyNow® system. General thoracic and cardiovascular surgery, 2015, Volume: 63, Issue:11 Topics: Aged; Aortic Valve; Bleeding Time; Cardiac Surgical Procedures; Clopidogrel; Coronary Artery Bypass,	2015
Coronary artery bypass grafting-related bleeding complications in patients treated with ticagrelor or clopidogrel: a nationwide study. European heart journal, 2016, Jan-07, Volume: 37, Issue:2 Topics: Adenosine; Aged; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Female; Humans; Male; Plate	2016
Increased Postoperative Bleeding Risk among Patients with Local Flap Surgery under Continued Clopidogrel Therapy. BioMed research international, 2015, Volume: 2015 Topics: Aged; Clopidogrel; Female; Humans; Male; Middle Aged; Postoperative Hemorrhage; Risk Factors; Surgic	2015
Aspirin and clopidogrel during robotic partial nephrectomy, is it safe? The Canadian journal of urology, 2015, Volume: 22, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Loss, Surgical; Clopidogrel; Feasibility Studies; Fem	2015
Low On-Treatment Platelet Reactivity Predicts Long-Term Risk of Bleeding After Elective PCI. Journal of interventional cardiology, 2015, Volume: 28, Issue:6 Topics: Aged; Aspirin; Clopidogrel; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; P	2015
Clopidogrel Versus Aspirin as an Antiplatelet Monotherapy After 12-Month Dual-Antiplatelet Therapy in the Era of Drug-Eluting Stents. Circulation. Cardiovascular interventions, 2016, Volume: 9, Issue:1 Topics: Aged; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Drug-Eluting Stents; Female; Humans; I	2016
Dental extraction without stopping single or dual antiplatelet therapy: results of a retrospective cohort study. International journal of oral and maxillofacial surgery, 2016, Volume: 45, Issue:10 Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Loss, Surgical; Female; Humans; Male; Middle Aged; Pl	2016
Impact of preoperative dual antiplatelet therapy on bleeding complications in patients with acute coronary syndromes who undergo urgent coronary artery bypass grafting. Journal of cardiology, 2017, Volume: 69, Issue:1 Topics: Acute Coronary Syndrome; Aged; Aspirin; Blood Transfusion; Clopidogrel; Coronary Angiography; Corona	2017
Safety of Continued Clopidogrel Use in the Preoperative Course of Gastrointestinal Surgery: A Retrospective Cohort Study. Annals of surgery, 2017, Volume: 265, Issue:2 Topics: Aged; Aged, 80 and over; Clopidogrel; Digestive System Surgical Procedures; Drug Administration Sche	2017
Timing of Coronary Bypass Surgery in Patients Receiving Clopidogrel: The Role of VerifyNow. The Canadian journal of cardiology, 2016, Volume: 32, Issue:6 Topics: Clopidogrel; Coronary Artery Bypass; Guidelines as Topic; Humans; Platelet Aggregation Inhibitors; P	2016
Continued vorapaxar versus withdrawed clopidogrel both on top of low dose aspirin in patients undergoing heart surgery: A call for randomized trial. International journal of cardiology, 2016, Jul-15, Volume: 215 Topics: Aspirin; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Female; Humans; Lactones; Mal	2016
Coronary artery bypass grafting-related bleeding complications in patients treated with dual antiplatelet treatment. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2016, Volume: 50, Issue:5 Topics: Adenosine; Aged; Aspirin; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Drug Administratio	2016
Preoperative antiplatelet use does not increase incidence of bleeding after major operations. Surgery, 2016, Volume: 160, Issue:4 Topics: Adult; Aged; Blood Loss, Surgical; Clopidogrel; Databases, Factual; Elective Surgical Procedures; Fe	2016
Dual Antiplatelet Therapy Does Not Increase the Risk of Bleeding After Carotid Endarterectomy: Results of a Prospective Study. Annals of vascular surgery, 2017, Volume: 40 Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Asymptomatic Diseases; Carotid Stenosis; Clopidogr	2017
Perioperative clopidogrel is associated with increased bleeding and blood transfusion at the time of lower extremity bypass. Journal of vascular surgery, 2017, Volume: 65, Issue:6 Topics: Aged; Blood Loss, Surgical; Blood Transfusion; Chi-Square Distribution; Clopidogrel; Databases, Fact	2017
