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ticlopidine and Acute Liver Injury, Drug-Induced

ticlopidine has been researched along with Acute Liver Injury, Drug-Induced in 81 studies

Ticlopidine: An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
ticlopidine : A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.

Research Excerpts

ExcerptRelevanceReference
"A 59-year-old woman developed fever and elevated hepatic enzyme levels within days of starting clopidogrel, which had been prescribed in conjunction with a percutaneous coronary intervention."7.73Clopidogrel-induced hepatotoxicity and fever. ( Goldberg, N; Ng, JA; Tafreshi, MJ, 2006)
" As for SCARs, associations of HLA-B*15:02 or HLA-A*31:01 and HLA-B*58:01 have been revealed for carbamazepine- and allopurinol-related Stevens-Johnson syndrome and toxic epidermal neclolysis, respectively."4.89Pharmacogenomics of severe cutaneous adverse reactions and drug-induced liver injury. ( Kaniwa, N; Saito, Y, 2013)
"Current guidelines offer a choice of P2Y12 receptor antagonist among clopidogrel, prasugrel or ticagrelor on top of aspirin (ASA) for dual antiplatelet therapy (DAPT) in patients after acute coronary syndromes (ACS)."3.79Gastrointestinal adverse events after dual antiplatelet therapy: clopidogrel is safer than ticagrelor, but prasugrel data are lacking or inconclusive. ( Can, MM; Dinicolantonio, JJ; Kuliczkowski, W; Pershukov, IV; Serebruany, VL, 2013)
" An objective causality assessment suggested that the liver hematoma was possibly related to the combination of clopidogrel and aspirin."3.78Dual antiplatelet agent-induced spontaneous liver hematoma. ( Darwish, OS; Iqbal, E, 2012)
"A 59-year-old woman developed fever and elevated hepatic enzyme levels within days of starting clopidogrel, which had been prescribed in conjunction with a percutaneous coronary intervention."3.73Clopidogrel-induced hepatotoxicity and fever. ( Goldberg, N; Ng, JA; Tafreshi, MJ, 2006)
"Six years later after a left cerebral transient ischemic attack aspirin was replaced by ticlopidine."2.41[Cholestatic hepatitis as a rare side effect of therapy with ticlopidine]. ( Auer, J; Berent, R; Haidenthaler, A; Hinterholzer, G; Höbling, W; Knoflach, P, 2000)
" These data demonstrate that UA is bio-transformed to less toxic metabolites in rat primary hepatocytes, probably mainly by CYP1A and 3A, but not 2B/2C."1.40Inhibition of cytochrome P450s enhances (+)-usnic acid cytotoxicity in primary cultured rat hepatocytes. ( Greenhaw, J; Salminen, WF; Shi, Q, 2014)
"Intrahepatic hemorrhage is a very rare complication of warfarin, and our patient experienced intrahepatic and subgaleal hemorrhage although she did not have any risk factors for bleeding or instability of the international normalized ratio control."1.39Simultaneous intrahepatic and subgaleal hemorrhage in antiphospholipid syndrome following anticoagulation therapy. ( Baek, YH; Cho, DS; Chung, WT; Han, SY; Kang, SH; Lee, SW; Park, IC, 2013)
" We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts."1.37FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011)
" Administration of radio-labeled TIC in combination with BSO resulted in significantly higher covalent binding to rat liver proteins than that observed after sole dosing of radio-labeled TIC."1.37Ticlopidine-induced hepatotoxicity in a GSH-depleted rat model. ( Atsumi, R; Izumi, T; Nakazawa, T; Okazaki, O; Saji, H; Shimizu, S; Sudo, K, 2011)
" An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems."1.36Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010)
"Hepatotoxicity is the most frequent adverse drug reaction (ADR) in Japanese treated with ticlopidine (TP)."1.36Enhanced susceptibility of HLA-mediated ticlopidine-induced idiosyncratic hepatotoxicity by CYP2B6 polymorphism in Japanese. ( Ariyoshi, N; Hirata, K; Iga, Y; Ishii, I; Kitada, M; Miura, G; Nagamori, S; Sato, Y, 2010)
"Genetic risk factors for ticlopidine-induced hepatotoxicity were determined in 22 Japanese patients with ticlopidine-induced hepatotoxicity and 85 Japanese patients who tolerated ticlopidine therapy without experiencing adverse reactions."1.35Ticlopidine-induced hepatotoxicity is associated with specific human leukocyte antigen genomic subtypes in Japanese patients: a preliminary case-control study. ( Hirata, K; Masumoto, H; Matsumoto, T; Mori, K; Nishiya, T; Okutani, Y; Shimizu, S; Takagi, H; Yamamoto, M, 2008)
"Ticlopidine has a relative high rate of side-effects."1.34Incidence of side-effects of ticlopidine after sirolimus-eluting stent implantation. ( Fukushima, K; Kobayashi, Y; Komuro, I; Kuroda, N; Miyazaki, A; Nakamura, Y; Nakayama, T; Okuno, T; Sakakibara, M; Shimizu, Y, 2007)
" Concretely, the prior odd is modified by several separate likelihood ratios: age; sex; AST level; ALT level; alkaline phosphatase level; total bilirubin level; latent period of adverse reaction appearance; and period of remission of adverse reaction."1.31A new Poisson and Bayesian-based method to assign risk and causality in patients with suspected hepatic adverse drug reactions: a report of two new cases of ticlopidine-induced hepatotoxicity. ( Horga, JF; Pérez-Mateo, M; Such, J; Zapater, P, 2002)
"Ticlopidine is a commonly prescribed drug in cerebrovascular or cardiovascular diseases."1.31Ticlopidine-induced hepatitis. ( Chen, LK; Chen, WC; Hou, MC; Hsieh, BH; Tsai, ST, 2001)

