ticlopidine has been researched along with Atheroma in 17 studies
Ticlopidine: An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
ticlopidine : A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This prospective randomized controlled, open-labeled trial, with blinded end point evaluation (PROBE design) tested superiority of aspirin 75 to 150 mg/d plus clopidogrel 75 mg/d (A+C) over warfarin therapy (international normalized ratio 2-3) in patients with ischemic stroke, transient ischemic attack, or peripheral embolism with plaque in the thoracic aorta>4 mm and no other identified embolic source." | 9.19 | Clopidogrel plus aspirin versus warfarin in patients with stroke and aortic arch plaques. ( Amarenco, P; Cohen, AA; Davis, S; Donnan, GA; Heiss, WD; Jones, EF; Kaste, M; Laouénan, C; Macleod, M; Young, D, 2014) |
| "The anti-platelet drug clopidogrel has been shown to modulate adhesion molecule and cytokine expression, both playing an important role in the pathogenesis of atherosclerosis." | 7.83 | Clopidogrel significantly lowers the development of atherosclerosis in ApoE-deficient mice in vivo. ( Ensminger, SM; Gebhardt, J; Heim, C; Jacobi, J; Ramsperger-Gleixner, M; Weyand, M, 2016) |
| "Transient monocular blindness (TMB) is a well-known warning symptom of impending cerebral or retinal infarction, which suggests vulnerable ipsilateral carotid disease." | 5.39 | Clopidogrel effective for frequent transient monocular blindness caused by vulnerable plaque. ( Bae, HJ; Choi, BS; Han, MK; Jung, C; Kang, J; Kim, BJ; Kim, HR; Kim, JH; Park, HK; Park, SH, 2013) |
| "This prospective randomized controlled, open-labeled trial, with blinded end point evaluation (PROBE design) tested superiority of aspirin 75 to 150 mg/d plus clopidogrel 75 mg/d (A+C) over warfarin therapy (international normalized ratio 2-3) in patients with ischemic stroke, transient ischemic attack, or peripheral embolism with plaque in the thoracic aorta>4 mm and no other identified embolic source." | 5.19 | Clopidogrel plus aspirin versus warfarin in patients with stroke and aortic arch plaques. ( Amarenco, P; Cohen, AA; Davis, S; Donnan, GA; Heiss, WD; Jones, EF; Kaste, M; Laouénan, C; Macleod, M; Young, D, 2014) |
| "The anti-platelet drug clopidogrel has been shown to modulate adhesion molecule and cytokine expression, both playing an important role in the pathogenesis of atherosclerosis." | 3.83 | Clopidogrel significantly lowers the development of atherosclerosis in ApoE-deficient mice in vivo. ( Ensminger, SM; Gebhardt, J; Heim, C; Jacobi, J; Ramsperger-Gleixner, M; Weyand, M, 2016) |
| "Within this retrospective observational spontaneous clinical study 44 patients (31 males and 13 females) all presenting stable coronary artery disease were evaluated; 25 subjects were treated with only acetylsalicylic acid and/or clopidogrel in association with statins (standard therapeutic protocol) while for the other 18 subjects the standard therapeutic protocol was integrated with Arnica comp." | 3.83 | Effects of Arnica comp.-Heel® on reducing cardiovascular events in patients with stable coronary disease. ( Bianchi, M; Di Nardo, V; Fioranelli, M; Roccia, MG, 2016) |