Improved Pig Model to Evaluate Heart Valve Thrombosis. The Journal of heart valve disease, 2016, Volume: 25, Issue:5 Topics: Animals; Aspirin; Blood Coagulation; Blood Platelets; Clopidogrel; Disease Models, Animal; Heart Val	2016
[Impact of preoperative clopidogrel in coronary artery bypass grafting]. Zhonghua wai ke za zhi [Chinese journal of surgery], 2008, Feb-15, Volume: 46, Issue:4 Topics: Aged; Clopidogrel; Coronary Artery Bypass; Female; Humans; Male; Middle Aged; Platelet Aggregation I	2008
Clopidogrel and bleeding after general surgery procedures. The American surgeon, 2008, Volume: 74, Issue:8 Topics: Aged; Blood Loss, Surgical; Clopidogrel; Female; Humans; Male; Platelet Aggregation Inhibitors; Post	2008
Impact of clopidogrel in patients with acute coronary syndromes requiring coronary artery bypass surgery: a multicenter analysis. Journal of the American College of Cardiology, 2008, Nov-18, Volume: 52, Issue:21 Topics: Acute Coronary Syndrome; Age Distribution; Aged; Analysis of Variance; Clopidogrel; Cohort Studies;	2008
Clopidogrel use and bleeding after coronary artery bypass graft surgery. American heart journal, 2008, Volume: 156, Issue:5 Topics: Clopidogrel; Coronary Artery Bypass; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibit	2008
[Bleeding or stent thrombosis in combination with drug-eluting stents]. Ugeskrift for laeger, 2009, Feb-23, Volume: 171, Issue:9 Topics: Aneurysm, False; Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass; Drug-Eluting St	2009
A survey of the peri-operative management of urological patients on clopidogrel. Annals of the Royal College of Surgeons of England, 2009, Volume: 91, Issue:4 Topics: Anesthesia; Clopidogrel; Elective Surgical Procedures; Humans; Intraoperative Care; Medical Staff, H	2009
[Percutaneous endoscopic gastrostomy. Complications with and without anticoagulation]. Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 2010, Volume: 81, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Child; Child, Preschool; Clopid	2010
Rethinking loading dose clopidogrel in light of increased bleeding complications in bypass patients. Journal of the American College of Cardiology, 2009, Jun-30, Volume: 54, Issue:1 Topics: Acute Coronary Syndrome; Clopidogrel; Coronary Artery Bypass; Humans; Platelet Aggregation Inhibitor	2009
Effect of clopidogrel on perioperative blood loss and transfusion in coronary artery bypass graft surgery. Interactive cardiovascular and thoracic surgery, 2010, Volume: 10, Issue:1 Topics: Aged; Aspirin; Blood Transfusion; Cardiopulmonary Bypass; Clopidogrel; Coronary Artery Bypass; Drug	2010
Perioperative clopidogrel is seven days enough? The American surgeon, 2009, Volume: 75, Issue:10 Topics: Adult; Aged; Aged, 80 and over; Blood Transfusion; Clopidogrel; Cohort Studies; Drug Administration	2009
eComment: Controversies on the antiplatelet therapy before coronary artery bypass grafting surgery. Interactive cardiovascular and thoracic surgery, 2010, Volume: 10, Issue:1 Topics: Aspirin; Blood Transfusion; Cardiopulmonary Bypass; Clopidogrel; Coronary Artery Bypass; Drug Therap	2010
The relationship between warfarin, aspirin, and clopidogrel continuation in the peri-procedural period and the incidence of hematoma formation after device implantation. Pacing and clinical electrophysiology : PACE, 2010, Volume: 33, Issue:4 Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Clopidogrel; Defibrillators, Implantable; Female;	2010
Impact of clopidogrel use on mortality and major bleeding in patients undergoing coronary artery bypass surgery. Interactive cardiovascular and thoracic surgery, 2010, Volume: 10, Issue:5 Topics: Analysis of Variance; Clopidogrel; Cohort Studies; Coronary Angiography; Coronary Artery Bypass; Cor	2010
Clopidogrel increases blood transfusion and hemorrhagic complications in patients undergoing cardiac surgery. The Annals of thoracic surgery, 2010, Volume: 89, Issue:2 Topics: Aged; Aged, 80 and over; Blood Transfusion; Cardiopulmonary Bypass; Clopidogrel; Coronary Artery Byp	2010
