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ticlopidine and Aging

ticlopidine has been researched along with Aging in 9 studies

Ticlopidine: An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
ticlopidine : A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"In the PRODIGY trial, prolonging clopidogrel-based DAPT beyond six months in elderly patients increased the risk of bleeding, without affording a significant prevention of ischaemic events."5.24Ischaemic and bleeding outcomes in elderly patients undergoing a prolonged versus shortened duration of dual antiplatelet therapy after percutaneous coronary intervention: insights from the PRODIGY randomised trial. ( Ariotti, S; Franzone, A; Gargiulo, G; Heg, D; Magnani, G; Marino, M; Piccolo, R; Santucci, A; Tebaldi, M; Valgimigli, M; Windecker, S, 2017)
"In our present study we investigated the association between platelet aggregation in patients treated with the most widely used antiplatelet agents (100 and 300-325 mg acetylsalicylic acid (ASA), 75 mg clopidogrel, 500 mg ticlopidine and the combination of 100 mg aspirin and 75 mg clopidogrel), fibrinogen levels and aging."3.74Relation of platelet aggregation and fibrinogen levels to advancing age in aspirin- and thienopyridine-treated patients. ( Alexy, T; Feher, G; Horvath, B; Kenyeres, P; Kesmarky, G; Koltai, K; Lenart, I; Marton, Z; Toth, K, 2008)
" There have been a limited number of studies investigating the pharmacokinetic profile of the drug."2.39Clinical pharmacokinetics of ticlopidine. ( Desager, JP, 1994)
"High interindividual variability in clinical outcomes following clopidogrel's standard dosing regimen continues to be a challenge even two decades after its approval."1.46Identifying clinically relevant sources of variability: The clopidogrel challenge. ( Horenstein, RB; Jiang, XL; Lesko, LJ; Lewis, JP; Peletier, LA; Samant, S; Schmidt, S; Shuldiner, AR, 2017)
" The longer t1/2,z and higher AUC values after multiple dosing probably reflect an increase in bioavailability of ticlopidine after repeated dosing, saturation of metabolism or insufficient analytical sensitivity to characterize the terminal elimination phase after single dose."1.28Single and multiple dose pharmacokinetics of ticlopidine in young and elderly subjects. ( Gabuzda, T; Massey, I; Molony, B; Shah, J; Teitelbaum, P, 1991)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (22.22)18.2507
2000's2 (22.22)29.6817
2010's5 (55.56)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dupouy, P1
Pongas, D1
Rubimbura, V1
Labbe, R1
Sotirov, I1
Pernes, JM1
Samant, S1
Jiang, XL1
Peletier, LA1
Shuldiner, AR1
Horenstein, RB1
Lewis, JP1
Lesko, LJ1
Schmidt, S1
Piccolo, R1
Magnani, G1
Ariotti, S1
Gargiulo, G1
Marino, M1
Santucci, A1
Franzone, A1
Tebaldi, M1
Heg, D1
Windecker, S1
Valgimigli, M1
Caruthers, RL1
Dorsch, MP1
Koltai, K1
Feher, G1
Kenyeres, P1
Lenart, I1
Alexy, T1
Horvath, B1
Marton, Z1
Kesmarky, G1
Toth, K1
Yokoyama, T1
Usui, T1
Kiyama, K1
Nakashima, R1
Yukawa, N1
Kawabata, D1
Nojima, T1
Ohmura, K1
Fujii, T1
Mimori, T1
Tidjane, MA1
Voisin, S1
Lhermusier, T1
Bongard, V1
SiƩ, P1
CarriƩ, D1
Desager, JP1
Shah, J1
Teitelbaum, P1
Molony, B1
Gabuzda, T1
Massey, I1

Reviews

2 reviews available for ticlopidine and Aging

ArticleYear
Two cases of late-onset drug-induced lupus erythematosus caused by ticlopidine in elderly men.
    Modern rheumatology, 2010, Volume: 20, Issue:4

    Topics: Aged; Aged, 80 and over; Aging; Autoantibodies; Histones; Humans; Lupus Erythematosus, Systemic; Mal

2010
Clinical pharmacokinetics of ticlopidine.
    Clinical pharmacokinetics, 1994, Volume: 26, Issue:5

    Topics: Adult; Aged; Aging; Animals; Bleeding Time; Blood Platelets; Cardiovascular Diseases; Drug Interacti

1994

Trials

1 trial available for ticlopidine and Aging

ArticleYear
Ischaemic and bleeding outcomes in elderly patients undergoing a prolonged versus shortened duration of dual antiplatelet therapy after percutaneous coronary intervention: insights from the PRODIGY randomised trial.
    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2017, May-15, Volume: 13, Issue:1

    Topics: Age Factors; Aged; Aged, 80 and over; Aging; Aspirin; Clopidogrel; Drug Therapy, Combination; Female

2017

Other Studies

6 other studies available for ticlopidine and Aging

ArticleYear
[A case review: About a STEMI in the very elderly].
    Annales de cardiologie et d'angeiologie, 2015, Volume: 64, Issue:6

    Topics: Aged, 80 and over; Aging; Angioplasty, Balloon, Coronary; Anti-Inflammatory Agents, Non-Steroidal; A

2015
Identifying clinically relevant sources of variability: The clopidogrel challenge.
    Clinical pharmacology and therapeutics, 2017, Volume: 101, Issue:2

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Body Mass Index; Clopidogrel; Computer Simulatio

2017
Letter by Caruthers and Dorsch regarding article, "Dosing of clopidogrel for platelet inhibition in infants and young children: primary results of the platelet inhibition in children on cLOpidogrel (PICOLO) trial".
    Circulation, 2008, Aug-12, Volume: 118, Issue:7

    Topics: Adolescent; Adult; Aging; Child; Child, Preschool; Clopidogrel; Cytochrome P-450 CYP3A; Dose-Respons

2008
Relation of platelet aggregation and fibrinogen levels to advancing age in aspirin- and thienopyridine-treated patients.
    Clinical hemorheology and microcirculation, 2008, Volume: 40, Issue:4

    Topics: Aged; Aging; Aspirin; Clopidogrel; Cohort Studies; Dose-Response Relationship, Drug; Drug Therapy, C

2008
More on: adenosine diphosphate-inducible platelet reactivity shows a pronounced age dependency in the initial phase of antiplatelet therapy with clopidogrel.
    Journal of thrombosis and haemostasis : JTH, 2011, Volume: 9, Issue:3

    Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Aging; Angioplasty, Balloon, Coronary; Clopidogrel;

2011
Single and multiple dose pharmacokinetics of ticlopidine in young and elderly subjects.
    British journal of clinical pharmacology, 1991, Volume: 32, Issue:6

    Topics: Administration, Oral; Adult; Aged; Aging; Chromatography, Gas; Female; Half-Life; Humans; Male; Ticl

1991