ticlopidine and Angina Pectoris studies

Ticlopidine: An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
ticlopidine : A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.

Angina Pectoris: The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.

Research Excerpts

Excerpt	Relevance	Reference
"This prospective registered study was conducted to investigate the impact of statins (pravastatin, fluvastatin, atorvastatin) on clopidogrel platelet inhibition in patients with acute coronary syndrome (ACS) or stable angina."	9.13	[Impact of statins on clopidogrel platelet inhibition in patients with acute coronary syndrome or stable angina]. ( Shen, J; Zhang, Q; Zhang, RY, 2008)
"Aspirin resistance may increase the risk of major adverse cardiac events (MACE) more than threefold in patients with stable coronary artery disease (CAD)."	9.12	Clinical relevance of aspirin resistance in patients with stable coronary artery disease: a prospective follow-up study (PROSPECTAR). ( Mercanoglu, F; Meric, M; Nisanci, Y; Oflaz, H; Oncul, A; Onur, I; Ozcan, M; Pamukcu, B; Umman, B, 2007)
" Therefore the effects of the platelet inhibitor ticlopidine (500 mg daily) on platelet function and on exercise tolerance were investigated in a double-blind placebo-controlled study in 38 middle-aged men with stable incapacitating angina pectoris."	9.06	Effects of the platelet inhibitor ticlopidine on exercise tolerance in stable angina pectoris. ( Berglund, U; Lassvik, C; Wallentin, L, 1987)
"The effects of ticlopidine (T) (500 mg daily) on platelet function were investigated in a double-blind placebo-controlled study in 38 middle-aged men with stable incapacitating angina pectoris."	9.05	Effects of ticlopidine of platelet function in men with stable angina pectoris. ( Berglund, U; von Schenck, H; Wallentin, L, 1985)
"To observe the relationship between ATP-binding cassette subfamily B member 1 (ABCB1) and cytochrome P450 (CYP)2C19 polymorphisms and the effect of clopidogrel post percutaneous coronary intervention in patients with coronary artery disease."	7.83	[Relationship between ATP-binding cassette subfamily B member 1 and cytochrome P450 2C19 polymorphisms and the effect of clopidogrel post percutaneous coronary intervention in patients with acute coronary syndrome]. ( Fu, ZH; Han, BS; Li, DY; Ren, YH; Song, YQ; Xue, Q; Yi, J; Zhou, CF, 2016)
"A 65-year-old man, who had been given a diagnosis of angina pectoris, developed pneumonia 6 months after the initiation of clopidogrel to inhibit platelet aggregation."	7.76	[A case of drug-induced pneumonia caused by clopidogrel]. ( Hirata, K; Matsushita, H; Suzumura, T; Tamagaki, G; Watanabe, T; Yamada, S, 2010)
" This study was designed to determine the relation between responses to aspirin and clopidogrel as assessed by a point-of-care assay (Verify Now, Accumetrics, San Diego, California) and periprocedural myocardial infarction (PMI) in patients undergoing elective PCI for stable angina."	7.74	Relation of low response to clopidogrel assessed with point-of-care assay to periprocedural myonecrosis in patients undergoing elective coronary stenting for stable angina pectoris. ( Barbato, E; Bartunek, J; Cuisset, T; De Bruyne, B; Hamilos, M; Sarma, J; Sarno, G; Vanderheyden, M; Wijns, W; Wyffels, E, 2008)
" All suffered stent thrombosis after discontinuation (in three cases prematurely) of clopidogrel therapy."	7.73	[Thrombosis of a coronary stent after discontinuing treatment with clopidogrel]. ( de Boer, MJ; Hautvast, RW; Heestermans, AA; Jaarsma, W; ten Berg, JM; van Werkum, JW, 2006)
"We evaluated the effect of high versus low loading doses of clopidogrel in patients with stable angina pectoris who underwent percutaneous coronary intervention (PCI) on periprocedural events, in-hospital complications, and 30-day outcomes."	7.73	Clopidogrel loading dose (300 versus 600 mg) strategies for patients with stable angina pectoris subjected to percutaneous coronary intervention. ( Gevorkian, N; Hassani, SE; Kent, KM; Pichard, AD; Satler, LF; Torguson, RL; Waksman, R; Wolfram, RM; Xue, Z, 2006)
"Dual antiplatelet therapy with aspirin and clopidogrel decreases the rate of stent thrombosis in patients undergoing percutaneous coronary intervention (PCI)."	7.72	Prevalence of clopidogrel non-responders among patients with stable angina pectoris scheduled for elective coronary stent placement. ( Besta, F; Gawaz, M; Massberg, S; Müller, I; Schönig, A; Schulz, C, 2003)
"In a large, randomized, placebo-controlled trial in centers that use a conservative approach to acute coronary syndromes, the antiplatelet drug clopidogrel (Plavix) decreased the rate of the combined end point of cardiovascular death, nonfatal myocardial infarction, or stroke by 20% in patients presenting with acute coronary syndromes without ST-segment elevation."	7.71	The CURE trial: using clopidogrel in acute coronary syndromes without ST-segment elevation. ( Bhatt, DL; Gerschutz, GP, 2002)
"Nifedipine-induced gingival hypertrophy is a rare side effect reported by the producers of this drug but, surely, not well known in all its aspects."	7.68	[Nifedipine and gingival hypertrophy]. ( Borgia, MC; Calpicchio, A; De Paola, G; Di Folco, G, 1991)
"When ticlopidine was given for 72 hours, TF levels were similar to normal laboratory values both in stable and unstable patients."	6.69	Effect of aspirin and ticlopidine on plasma tissue factor levels in stable and unstable angina pectoris. ( Ariëns, RA; Bernies, M; Bossi, IM; Brambilla, GM; Donatelli, F; Fajadet, J; Gregorini, L; Marco, I; Marco, J; Mari, D; Romano, SM; Somalvico, F, 2000)
"Ticlopidine is a drug that inhibits the ADP-induced aggregation of blood platelets and it also has been described that ticlopidine can decrease the plasma fibrinogen level in patients with vascular diseases."	6.68	Modulation of plasma fibrinogen levels by ticlopidine in healthy volunteers and patients with stable angina pectoris. ( Arnold, AE; de Maat, MP; Kluft, C; van Buuren, S; Wilson, JH, 1996)
"Patients with more extensive coronary atherosclerosis have a higher rate of HPR, which might partly account for higher risk of periprocedural MI."	5.36	High residual platelet reactivity after clopidogrel: extent of coronary atherosclerosis and periprocedural myocardial infarction in patients with stable angina undergoing percutaneous coronary intervention. ( Barbato, E; Bartunek, J; De Bruyne, B; Di Sciascio, G; Heyndrickx, G; Mangiacapra, F; Muller, O; Ntalianis, A; Trana, C; Wijns, W, 2010)
"Aspirin was given as 160 mg/day and clopidogrel as 300 mg loading dose followed by 75 mg/day."	5.35	Clopidogrel inhibits platelet aggregation in patients on aspirin with stable chronic angina pectoris. ( Agewall, S; Berglund, M; Gordon, A; Saha, S; Sylvén, C, 2008)
"Definite/probable ST and MB (TIMI major and Bleeding Academic Research Consortium (BARC) ≥ 3) were compared in 2 subsequent trials with similar inclusion criteria but different DAPT duration, that is, BASKET (6 months; n = 557) and BASKET-PROVE (12 months; n = 2,314), between months 0 to 6 (DAPT in both trials), 7 to 12 (DAPT in BASKET-PROVE only), and 13 to 24 (aspirin in both trials) using propensity score-adjusted, time-stratified Cox proportional hazard models."	5.19	Tradeoff between bleeding and stent thrombosis in different dual antiplatelet therapy regimes: Importance of case fatality rates and effective treatment durations. ( Alber, H; Bonetti, PO; Eberli, F; Erne, P; Galatius, S; Jeger, RV; Kaiser, CA; Pedrazzini, G; Pfisterer, ME; Rickli, H; Sørensen, R; von Felten, S, 2014)
"We assessed in a prospective and randomized study the benefit of higher dose of aspirin, in association with clopidogrel, on aspirin response and non COX-specific platelet testing in patients receiving Drug Eluting Stent (DES) for stable angina pectoris."	5.14	Effect of increased aspirin dose after stenting in association with ClOpidogrel: the FIASCO randomized study. ( Bali, L; Bonnet, JL; Cuisset, T; Frere, C; Gaborit, B; Lambert, M; Morange, PE; Moro, PJ; Mouret, JP; Quilici, J; Uhry, S, 2009)
"This prospective registered study was conducted to investigate the impact of statins (pravastatin, fluvastatin, atorvastatin) on clopidogrel platelet inhibition in patients with acute coronary syndrome (ACS) or stable angina."	5.13	[Impact of statins on clopidogrel platelet inhibition in patients with acute coronary syndrome or stable angina]. ( Shen, J; Zhang, Q; Zhang, RY, 2008)
"Aspirin resistance may increase the risk of major adverse cardiac events (MACE) more than threefold in patients with stable coronary artery disease (CAD)."	5.12	Clinical relevance of aspirin resistance in patients with stable coronary artery disease: a prospective follow-up study (PROSPECTAR). ( Mercanoglu, F; Meric, M; Nisanci, Y; Oflaz, H; Oncul, A; Onur, I; Ozcan, M; Pamukcu, B; Umman, B, 2007)
"In elective stenting without clopidogrel pretreatment, use of a GPIIb/IIIa inhibitor produces superior platelet inhibition and lower myocardial necrosis compared with high-dose (600 mg) or standard-dose (300 mg) clopidogrel loading alone."	5.11	Clopidogrel loading with eptifibatide to arrest the reactivity of platelets: results of the Clopidogrel Loading With Eptifibatide to Arrest the Reactivity of Platelets (CLEAR PLATELETS) study. ( Bliden, KP; Gurbel, PA; Hayes, KM; Tantry, US; Yoho, JA; Zaman, KA, 2005)
" Thirty-nine patients with angina pectoris who were scheduled for coronary stent implantation were assigned to either group 1 (160 mg aspirin + 500 mg ticlopidine post-stent), group 2 (160 mg aspirin + abciximab + 500 mg ticlopidine post-stent) or group 3 (160 mg aspirin + loading dose (375/450 mg) clopidogrel pre-stent and 75 mg clopidogrel post-stent)."	5.10	Comparison of antiplatelet effect of loading dose of clopidogrel versus abciximab during coronary intervention. ( Bosmans, JM; Claeys, MJ; Dilling, D; Michiels, JJ; Van Der Planken, MG; Vertessen, F; Vrints, CJ, 2002)