Triple therapy: the future or from the past? EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2010, Volume: 5, Issue:6 Topics: Administration, Oral; Anticoagulants; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combinatio	2010
[Comment about patients with dual antiplatelet therapy]. Actas dermo-sifiliograficas, 2010, Volume: 101, Issue:2 Topics: Anticoagulants; Aspirin; Blood Loss, Surgical; Clopidogrel; Contraindications; Drug Therapy, Combina	2010
Postpolypectomy bleeding in patients undergoing colonoscopy on uninterrupted clopidogrel therapy. Gastrointestinal endoscopy, 2010, Volume: 71, Issue:6 Topics: Aged; Clopidogrel; Colonic Polyps; Colonoscopy; Female; Gastrointestinal Hemorrhage; Humans; Logisti	2010
Comment on "variations in the pharmacological management of patients treated with carotid endarterectomy: a survey of European vascular surgeons". European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2010, Volume: 39, Issue:6 Topics: Aspirin; Carotid Artery Diseases; Clopidogrel; Endarterectomy, Carotid; Europe; Humans; Incidence; P	2010
Usefulness of monitoring platelet function by multiple electrode aggregometry in primary coronary artery bypass surgery. Journal of cardiothoracic and vascular anesthesia, 2011, Volume: 25, Issue:1 Topics: Aged; Anesthesia, General; Aspirin; Blood Transfusion; Blood Volume; Clopidogrel; Coronary Artery By	2011
Plasma sequestration: a good therapy to prevent the deleterious effect of clopidogrel when clopidogrel is used within one to four days of coronary bypass surgery. Perfusion, 2010, Volume: 25, Issue:2 Topics: Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Critical Care; Erythrocyte Transfusion	2010
Increased risk of bleeding in patients on clopidogrel therapy after drug-eluting stents implantation: insights from the HMO Research Network-Stent Registry (HMORN-stent). Circulation. Cardiovascular interventions, 2010, Jun-01, Volume: 3, Issue:3 Topics: Aged; Clopidogrel; Comorbidity; Drug-Eluting Stents; Female; Follow-Up Studies; Health Maintenance O	2010
Dual antiplatelet therapy and heparin "bridging" significantly increase the risk of bleeding complications after pacemaker or implantable cardioverter-defibrillator device implantation. Journal of the American College of Cardiology, 2010, May-25, Volume: 55, Issue:21 Topics: Aged; Aged, 80 and over; Aspirin; Case-Control Studies; Clopidogrel; Confidence Intervals; Defibrill	2010
Efficiency of preoperative tranexamic Acid in coronary bypass surgery: an analysis correlated with preoperative clopidogrel use. The heart surgery forum, 2010, Volume: 13, Issue:3 Topics: Aged; Antifibrinolytic Agents; Blood Transfusion; Clopidogrel; Confidence Intervals; Coronary Artery	2010
Clopidogrel and burns: platelet replacement therapy may not prevent postoperative bleeding. Burns : journal of the International Society for Burn Injuries, 2010, Volume: 36, Issue:7 Topics: Aged; Burns; Clopidogrel; Epinephrine; Hemostatics; Humans; Ischemic Attack, Transient; Male; Platel	2010
Initial experience with an institutional bridging protocol for patients with recent coronary stent implantation requiring discontinuation of dual antiplatelet therapy resulting from urgent surgery. American journal of therapeutics, 2011, Volume: 18, Issue:6 Topics: Antithrombins; Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Thrombosis; Drug-Eluting Stents;	2011
Hand surgery on anticoagulated patients: a prospective study of 121 operations. Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand, 2010, Volume: 15, Issue:2 Topics: Anticoagulants; Aspirin; Clopidogrel; Hand; Hemostasis, Surgical; Humans; International Normalized R	2010
General thoracic surgery is safe in patients taking clopidogrel (Plavix). The Journal of thoracic and cardiovascular surgery, 2010, Volume: 140, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Alabama; Angioplasty, Balloon, Coronary; Blood Loss, Surgical; Case-	2010