Research

Studies (81)

TimeframeStudies, this research(%)All Research%
pre-19901 (1.23)18.7374
1990's25 (30.86)18.2507
2000's28 (34.57)29.6817
2010's26 (32.10)24.3611
2020's1 (1.23)2.80

Authors

AuthorsStudies
Fourches, D1
Barnes, JC1
Day, NC1
Bradley, P1
Reed, JZ1
Tropsha, A1
Greene, N1
Fisk, L1
Naven, RT1
Note, RR1
Patel, ML1
Pelletier, DJ1
Ekins, S1
Williams, AJ1
Xu, JJ1
Chen, M2
Vijay, V1
Shi, Q3
Liu, Z2
Fang, H2
Tong, W3
Dawson, S1
Stahl, S2
Paul, N1
Barber, J1
Kenna, JG2
Ding, D1
Kelly, R1
Sakatis, MZ1
Reese, MJ1
Harrell, AW1
Taylor, MA1
Baines, IA1
Chen, L1
Bloomer, JC1
Yang, EY1
Ellens, HM1
Ambroso, JL1
Lovatt, CA1
Ayrton, AD1
Clarke, SE1
Warner, DJ1
Chen, H1
Cantin, LD1
Walker, CL1
Noeske, T1
Suzuki, A1
Thakkar, S1
Yu, K1
Hu, C1
Gabbi, C1
Bertolotti, M1
Usui, T1
Tailor, A1
Faulkner, L1
Meng, X1
Farrell, J1
Daly, AK2
Dear, GJ1
Park, BK1
Naisbitt, DJ1
Kaniwa, N1
Saito, Y1
Greenhaw, J1
Salminen, WF1
Serebruany, VL1
Dinicolantonio, JJ1
Can, MM1
Pershukov, IV1
Kuliczkowski, W1
Park, IC1
Baek, YH1
Han, SY1
Lee, SW2
Chung, WT1
Kang, SH1
Cho, DS1
Kapila, A1
Chhabra, L1
Locke, AD1
Patel, P1
Khanna, A1
Reddy, CM1
Young, MF2
Zhai, Y1
Wang, L1
Yang, F1
Feng, G1
Feng, S1
Cui, T1
An, L1
He, X1
Etxeberria-Lekuona, D1
Méndez-López, I1
Mercado, MR1
Oteiza, J1
Arteaga, M1
Jarne, V1
Joshi, N1
Kopec, AK1
Ray, JL1
Luyendyk, JP1
Nicoletti, P1
Aithal, GP1
Bjornsson, ES1
Andrade, RJ1
Sawle, A1
Arrese, M1
Barnhart, HX1
Bondon-Guitton, E1
Hayashi, PH1
Bessone, F1
Carvajal, A2
Cascorbi, I1
Cirulli, ET1
Chalasani, N1
Conforti, A1
Coulthard, SA1
Daly, MJ1
Day, CP1
Dillon, JF1
Fontana, RJ1
Grove, JI1
Hallberg, P1
Hernández, N1
Ibáñez, L1
Kullak-Ublick, GA1
Laitinen, T1
Larrey, D2
Lucena, MI1
Maitland-van der Zee, AH1
Martin, JH1
Molokhia, M1
Pirmohamed, M1
Powell, EE1
Qin, S1
Serrano, J1
Stephens, C1
Stolz, A1
Wadelius, M1
Watkins, PB1
Floratos, A1
Shen, Y1
Nelson, MR1
Urban, TJ1
Kowalski, R1
Dropiński, J1
Brzostek, T1
Szot, P1
Rzeszutko, M1
Kasper, M1
Sawicka, A1
Szczeklik, A1
Goyal, RK1
Srivastava, D1
Lessnau, KD1
Blombery, PA1
Russell, PA1
Daffy, JR1
Kastalli, S1
El Aïdli, S1
Zaïem, A1
ben Abdallah, H1
Daghfous, R1
Anselmino, M1
Moretti, C1
Ravera, L1
Sheiban, I1
Ariyoshi, N1
Iga, Y1
Hirata, K2
Sato, Y1
Miura, G1
Ishii, I1
Nagamori, S1
Kitada, M1
Shimizu, S2
Atsumi, R1
Nakazawa, T1
Izumi, T1
Sudo, K1
Okazaki, O1
Saji, H1
Leighton, SP1
Gordon, C1
Shand, A1
Darwish, OS1
Iqbal, E1
Yoshikado, T1
Takada, T1
Yamamoto, H1
Tan, JK1
Ito, K1
Santa, T1
Suzuki, H1
Zapater, P1
Such, J1
Pérez-Mateo, M1
Horga, JF1
Ramos Ramos, JC1
Sanz Moreno, J1
Calvo Carrasco, L1
García Díaz, Jde D1
Skurnik, YD1
Tcherniak, A1
Edlan, K1
Sthoeger, Z1
Gandolfi, A1
Mengoli, M1
Rota, E1
Tolomelli, S1