" Therefore the effects of the platelet inhibitor ticlopidine (500 mg daily) on platelet function and on exercise tolerance were investigated in a double-blind placebo-controlled study in 38 middle-aged men with stable incapacitating angina pectoris."	5.06	Effects of the platelet inhibitor ticlopidine on exercise tolerance in stable angina pectoris. ( Berglund, U; Lassvik, C; Wallentin, L, 1987)
"The influence of the platelet inhibitory drug Ticlopidine (T) (500 mg daily) on lipoprotein metabolism was investigated in a double-blind placebo-controlled study of 38 middle-aged men with incapacitating stable angina pectoris."	5.06	Influence on lipoprotein metabolism of the platelet inhibitory drug ticlopidine. ( Berglund, U; Wallentin, L, 1986)
"The effects of ticlopidine (T) (500 mg daily) on platelet function were investigated in a double-blind placebo-controlled study in 38 middle-aged men with stable incapacitating angina pectoris."	5.05	Effects of ticlopidine of platelet function in men with stable angina pectoris. ( Berglund, U; von Schenck, H; Wallentin, L, 1985)
" Eligibility criteria for selecting studies Original full length reports assessing the cumulative incidence of major adverse cardiovascular events or stent thrombosis over a follow-up period of at least a month in association with carrier status for the loss of function or gain of function CYP2C19 allele in adult patients with coronary artery disease and a clinical presentation of acute coronary syndrome or stable angina pectoris who were taking clopidogrel."	4.87	Impact of CYP2C19 variant genotypes on clinical efficacy of antiplatelet treatment with clopidogrel: systematic review and meta-analysis. ( Bauer, T; Bouman, HJ; Ford, NF; Taubert, D; ten Berg, JM; van Werkum, JW, 2011)
"Appropriate oral first-line antiplatelet therapy is aspirin for individuals with ST-segment elevation myocardial infarction; aspirin or clopidogrel for those with TIA or stroke, chronic stable angina, or peripheral arterial disease; and aspirin combined with clopidogrel for those with non-ST-segment elevation acute coronary syndrome."	4.82	Oral antiplatelet therapy in cerebrovascular disease, coronary artery disease, and peripheral arterial disease. ( Anand, SS; Tran, H, 2004)
" In elective de novo lesions has shown remarkably clear lumens at follow-up angiography and intravascular ultrasound within the stented segments were observed with no lesion progression at the stent margins or thrombosis after a 2 month regimen of aspirin, and ticlopodine or clopidogrel."	4.81	Sirolimus-eluting stents: a review of experimental and clinical findings. ( Albiero, R; Colombo, A; Corvaja, N; Di Mario, C; Falotico, R; Stankovic, G; Takagi, T; Toutouzas, K, 2002)
" Strategies used for plaque stabilisation resulting in a reduction in cardiovascular mortality and morbidity are: smoking cessation; aspirin (acetylsalicylic acid); blood pressure control; lipid lowering agents when low density lipoprotein cholesterol is elevated despite dietary therapy; coronary bypass surgery in patients with left main stem disease or triple vessel coronary disease and diminished left ventricular function; and use of estrogen in postmenopausal women."	4.80	Choosing the most appropriate treatment for stable angina. Safety considerations. ( Asirvatham, S; Sebastian, C; Thadani, U, 1998)
"To observe the relationship between ATP-binding cassette subfamily B member 1 (ABCB1) and cytochrome P450 (CYP)2C19 polymorphisms and the effect of clopidogrel post percutaneous coronary intervention in patients with coronary artery disease."	3.83	[Relationship between ATP-binding cassette subfamily B member 1 and cytochrome P450 2C19 polymorphisms and the effect of clopidogrel post percutaneous coronary intervention in patients with acute coronary syndrome]. ( Fu, ZH; Han, BS; Li, DY; Ren, YH; Song, YQ; Xue, Q; Yi, J; Zhou, CF, 2016)
"The authors studied efficacy of the generic clopidogrel Еgithromb manufactured by EGIS PHARMACEUTICALS (Hungary) based on clinical data and parameters of light aggregometry in a total of 30 patients subjected to planned subcutaneous coronary intervention for stable angina pectoris."	3.79	[Assessment of clinical and antiaggregation efficacy of generic clopidogrel 'Egithromb' in roentgenosurgical practice]. ( Faĭl', IL; Loenko, VB; Smialovskiĭ, DV; Sorokina, EA, 2013)
"A 65-year-old man, who had been given a diagnosis of angina pectoris, developed pneumonia 6 months after the initiation of clopidogrel to inhibit platelet aggregation."	3.76	[A case of drug-induced pneumonia caused by clopidogrel]. ( Hirata, K; Matsushita, H; Suzumura, T; Tamagaki, G; Watanabe, T; Yamada, S, 2010)
"A database of deidentified electronic medical records from hospitals and hospital-affiliated outpatient facilities throughout the United States was analyzed for PCI patients with or without a diagnosis of acute coronary syndrome (ACS) who received clopidogrel loading doses of > or =300 mg between 48 hours before and 6 hours after PCI."	3.76	Pattern of clopidogrel use in hospitalized patients receiving percutaneous coronary interventions. ( Bae, JP; Dean, BB; Emons, MF; Fiske, S; Meadows, E; Xiong, Y; Yu, HT, 2010)
" This study was designed to determine the relation between responses to aspirin and clopidogrel as assessed by a point-of-care assay (Verify Now, Accumetrics, San Diego, California) and periprocedural myocardial infarction (PMI) in patients undergoing elective PCI for stable angina."	3.74	Relation of low response to clopidogrel assessed with point-of-care assay to periprocedural myonecrosis in patients undergoing elective coronary stenting for stable angina pectoris. ( Barbato, E; Bartunek, J; Cuisset, T; De Bruyne, B; Hamilos, M; Sarma, J; Sarno, G; Vanderheyden, M; Wijns, W; Wyffels, E, 2008)
" All suffered stent thrombosis after discontinuation (in three cases prematurely) of clopidogrel therapy."	3.73	[Thrombosis of a coronary stent after discontinuing treatment with clopidogrel]. ( de Boer, MJ; Hautvast, RW; Heestermans, AA; Jaarsma, W; ten Berg, JM; van Werkum, JW, 2006)
"We evaluated the effect of high versus low loading doses of clopidogrel in patients with stable angina pectoris who underwent percutaneous coronary intervention (PCI) on periprocedural events, in-hospital complications, and 30-day outcomes."	3.73	Clopidogrel loading dose (300 versus 600 mg) strategies for patients with stable angina pectoris subjected to percutaneous coronary intervention. ( Gevorkian, N; Hassani, SE; Kent, KM; Pichard, AD; Satler, LF; Torguson, RL; Waksman, R; Wolfram, RM; Xue, Z, 2006)
"Dual antiplatelet therapy with aspirin and clopidogrel decreases the rate of stent thrombosis in patients undergoing percutaneous coronary intervention (PCI)."	3.72	Prevalence of clopidogrel non-responders among patients with stable angina pectoris scheduled for elective coronary stent placement. ( Besta, F; Gawaz, M; Massberg, S; Müller, I; Schönig, A; Schulz, C, 2003)
"In a large, randomized, placebo-controlled trial in centers that use a conservative approach to acute coronary syndromes, the antiplatelet drug clopidogrel (Plavix) decreased the rate of the combined end point of cardiovascular death, nonfatal myocardial infarction, or stroke by 20% in patients presenting with acute coronary syndromes without ST-segment elevation."	3.71	The CURE trial: using clopidogrel in acute coronary syndromes without ST-segment elevation. ( Bhatt, DL; Gerschutz, GP, 2002)
"Nifedipine-induced gingival hypertrophy is a rare side effect reported by the producers of this drug but, surely, not well known in all its aspects."	3.68	[Nifedipine and gingival hypertrophy]. ( Borgia, MC; Calpicchio, A; De Paola, G; Di Folco, G, 1991)
"Treatment with sarpogrelate in addition to aspirin and ticlopidine caused no major adverse cardiovascular events or hemorrhagic adverse effects during the 6-month follow-up period."	2.71	Sarpogrelate treatment reduces restenosis after coronary stenting. ( Fujita, M; Ho, M; Ishii, K; Miki, O; Miwa, K; Miyamoto, A; Mizuno, K; Tsukahara, R, 2003)
"When ticlopidine was given for 72 hours, TF levels were similar to normal laboratory values both in stable and unstable patients."	2.69	Effect of aspirin and ticlopidine on plasma tissue factor levels in stable and unstable angina pectoris. ( Ariëns, RA; Bernies, M; Bossi, IM; Brambilla, GM; Donatelli, F; Fajadet, J; Gregorini, L; Marco, I; Marco, J; Mari, D; Romano, SM; Somalvico, F, 2000)
"Ticlopidine is a drug that inhibits the ADP-induced aggregation of blood platelets and it also has been described that ticlopidine can decrease the plasma fibrinogen level in patients with vascular diseases."	2.68	Modulation of plasma fibrinogen levels by ticlopidine in healthy volunteers and patients with stable angina pectoris. ( Arnold, AE; de Maat, MP; Kluft, C; van Buuren, S; Wilson, JH, 1996)
"Patients with more extensive coronary atherosclerosis have a higher rate of HPR, which might partly account for higher risk of periprocedural MI."	1.36	High residual platelet reactivity after clopidogrel: extent of coronary atherosclerosis and periprocedural myocardial infarction in patients with stable angina undergoing percutaneous coronary intervention. ( Barbato, E; Bartunek, J; De Bruyne, B; Di Sciascio, G; Heyndrickx, G; Mangiacapra, F; Muller, O; Ntalianis, A; Trana, C; Wijns, W, 2010)
"Aspirin was given as 160 mg/day and clopidogrel as 300 mg loading dose followed by 75 mg/day."	1.35	Clopidogrel inhibits platelet aggregation in patients on aspirin with stable chronic angina pectoris. ( Agewall, S; Berglund, M; Gordon, A; Saha, S; Sylvén, C, 2008)
" Specifically, there was no difference in the tirofiban dose-response curves with either platelet agonist for any of the three time points (before, and three and six hours after, clopidogrel administration)."	1.32	Does clopidogrel increase the degree of platelet inhibition when a platelet glycoprotein IIb/IIIa inhibitor has been given? Insights from an optical platelet aggregometry study. ( Berger, PB; DiBattiste, PM; Lennon, R; Lubbe, D; Orford, JL; Talreja, D, 2004)