Outcomes related to antiplatelet or anticoagulation use in patients undergoing carotid endarterectomy. Annals of vascular surgery, 2011, Volume: 25, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Chi-Square Distribution; Clopidogrel; Endar	2011
Assessing the risk of clopidogrel-related bleeding complications in patients undergoing inguinal herniorrhaphy. Hernia : the journal of hernias and abdominal wall surgery, 2011, Volume: 15, Issue:1 Topics: Aged; Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Critical Care; Female; Hematoma; Hernia,	2011
Letter by Lozano et al regarding article, "Increased risk of bleeding in patients on clopidogrel therapy after drug-eluting stents implantation: insights from the HMO Research Network-Stent Registry (HMORN-stent)". Circulation. Cardiovascular interventions, 2010, Volume: 3, Issue:5 Topics: Clopidogrel; Coronary Artery Disease; Drug-Eluting Stents; Humans; Myocardial Infarction; Postoperat	2010
Thromboresistant surfaces with low-dose anticoagulation alleviate clopidogrel-related complications in patients undergoing coronary artery bypass grafting. The Journal of thoracic and cardiovascular surgery, 2011, Volume: 141, Issue:3 Topics: Aged; Anticoagulants; Biocompatible Materials; Blood Loss, Surgical; Blood Transfusion; Boston; Ches	2011
Ticagrelor versus clopidogrel in patients with acute coronary syndromes undergoing coronary artery bypass surgery: results from the PLATO (Platelet Inhibition and Patient Outcomes) trial. Journal of the American College of Cardiology, 2011, Feb-08, Volume: 57, Issue:6 Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Coronary Artery Bypass; Double-Blind Method;	2011
Mechanisms potentially contributing to the reduction in mortality associated with ticagrelor therapy. Journal of the American College of Cardiology, 2011, Feb-08, Volume: 57, Issue:6 Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Coronary Artery Bypass; Female; Humans; Male; Posto	2011
The effect of clopidogrel and aspirin on blood loss in hip fracture surgery. Injury, 2011, Volume: 42, Issue:11 Topics: Aged; Aged, 80 and over; Aspirin; Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Drug Therapy	2011
Does preoperative clopidogrel increase bleeding after coronary bypass surgery? Asian cardiovascular & thoracic annals, 2011, Volume: 19, Issue:1 Topics: Adult; Aged; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Drug Administration Schedule; F	2011
Antiplatelet and anticoagulation therapy in vitreoretinal surgery. American journal of ophthalmology, 2011, Volume: 151, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Case-Control Studies; Child; Cl	2011
Cessation of clopidogrel before major abdominal procedures. Archives of surgery (Chicago, Ill. : 1960), 2011, Volume: 146, Issue:3 Topics: Abdomen; Aged; Analysis of Variance; Blood Loss, Surgical; Clopidogrel; Cohort Studies; Confidence I	2011
Complications of cutaneous surgery in patients taking clopidogrel-containing anticoagulation. Journal of the American Academy of Dermatology, 2011, Volume: 65, Issue:3 Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Clopidogrel; Dermatologic Surgical Procedures; Fem	2011
How do we manage patients treated with antithrombotic therapy in the perioperative interval. Transfusion, 2011, Volume: 51, Issue:10 Topics: Anticoagulants; Antifibrinolytic Agents; Antithrombins; Aspirin; Blood Loss, Surgical; Blood Transfu	2011
Clopidogrel is not associated with major bleeding complications during peripheral arterial surgery. Journal of vascular surgery, 2011, Volume: 54, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Aspirin; Blood Transfusion; Chi-Square Distrib	2011
Predictors of neck bleeding after eversion carotid endarterectomy. Journal of vascular surgery, 2011, Volume: 54, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Carotid Artery Diseases; Chi-Square Distribution; Clopidogrel; Drug	2011
Prospective evaluation of dermatologic surgery complications including patients on multiple antiplatelet and anticoagulant medications. Journal of the American Academy of Dermatology, 2011, Volume: 65, Issue:3 Topics: Aged; Ambulatory Surgical Procedures; Antibiotic Prophylaxis; Anticoagulants; Clopidogrel; Dermatolo	2011