| "Twenty patients with ≥50 % angiographic stenosis of the SFA had blood drawn just proximal to the lesion and from a contralateral site free of disease." | 2.78 | Increased local cytokine production at culprit superficial femoral artery plaques. ( Adams, JE; Ashikaga, T; Bertges, DJ; Dauerman, HL; Donaldson, CW; Elgharib, NZ; Mueller, EL; Prabhu, W; Schneider, DJ, 2013) |
| "24." | 1.43 | Relationship Between Platelet Reactivity and Culprit Lesion Morphology: An Assessment From the ADAPT-DES Intravascular Ultrasound Substudy. ( Brodie, BR; Duffy, PL; Inaba, S; Kirtane, AJ; Maehara, A; Mazzaferri, EL; Metzger, DC; Mintz, GS; Rinaldi, MJ; Shimizu, T; Stone, GW; Stuckey, TD; Weisz, G; Witzenbichler, B; Yun, KH, 2016) |
| "Human atherosclerotic plaques produced PGE2, which facilitated platelet aggregation in human blood and rescued the function of P2Y12-blocked platelets." | 1.40 | Blocking the EP3 receptor for PGE2 with DG-041 decreases thrombosis without impairing haemostatic competence. ( Charles, AL; Fabre, JE; Geny, B; Gross, S; Gurney, ME; Ludwig, S; Meilhac, O; Slimani, F; Stefansson, K; Tilly, P, 2014) |
| "Transient monocular blindness (TMB) is a well-known warning symptom of impending cerebral or retinal infarction, which suggests vulnerable ipsilateral carotid disease." | 1.39 | Clopidogrel effective for frequent transient monocular blindness caused by vulnerable plaque. ( Bae, HJ; Choi, BS; Han, MK; Jung, C; Kang, J; Kim, BJ; Kim, HR; Kim, JH; Park, HK; Park, SH, 2013) |
| "Needle injury induces atherosclerotic plaque rupture with exposure of plaque material and formation of a thrombus that is larger, nearly occlusive and more stable as compared to that formed by application of ultrasounds." | 1.37 | Comparison of two murine models of thrombosis induced by atherosclerotic plaque injury. ( Gachet, C; Hechler, B, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 16 (94.12) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Deguchi, I | 1 |
| Osada, T | 1 |
| Takahashi, S | 1 |
| Su, J | 1 |
| Yu, Q | 1 |
| Zhu, H | 1 |
| Li, X | 1 |
| Cui, H | 1 |
| Du, W | 1 |
| Ji, L | 1 |
| Tong, M | 1 |
| Zheng, Y | 1 |
| Xu, H | 1 |
| Zhang, J | 1 |
| Zhu, Y | 1 |
| Xia, Y | 1 |
| Liu, T | 1 |
| Yao, Q | 1 |
| Yang, J | 1 |
| Chen, X | 1 |
| Yu, J | 1 |
| Park, HK | 1 |
| Kim, HR | 1 |
| Kim, BJ | 1 |
| Kang, J | 1 |
| Jung, C | 1 |
| Choi, BS | 1 |
| Kim, JH | 1 |
| Han, MK | 1 |
| Park, SH | 1 |
| Bae, HJ | 1 |
| Tilly, P | 1 |
| Charles, AL | 1 |
| Ludwig, S | 1 |
| Slimani, F | 1 |
| Gross, S | 1 |
| Meilhac, O | 1 |
| Geny, B | 1 |
| Stefansson, K | 1 |
| Gurney, ME | 1 |
| Fabre, JE | 1 |
| Amarenco, P | 1 |
| Davis, S | 1 |
| Jones, EF | 1 |
| Cohen, AA | 1 |
| Heiss, WD | 1 |
| Kaste, M | 1 |
| Laouénan, C | 1 |
| Young, D | 1 |
| Macleod, M | 1 |
| Donnan, GA | 1 |
| Yamamoto, Y | 1 |
| Heim, C | 1 |
| Gebhardt, J | 1 |
| Ramsperger-Gleixner, M | 1 |