Research

Studies (121)

Authors

Clinical Trials (18)

Trial Overview

Trial Outcomes

Area Under Curve of Serial Cardiac Biomarkers

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (9.09)	18.7374
1990's	11 (9.09)	18.2507
2000's	69 (57.02)	29.6817
2010's	30 (24.79)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Kim, JB	1
Choi, BG	1
Rha, SW	1
Seo, HS	1
Choi, SY	1
Byun, JK	1
Na, JO	1
Choi, CU	1
Kim, EJ	1
Park, CG	1
Oh, DJ	1
Grinshtein, YI	1
Kosinova, AA	1
Grinshtein, IY	1
Subbotina, TN	1
Savchenko, AA	1
Deo, SV	1
Dunlay, SM	1
Shah, IK	1
Altarabsheh, SE	1
Erwin, PJ	1
Boilson, BA	1
Park, SJ	1
Joyce, LD	1
Loenko, VB	1
Sorokina, EA	1
Faĭl', IL	1
Smialovskiĭ, DV	1
Martínez-Quintana, E	1
Medina-Gil, JM	1
Rodríguez-González, F	1
Garay-Sánchez, P	1
Limiñana, JM	1
Saavedra, P	1
Tugores, A	1
López Mínguez, JR	1
Nogales Asensio, JM	1
Doncel Vecino, LJ	1
Sandoval, J	1
Romany, S	1
Martínez Romero, P	1
Fernández Díaz, JA	1
Fernández Portales, J	1
González Fernández, R	1
Martínez Cáceres, G	1
Merchán Herrera, A	1
Alfonso Manterola, F	1
Jeger, RV	1
Pfisterer, ME	2
Sørensen, R	1
von Felten, S	1
Alber, H	1
Bonetti, PO	1
Eberli, F	1
Erne, P	1
Pedrazzini, G	1
Rickli, H	1
Galatius, S	1
Kaiser, CA	3
Ichikawa, M	1
Takei, Y	1
Hamasaki, T	1
Kijima, Y	1
Wei, YQ	1
Wang, DG	1
Yang, H	1
Cao, H	1
Zhou, CF	1
Ren, YH	1
Song, YQ	1
Yi, J	1
Han, BS	1
Xue, Q	1
Fu, ZH	1
Li, DY	1
Godfrey, A	1
Cajigas, HR	1
Cuisset, T	2
Hamilos, M	2
Sarma, J	1
Sarno, G	1
Wyffels, E	1
Vanderheyden, M	1
Barbato, E	4
Bartunek, J	3
De Bruyne, B	3
Wijns, W	4
Walter, T	1
Szabo, S	1
Kazmaier, S	1
Swoboda, S	1
Suselbeck, T	1
Brueckmann, M	1
Borggrefe, M	1
Beyer, ME	1
Hoffmeister, HM	1
Lim, SY	1
Kim, KS	1
Joo, SJ	1
Jeong, MH	1
Burgstahler, C	1
Geisler, T	2
Lindemann, S	1
Brodoefel, H	1
Reimann, A	1
Heuschmid, M	1
Gawaz, M	5
Schroeder, S	1
Schneider, DJ	1
Sobel, BE	1
Kastrati, A	5
Neumann, FJ	4
Mehilli, J	5
Byrne, RA	1
Iijima, R	1
Büttner, HJ	2
Khattab, AA	1
Schulz, S	2
Blankenship, JC	2
Pache, J	3
Minners, J	1
Seyfarth, M	4
Graf, I	2
Skelding, KA	1
Dirschinger, J	4
Richardt, G	1
Berger, PB	3
Schömig, A	5
Weintraub, WS	1
Spertus, JA	2
Kolm, P	1
Maron, DJ	1
Zhang, Z	1
Jurkovitz, C	1
Zhang, W	1
Hartigan, PM	1
Lewis, C	1
Veledar, E	1
Bowen, J	1
Dunbar, SB	1
Deaton, C	1
Kaufman, S	1
O'Rourke, RA	1
Goeree, R	1
Barnett, PG	1
Teo, KK	1
Boden, WE	1
Mancini, GB	1
de la Cruz, KI	1
Tsai, PI	1
Cohn, WE	1
Cooley, DA	1
Ramsdale, DR	1
Rao, A	1
Asghar, O	1
Ramsdale, KA	1
McKay, E	1
Frere, C	1
Quilici, J	1
Uhry, S	1
Morange, PE	1
Mouret, JP	1
Gaborit, B	1
Bali, L	1
Moro, PJ	1
Lambert, M	1
Bonnet, JL	1
Wang, ZJ	1
Zhou, YJ	1
Liu, YY	1
Yu, M	1
Shi, DM	1
Zhao, YX	1
Guo, YH	1
Cheng, WJ	1
Jia, de A	1
Cao, Z	1
Nie, B	1
Ge, HL	1
Yang, SW	1
Yan, ZX	1
Bonello, L	2
Camoin-Jau, L	2
Armero, S	1
Com, O	1
Arques, S	1
Burignat-Bonello, C	1
Giacomoni, MP	1
Bonello, R	1
Collet, F	1
Rossi, P	1
Barragan, P	1
Dignat-George, F	2
Paganelli, F	2
Shen, J	1
Zhang, RY	1
Zhang, Q	1
Leibundgut, G	1
Nietlispach, F	1
Pittl, U	1
Brunner-La Rocca, H	1
Davlouros, PA	1
Arseniou, A	1
Hahalis, G	1
Chiladakis, J	1
Mazarakis, A	1
Damelou, A	1
Karakantza, M	1
Paliogianni, F	1
Karogiannis, N	1
Alexopoulos, D	2
Stellos, K	2
Bigalke, B	2
Stakos, D	1
Henkelmann, N	1
Xue, F	1
Yang, XJ	1
Cheng, XJ	1
Hui, J	1
Jiang, TB	1
Chen, T	1
Liu, ZH	1
Song, JP	1
Jiang, WP	1
Muller, O	2
Ulrichts, H	1
Mangiacapra, F	3
Holz, JB	1
Ntalianis, A	2
Trana, C	2
Dierickx, K	1
Vercruysse, K	1
Heyndrickx, G	1
Di Sciascio, G	2
Tamagaki, G	1
Matsushita, H	1
Suzumura, T	1
Watanabe, T	1
Yamada, S	1
Hirata, K	1
Aradi, D	2
Magyarlaki, T	1
Tokés-Füzesi, M	1
Rideg, O	1
Vorobcsuk, A	1
Komócsi, A	1
Dean, BB	1
Yu, HT	1
Bae, JP	1
Fiske, S	1
Meadows, E	1
Xiong, Y	1
Emons, MF	1
Schuster, T	1
Massberg, S	3
Valina, C	1
Laugwitz, KL	1
Ndrepepa, G	1
Harhouri, K	1
Sabatier, F	1
Arnaud, L	1
Baumstarck-Barrau, K	1
Ait-Mokhtar, O	1
Roubille, F	1
Piot, C	1
Lesavre, N	1
Batyraliev, TA	1
Fettser, DV	1
Samko, AN	1
Sidorenko, BA	1
Menown, IB	1
Peace, AJ	1
Beitelshees, AL	1
Horenstein, RB	1
Vesely, MR	1
Mehra, MR	1
Shuldiner, AR	1
Ulus, T	1
Ozduman, H	1
Cavuşoğlu, Y	1
Bauer, T	1
Bouman, HJ	1
van Werkum, JW	3
Ford, NF	1
ten Berg, JM	3
Taubert, D	1
Hazarbasanov, D	1
Velchev, V	1
Finkov, B	1
Postadjian, A	1
Kostov, E	1
Rifai, N	1
Linares Vicente, JA	1
Pérez, JO	1
Lacasa, RC	1
Fihn, SD	1
Gardin, JM	1
Abrams, J	1
Berra, K	1
Dallas, AP	1
Douglas, PS	1
Foody, JM	1
Gerber, TC	1
Hinderliter, AL	1
King, SB	1
Kligfield, PD	1
Krumholz, HM	1
Kwong, RY	1
Lim, MJ	1
Linderbaum, JA	1
Mack, MJ	1
Munger, MA	1
Prager, RL	1
Sabik, JF	1
Shaw, LJ	1
Sikkema, JD	1
Smith, CR	1
Smith, SC	1
Williams, SV	1
Järemo, P	1
Lindahl, TL	1
Fransson, SG	1
Richter, A	1
Cannon, CP	1
Toutouzas, K	1
Di Mario, C	1
Falotico, R	1
Takagi, T	1
Stankovic, G	1
Albiero, R	1
Corvaja, N	1
Colombo, A	2
Fujita, M	1
Mizuno, K	1
Ho, M	1
Tsukahara, R	1
Miyamoto, A	1
Miki, O	1
Ishii, K	1
Miwa, K	1
Borja, J	1
Pérez, I	1
De la Cruz, G	1
Müller, I	2
Besta, F	2
Schulz, C	2
Schönig, A	1
Kopp, CW	1
Steiner, S	1
Priglinger, U	1
Christ, G	2
Probst, P	1
Maurer, G	1
Minar, E	1
Huber, K	2
Pogatsa-Murray, G	1
Bollwein, H	2
Bestehorn, HP	1
Schmitt, C	1
Li, Z	1
SoRelle, R	1
Van der Planken, MG	2
Claeys, MJ	2
Vertessen, FJ	1
Dilling, D	2
Bosmans, JM	2
Berneman, ZN	1
Michiels, JJ	2
Vrints, C	1
Jaster, M	1
Fuster, V	1
Rosenthal, P	1
Pauschinger, M	1
Tran, QV	1
Janssen, D	1
Hinkelbein, W	1
Schwimmbeck, P	1
Schultheiss, HP	1
Rauch, U	1
Weltermann, A	1
Fritsch, P	1
Kyrle, PA	1
Schoenauer, V	1
Heinze, G	1
Wojta, J	1
Eriksson, P	1
Genest, M	1
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Andersohn, F	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
Effect of Tailored Use of Tirofiban in Patients With Non-ST-elevation Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention[NCT03114995]	Phase 4	140 participants (Actual)	Interventional	2012-02-01	Completed
Prospective, Randomized, Double-Blind, Active-Controlled, Multicenter Trial of Bivalirudin and Un-fractionated Heparin in Patients Undergoing Percutaneous Coronary Interventions. ISAR-REACT-3[NCT00262054]	Phase 4	4,570 participants (Actual)	Interventional	2005-11-30	Completed
Non-randomized, Open-label, Historical Control, Single Group Assignment Trial of a Reduced Dose of Unfractionated Heparin in Patients Undergoing Percutaneous Coronary Interventions[NCT00735280]	Phase 4	2,505 participants (Actual)	Interventional	2008-08-31	Completed
CSP #424 - Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation[NCT00007657]	Phase 3	3,260 participants (Anticipated)	Interventional	1998-12-31	Completed
Quality of Life and Achievement of Target of Treatment After Optimized Medical Treatment, Physical Training and Smoking Cessation With or Without Percutaneous Coronary Intervention in Patients With Stable Angina Pectoris.[NCT00825604]	Phase 2	0 participants (Actual)	Interventional	2009-01-31	Withdrawn (stopped due to Because of poor inclusion difficulties to find patient)
Impact of Coronary Artery Stenting on Quantitative Myocardial Blood Flow and Health Status[NCT04475094]		75 participants (Anticipated)	Observational	2019-12-23	Recruiting
Routine Or Selective Stress Testing After Revascularization: ROSSTAR Trial RCT Outline[NCT03067402]		1,100 participants (Anticipated)	Interventional	2017-03-20	Not yet recruiting
Register of Cardiovascular Complications Among People Living With HIV[NCT02453919]		800 participants (Anticipated)	Observational [Patient Registry]	2010-02-28	Recruiting
Clopidogrel Hyper-Responsiveness: Incidence and Associated Outcomes in Patients With Cerebral Aneurysms[NCT05945563]		208 participants (Anticipated)	Observational [Patient Registry]	2023-01-17	Recruiting
Prospective, Randomized, Double-Blind, Placebo-Controlled Trial of the Glycoprotein IIb/IIIa Inhibition With Abciximab in Patients With ACS Undergoing Coronary Stenting After Pretreatment With a High Loading Dose of Clopidogrel (ISAR-REACT-2)[NCT00133003]	Phase 4	2,022 participants (Actual)	Interventional	2003-03-31	Completed
Acute Angioplasty (Primary PCI) Versus Traditional Early Invasive Treatment of Patients Presenting With NSTEMI (The Second Danish Non-ST-Elevation MI Trial - DaNSTEMI-2)[NCT00493584]		14 participants (Actual)	Interventional	2008-03-31	Terminated (stopped due to Due to insufficient patient inclusion the study has been stopped prematurely.)
Randomized, Double-Blind, Active-Controlled, Multicenter Trial of Abciximab And Bivalirudin in Patients With Non-ST-Segment Elevation Myocardial Infarction Undergoing Percutaneous Coronary Interventions (ISAR-REACT-4)[NCT00373451]	Phase 4	1,721 participants (Actual)	Interventional	2006-07-31	Completed
The Effect of Ticagrelor on Acute Coronary Syndrome Patients With Clopidogrel Resistance Undergoing Percutaneous Coronary Intervention[NCT01812330]	Phase 3	180 participants (Anticipated)	Interventional	2013-01-31	Recruiting
A Pilot Study of The Effects of a Single High Dose Bolus Tirofiban in Diabetic Patients Undergoing Elective Percutaneous Coronary Intervention[NCT00407771]	Phase 4	44 participants (Anticipated)	Interventional	2007-11-30	Not yet recruiting
"Evaluation of Antiplatelet Effects and Safety of Intraoperative Administration of Ticagrelor Versus Clopidogrel in Patients Undergoing One-stop Hybrid Coronary Revascularization"[NCT02513004]	Phase 4	60 participants (Anticipated)	Interventional	2015-06-30	Recruiting
REduction of Myocardial Necrosis Achieved With Nose-dive Manual Thrombus Aspiration[NCT01342848]		76 participants (Actual)	Observational	2011-03-31	Completed
Are Serial Electrocardiograms Additive to SeriAl Second-generations Troponins in Predicting Acute CoronAry Syndromes in PatienTs With Undifferentiated cHest Pain (ASAP CATH) Study[NCT01953276]		382 participants (Anticipated)	Observational	2013-01-31	Completed
Uninterrupted Direct-acting Oral Anticoagulation in Patients Undergoing Transradial Percutaneous Coronary Procedures[NCT05292846]	Phase 4	200 participants (Anticipated)	Interventional	2022-01-20	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