Zanghieri, G1
Bernini, MV1
Lusetti, L1
Beltran-Robles, M1
Marquez Saavedra, E1
Sanchez-Muñoz, D1
Romero-Gomez, M1
Chau, TN1
Yim, KF1
Mok, NS1
Chan, WK1
Leung, VK1
Leung, MF1
Lai, ST1
Höllmüller, I1
Stadlmann, S1
Graziadei, I1
Vogel, W1
Ng, JA1
Goldberg, N1
Tafreshi, MJ1
Takagi, H1
Yamamoto, M1
Matsumoto, T1
Nishiya, T1
Mori, K1
Masumoto, H1
Okutani, Y1
Fukushima, K1
Kobayashi, Y1
Okuno, T1
Nakamura, Y1
Sakakibara, M1
Nakayama, T1
Kuroda, N1
Miyazaki, A1
Shimizu, Y1
Komuro, I1
López-Vicente, J1
Garfia, C1
López-Medrano, F1
Yela, C1
Mambelli, E1
Mancini, E1
Casanova, S1
Di Felice, A1
Santoro, A1
Lee, JY1
Park, EB1
Ahn, JH1
Suh, SJ1
Jung, YK1
Kim, JH1
Shin, BK1
Yang, JH1
Yeon, JE1
Byun, KS1
Eugene, C1
Lefebvre, JF1
Gury, B1
Quevauvilliers, J1
Miras Parra, FJ1
Gómez Jiménez, FJ1
García Contreras, T1
Valverde Romera, M1
Naschitz, JE1
Khamessi, R1
Elias, N1
Yeshurun, D1
Ruiz-Valverde, P1
Zafon, C1
Segarra, A1
Ribera, R1
Piera, L1
Cassidy, LJ1
Schuster, BG1
Halparin, LS1
Weber, E1
Donckier, J1
López, P1
Castiella, A1
Bujanda, L1
Arenas, JI1
Pascual, S1
Sarrión, JV1
Jarque, I1
Argüello, L1
Berenguer, J1
Bruguera, M1
Shimizu, A1
Koyama, M1
Miyazaki, K1
Tagawa, S1
Takase, K1
Nakano, T1
Tameda, Y1
Kosaka, Y1
Friedman, ND1
Sitlington, R1
Lodge, RS1
Artímez, ML1
Fernández, E1
Rodríguez, M1
González, M1
Rodrigo, L1
San Juan Portugal, F1
Jiménez Saez, J1
Naya Manchado, J1
Fuentes Solsona, F1
Wegmann, C1
Münzenmaier, R1
Dormann, AJ1
Huchzermeyer, H1
Pittau, S1
Morelli, S1
Venturini, E1
Boldorini, R1
Sartori, M1
Grieco, A1
Vecchio, FM1
Greco, AV1
Gasbarrini, G1
Iqbal, M1
Goenka, P1
Thomas, E1
Borthwick, TR1
Ceylan, C1
Kirimli, O1
Akarsu, M1
Undar, B1
Güneri, S1
Ennamany, R1
Bingen, A1
Creppy, EE1
Kretz, O1
Gut, JP1
Dubuisson, L1
Balabaud, C1
Bioulac Sage, P1
Kirn, A1
Sossai, P1
Corte, GD1
Marenzi, R1
Remy, AJ1
Heran, B1
Galindo, G1
Tapie, C1
Khemissa, F1
Carvajal García-Pando, A1
García Ortega, P2
Rueda de Castro, AM1
García del Pozo, J2
Torrano Larrión, F1
Kubin, CJ1
Sherman, O1
Hussain, KB1
Feinman, L1
Zeolla, MM1
Carson, JJ1
Meyer, MI1
Kuhn, M1
Bühler, H1
Bertschinger, P1
Berent, R1
Hinterholzer, G1
Höbling, W1
Auer, J1
Haidenthaler, A1
Knoflach, P1
Wu, MS1
Chan, P1
Lien, GS1
Cheng, YS1
Pan, S1
Tsai, MH1
Tsai, SL1
Chen, TC1
Liaw, YF1
José Navarro, J1
Chen, LK1
Hsieh, BH1
Chen, WC1
Tsai, ST1
Hou, MC1
Willens, HJ1
Blanco, JR1
Márquez, M1
Salcedo, J1
Zabala, M1
López López, M1
Martín López, A1
Moreno Feliu, R1
Placci, A1
Melandri, G1
Cecilioni, L1
Valgimigli, M1
Bolondi, L1
Branzi, A1
Rivera Vaquerizo, P1
Solís García del Pozo, J1
Villanueva Hernández, P1
Durán Quintana, JA1
Jiménez Sáenz, M1
Montero, AR1
Gutiérrez, MH1
Adams, L1
Jeffrey, GP1
Deboer, B1
Garas, G1