| Jacobi, J | 1 |
| Weyand, M | 1 |
| Ensminger, SM | 1 |
| Yun, KH | 1 |
| Mintz, GS | 2 |
| Witzenbichler, B | 1 |
| Inaba, S | 1 |
| Shimizu, T | 1 |
| Metzger, DC | 1 |
| Rinaldi, MJ | 1 |
| Mazzaferri, EL | 1 |
| Duffy, PL | 1 |
| Weisz, G | 2 |
| Stuckey, TD | 1 |
| Brodie, BR | 1 |
| Kirtane, AJ | 1 |
| Stone, GW | 1 |
| Maehara, A | 2 |
| Fioranelli, M | 1 |
| Bianchi, M | 1 |
| Roccia, MG | 1 |
| Di Nardo, V | 1 |
| Oh, M | 1 |
| Lee, CW | 1 |
| Lee, HS | 1 |
| Chang, M | 1 |
| Ahn, JM | 1 |
| Park, DW | 1 |
| Kang, SJ | 1 |
| Lee, SW | 1 |
| Kim, YH | 1 |
| Moon, DH | 1 |
| Park, SW | 1 |
| Park, SJ | 1 |
| Sasaki, K | 1 |
| Ueno, T | 1 |
| Masumura, Y | 1 |
| Ueda, Y | 1 |
| Matsuo, K | 1 |
| Akazawa, Y | 1 |
| Nishio, M | 1 |
| Hirata, A | 1 |
| Kashiwase, K | 1 |
| Nemoto, T | 1 |
| Kashiyama, T | 1 |
| Wada, M | 1 |
| Muller, JE | 1 |
| Kodama, K | 1 |
| Hechler, B | 1 |
| Gachet, C | 1 |
| Takeda, M | 1 |
| Yamashita, T | 1 |
| Shinohara, M | 1 |
| Sasaki, N | 1 |
| Tawa, H | 1 |
| Nakajima, K | 1 |
| Momose, A | 1 |
| Hirata, K | 1 |
| Chirumamilla, AP | 1 |
| Mehran, R | 1 |
| Kanwal, S | 1 |
| Hassanin, A | 1 |
| Hakim, D | 1 |
| Guo, N | 1 |
| Baber, U | 1 |
| Pyo, R | 1 |
| Moses, JW | 1 |
| Fahy, M | 1 |
| Kovacic, JC | 1 |
| Dangas, GD | 1 |
| Reinhart, WH | 1 |
| Donaldson, CW | 1 |
| Schneider, DJ | 1 |
| Bertges, DJ | 1 |
| Adams, JE | 1 |
| Elgharib, NZ | 1 |
| Mueller, EL | 1 |
| Prabhu, W | 1 |
| Ashikaga, T | 1 |
| Dauerman, HL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prevention of New Vascular Events in Patients With Brain Infarction or Peripheral Embolism and Thoracic Aortic Plaques ≥ 4 mm in Thickness in the Aortic Arch or Descending Aortic Upstream to the Embolized Artery[NCT00235248] | Phase 3 | 350 participants (Actual) | Interventional | 2002-02-28 | Completed | ||
| Assessment of Dual AntiPlatelet Therapy With Drug Eluting Stents[NCT00638794] | 8,575 participants (Actual) | Observational | 2008-01-31 | Completed | |||
| Ticagrelor With Aspirin or Alone in High-Risk Patients After Coronary Intervention[NCT02270242] | Phase 4 | 9,006 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of participants with first occurrence of clinically relevant bleeding episode, defined as Bleeding Academic Research Consortium (BARC) Types 2, 3 or 5 bleeding. BARC bleeding types range from 0 (no bleeding) to 5 (fatal bleeding). (NCT02270242)
Timeframe: 12 months after randomization
| Intervention | Participants (Count of Participants) |
|---|---|
| Placebo + Ticagrelor | 141 |
| Aspirin + Ticagrelor | 250 |
Number of participants with first occurrence of confirmed all-cause death, non-fatal myocardial infarction or stroke. (NCT02270242)
Timeframe: 12 months after randomization
| Intervention | Participants (Count of Participants) |
|---|---|
| Placebo + Ticagrelor | 135 |
| Aspirin + Ticagrelor | 137 |
1 review available for ticlopidine and Atheroma
| Article | Year |
|---|---|
[Concept, pathophysiology and treatment for branch atheromatous disease].