An area under the curve of serial levels of Troponin I and creatine kinase-MB isoenzyme during 36 hours (NCT03114995)
Timeframe: 0,6,12,18,24,30,36 hours

Percentage of Participants With Periprocedural Myonecrosis

Intervention	Hours*ng/ml (Median)
	Troponin I	creatine kinase-MB isoenzyme
Control C1 (High Platelet Reactivity - no Tirofiban)	38.0	92.7
Control C2 (Low Platelet Reactivity - no Tirofiban)	121.4	185.6
Group A (High Platelet Reactivity - Tirofiban)	197.2	252.5

"Percentage of participants with periprocedural myonecrosis under the criteria described below.~When the cardiac biomarkers before the procedure were within the 99th percentile upper reference limit (URL), more than a 5-fold elevation in the URL within 12 hours after percutaneous coronary intervention (PCI) was defined as periprocedural myonecrosis. If the cardiac biomarker level was already above the 99th percentile URL before the procedure and the trend was stationary or decreasing, a ≥20% increase compared to the previous level was considered periprocedural myonecrosis. If the trend was still increasing, the levels at the post-6 hour and 12-hour were compared to determine periprocedural myonecrosis." (NCT03114995)
Timeframe: 0,6,12,18,24,30,36 hours

Article	Year
Dual anti-platelet therapy after coronary artery bypass grafting: is there any benefit? A systematic review and meta-analysis. Journal of cardiac surgery, 2013, Volume: 28, Issue:2 Topics: Angina Pectoris; Aspirin; Clopidogrel; Coronary Artery Bypass; Drug Therapy, Combination; Graft Occl	2013
Revascularization treatment recommendations based on atherosclerotic disease distribution: coronary artery bypass grafting versus stenting. Current atherosclerosis reports, 2008, Volume: 10, Issue:5 Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Bypass; Coronary Arter	2008
Contemporary management of coronary heart disease. The journal of the Royal College of Physicians of Edinburgh, 2010, Volume: 40, Issue:1 Topics: Acute Coronary Syndrome; Administration, Oral; Angina Pectoris; Angioplasty, Balloon, Coronary; Anti	2010
Impact of CYP2C19 variant genotypes on clinical efficacy of antiplatelet treatment with clopidogrel: systematic review and meta-analysis. BMJ (Clinical research ed.), 2011, Aug-04, Volume: 343 Topics: Acute Coronary Syndrome; Angina Pectoris; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-4	2011
Sirolimus-eluting stents: a review of experimental and clinical findings. Zeitschrift fur Kardiologie, 2002, Volume: 91 Suppl 3 Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Animals; Aspirin; Clopidogrel; Coronary Angiography	2002
[Acute coronary syndromes without ST segment elevation]. Presse medicale (Paris, France : 1983), 2004, May-22, Volume: 33, Issue:9 Pt 1 Topics: Acute Disease; Adrenergic beta-Antagonists; Analgesics, Opioid; Angina Pectoris; Angiotensin-Convert	2004
Oral antiplatelet therapy in cerebrovascular disease, coronary artery disease, and peripheral arterial disease. JAMA, 2004, Oct-20, Volume: 292, Issue:15 Topics: Administration, Oral; Angina Pectoris; Arteriosclerosis; Aspirin; Cerebrovascular Disorders; Clopido	2004
[Prevention of periprocedural myocardial damage in patients undergoing percutaneous coronary intervention]. Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology, 2005, Volume: 6, Issue:9 Topics: Actuarial Analysis; Adenosine; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Anticholestere	2005
Choosing the most appropriate treatment for stable angina. Safety considerations. Drug safety, 1998, Volume: 19, Issue:1 Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Angiotensin-Converting Enzyme Inhibitors; Aspiri	1998
[Therapeutic inhibition of platelets in a acute coronary syndrome and in coronary intervention: mechanisms and clinical results]. Zeitschrift fur Kardiologie, 2000, Volume: 89 Suppl 7 Topics: Abciximab; Acute Disease; Adult; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary;	2000
New approaches to the pharmacological treatment of angina. Current opinion in pharmacology, 2001, Volume: 1, Issue:2 Topics: Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary; Angiotensin-Converting Enzyme Inh	2001