Reviews

9 reviews available for ticlopidine and Acute Liver Injury, Drug-Induced

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr

2016
Pharmacogenomics of severe cutaneous adverse reactions and drug-induced liver injury.
    Journal of human genetics, 2013, Volume: 58, Issue:6

    Topics: Alleles; Allopurinol; Amoxicillin-Potassium Clavulanate Combination; Azetidines; Benzylamines; Carba

2013
[Cholestasic toxic hepatitis due to clopidogrel in a patient with multiple conditions].
    Anales del sistema sanitario de Navarra, 2016, 04-29, Volume: 39, Issue:1

    Topics: Chemical and Drug Induced Liver Injury; Clopidogrel; Coronary Artery Disease; Humans; Platelet Aggre

2016
Clopidogrel-induced hepatocellular injury and cholestatic jaundice in an elderly patient: case report and review of the literature.
    Pharmacotherapy, 2009, Volume: 29, Issue:5

    Topics: Aged; Angioplasty, Balloon, Coronary; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests;

2009
Clinico-histopathological characteristics of clopidogrel-induced hepatic injury: case report and review of literature.
    European journal of gastroenterology & hepatology, 2006, Volume: 18, Issue:8

    Topics: Aged, 80 and over; Chemical and Drug Induced Liver Injury; Clopidogrel; Humans; Male; Platelet Aggre

2006
[A case report of drug induced hepatitis and pancreatitis].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1997, Volume: 94, Issue:5

    Topics: Aged; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; Fibrinolytic Agents; Hu

1997
Cholestatic hepatitis due to ticlopidine: clinical and histological recovery after drug withdrawal. Case report and review of the literature.
    European journal of gastroenterology & hepatology, 1998, Volume: 10, Issue:8

    Topics: Aged; Biopsy; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Female; Fibrinolyti

1998
Ticlopidine-induced cholestatic hepatitis: report of three cases and review of the literature.
    Digestive diseases and sciences, 1998, Volume: 43, Issue:10

    Topics: Aged; Aged, 80 and over; Cerebrovascular Disorders; Chemical and Drug Induced Liver Injury; Cholesta

1998
[Cholestatic hepatitis as a rare side effect of therapy with ticlopidine].
    Zeitschrift fur Gastroenterologie, 2000, Volume: 38, Issue:7