Topics: Antipyrine; Arginine; Cerebral Infarction; Cilostazol; Clopidogrel; Contraindications; Drug Therapy, | 2014 |
3 trials available for ticlopidine and Atheroma
| Article | Year |
|---|---|
Clopidogrel plus aspirin versus warfarin in patients with stroke and aortic arch plaques.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aorta, Thoracic; Aortic Diseases; Aspirin; Brain Ischemia; | 2014 |
Similar Impact of Clopidogrel or Ticagrelor on Carotid Atherosclerotic Plaque Inflammation.
Topics: Adenosine; Aged; Anti-Inflammatory Agents; Carotid Arteries; Carotid Stenosis; Clopidogrel; Female; | 2016 |
Increased local cytokine production at culprit superficial femoral artery plaques.
Topics: Aspirin; CD40 Ligand; Clopidogrel; Constriction, Pathologic; Female; Femoral Artery; Humans; Hydroxy | 2013 |
13 other studies available for ticlopidine and Atheroma
| Article | Year |
|---|---|
Efficacy of Treatment with and without Initial Clopidogrel Loading in Branch Atheromatous Disease.
Topics: Cerebral Infarction; Clopidogrel; Humans; Plaque, Atherosclerotic; Platelet Aggregation Inhibitors; | 2023 |
The risk of clopidogrel resistance is associated with ABCB1 polymorphisms but not promoter methylation in a Chinese Han population.
Topics: Aged; ATP Binding Cassette Transporter, Subfamily B; Clopidogrel; DNA Methylation; Drug Resistance; | 2017 |
Clopidogrel effective for frequent transient monocular blindness caused by vulnerable plaque.
Topics: Angiography, Digital Subtraction; Blindness; Clopidogrel; Humans; Magnetic Resonance Angiography; Ma | 2013 |
Blocking the EP3 receptor for PGE2 with DG-041 decreases thrombosis without impairing haemostatic competence.
Topics: Acrylamides; Animals; Blood Platelets; Clopidogrel; Dinoprostone; Disease Models, Animal; Mice; Plaq | 2014 |
Clopidogrel significantly lowers the development of atherosclerosis in ApoE-deficient mice in vivo.
Topics: Animals; Aorta, Thoracic; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Biomarkers; Chemokine | 2016 |
Relationship Between Platelet Reactivity and Culprit Lesion Morphology: An Assessment From the ADAPT-DES Intravascular Ultrasound Substudy.
Topics: Aged; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Coronary Vessels; Drug Resistan | 2016 |
Effects of Arnica comp.-Heel® on reducing cardiovascular events in patients with stable coronary disease.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents; Aspirin; Clopidogrel; Coronary Artery Disease; Dr | 2016 |
[CHARISMA study].
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Embolism; Female; Humans; Male; Middle Aged; Plaque, | 2016 |
Frequency and location of yellow and disrupted coronary plaques in patients as detected by angioscopy.
Topics: Acute Coronary Syndrome; Aged; Angioscopy; Aspirin; Clopidogrel; Coronary Artery Disease; Disease Pr | 2011 |
Comparison of two murine models of thrombosis induced by atherosclerotic plaque injury.
Topics: Animals; Apolipoproteins E; Blood Platelets; Carotid Arteries; Clopidogrel; Coronary Thrombosis; Dis | 2011 |
Beneficial effect of anti-platelet therapies on atherosclerotic lesion formation assessed by phase-contrast X-ray CT imaging.
Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Body Weight; Brachiocephalic Trunk; Cell Adhesio | 2012 |
High platelet reactivity on clopidogrel therapy correlates with increased coronary atherosclerosis and calcification: a volumetric intravascular ultrasound study.
Topics: Aged; Angioplasty, Balloon, Coronary; Blood Platelets; Chi-Square Distribution; Clopidogrel; Coronar | 2012 |
Platelets in vascular disease.
Topics: Aspirin; Atherosclerosis; Blood Platelets; Clopidogrel; Hemostasis; Humans; Plaque, Atherosclerotic; | 2013 |