Article	Year
A prospective randomised study of the paclitaxel-coated balloon catheter in bifurcated coronary lesions (BABILON trial): 24-month clinical and angiographic results. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2014, Volume: 10, Issue:1 Topics: Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; C	2014
Tradeoff between bleeding and stent thrombosis in different dual antiplatelet therapy regimes: Importance of case fatality rates and effective treatment durations. American heart journal, 2014, Volume: 168, Issue:5 Topics: Aged; Angina Pectoris; Aspirin; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combination; Drug-El	2014
Effect of clopidogrel on adhesion molecules, hemostasis, and fibrinolysis in coronary heart disease. Journal of cardiovascular pharmacology, 2008, Volume: 51, Issue:6 Topics: Aged; Angina Pectoris; Aspirin; Cell Adhesion Molecules; Chronic Disease; Clopidogrel; Double-Blind	2008
Bivalirudin versus unfractionated heparin during percutaneous coronary intervention. The New England journal of medicine, 2008, Aug-14, Volume: 359, Issue:7 Topics: Aged; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Clopidogrel	2008
Bivalirudin versus unfractionated heparin during percutaneous coronary intervention. The New England journal of medicine, 2008, Aug-14, Volume: 359, Issue:7 Topics: Aged; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Clopidogrel	2008
Bivalirudin versus unfractionated heparin during percutaneous coronary intervention. The New England journal of medicine, 2008, Aug-14, Volume: 359, Issue:7 Topics: Aged; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Clopidogrel	2008
Bivalirudin versus unfractionated heparin during percutaneous coronary intervention. The New England journal of medicine, 2008, Aug-14, Volume: 359, Issue:7 Topics: Aged; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Clopidogrel	2008
Effect of PCI on quality of life in patients with stable coronary disease. The New England journal of medicine, 2008, Aug-14, Volume: 359, Issue:7 Topics: Adrenergic beta-Antagonists; Amlodipine; Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; C	2008
Effect of PCI on quality of life in patients with stable coronary disease. The New England journal of medicine, 2008, Aug-14, Volume: 359, Issue:7 Topics: Adrenergic beta-Antagonists; Amlodipine; Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; C	2008
Effect of PCI on quality of life in patients with stable coronary disease. The New England journal of medicine, 2008, Aug-14, Volume: 359, Issue:7 Topics: Adrenergic beta-Antagonists; Amlodipine; Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; C	2008
Effect of PCI on quality of life in patients with stable coronary disease. The New England journal of medicine, 2008, Aug-14, Volume: 359, Issue:7 Topics: Adrenergic beta-Antagonists; Amlodipine; Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; C	2008
Effect of PCI on quality of life in patients with stable coronary disease. The New England journal of medicine, 2008, Aug-14, Volume: 359, Issue:7 Topics: Adrenergic beta-Antagonists; Amlodipine; Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; C	2008
Effect of PCI on quality of life in patients with stable coronary disease. The New England journal of medicine, 2008, Aug-14, Volume: 359, Issue:7 Topics: Adrenergic beta-Antagonists; Amlodipine; Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; C	2008
Effect of PCI on quality of life in patients with stable coronary disease. The New England journal of medicine, 2008, Aug-14, Volume: 359, Issue:7 Topics: Adrenergic beta-Antagonists; Amlodipine; Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; C	2008
Effect of PCI on quality of life in patients with stable coronary disease. The New England journal of medicine, 2008, Aug-14, Volume: 359, Issue:7 Topics: Adrenergic beta-Antagonists; Amlodipine; Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; C	2008
Effect of PCI on quality of life in patients with stable coronary disease. The New England journal of medicine, 2008, Aug-14, Volume: 359, Issue:7 Topics: Adrenergic beta-Antagonists; Amlodipine; Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; C	2008
Effect of increased aspirin dose after stenting in association with ClOpidogrel: the FIASCO randomized study. Thrombosis research, 2009, Volume: 124, Issue:1 Topics: Adenosine Diphosphate; Aged; Angina Pectoris; Arachidonic Acid; Aspirin; Blood Platelets; Clopidogre	2009
Tailored clopidogrel loading dose according to platelet reactivity monitoring to prevent acute and subacute stent thrombosis. The American journal of cardiology, 2009, Jan-01, Volume: 103, Issue:1 Topics: Acute Disease; Aged; Angina Pectoris; Blood Platelets; Clopidogrel; Coronary Angiography; Coronary T	2009
[Impact of statins on clopidogrel platelet inhibition in patients with acute coronary syndrome or stable angina]. Zhonghua xin xue guan bing za zhi, 2008, Volume: 36, Issue:9 Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Angina Pectoris; Atorvastatin; Clopidogrel; Dr	2008
Stent thrombosis up to 3 years after stenting for ST-segment elevation myocardial infarction versus for stable angina--comparison of the effects of drug-eluting versus bare-metal stents. American heart journal, 2009, Volume: 158, Issue:2 Topics: Angina Pectoris; Clopidogrel; Drug-Eluting Stents; Endpoint Determination; Humans; Myocardial Infarc	2009
Timing of clopidogrel loading before percutaneous coronary intervention in clopidogrel-naive patients with stable or unstable angina: a comparison of two strategies. American heart journal, 2009, Volume: 158, Issue:4 Topics: Aged; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary; C-Reactive Protein; Clopido	2009
ISAR-REACT 3A: a study of reduced dose of unfractionated heparin in biomarker negative patients undergoing percutaneous coronary intervention. European heart journal, 2010, Volume: 31, Issue:20 Topics: Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Anticoagulants; Biomarkers; Clopidogrel; Deat	2010
Level of adenosine diphosphate receptor P2Y12 blockade during percutaneous coronary intervention predicts the extent of endothelial injury, assessed by circulating endothelial cell measurement. Journal of the American College of Cardiology, 2010, Sep-21, Volume: 56, Issue:13 Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Blood Platelets; Clopidogrel; Endothelial Cells; En	2010
[Implantation of the paclitaxel-eluting stent Apollo in patients with stable angina pectoris: long-term angiographic and clinical results]. Terapevticheskii arkhiv, 2010, Volume: 82, Issue:8 Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Coronar	2010
Tailoring clopidogrel dose according to multiple electrode aggregometry decreases the rate of ischemic complications after percutaneous coronary intervention. Journal of thrombosis and thrombolysis, 2012, Volume: 34, Issue:1 Topics: Acute Coronary Syndrome; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Clopidogrel; Disease	2012
Individual variations of platelet inhibition after loading doses of clopidogrel. Journal of internal medicine, 2002, Volume: 252, Issue:3 Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Blood Platelets; Clopidogrel; Dose-Response Relatio	2002
Sarpogrelate treatment reduces restenosis after coronary stenting. American heart journal, 2003, Volume: 145, Issue:3 Topics: Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; Cell Division; Coronary Angiography;	2003
Parameters of the tissue factor pathway with coumadin/dipyridamole versus ticlopidine as adjunct antithrombotic-drug regimen in coronary artery stenting. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2003, Volume: 14, Issue:4 Topics: Adult; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; C	2003
Evaluation of prolonged antithrombotic pretreatment ("cooling-off" strategy) before intervention in patients with unstable coronary syndromes: a randomized controlled trial. JAMA, 2003, Sep-24, Volume: 290, Issue:12 Topics: Aged; Angina Pectoris; Aspirin; Catheterization; Clopidogrel; Female; Fibrinolytic Agents; Heparin;	2003
Evaluation of prolonged antithrombotic pretreatment ("cooling-off" strategy) before intervention in patients with unstable coronary syndromes: a randomized controlled trial. JAMA, 2003, Sep-24, Volume: 290, Issue:12 Topics: Aged; Angina Pectoris; Aspirin; Catheterization; Clopidogrel; Female; Fibrinolytic Agents; Heparin;	2003
Evaluation of prolonged antithrombotic pretreatment ("cooling-off" strategy) before intervention in patients with unstable coronary syndromes: a randomized controlled trial. JAMA, 2003, Sep-24, Volume: 290, Issue:12 Topics: Aged; Angina Pectoris; Aspirin; Catheterization; Clopidogrel; Female; Fibrinolytic Agents; Heparin;	2003
Evaluation of prolonged antithrombotic pretreatment ("cooling-off" strategy) before intervention in patients with unstable coronary syndromes: a randomized controlled trial. JAMA, 2003, Sep-24, Volume: 290, Issue:12 Topics: Aged; Angina Pectoris; Aspirin; Catheterization; Clopidogrel; Female; Fibrinolytic Agents; Heparin;	2003
Evaluation of prolonged antithrombotic pretreatment ("cooling-off" strategy) before intervention in patients with unstable coronary syndromes: a randomized controlled trial. JAMA, 2003, Sep-24, Volume: 290, Issue:12 Topics: Aged; Angina Pectoris; Aspirin; Catheterization; Clopidogrel; Female; Fibrinolytic Agents; Heparin;	2003
Evaluation of prolonged antithrombotic pretreatment ("cooling-off" strategy) before intervention in patients with unstable coronary syndromes: a randomized controlled trial. JAMA, 2003, Sep-24, Volume: 290, Issue:12 Topics: Aged; Angina Pectoris; Aspirin; Catheterization; Clopidogrel; Female; Fibrinolytic Agents; Heparin;	2003
Evaluation of prolonged antithrombotic pretreatment ("cooling-off" strategy) before intervention in patients with unstable coronary syndromes: a randomized controlled trial. JAMA, 2003, Sep-24, Volume: 290, Issue:12 Topics: Aged; Angina Pectoris; Aspirin; Catheterization; Clopidogrel; Female; Fibrinolytic Agents; Heparin;	2003
Evaluation of prolonged antithrombotic pretreatment ("cooling-off" strategy) before intervention in patients with unstable coronary syndromes: a randomized controlled trial. JAMA, 2003, Sep-24, Volume: 290, Issue:12 Topics: Aged; Angina Pectoris; Aspirin; Catheterization; Clopidogrel; Female; Fibrinolytic Agents; Heparin;	2003
Evaluation of prolonged antithrombotic pretreatment ("cooling-off" strategy) before intervention in patients with unstable coronary syndromes: a randomized controlled trial. JAMA, 2003, Sep-24, Volume: 290, Issue:12 Topics: Aged; Angina Pectoris; Aspirin; Catheterization; Clopidogrel; Female; Fibrinolytic Agents; Heparin;	2003
Effects of statins on platelet inhibition by a high loading dose of clopidogrel. Circulation, 2003, Nov-04, Volume: 108, Issue:18 Topics: Aged; Angina Pectoris; Blood Platelets; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy,	2003
Effects of pretreatment with clopidogrel on platelet and coagulation activation in patients undergoing elective coronary stenting. Thrombosis research, 2003, Volume: 112, Issue:1-2 Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; beta-Thromboglobulin; Blood Vessel Prosthesis; Clop	2003
The effect of long-term clopidogrel use on neointimal formation after percutaneous coronary intervention. Coronary artery disease, 2004, Volume: 15, Issue:6 Topics: Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; C	2004
Variable extent of clopidogrel responsiveness in patients after coronary stenting. Thrombosis and haemostasis, 2004, Volume: 92, Issue:6 Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Angina Pectoris; Angioplasty, Balloon, Corona	2004
Clopidogrel loading with eptifibatide to arrest the reactivity of platelets: results of the Clopidogrel Loading With Eptifibatide to Arrest the Reactivity of Platelets (CLEAR PLATELETS) study. Circulation, 2005, Mar-08, Volume: 111, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Angioplasty, Balloon, Coronary; Cardiovascular Agen	2005