    Topics: Aged; Atrial Fibrillation; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Cholestasis; Chro

2000

Other Studies

72 other studies available for ticlopidine and Acute Liver Injury, Drug-Induced

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship;

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des

2011
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters

2012
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
    PLoS computational biology, 2011, Volume: 7, Issue:12

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da

2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters

2012
Reduced multidrug resistance-associated protein 2 in ticlopidine-induced cholestatic liver injury.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2020, Volume: 52, Issue:2

    Topics: Aged, 80 and over; Biomarkers; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Humans;

2020
HLA-A*33:03-Restricted Activation of Ticlopidine-Specific T-Cells from Human Donors.
    Chemical research in toxicology, 2018, 10-15, Volume: 31, Issue:10

    Topics: CD8-Positive T-Lymphocytes; Cell Proliferation; Chemical and Drug Induced Liver Injury; Genotype; HL

2018
Inhibition of cytochrome P450s enhances (+)-usnic acid cytotoxicity in primary cultured rat hepatocytes.
    Journal of applied toxicology : JAT, 2014, Volume: 34, Issue:8

    Topics: Animals; Benzoflavones; Benzofurans; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytoch

2014
Gastrointestinal adverse events after dual antiplatelet therapy: clopidogrel is safer than ticagrelor, but prasugrel data are lacking or inconclusive.
    Cardiology, 2013, Volume: 126, Issue:1

    Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Chemical and Drug Induced Liver Injury; Clinical Trials

2013
Simultaneous intrahepatic and subgaleal hemorrhage in antiphospholipid syndrome following anticoagulation therapy.
    World journal of gastroenterology, 2013, Oct-14, Volume: 19, Issue:38

    Topics: Adolescent; Anticoagulants; Antiphospholipid Syndrome; Chemical and Drug Induced Liver Injury; Clopi

2013
An idiosyncratic reaction to clopidogrel.
    The Permanente journal, 2015,Winter, Volume: 19, Issue:1

    Topics: Aged; Chemical and Drug Induced Liver Injury; Clopidogrel; Female; Humans; Platelet Aggregation Inhi

2015
The mechanism and risk factors of clopidogrel-induced liver injury.
    Drug and chemical toxicology, 2016, Volume: 39, Issue:4

    Topics: Animals; Chemical and Drug Induced Liver Injury; Clopidogrel; Cytochrome P-450 CYP2B6; Cytochrome P-

2016
Inhibition of PAR-4 and P2Y12 receptor-mediated platelet activation produces distinct hepatic pathologies in experimental xenobiotic-induced cholestatic liver disease.
    Toxicology, 2016, 07-15, Volume: 365

    Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Cholestasis; Clopidogrel;

2016
Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study.
    Gastroenterology, 2017, Volume: 152, Issue:5

    Topics: Alleles; Antidepressive Agents; Antifungal Agents; Chemical and Drug Induced Liver Injury; Chromosom

2017
[Cholestatic hepatitis as a ticlopidine-induced complication of treatment - a case report].
    Kardiologia polska, 2008, Volume: 66, Issue:7

    Topics: Aged; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Female; Humans; Hypertensio

2008
An unusual case of recurrent fever, jaundice and right upper quadrant pain.
    The Medical journal of Australia, 2009, Oct-05, Volume: 191, Issue:7

    Topics: Abdominal Pain; Aged; Chemical and Drug Induced Liver Injury; Clopidogrel; Fever; Humans; Jaundice;

2009
Fatal liver injury associated with clopidogrel.
    Fundamental & clinical pharmacology, 2010, Volume: 24, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Clopidogrel; Fatal Outcome; Humans; Liver Function Tests; Ma

2010
Clopidogrel treatment in a patient with ticlopidine-induced hepatitis following percutaneous coronary stenting.
    Minerva cardioangiologica, 2010, Volume: 58, Issue:2

    Topics: Aged, 80 and over; Angioplasty, Balloon, Coronary; Chemical and Drug Induced Liver Injury; Clopidogr

2010
Enhanced susceptibility of HLA-mediated ticlopidine-induced idiosyncratic hepatotoxicity by CYP2B6 polymorphism in Japanese.
    Drug metabolism and pharmacokinetics, 2010, Volume: 25, Issue:3

    Topics: Aryl Hydrocarbon Hydroxylases; Biotransformation; Case-Control Studies; Chemical and Drug Induced Li