Safety of dental extractions during uninterrupted single or dual antiplatelet treatment. The American journal of cardiology, 2011, Oct-01, Volume: 108, Issue:7 Topics: Aged; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fol	2011
Non-cardiac surgery in patients with coronary stents: the RECO study. Heart (British Cardiac Society), 2011, Volume: 97, Issue:19 Topics: Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Cerebr	2011
Non-cardiac surgery in patients with coronary stents: the RECO study. Heart (British Cardiac Society), 2011, Volume: 97, Issue:19 Topics: Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Cerebr	2011
Non-cardiac surgery in patients with coronary stents: the RECO study. Heart (British Cardiac Society), 2011, Volume: 97, Issue:19 Topics: Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Cerebr	2011
Non-cardiac surgery in patients with coronary stents: the RECO study. Heart (British Cardiac Society), 2011, Volume: 97, Issue:19 Topics: Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Cerebr	2011
[Antiplatelet agents increase hemorrhagic risk in patients undergoing a cardiac pacemaker or ICD implantation]. Annales de cardiologie et d'angeiologie, 2011, Volume: 60, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Algorithms; Aspirin; Clopidogrel; Defibrillators, Implantable; Drug	2011
Risk factors for re-exploration due to bleeding after coronary artery bypass grafting. Scandinavian cardiovascular journal : SCJ, 2012, Volume: 46, Issue:1 Topics: Aged; Antifibrinolytic Agents; Aprotinin; Case-Control Studies; Clopidogrel; Coronary Artery Bypass;	2012
Correlation between point-of-care platelet function testing and bleeding after coronary artery surgery. Scandinavian cardiovascular journal : SCJ, 2012, Volume: 46, Issue:1 Topics: Aged; Aspirin; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Coronary Vessels; Female; Hem	2012
[Diagnostic laparoscopy under dual antiplatelet therapy with clopidogrel and aspirin]. Medizinische Klinik, Intensivmedizin und Notfallmedizin, 2011, Volume: 106, Issue:1 Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Diagnosis, Differential; Drug Substituti	2011
Major abdominal surgery with continued dual antiplatelet therapy. Archives of surgery (Chicago, Ill. : 1960), 2011, Volume: 146, Issue:11 Topics: Humans; Male; Postoperative Hemorrhage; Preoperative Care; Surgical Procedures, Operative; Ticlopidi	2011
Risk of bleeding after percutaneous endoscopic gastrostomy (PEG). Digestive diseases and sciences, 2012, Volume: 57, Issue:4 Topics: Aged; Anticoagulants; Clopidogrel; Female; Gastrointestinal Hemorrhage; Gastroscopy; Gastrostomy; Hu	2012
Impact of clopidogrel on bleeding complications and survival in off-pump coronary artery bypass grafting. Interactive cardiovascular and thoracic surgery, 2012, Volume: 14, Issue:3 Topics: Aged; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass, Off-Pump; Coronary Restenosis; Dose	2012
[Perioperative management of antiplatelet therapy in thoracic surgery. A survey of German hospitals]. Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 2012, Volume: 83, Issue:6 Topics: Arterial Occlusive Diseases; Aspirin; Attitude of Health Personnel; Brain Ischemia; Clopidogrel; Com	2012
eComment. Impact of clopidogrel on bleeding complications and survival in off-pump coronary artery bypass grafting. Interactive cardiovascular and thoracic surgery, 2012, Volume: 14, Issue:3 Topics: Clopidogrel; Coronary Artery Bypass, Off-Pump; Coronary Restenosis; Female; Humans; Male; Postoperat	2012
Perioperative clopidogrel and postoperative events after hip and knee arthroplasties. Clinical orthopaedics and related research, 2012, Volume: 470, Issue:5 Topics: Age Factors; Aged; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Clopidogrel; Dat	2012