Clopidogrel loading with eptifibatide to arrest the reactivity of platelets: results of the Clopidogrel Loading With Eptifibatide to Arrest the Reactivity of Platelets (CLEAR PLATELETS) study. Circulation, 2005, Mar-08, Volume: 111, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Angioplasty, Balloon, Coronary; Cardiovascular Agen	2005
Clopidogrel loading with eptifibatide to arrest the reactivity of platelets: results of the Clopidogrel Loading With Eptifibatide to Arrest the Reactivity of Platelets (CLEAR PLATELETS) study. Circulation, 2005, Mar-08, Volume: 111, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Angioplasty, Balloon, Coronary; Cardiovascular Agen	2005
Clopidogrel loading with eptifibatide to arrest the reactivity of platelets: results of the Clopidogrel Loading With Eptifibatide to Arrest the Reactivity of Platelets (CLEAR PLATELETS) study. Circulation, 2005, Mar-08, Volume: 111, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Angioplasty, Balloon, Coronary; Cardiovascular Agen	2005
Clopidogrel loading with eptifibatide to arrest the reactivity of platelets: results of the Clopidogrel Loading With Eptifibatide to Arrest the Reactivity of Platelets (CLEAR PLATELETS) study. Circulation, 2005, Mar-08, Volume: 111, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Angioplasty, Balloon, Coronary; Cardiovascular Agen	2005
Clopidogrel loading with eptifibatide to arrest the reactivity of platelets: results of the Clopidogrel Loading With Eptifibatide to Arrest the Reactivity of Platelets (CLEAR PLATELETS) study. Circulation, 2005, Mar-08, Volume: 111, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Angioplasty, Balloon, Coronary; Cardiovascular Agen	2005
Clopidogrel loading with eptifibatide to arrest the reactivity of platelets: results of the Clopidogrel Loading With Eptifibatide to Arrest the Reactivity of Platelets (CLEAR PLATELETS) study. Circulation, 2005, Mar-08, Volume: 111, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Angioplasty, Balloon, Coronary; Cardiovascular Agen	2005
Clopidogrel loading with eptifibatide to arrest the reactivity of platelets: results of the Clopidogrel Loading With Eptifibatide to Arrest the Reactivity of Platelets (CLEAR PLATELETS) study. Circulation, 2005, Mar-08, Volume: 111, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Angioplasty, Balloon, Coronary; Cardiovascular Agen	2005
Clopidogrel loading with eptifibatide to arrest the reactivity of platelets: results of the Clopidogrel Loading With Eptifibatide to Arrest the Reactivity of Platelets (CLEAR PLATELETS) study. Circulation, 2005, Mar-08, Volume: 111, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Angioplasty, Balloon, Coronary; Cardiovascular Agen	2005
Matching the evaluation of the clinical efficacy of clopidogrel to platelet function tests relevant to the biological properties of the drug. Journal of the American College of Cardiology, 2005, Aug-16, Volume: 46, Issue:4 Topics: Aged; Angina Pectoris; Anticoagulants; Aspirin; Blood Platelets; Case-Control Studies; Clopidogrel;	2005
Impact of heparin neutralization by protamine on restenosis after coronary stent implantation. International journal of cardiology, 2005, Oct-20, Volume: 105, Issue:1 Topics: Aged; Angina Pectoris; Anticoagulants; Aspirin; Blood Vessel Prosthesis Implantation; Coronary Reste	2005
Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: the ISAR-REACT 2 randomized trial. JAMA, 2006, Apr-05, Volume: 295, Issue:13 Topics: Abciximab; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogre	2006
Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: the ISAR-REACT 2 randomized trial. JAMA, 2006, Apr-05, Volume: 295, Issue:13 Topics: Abciximab; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogre	2006
Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: the ISAR-REACT 2 randomized trial. JAMA, 2006, Apr-05, Volume: 295, Issue:13 Topics: Abciximab; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogre	2006
Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: the ISAR-REACT 2 randomized trial. JAMA, 2006, Apr-05, Volume: 295, Issue:13 Topics: Abciximab; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogre	2006
Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: the ISAR-REACT 2 randomized trial. JAMA, 2006, Apr-05, Volume: 295, Issue:13 Topics: Abciximab; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogre	2006
Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: the ISAR-REACT 2 randomized trial. JAMA, 2006, Apr-05, Volume: 295, Issue:13 Topics: Abciximab; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogre	2006
Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: the ISAR-REACT 2 randomized trial. JAMA, 2006, Apr-05, Volume: 295, Issue:13 Topics: Abciximab; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogre	2006
Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: the ISAR-REACT 2 randomized trial. JAMA, 2006, Apr-05, Volume: 295, Issue:13 Topics: Abciximab; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogre	2006
Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: the ISAR-REACT 2 randomized trial. JAMA, 2006, Apr-05, Volume: 295, Issue:13 Topics: Abciximab; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogre	2006
Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: the ISAR-REACT 2 randomized trial. JAMA, 2006, Apr-05, Volume: 295, Issue:13 Topics: Abciximab; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogre	2006
Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: the ISAR-REACT 2 randomized trial. JAMA, 2006, Apr-05, Volume: 295, Issue:13 Topics: Abciximab; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogre	2006
Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: the ISAR-REACT 2 randomized trial. JAMA, 2006, Apr-05, Volume: 295, Issue:13 Topics: Abciximab; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogre	2006
Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: the ISAR-REACT 2 randomized trial. JAMA, 2006, Apr-05, Volume: 295, Issue:13 Topics: Abciximab; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogre	2006
Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: the ISAR-REACT 2 randomized trial. JAMA, 2006, Apr-05, Volume: 295, Issue:13 Topics: Abciximab; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogre	2006
Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: the ISAR-REACT 2 randomized trial. JAMA, 2006, Apr-05, Volume: 295, Issue:13 Topics: Abciximab; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogre	2006
Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: the ISAR-REACT 2 randomized trial. JAMA, 2006, Apr-05, Volume: 295, Issue:13 Topics: Abciximab; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogre	2006
The flow cytometric VASP assay can be used to determine the effectiveness of clopidogrel in patients treated with abciximab. Journal of thrombosis and haemostasis : JTH, 2007, Volume: 5, Issue:4 Topics: Abciximab; Angina Pectoris; Animals; Antibodies, Monoclonal; Anticoagulants; Cell Adhesion Molecules	2007
Clinical relevance of aspirin resistance in patients with stable coronary artery disease: a prospective follow-up study (PROSPECTAR). Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2007, Volume: 18, Issue:2 Topics: Aged; Angina Pectoris; Aspirin; Clopidogrel; Coronary Artery Disease; Death; Drug Resistance; Female	2007
Clopidogrel pre-treatment in stable angina: for all patients > 6 h before elective coronary angiography or only for angiographically selected patients a few minutes before PCI? A randomized multicentre trial PRAGUE-8. European heart journal, 2008, Volume: 29, Issue:12 Topics: Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Blood Loss, Surgical; Chronic Disease; Clopid	2008
Effects of platelet inhibition on myocardial ischaemia. Lancet (London, England), 1982, Oct-02, Volume: 2, Issue:8301 Topics: Angina Pectoris; Animals; Clinical Trials as Topic; Coronary Circulation; Coronary Disease; Dogs; Do	1982
Modulation of plasma fibrinogen levels by ticlopidine in healthy volunteers and patients with stable angina pectoris. Thrombosis and haemostasis, 1996, Volume: 76, Issue:2 Topics: Adult; Aged; Angina Pectoris; Antigens; C-Reactive Protein; Case-Control Studies; Cross-Over Studies	1996
Enhancement of platelet inhibition of ticlopidine plus aspirin vs aspirin alone given prior to elective PTCA. European heart journal, 1998, Volume: 19, Issue:1 Topics: Adult; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; Female; Humans; Male; Middle	1998
Enhanced onset of platelet inhibition with a loading dose of ticlopidine in ASA-treated stable coronary patients. International journal of cardiology, 1998, Apr-01, Volume: 64, Issue:2 Topics: Angina Pectoris; Aspirin; Blood Platelets; Female; Humans; Male; Middle Aged; Platelet Aggregation I	1998
Randomised comparison of implantation of heparin-coated stents with balloon angioplasty in selected patients with coronary artery disease (Benestent II) Lancet (London, England), 1998, Aug-29, Volume: 352, Issue:9129 Topics: Adult; Aged; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Aspi	1998
Antiplatelet is superior to anticoagulant treatment after coronary stenting: fewer coronary and other events within 30 days after stenting. Angiology, 2000, Volume: 51, Issue:4 Topics: Acenocoumarol; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Coron	2000
Effect of aspirin and ticlopidine on plasma tissue factor levels in stable and unstable angina pectoris. The American journal of cardiology, 2000, Mar-01, Volume: 85, Issue:5 Topics: Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary; Antithrombin III; Aspirin; Athere	2000
Comparison of antiplatelet effect of loading dose of clopidogrel versus abciximab during coronary intervention. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2002, Volume: 13, Issue:4 Topics: Abciximab; Adenosine Diphosphate; Aged; Aged, 80 and over; Angina Pectoris; Antibodies, Monoclonal;	2002
Ticlopidine in unstable angina. A more expensive aspirin? Circulation, 1990, Volume: 82, Issue:1 Topics: Angina Pectoris; Angina, Unstable; Aspirin; Clinical Trials as Topic; Cost-Benefit Analysis; Cycloox	1990
Antiplatelet treatment with ticlopidine in unstable angina. A controlled multicenter clinical trial. The Studio della Ticlopidina nell'Angina Instabile Group. Circulation, 1990, Volume: 82, Issue:1 Topics: Angina Pectoris; Angina, Unstable; Female; Humans; Male; Multicenter Studies as Topic; Patient Dropo	1990
Effects of the platelet inhibitor ticlopidine on exercise tolerance in stable angina pectoris. European heart journal, 1987, Volume: 8, Issue:1 Topics: Adult; Angina Pectoris; beta-Thromboglobulin; Blood Platelets; Clinical Trials as Topic; Double-Blin	1987
Does placebo improve indexes of effort-induced myocardial ischemia? An objective study in 150 patients with chronic stable angina pectoris. The American journal of cardiology, 1986, Apr-15, Volume: 57, Issue:11 Topics: Adult; Aged; Angina Pectoris; Chronic Disease; Clinical Trials as Topic; Coronary Disease; Double-Bl	1986
Influence on lipoprotein metabolism of the platelet inhibitory drug ticlopidine. Atherosclerosis, 1986, Volume: 59, Issue:3 Topics: Adult; Aged; Angina Pectoris; Arteriosclerosis; Clinical Trials as Topic; Double-Blind Method; Human	1986
Are anti-platelet drugs of value in the management of patients with chronic stable angina? A study with ticlopidine. Clinical cardiology, 1986, Volume: 9, Issue:10 Topics: Administration, Oral; Aged; Angina Pectoris; Chronic Disease; Clinical Trials as Topic; Double-Blind	1986
Effects of ticlopidine of platelet function in men with stable angina pectoris. Thrombosis and haemostasis, 1985, Dec-17, Volume: 54, Issue:4 Topics: Adenosine Diphosphate; Adult; Aged; Angina Pectoris; Blood Platelets; Clinical Trials as Topic; Coll	1985