2010
Ticlopidine-induced hepatotoxicity in a GSH-depleted rat model.
    Archives of toxicology, 2011, Volume: 85, Issue:4

    Topics: Animals; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dru

2011
Clopidogrel, Turkey and a red herring?
    BMJ case reports, 2011, Apr-09, Volume: 2011

    Topics: Chemical and Drug Induced Liver Injury; Clopidogrel; Diagnosis, Differential; Hepatitis E; Humans; M

2011
Dual antiplatelet agent-induced spontaneous liver hematoma.
    The Annals of pharmacotherapy, 2012, Volume: 46, Issue:11

    Topics: Aged; Aspirin; Chemical and Drug Induced Liver Injury; Clopidogrel; Coronary Artery Disease; Drug Th

2012
Ticlopidine, a cholestatic liver injury-inducible drug, causes dysfunction of bile formation via diminished biliary secretion of phospholipids: involvement of biliary-excreted glutathione-conjugated ticlopidine metabolites.
    Molecular pharmacology, 2013, Volume: 83, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Bile; Bil

2013
A new Poisson and Bayesian-based method to assign risk and causality in patients with suspected hepatic adverse drug reactions: a report of two new cases of ticlopidine-induced hepatotoxicity.
    Drug safety, 2002, Volume: 25, Issue:10

    Topics: Adult; Aged; Bayes Theorem; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Female

2002
[Clopidogrel-induced hepatotoxicity].
    Medicina clinica, 2003, Feb-08, Volume: 120, Issue:4

    Topics: Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Clopidogrel; Female; Humans; Liver

2003
Ticlopidine-induced cholestatic hepatitis.
    The Annals of pharmacotherapy, 2003, Volume: 37, Issue:3

    Topics: Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Cholestasis; Humans; Male; Platelet

2003
[Ticlopidine-induced acute cholestatic hepatitis. A case report].
    Recenti progressi in medicina, 2004, Volume: 95, Issue:2

    Topics: Acute Disease; Aged; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Humans; Male

2004
Hepatotoxicity induced by clopidogrel.
    Journal of hepatology, 2004, Volume: 40, Issue:3

    Topics: Chemical and Drug Induced Liver Injury; Clopidogrel; Humans; Male; Middle Aged; Platelet Aggregation

2004
Clopidogrel-induced hepatotoxicity after percutaneous coronary stenting.
    Hong Kong medical journal = Xianggang yi xue za zhi, 2005, Volume: 11, Issue:5

    Topics: Aged; Chemical and Drug Induced Liver Injury; Clopidogrel; Combined Modality Therapy; Coronary Disea

2005
Clopidogrel-induced hepatotoxicity and fever.
    Pharmacotherapy, 2006, Volume: 26, Issue:7

    Topics: Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Chemical and Drug Induced L

2006
Ticlopidine-induced hepatotoxicity is associated with specific human leukocyte antigen genomic subtypes in Japanese patients: a preliminary case-control study.
    The pharmacogenomics journal, 2008, Volume: 8, Issue:1

    Topics: Biotransformation; Case-Control Studies; Chemical and Drug Induced Liver Injury; Cholestasis, Intrah

2008
Incidence of side-effects of ticlopidine after sirolimus-eluting stent implantation.
    Circulation journal : official journal of the Japanese Circulation Society, 2007, Volume: 71, Issue:4

    Topics: Aged; Blood Vessel Prosthesis Implantation; Chemical and Drug Induced Liver Injury; Coronary Thrombo

2007
[Hepatic toxicity and clopidogrel-induced systemic inflammatory response syndrome].
    Revista espanola de cardiologia, 2007, Volume: 60, Issue:3

    Topics: Chemical and Drug Induced Liver Injury; Clopidogrel; Humans; Male; Middle Aged; Platelet Aggregation

2007
Severe ticlopidine-induced cholestatic syndrome.
    Blood purification, 2007, Volume: 25, Issue:5-6

    Topics: Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Humans; Kidney Failure, Chronic;

2007
[A case of ticlopidine induced acute cholestatic hepatitis and pure red cell aplasia].
    The Korean journal of hepatology, 2008, Volume: 14, Issue:1

    Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Humans; Liver Function T

2008
[Cholestatic hepatitis. Presumptive role of ticlopidine].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1983, Nov-17, Volume: 59, Issue:42

    Topics: Aged; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Humans; Thiophenes; Ticlopidine