Platelet transfusion for reversal of dual antiplatelet therapy in patients requiring urgent surgery: a pilot study. Journal of thrombosis and haemostasis : JTH, 2012, Volume: 10, Issue:5 Topics: Aged; Aged, 80 and over; Aspirin; Blood Loss, Surgical; Clopidogrel; Drug Administration Schedule; D	2012
The effects of clopidogrel (Plavix) and other oral anticoagulants on early hip fracture surgery. Journal of orthopaedic trauma, 2012, Volume: 26, Issue:10 Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Blood Loss, Surgical; Clopidogrel; Cohort Studies;	2012
Bridging with glycoprotein IIb/IIIa inhibitors for periprocedural management of antiplatelet therapy in patients with drug eluting stents. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2012, Mar-01, Volume: 79, Issue:4 Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Cardiac Surgical Procedures; Clopidogrel; Drug Administ	2012
Maintenance of anticoagulant and antiplatelet agents for patients undergoing peribulbar anesthesia and vitreoretinal surgery. Retina (Philadelphia, Pa.), 2012, Volume: 32, Issue:9 Topics: Acenocoumarol; Adult; Aged; Aged, 80 and over; Anesthesia, Local; Anticoagulants; Aspirin; Clopidogr	2012
Do we have to stop anticoagulant and platelet-inhibitor treatments during proctological surgery? Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2012, Volume: 14, Issue:12 Topics: Adult; Anticoagulants; Aspirin; Blood Transfusion; Chi-Square Distribution; Clopidogrel; Female; Hem	2012
Blood loss and complications following carotid endarterectomy in patients treated with clopidogrel. Vascular, 2012, Volume: 20, Issue:4 Topics: Aged; Aged, 80 and over; Aspirin; Blood Loss, Surgical; Carotid Artery Diseases; Clopidogrel; Drug T	2012
Letter by Petricevic and Biocina regarding article, "Platelet function measurement-based strategy to reduce bleeding and waiting time in clopidogrel-treated patients undergoing coronary artery bypass graft surgery: the Timing Based on Platelet Function St Circulation. Cardiovascular interventions, 2012, Volume: 5, Issue:3 Topics: Blood Transfusion; Coronary Artery Bypass; Drainage; Female; Humans; Male; Postoperative Hemorrhage;	2012
Combined clopidogrel and aspirin treatment up to surgery increases the risk of postoperative myocardial infarction, blood loss and reoperation for bleeding in patients undergoing coronary artery bypass grafting. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2013, Volume: 43, Issue:4 Topics: Aged; Aspirin; Blood Transfusion; Chi-Square Distribution; Clopidogrel; Coronary Artery Bypass; Fema	2013
[Surgery shortly after stent implantation?]. Deutsche medizinische Wochenschrift (1946), 2012, Volume: 137, Issue:39 Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Contr	2012
Treatment of blood blister-like aneurysms of the internal carotid artery with stent-assisted coil embolization. Clinical neurology and neurosurgery, 2013, Volume: 115, Issue:7 Topics: Aspirin; Carotid Artery Diseases; Carotid Artery, Internal; Cerebral Angiography; Clopidogrel; Embol	2013
Management and outcomes of patients on preoperative plavix (clopidogrel) undergoing general thoracic surgery. The Thoracic and cardiovascular surgeon, 2013, Volume: 61, Issue:6 Topics: Aged; Aged, 80 and over; Blood Loss, Surgical; Blood Transfusion; Cardiovascular Diseases; Clopidogr	2013
Current antiplatelet therapy for Japanese patients with ST elevation acute myocardial infarction: J-AMI registry. Cardiovascular intervention and therapeutics, 2013, Volume: 28, Issue:2 Topics: Aged; Aged, 80 and over; Aspirin; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combination; Femal	2013
Safety of ultrasound-guided small-bore chest tube insertion in patients on clopidogrel. Journal of bronchology & interventional pulmonology, 2013, Volume: 20, Issue:1 Topics: Aged; Chest Tubes; Clopidogrel; Contraindications; Female; Hematoma; Hemothorax; Humans; Male; Plate	2013
Safety of clopidogrel in hip fracture surgery. Mayo Clinic proceedings, 2013, Volume: 88, Issue:2 Topics: Aged; Aged, 80 and over; Blood Loss, Surgical; Case-Control Studies; Clopidogrel; Cohort Studies; Fe	2013