Article	Year
Recommendations on the Clinical Use of Compound Danshen Dripping Pills. Chinese medical journal, 2017, Apr-20, Volume: 130, Issue:8 Topics: Angina Pectoris; Aspirin; Camphanes; Clopidogrel; Coronary Disease; Diabetes Mellitus; Diabetic Neph	2017
Clinical characteristics and outcomes of patients with coronary artery spasm who initially presented with acute myocardial infarction. Coronary artery disease, 2018, Volume: 29, Issue:1 Topics: Adult; Aged; Angina Pectoris; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Cardiovascular Dise	2018
The Prognostic Value of Combinations of Genetic Polymorphisms in the ITGB3, ITGA2, and CYP2C192 Genes in Predicting Cardiovascular Outcomes After Coronary Bypass Grafting. Genetic testing and molecular biomarkers, 2018, Volume: 22, Issue:4* Topics: Aged; Alleles; Angina Pectoris; Aspirin; Clopidogrel; Combined Modality Therapy; Coronary Artery Byp	2018
[Assessment of clinical and antiaggregation efficacy of generic clopidogrel 'Egithromb' in roentgenosurgical practice]. Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery, 2013, Volume: 19, Issue:1 Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Coronar	2013
Positive clinical response to clopidogrel is independent of paraoxonase 1 Q192R and CYP2C19 genetic variants. Journal of clinical pharmacology, 2014, Volume: 54, Issue:8 Topics: Aged; Alleles; Angina Pectoris; Aryldialkylphosphatase; Aspirin; Clopidogrel; Cohort Studies; Corona	2014
Characterization of patients with angioscopically-detected in-stent mural thrombi – genetics of clopidogrel responsiveness and generations of drug-eluting stents. Circulation journal : official journal of the Japanese Circulation Society, 2015, Volume: 79, Issue:1 Topics: Activation, Metabolic; Aged; Alleles; Angina Pectoris; Angioscopy; Aspirin; Clopidogrel; Coronary An	2015
Cytochrome P450 CYP 2C192 Associated with Adverse 1-Year Cardiovascular Events in Patients with Acute Coronary Syndrome. PloS one, 2015, Volume: 10, Issue:7* Topics: Activation, Metabolic; Acute Coronary Syndrome; Aged; Alleles; Angina Pectoris; Aspirin; Clopidogrel	2015
[Relationship between ATP-binding cassette subfamily B member 1 and cytochrome P450 2C19 polymorphisms and the effect of clopidogrel post percutaneous coronary intervention in patients with acute coronary syndrome]. Zhonghua xin xue guan bing za zhi, 2016, Apr-24, Volume: 44, Issue:4 Topics: Acute Coronary Syndrome; Alleles; Angina Pectoris; ATP Binding Cassette Transporter, Subfamily B; Cl	2016
A 55-Year-Old Woman With Pulmonary Hypertension, Worsening Dyspnea, and Chest Pain. Chest, 2014, Volume: 145, Issue:3 Topics: Angina Pectoris; Aspirin; Clopidogrel; Compartment Syndromes; Coronary Vessels; Diagnosis, Different	2014
Relation of low response to clopidogrel assessed with point-of-care assay to periprocedural myonecrosis in patients undergoing elective coronary stenting for stable angina pectoris. The American journal of cardiology, 2008, Jun-15, Volume: 101, Issue:12 Topics: Aged; Angina Pectoris; Aspirin; Clopidogrel; Confidence Intervals; Elective Surgical Procedures; Fem	2008
Very late stent thrombosis after drug-eluting stent implantation in a patient without aspirin and clopidogrel resistance. Journal of Korean medical science, 2008, Volume: 23, Issue:3 Topics: Aged; Angina Pectoris; Aspirin; Clopidogrel; Coronary Angiography; Coronary Thrombosis; Drug Resista	2008
Elevated coronary calcium scores are associated with higher residual platelet aggregation after clopidogrel treatment in patients with stable angina pectoris. International journal of cardiology, 2009, Jun-12, Volume: 135, Issue:1 Topics: Aged; Angina Pectoris; Calcium; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardium; Platelet	2009
Lack of early augmentation of platelet reactivity after coronary intervention in patients treated with bivalirudin. Journal of thrombosis and thrombolysis, 2009, Volume: 28, Issue:1 Topics: Adenosine Diphosphate; Angina Pectoris; Anticoagulants; Aspirin; Cardiac Catheterization; Clopidogre	2009
Late outcomes after drug-eluting stent implantation in "real-world" clinical practice. The Journal of invasive cardiology, 2008, Volume: 20, Issue:10 Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Angina Pectoris; Angioplasty, Balloon, Coro	2008
Impact of clopidogrel resistance on thrombotic events after percutaneous coronary intervention with drug-eluting stent. Thrombosis research, 2009, Volume: 124, Issue:1 Topics: Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Thrombosis; Drug Resist	2009
Platelet-bound P-selectin expression in patients with coronary artery disease: impact on clinical presentation and myocardial necrosis, and effect of diabetes mellitus and anti-platelet medication. Journal of thrombosis and haemostasis : JTH, 2010, Volume: 8, Issue:1 Topics: Acute Coronary Syndrome; Angina Pectoris; Aspirin; Biomarkers; Blood Platelets; Clopidogrel; Coronar	2010
Antiplatelet drugs for patients at high cardiovascular risk. Aspirin generally remains the best choice. Prescrire international, 2009, Volume: 18, Issue:104 Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; Atrial Fibrillation; Brain Ischemia; Clini	2009
Subacute coronary stent thrombosis in a patient with angina treated with double antiplatelet drugs for six days. Chinese medical journal, 2009, Oct-05, Volume: 122, Issue:19 Topics: Adult; Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Thrombosis; D	2009
Relation of endothelial function to residual platelet reactivity after clopidogrel in patients with stable angina pectoris undergoing percutaneous coronary intervention. The American journal of cardiology, 2010, Feb-01, Volume: 105, Issue:3 Topics: Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; Biomarkers; Blood Platelets; Clopido	2010
High residual platelet reactivity after clopidogrel: extent of coronary atherosclerosis and periprocedural myocardial infarction in patients with stable angina undergoing percutaneous coronary intervention. JACC. Cardiovascular interventions, 2010, Volume: 3, Issue:1 Topics: Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Blood Platelets; Clopidogrel; Coronary Angiog	2010
[A case of drug-induced pneumonia caused by clopidogrel]. Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2010, Volume: 48, Issue:5 Topics: Aged; Angina Pectoris; Clopidogrel; Humans; Male; Platelet Aggregation Inhibitors; Pneumonia; Ticlop	2010
Comparison of conventional aggregometry with VASP for monitoring P2Y12-specific platelet inhibition. Platelets, 2010, Volume: 21, Issue:7 Topics: Adenosine Diphosphate; Angina Pectoris; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Flow	2010
Pattern of clopidogrel use in hospitalized patients receiving percutaneous coronary interventions. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2010, Sep-01, Volume: 67, Issue:17 Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Angina Pectoris; Angioplasty, Balloon, Coro	2010
[Current status of medical therapy of chronic stable angina pectoris in mainland of China: the second survey]. Zhonghua xin xue guan bing za zhi, 2010, Volume: 38, Issue:12 Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Angina Pectoris; Angiotensin Receptor A	2010
Lack of correlation between platelet reactivity and glycaemic control in type 2 diabetes mellitus patients treated with aspirin and clopidogrel. Journal of thrombosis and thrombolysis, 2011, Volume: 32, Issue:1 Topics: Aged; Aged, 80 and over; Angina Pectoris; Aspirin; Blood Glucose; Blood Platelets; Clopidogrel; Diab	2011
Pharmacogenetics and clopidogrel response in patients undergoing percutaneous coronary interventions. Clinical pharmacology and therapeutics, 2011, Volume: 89, Issue:3 Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochr	2011
A 23-year patency of a saphenous vein graft in a patient with diabetes mellitus. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, 2011, May-25, Volume: 11, Issue:3 Topics: Aged; Angina Pectoris; Clopidogrel; Coronary Artery Bypass; Diabetes Mellitus, Type 2; Humans; Male;	2011
Long-term successful percutaneous coronary intervention in factor VII deficiency. The Journal of invasive cardiology, 2012, Volume: 24, Issue:6 Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Stenosis; Diabetes M	2012
2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, and the Journal of the American College of Cardiology, 2012, Dec-18, Volume: 60, Issue:24 Topics: Acute Coronary Syndrome; Adrenergic beta-Antagonists; Alcohol Drinking; Angina Pectoris; Body Weight	2012
2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, and the Journal of the American College of Cardiology, 2012, Dec-18, Volume: 60, Issue:24 Topics: Acute Coronary Syndrome; Adrenergic beta-Antagonists; Alcohol Drinking; Angina Pectoris; Body Weight	2012
2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, and the Journal of the American College of Cardiology, 2012, Dec-18, Volume: 60, Issue:24 Topics: Acute Coronary Syndrome; Adrenergic beta-Antagonists; Alcohol Drinking; Angina Pectoris; Body Weight	2012
2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, and the Journal of the American College of Cardiology, 2012, Dec-18, Volume: 60, Issue:24 Topics: Acute Coronary Syndrome; Adrenergic beta-Antagonists; Alcohol Drinking; Angina Pectoris; Body Weight	2012
Evidence-based risk stratification to target therapies in acute coronary syndromes. Circulation, 2002, Sep-24, Volume: 106, Issue:13 Topics: Acute Disease; Angina Pectoris; Anticoagulants; Biomarkers; Cardiac Catheterization; Clopidogrel; Co	2002
Clopidogrel and percutaneous coronary interventions. JAMA, 2003, Apr-16, Volume: 289, Issue:15 Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Administration Schedule;	2003