1983
[Ticlopidine-induced cholestatic hepatitis].
    Revista espanola de enfermedades digestivas, 1995, Volume: 87, Issue:5

    Topics: Aged; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Humans; Thrombophlebitis; Ticlopi

1995
Ticlopidine-induced prolonged cholestasis.
    Journal of toxicology. Clinical toxicology, 1995, Volume: 33, Issue:4

    Topics: Aged; Chemical and Drug Induced Liver Injury; Cholestasis; Cholestyramine Resin; Female; Humans; Tic

1995
Ticlopidine-induced granulomatous hepatitis.
    The Annals of pharmacotherapy, 1995, Volume: 29, Issue:6

    Topics: Aged; Chemical and Drug Induced Liver Injury; Granuloma; Humans; Male; Ticlopidine

1995
Probable ticlopidine-induced cholestatic hepatitis.
    The Annals of pharmacotherapy, 1995, Volume: 29, Issue:1

    Topics: Aged; Chemical and Drug Induced Liver Injury; Cholestasis; Humans; Male; Ticlopidine

1995
[Cholestatic jaundice due to ticlopidine: a new case].
    Acta clinica Belgica, 1994, Volume: 49, Issue:6

    Topics: Chemical and Drug Induced Liver Injury; Cholestasis; Coronary Disease; Diagnosis, Differential; Huma

1994
[Ticlopidine-induced cholestatic hepatitis. A case report].
    Revista espanola de enfermedades digestivas, 1995, Volume: 87, Issue:10

    Topics: Aged; Chemical and Drug Induced Liver Injury; Cholestasis; Fibrinolytic Agents; Humans; Male; Ticlop

1995
[Cholestatic hepatitis and anemia induced by ticlopidine].
    Gastroenterologia y hepatologia, 1996, Volume: 19, Issue:4

    Topics: Acute Disease; Aged; Anemia; Cerebrovascular Disorders; Chemical and Drug Induced Liver Injury; Chol

1996
[Cholestatic hepatitis associated with ticlopidine].
    Gastroenterologia y hepatologia, 1997, Volume: 20, Issue:3

    Topics: Aged; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Humans; Middle Aged; Platelet Agg

1997
Thrombocytopenia and hepatitis complicating ticlopidine therapy.
    Australian and New Zealand journal of medicine, 1997, Volume: 27, Issue:5

    Topics: Aged; Chemical and Drug Induced Liver Injury; Humans; Male; Platelet Aggregation Inhibitors; Thrombo

1997
[Toxic hepatitis by ticlopidine. Three new cases].
    Revista espanola de enfermedades digestivas, 1997, Volume: 89, Issue:10

    Topics: Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Female; Fibrinolytic Agents; Humans

1997
[Cholestatic hepatitis due to ticlopidine: a report of a new case].
    Anales de medicina interna (Madrid, Spain : 1984), 1997, Volume: 14, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cholestasis; Humans; Male; Middle Aged; Platelet Aggregation

1997
[Ticlopidine-induced acute cholestatic hepatitis].
    Deutsche medizinische Wochenschrift (1946), 1998, Feb-06, Volume: 123, Issue:6

    Topics: Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Biopsy; Cerebell

1998
[Post-infantile giant cell hepatitis. Clinical and histological response to immunosuppressive therapy].
    Recenti progressi in medicina, 1998, Volume: 89, Issue:3

    Topics: Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Fibrinolytic Agents; Glucocorticoids; H

1998
Early ticlopidine-induced hepatic dysfunction, dermatitis and irreversible aplastic anemia after coronary artery stenting.
    American journal of hematology, 1998, Volume: 59, Issue:3

    Topics: Aged; Anemia, Aplastic; Angioplasty, Balloon, Coronary; Chemical and Drug Induced Liver Injury; Drug

1998
Aspirin and heparin prevent hepatic blood stasis and thrombosis induced by the toxic glycoprotein Bolesatine in mice.
    Human & experimental toxicology, 1998, Volume: 17, Issue:11

    Topics: Agglutination; Animals; Aspirin; Blood Platelets; Chemical and Drug Induced Liver Injury; Dose-Respo

1998
Liver injury with the use of ticlopidine.
    The Annals of pharmacotherapy, 1998, Volume: 32, Issue:12

    Topics: Chemical and Drug Induced Liver Injury; Humans; Liver Function Tests; Male; Middle Aged; Platelet Ag

1998
[A new drug responsible for microvesicular steatosis: ticlopidine].
    Gastroenterologie clinique et biologique, 1999, Volume: 23, Issue:1