Influence of oral antiplatelet therapy on hemorrhagic complications of pacemaker implantation. Clinical research in cardiology : official journal of the German Cardiac Society, 2013, Volume: 102, Issue:5 Topics: Administration, Oral; Aged; Aspirin; Biomarkers; Blood Transfusion; Cardiac Pacing, Artificial; Clop	2013
Urgent or emergent coronary revascularization using bilateral internal thoracic artery after previous clopidogrel antiplatelet therapy. The Thoracic and cardiovascular surgeon, 2003, Volume: 51, Issue:4 Topics: Aged; Aged, 80 and over; Aspirin; Blood Transfusion; Chest Tubes; Clopidogrel; Coronary Artery Bypas	2003
Off-pump coronary artery bypass grafting attenuates postoperative bleeding associated with preoperative clopidogrel administration. The heart surgery forum, 2003, Volume: 6, Issue:5 Topics: Case-Control Studies; Clopidogrel; Coronary Angiography; Coronary Artery Bypass; Humans; Platelet Ag	2003
A feasibility study of the safety and efficacy of a combined clopidogrel and aspirin regimen following off-pump coronary artery bypass grafting. The heart surgery forum, 2003, Volume: 6, Issue:5 Topics: Anticoagulants; Aspirin; Clopidogrel; Coronary Artery Bypass; Drug Therapy, Combination; Feasibility	2003
Impact of clopidogrel in coronary artery bypass grafting. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2004, Volume: 26, Issue:1 Topics: Aged; Chest Tubes; Clopidogrel; Coronary Artery Bypass; Drug Administration Schedule; Female; Hemost	2004
Clopidogrel before coronary artery surgery: bleeding or no bleeding? European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2004, Volume: 26, Issue:1 Topics: Clopidogrel; Humans; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Preoperative Care; T	2004
Antiplatelet and anticoagulant prophylaxis and postoperative blood loss in cardiac surgery. Anesthesia and analgesia, 2004, Volume: 99, Issue:3 Topics: Anticoagulants; Cardiac Surgical Procedures; Clopidogrel; Humans; Platelet Aggregation Inhibitors; P	2004
Antiplatelet agents and bleeding after cardiac surgery. Anesthesia and analgesia, 2004, Volume: 99, Issue:3 Topics: Anticoagulants; Cardiac Surgical Procedures; Clopidogrel; Humans; Platelet Aggregation Inhibitors; P	2004
Clopidogrel (Plavix) and cardiac surgical patients: implications for platelet function monitoring and postoperative bleeding. Platelets, 2004, Volume: 15, Issue:5 Topics: Adenosine; Adenosine Diphosphate; Aged; Aged, 80 and over; Blood Platelets; Cardiovascular Diseases;	2004
Clopidogrel in coronary artery surgery. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2004, Volume: 26, Issue:4 Topics: Clopidogrel; Coronary Artery Bypass; Humans; Platelet Aggregation Inhibitors; Postoperative Hemorrha	2004
Clopidogrel and postoperative bleeding. The Annals of thoracic surgery, 2004, Volume: 78, Issue:5 Topics: Aprotinin; Aspirin; Blood Transfusion; Cardiopulmonary Bypass; Clopidogrel; Coronary Artery Bypass;	2004
Does clopidogrel increase blood loss following coronary artery bypass surgery? The Annals of thoracic surgery, 2004, Volume: 78, Issue:5 Topics: Aged; Aspirin; Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Critica	2004
Impact of clopidogrel in coronary artery bypass grafting. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2005, Volume: 27, Issue:1 Topics: Clopidogrel; Coronary Artery Bypass; Humans; Platelet Aggregation Inhibitors; Postoperative Hemorrha	2005
Secondary haemorrhage after rubber band ligation of haemorrhoids in patients taking clopidogrel--a cautionary note. The Ulster medical journal, 2004, Volume: 73, Issue:2 Topics: Aged; Blood Transfusion; Catheterization; Clopidogrel; Female; Hemorrhoids; Humans; Ligation; Middle	2004
Clopidogrel administration prior to coronary artery bypass grafting surgery: the cardiologist's panacea or the surgeon's headache? European heart journal, 2005, Volume: 26, Issue:6 Topics: Aged; Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Coronary Disease	2005
Intralamellar haemorrhage 44 years following lamellar keratoplasty. Eye (London, England), 2006, Volume: 20, Issue:8 Topics: Blindness; Clopidogrel; Corneal Neovascularization; Corneal Transplantation; Eye Hemorrhage; Humans;	2006