Prevalence of clopidogrel non-responders among patients with stable angina pectoris scheduled for elective coronary stent placement. Thrombosis and haemostasis, 2003, Volume: 89, Issue:5 Topics: Adenosine Diphosphate; Aged; Angina Pectoris; Clopidogrel; Drug Resistance; Female; Humans; Male; Mi	2003
The plunger, fine tuned. Circulation, 2003, Nov-04, Volume: 108, Issue:18 Topics: Angina Pectoris; Cardiopulmonary Resuscitation; Clopidogrel; Drug Therapy, Combination; Emergency Tr	2003
Comparison of turbidimetric aggregation and in vitro bleeding time (PFA-100) for monitoring the platelet inhibitory profile of antiplatelet agents in patients undergoing stent implantation. Thrombosis research, 2003, Volume: 111, Issue:3 Topics: Abciximab; Adenosine Diphosphate; Aged; Angina Pectoris; Antibodies, Monoclonal; Aspirin; Bleeding T	2003
Catheter based intracoronary brachytherapy leads to increased platelet activation. Heart (British Cardiac Society), 2004, Volume: 90, Issue:2 Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Blood Platelets; Brachythe	2004
Long-term clopidogrel therapy after percutaneous coronary intervention in PCI-CURE and CREDO: the "Emperor's New Clothes" revisited. European heart journal, 2004, Volume: 25, Issue:9 Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Clinical Trials as Topic; Clopidogrel; Humans; Long	2004
Thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome associated with clopidogrel: report of two new cases. Heart (British Cardiac Society), 2004, Volume: 90, Issue:9 Topics: Adult; Aged; Angina Pectoris; Carotid Artery, Internal; Carotid Stenosis; Clopidogrel; Hemolytic-Ure	2004
Elevations in troponin I after percutaneous coronary interventions are associated with abnormal tissue-level perfusion in high-risk patients with non-ST-segment-elevation acute coronary syndromes. Circulation, 2004, Sep-21, Volume: 110, Issue:12 Topics: Abciximab; Acute Disease; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Antibodies, Monoclo	2004
Does clopidogrel increase the degree of platelet inhibition when a platelet glycoprotein IIb/IIIa inhibitor has been given? Insights from an optical platelet aggregometry study. Journal of thrombosis and thrombolysis, 2004, Volume: 18, Issue:1 Topics: Aged; Aged, 80 and over; Angina Pectoris; Clopidogrel; Drug Combinations; Drug Interactions; Female;	2004
Inflammatory response after intervention assessed by serial C-reactive protein measurements correlates with restenosis in patients treated with coronary stenting. American heart journal, 2005, Volume: 150, Issue:2 Topics: Abciximab; Aged; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary; Antibodies, Mono	2005
Successful lysis of coronary thrombi by long term warfarin treatment after a failed course of tirofiban infusion. International journal of cardiology, 2006, Mar-22, Volume: 108, Issue:1 Topics: Angina Pectoris; Anticoagulants; Aspirin; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combinatio	2006
Clopidogrel treatment prior to percutaneous coronary intervention: when enough isn't enough. JAMA, 2006, Apr-05, Volume: 295, Issue:13 Topics: Abciximab; Angina Pectoris; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogrel; Hum	2006
Clopidogrel loading dose (300 versus 600 mg) strategies for patients with stable angina pectoris subjected to percutaneous coronary intervention. The American journal of cardiology, 2006, Apr-01, Volume: 97, Issue:7 Topics: Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Clopidogrel; Dose-Response Relationship, Drug	2006
[Thrombosis of a coronary stent after discontinuing treatment with clopidogrel]. Nederlands tijdschrift voor geneeskunde, 2006, Apr-15, Volume: 150, Issue:15 Topics: Adult; Aged; Angina Pectoris; Aspirin; Clopidogrel; Female; Humans; Male; Myocardial Infarction; Pla	2006
Clinical policy: critical issues in the evaluation and management of adult patients with non-ST-segment elevation acute coronary syndromes. Annals of emergency medicine, 2006, Volume: 48, Issue:3 Topics: Adult; Angina Pectoris; Biomarkers; Cardiology; Clopidogrel; Electrocardiography; Emergency Service,	2006
[Heart catheter in angina pectoris: must we set stricter indications?]. MMW Fortschritte der Medizin, 2006, Sep-21, Volume: 148, Issue:38 Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Cardiac Catheterization; Clopidogrel; Exercise; Fol	2006
Clopidogrel inhibits platelet aggregation in patients on aspirin with stable chronic angina pectoris. International journal of cardiology, 2008, Jan-11, Volume: 123, Issue:2 Topics: Angina Pectoris; Aspirin; Chronic Disease; Clopidogrel; Humans; Platelet Aggregation; Platelet Aggre	2008
Increased incidence of stent thrombosis in patients with cocaine use. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2007, Jun-01, Volume: 69, Issue:7 Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Cocaine-Related Disorders; Co	2007
[Treatment of intrastent restenosis by drug eluting stents: experience from one cardiology centre]. Archives des maladies du coeur et des vaisseaux, 2007, Volume: 100, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Aspirin; Clopidogrel; Coronary Angiography; Coronar	2007
Evaluation of platelet and leukocyte functions in effort angina patients using high shear conditions in small-sized collagen bead columns. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2007, Volume: 13, Issue:4 Topics: Aged; Angina Pectoris; Aspirin; Blood Platelets; Case-Control Studies; Collagen; Female; Hemorheolog	2007
The Residual Platelet Aggregation after Deployment of Intracoronary Stent (PREDICT) score. Journal of thrombosis and haemostasis : JTH, 2008, Volume: 6, Issue:1 Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Angina Pectoris; Clopidogrel; Cohort Studies;	2008
[Antiplatelet treatment after acute and chronic ischemic heart and brain events is insufficient according to recommendations]. Ugeskrift for laeger, 2008, Mar-31, Volume: 170, Issue:14 Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Angina Pectoris; Angina, Unstable; Aspirin;	2008
Routine pre-treatment with clopidogrel before diagnostic coronary angiography: the question is right, but what about the answer? European heart journal, 2008, Volume: 29, Issue:12 Topics: Angina Pectoris; Clopidogrel; Coronary Angiography; Humans; Platelet Aggregation Inhibitors; Premedi	2008
[Changes in the unmodified vessels after aortocoronary bypass surgery]. RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 1983, Volume: 139, Issue:6 Topics: Angina Pectoris; Anticoagulants; Arterial Occlusive Diseases; Coronary Artery Bypass; Coronary Disea	1983
Clinical and angiographic outcome of Micro Stent II implantation in native coronary arteries. The American journal of cardiology, 1998, Jan-15, Volume: 81, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Aspirin; Blood Vessel Prosthesis Implantation; Coro	1998
Emergency coronary artery bypass grafting (CABG) after failed coronary artery intervention--caution regarding the combined use of aspirin, ticlopidine and abciximab. Australian and New Zealand journal of medicine, 1998, Volume: 28, Issue:4 Topics: Abciximab; Adult; Angina Pectoris; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin;	1998
[Ticlopidine-induced cholestasis]. Schweizerische medizinische Wochenschrift, 1999, Oct-02, Volume: 129, Issue:39 Topics: Aged; Aged, 80 and over; Angina Pectoris; Aspirin; Chemical and Drug Induced Liver Injury; Cholestas	1999
Ticlopidine and aspirin fail to suppress the increased platelet aggregability that follows percutaneous coronary interventions. Journal of thrombosis and thrombolysis, 2000, Volume: 10, Issue:3 Topics: Aged; Angina Pectoris; Angioplasty, Balloon; Aspirin; Blood Coagulation Tests; Coronary Angiography;	2000
[Late stent thrombosis after intracoronary brachytherapy. A case report and review of the literature]. Zeitschrift fur Kardiologie, 2001, Volume: 90, Issue:2 Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; Brachytherapy; Clinical Trials as Topic; C	2001
Is ticlopidine more effective than aspirin in preventing adverse cardiovascular events after myocardial infarction (MI)? The Journal of family practice, 2001, Volume: 50, Issue:7 Topics: Angina Pectoris; Aspirin; Double-Blind Method; Fibrinolytic Agents; Humans; Multicenter Studies as T	2001
The CURE trial: using clopidogrel in acute coronary syndromes without ST-segment elevation. Cleveland Clinic journal of medicine, 2002, Volume: 69, Issue:5 Topics: Angina Pectoris; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Random	2002
[Nifedipine and gingival hypertrophy]. Cardiologia (Rome, Italy), 1991, Volume: 36, Issue:7 Topics: Angina Pectoris; Drug Therapy, Combination; Gingival Hypertrophy; Humans; Male; Middle Aged; Nifedip	1991
[Antiplatelet effects of combined therapy with ticlopidine and low doses of aspirin on patients with ischemic cardiopathy]. Cardiologia (Rome, Italy), 1989, Volume: 34, Issue:1 Topics: Aged; Angina Pectoris; Aspirin; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Ag	1989
Effects of ticlopidine on platelet function and on coronary insufficiency in patients with angina pectoris. Advances in prostaglandin, thromboxane, and leukotriene research, 1985, Volume: 13 Topics: Adult; Aged; Angina Pectoris; Blood Platelets; Coronary Disease; Humans; Male; Middle Aged; Nitrogly	1985
Metabolic side effects of the platelet-inhibitory drug ticlopidine. Advances in prostaglandin, thromboxane, and leukotriene research, 1985, Volume: 13 Topics: Adult; Aged; Angina Pectoris; Blood Platelets; Cholesterol; Humans; Male; Middle Aged; Thiophenes; T	1985
Thromboxane A2 synthesizing activity of platelets in coronary artery diseases. Japanese circulation journal, 1987, Volume: 51, Issue:4 Topics: Adolescent; Adult; Aged; Angina Pectoris; Blood Platelets; Coronary Disease; Female; Humans; Male; M	1987

ticlopidine and Angina Pectoris