    Topics: Aged; Aged, 80 and over; Biopsy; Chemical and Drug Induced Liver Injury; Fatty Liver; Female; Humans

1999
[Ticlopidine and hepatic adverse reactions. Data from the Spanish drug surveillance system].
    Medicina clinica, 1999, Apr-24, Volume: 112, Issue:14

    Topics: Aged; Aged, 80 and over; Cerebrovascular Disorders; Chemical and Drug Induced Liver Injury; Female;

1999
[Cholestatic hepatitis from ticlopidine].
    Atencion primaria, 1999, Jun-30, Volume: 24, Issue:2

    Topics: Aged; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Fibrinolytic Agents; Humans; Ticl

1999
Delayed-onset ticlopidine-induced cholestatic jaundice.
    Pharmacotherapy, 1999, Volume: 19, Issue:8

    Topics: Aged; Chemical and Drug Induced Liver Injury; Cholestasis; Humans; Liver Function Tests; Male; Plate

1999
Successful use of clopidogrel for cerebrovascular accident in a patient with suspected ticlopidine-induced hepatotoxicity.
    The Annals of pharmacotherapy, 1999, Volume: 33, Issue:9

    Topics: Aged; Cerebrovascular Disorders; Chemical and Drug Induced Liver Injury; Clopidogrel; Female; Humans

1999
[Ticlopidine-induced cholestasis].
    Schweizerische medizinische Wochenschrift, 1999, Oct-02, Volume: 129, Issue:39

    Topics: Aged; Aged, 80 and over; Angina Pectoris; Aspirin; Chemical and Drug Induced Liver Injury; Cholestas

1999
Ticlopidine-induced severe cholestatic hepatitis.
    Zhonghua yi xue za zhi = Chinese medical journal; Free China ed, 2000, Volume: 63, Issue:8

    Topics: Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Humans; Platel

2000
Ticlopidine-induced cholestatic hepatitis with anti-nuclear antibody in serum.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2000, Volume: 99, Issue:11

    Topics: Antibodies, Antinuclear; Chemical and Drug Induced Liver Injury; Cholestasis; Humans; Liver; Male; M

2000
[Cholestatic hepatitis by ticlopidin].
    Medicina clinica, 2001, Jan-27, Volume: 116, Issue:3

    Topics: Chemical and Drug Induced Liver Injury; Cholestasis; Humans; Male; Middle Aged; Platelet Aggregation

2001
Ticlopidine-induced hepatitis.
    Zhonghua yi xue za zhi = Chinese medical journal; Free China ed, 2001, Volume: 64, Issue:1

    Topics: Aged; Alanine Transaminase; Alkaline Phosphatase; Chemical and Drug Induced Liver Injury; Humans; Ma

2001
Clopidogrel-induced mixed hepatocellular and cholestatic liver injury.
    American journal of therapeutics, 2000, Volume: 7, Issue:5

    Topics: Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Hepatocytes; H

2000
[Early hepatopathy induced by ticlopidine].
    Anales de medicina interna (Madrid, Spain : 1984), 2001, Volume: 18, Issue:1

    Topics: Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Humans; Male; Platelet Aggregation

2001
[Ticlopidine, cholestasis and hepatic nodules].
    Medicina clinica, 2001, Oct-20, Volume: 117, Issue:12

    Topics: Chemical and Drug Induced Liver Injury; Cholestasis; Humans; Male; Middle Aged; Ticlopidine

2001
[Late-appearing cholestatic icterus after a month of treatment with ticlopidine].
    Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology, 2001, Volume: 2, Issue:11

    Topics: Aged; Angioplasty, Balloon, Coronary; Chemical and Drug Induced Liver Injury; Coronary Stenosis; Hum

2001
[Ticlopidine-induced hepatitis. Report of a new case].
    Anales de medicina interna (Madrid, Spain : 1984), 2002, Volume: 19, Issue:2

    Topics: Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Platelet Aggregation Inhibitors; Ticlo

2002
[Clopidogrel probably induced hepatic toxicity].
    Medicina clinica, 2002, Jun-08, Volume: 119, Issue:1

    Topics: Aged; Chemical and Drug Induced Liver Injury; Clopidogrel; Humans; Male; Platelet Aggregation Inhibi

2002
Ticlopidine-associated cholestatic hepatitis.
    Internal medicine journal, 2002, Volume: 32, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Cholestasis; Diagnosis, Differential; Humans; Male; Middle A

2002