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ticlopidine and Acute Lung Injury

ticlopidine has been researched along with Acute Lung Injury in 4 studies

Ticlopidine: An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
ticlopidine : A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.

Acute Lung Injury: A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).

Research Excerpts

ExcerptRelevanceReference
"Oral reversible platelet P2Y12 receptor inhibitors (ticagrelor and elinogrel) cause double-digit rates of dyspnea, while irreversible oral antiplatelet drugs (aspirin, ticlopidoine, clopidogrel, and prasugrel) or intravenous glycoprotein IIb/IIIa inhibitors (abciximab, eptifibatide, or tirofiban) do not increase the incidence of dyspnea in randomized trials."8.90Dyspnea and reversibility of antiplatelet agents: ticagrelor, elinogrel, cangrelor, and beyond. ( DiNicolantonio, JJ; Serebruany, VL; Sibbing, D, 2014)
"Pretreatment with isoflurane abrogated ALI as measured by both BAL fluid protein and pulmonary immunofluorescence (P < ."5.38Isoflurane prevents acute lung injury through ADP-mediated platelet inhibition. ( Banerjee, A; Fragoso, M; Gamboni, F; Harr, JN; Jones, WL; Moore, EE; Silliman, CC; Stringham, J; Wohlauer, MV, 2012)
"Oral reversible platelet P2Y12 receptor inhibitors (ticagrelor and elinogrel) cause double-digit rates of dyspnea, while irreversible oral antiplatelet drugs (aspirin, ticlopidoine, clopidogrel, and prasugrel) or intravenous glycoprotein IIb/IIIa inhibitors (abciximab, eptifibatide, or tirofiban) do not increase the incidence of dyspnea in randomized trials."4.90Dyspnea and reversibility of antiplatelet agents: ticagrelor, elinogrel, cangrelor, and beyond. ( DiNicolantonio, JJ; Serebruany, VL; Sibbing, D, 2014)
"Using a mouse model of intra-abdominal sepsis and acute lung injury, we investigated the role of the P2Y12 receptor in neutrophil migration and lung inflammation in P2Y12 null mice and in mice pretreated with the P2Y12 antagonist clopidogrel."3.83P2Y12 Receptor Modulates Sepsis-Induced Inflammation. ( Kilpatrick, LE; Kunapuli, SP; Liverani, E; Rico, MC; Tsygankov, AY, 2016)
"Use of aspirin (acetylsalicylic acid [ASA]) was found to improve outcome in animal models of acute lung injury (ALI) or its more severe form, acute respiratory distress syndrome."3.79High-dose acetylsalicylic acid is superior to low-dose as well as to clopidogrel in preventing lipopolysaccharide-induced lung injury in mice. ( Hegeman, MA; Jongsma, G; Juffermans, NP; Müller, MC; Tuinman, PR, 2013)
"Pretreatment with isoflurane abrogated ALI as measured by both BAL fluid protein and pulmonary immunofluorescence (P < ."1.38Isoflurane prevents acute lung injury through ADP-mediated platelet inhibition. ( Banerjee, A; Fragoso, M; Gamboni, F; Harr, JN; Jones, WL; Moore, EE; Silliman, CC; Stringham, J; Wohlauer, MV, 2012)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tuinman, PR1
Müller, MC1
Jongsma, G1
Hegeman, MA1
Juffermans, NP1
Serebruany, VL1
Sibbing, D1
DiNicolantonio, JJ1
Liverani, E1
Rico, MC1
Tsygankov, AY1
Kilpatrick, LE1
Kunapuli, SP1
Harr, JN1
Moore, EE1
Stringham, J1
Wohlauer, MV1
Fragoso, M1
Jones, WL1
Gamboni, F1
Silliman, CC1
Banerjee, A1

Reviews

1 review available for ticlopidine and Acute Lung Injury

ArticleYear
Dyspnea and reversibility of antiplatelet agents: ticagrelor, elinogrel, cangrelor, and beyond.
    Cardiology, 2014, Volume: 127, Issue:1

    Topics: Acute Lung Injury; Adenosine; Adenosine Monophosphate; Administration, Oral; Clopidogrel; Dyspnea; H

2014

Other Studies

3 other studies available for ticlopidine and Acute Lung Injury

ArticleYear
High-dose acetylsalicylic acid is superior to low-dose as well as to clopidogrel in preventing lipopolysaccharide-induced lung injury in mice.
    Shock (Augusta, Ga.), 2013, Volume: 40, Issue:4

    Topics: Acute Lung Injury; Animals; Aspirin; Blood Platelets; Bronchoalveolar Lavage Fluid; Clopidogrel; Lip

2013
P2Y12 Receptor Modulates Sepsis-Induced Inflammation.
    Arteriosclerosis, thrombosis, and vascular biology, 2016, Volume: 36, Issue:5

    Topics: Acute Lung Injury; Animals; Blood Platelets; Clopidogrel; Cytokines; Genetic Predisposition to Disea

2016
Isoflurane prevents acute lung injury through ADP-mediated platelet inhibition.
    Surgery, 2012, Volume: 152, Issue:2

    Topics: Acute Lung Injury; Anesthetics, Inhalation; Animals; Blood Platelets; Clopidogrel; Fluorescent Antib

2012