Aspirin and clopidogrel taken until 2 days prior to coronary artery bypass graft surgery is associated with increased postoperative drainage loss. The Thoracic and cardiovascular surgeon, 2005, Volume: 53, Issue:6 Topics: Aged; Aspirin; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Female; Humans; Male; Middle	2005
Clopidogrel (PLAVIX) increases risk of bleeding in a patient undergoing coronary artery bypass grafting. The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi, 2006, Volume: 54, Issue:9 Topics: Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Humans; Meta-Analysis	2006
Impact of aspirin with or without clopidogrel on postoperative bleeding and blood transfusion in coronary surgical patients treated prophylactically with a low-dose of aprotinin. European heart journal, 2007, Volume: 28, Issue:8 Topics: Aged; Aprotinin; Aspirin; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Drug Therapy, Comb	2007
Is clopidogrel stopped prior to hip fracture surgery--A survey of current practice in the United Kingdom. Injury, 2007, Volume: 38, Issue:11 Topics: Anticoagulants; Aspirin; Clinical Protocols; Clopidogrel; Contraindications; Femoral Neck Fractures;	2007
The effect of platelet-altering medications on bleeding from minor oral surgery procedures. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2008, Volume: 66, Issue:1 Topics: Analysis of Variance; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bl	2008
Effects of a waiting period after clopidogrel treatment before performing coronary artery bypass grafting. Pharmacotherapy, 2008, Volume: 28, Issue:2 Topics: Academic Medical Centers; Blood Loss, Surgical; Blood Volume; Clopidogrel; Coronary Artery Bypass; D	2008
Clopidogrel treatment before coronary artery bypass graft surgery increases postoperative morbidity and blood product requirements. Journal of cardiothoracic and vascular anesthesia, 2008, Volume: 22, Issue:1 Topics: Aged; Blood Coagulation Tests; Clopidogrel; Cohort Studies; Coronary Artery Bypass; Erythrocyte Tran	2008
Which patients receiving warfarin can be treated safely with a drug-eluting stent? Heart (British Cardiac Society), 2008, Volume: 94, Issue:3 Topics: Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Coronary Restenosis; Cor	2008
A critically severe gingival bleeding following non-surgical periodontal treatment in patients medicated with anti-platelet. Journal of clinical periodontology, 2008, Volume: 35, Issue:4 Topics: Aspirin; Clopidogrel; Drug Combinations; Female; Gingival Hemorrhage; Humans; Middle Aged; Periodont	2008
Effects of continuous administration of clopidogrel before off-pump coronary artery bypass grafting in patients with acute coronary syndrome. Circulation journal : official journal of the Japanese Circulation Society, 2008, Volume: 72, Issue:4 Topics: Acute Coronary Syndrome; Aged; Blood Transfusion; Clopidogrel; Coronary Artery Bypass, Off-Pump; Fem	2008
Bleeding complications in dermatologic surgery. Seminars in cutaneous medicine and surgery, 2007, Volume: 26, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Clopidogrel; Humans; Intraoperative Complic	2007
Operative delay for orthopedic patients on clopidogrel (plavix): a complete lack of consensus. The Journal of trauma, 2008, Volume: 64, Issue:4 Topics: Adult; Clopidogrel; Emergency Treatment; Female; Fracture Fixation, Internal; Health Care Surveys; H	2008
Effect of clopidogrel on bleeding and transfusions after off-pump coronary artery bypass graft surgery: impact of discontinuation prior to surgery. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2008, Volume: 34, Issue:1 Topics: Aged; Analysis of Variance; Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Coronary Artery By	2008
Effect of clopidogrel on bleeding after coronary artery bypass surgery. Critical care medicine, 2001, Volume: 29, Issue:12 Topics: Aspirin; Blood Transfusion; Case-Control Studies; Clopidogrel; Coronary Artery Bypass; Drug Therapy,	2001

ticlopidine and Blood Loss, Postoperative