ticlopidine has been researched along with Acute Liver Injury, Drug-Induced in 81 studies
Ticlopidine: An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.
ticlopidine : A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 59-year-old woman developed fever and elevated hepatic enzyme levels within days of starting clopidogrel, which had been prescribed in conjunction with a percutaneous coronary intervention." | 7.73 | Clopidogrel-induced hepatotoxicity and fever. ( Goldberg, N; Ng, JA; Tafreshi, MJ, 2006) |
| " As for SCARs, associations of HLA-B*15:02 or HLA-A*31:01 and HLA-B*58:01 have been revealed for carbamazepine- and allopurinol-related Stevens-Johnson syndrome and toxic epidermal neclolysis, respectively." | 4.89 | Pharmacogenomics of severe cutaneous adverse reactions and drug-induced liver injury. ( Kaniwa, N; Saito, Y, 2013) |
| "Current guidelines offer a choice of P2Y12 receptor antagonist among clopidogrel, prasugrel or ticagrelor on top of aspirin (ASA) for dual antiplatelet therapy (DAPT) in patients after acute coronary syndromes (ACS)." | 3.79 | Gastrointestinal adverse events after dual antiplatelet therapy: clopidogrel is safer than ticagrelor, but prasugrel data are lacking or inconclusive. ( Can, MM; Dinicolantonio, JJ; Kuliczkowski, W; Pershukov, IV; Serebruany, VL, 2013) |
| " An objective causality assessment suggested that the liver hematoma was possibly related to the combination of clopidogrel and aspirin." | 3.78 | Dual antiplatelet agent-induced spontaneous liver hematoma. ( Darwish, OS; Iqbal, E, 2012) |
| "A 59-year-old woman developed fever and elevated hepatic enzyme levels within days of starting clopidogrel, which had been prescribed in conjunction with a percutaneous coronary intervention." | 3.73 | Clopidogrel-induced hepatotoxicity and fever. ( Goldberg, N; Ng, JA; Tafreshi, MJ, 2006) |
| "Six years later after a left cerebral transient ischemic attack aspirin was replaced by ticlopidine." | 2.41 | [Cholestatic hepatitis as a rare side effect of therapy with ticlopidine]. ( Auer, J; Berent, R; Haidenthaler, A; Hinterholzer, G; Höbling, W; Knoflach, P, 2000) |
| " These data demonstrate that UA is bio-transformed to less toxic metabolites in rat primary hepatocytes, probably mainly by CYP1A and 3A, but not 2B/2C." | 1.40 | Inhibition of cytochrome P450s enhances (+)-usnic acid cytotoxicity in primary cultured rat hepatocytes. ( Greenhaw, J; Salminen, WF; Shi, Q, 2014) |
| "Intrahepatic hemorrhage is a very rare complication of warfarin, and our patient experienced intrahepatic and subgaleal hemorrhage although she did not have any risk factors for bleeding or instability of the international normalized ratio control." | 1.39 | Simultaneous intrahepatic and subgaleal hemorrhage in antiphospholipid syndrome following anticoagulation therapy. ( Baek, YH; Cho, DS; Chung, WT; Han, SY; Kang, SH; Lee, SW; Park, IC, 2013) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| " Administration of radio-labeled TIC in combination with BSO resulted in significantly higher covalent binding to rat liver proteins than that observed after sole dosing of radio-labeled TIC." | 1.37 | Ticlopidine-induced hepatotoxicity in a GSH-depleted rat model. ( Atsumi, R; Izumi, T; Nakazawa, T; Okazaki, O; Saji, H; Shimizu, S; Sudo, K, 2011) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| "Hepatotoxicity is the most frequent adverse drug reaction (ADR) in Japanese treated with ticlopidine (TP)." | 1.36 | Enhanced susceptibility of HLA-mediated ticlopidine-induced idiosyncratic hepatotoxicity by CYP2B6 polymorphism in Japanese. ( Ariyoshi, N; Hirata, K; Iga, Y; Ishii, I; Kitada, M; Miura, G; Nagamori, S; Sato, Y, 2010) |
| "Genetic risk factors for ticlopidine-induced hepatotoxicity were determined in 22 Japanese patients with ticlopidine-induced hepatotoxicity and 85 Japanese patients who tolerated ticlopidine therapy without experiencing adverse reactions." | 1.35 | Ticlopidine-induced hepatotoxicity is associated with specific human leukocyte antigen genomic subtypes in Japanese patients: a preliminary case-control study. ( Hirata, K; Masumoto, H; Matsumoto, T; Mori, K; Nishiya, T; Okutani, Y; Shimizu, S; Takagi, H; Yamamoto, M, 2008) |
| "Ticlopidine has a relative high rate of side-effects." | 1.34 | Incidence of side-effects of ticlopidine after sirolimus-eluting stent implantation. ( Fukushima, K; Kobayashi, Y; Komuro, I; Kuroda, N; Miyazaki, A; Nakamura, Y; Nakayama, T; Okuno, T; Sakakibara, M; Shimizu, Y, 2007) |
| " Concretely, the prior odd is modified by several separate likelihood ratios: age; sex; AST level; ALT level; alkaline phosphatase level; total bilirubin level; latent period of adverse reaction appearance; and period of remission of adverse reaction." | 1.31 | A new Poisson and Bayesian-based method to assign risk and causality in patients with suspected hepatic adverse drug reactions: a report of two new cases of ticlopidine-induced hepatotoxicity. ( Horga, JF; Pérez-Mateo, M; Such, J; Zapater, P, 2002) |
| "Ticlopidine is a commonly prescribed drug in cerebrovascular or cardiovascular diseases." | 1.31 | Ticlopidine-induced hepatitis. ( Chen, LK; Chen, WC; Hou, MC; Hsieh, BH; Tsai, ST, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.23) | 18.7374 |
| 1990's | 25 (30.86) | 18.2507 |
| 2000's | 28 (34.57) | 29.6817 |
| 2010's | 26 (32.10) | 24.3611 |
| 2020's | 1 (1.23) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 3 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 3 |
| Dawson, S | 1 |
| Stahl, S | 2 |
| Paul, N | 1 |
| Barber, J | 1 |
| Kenna, JG | 2 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Gabbi, C | 1 |
| Bertolotti, M | 1 |
| Usui, T | 1 |
| Tailor, A | 1 |
| Faulkner, L | 1 |
| Meng, X | 1 |
| Farrell, J | 1 |
| Daly, AK | 2 |
| Dear, GJ | 1 |
| Park, BK | 1 |
| Naisbitt, DJ | 1 |
| Kaniwa, N | 1 |
| Saito, Y | 1 |
| Greenhaw, J | 1 |
| Salminen, WF | 1 |
| Serebruany, VL | 1 |
| Dinicolantonio, JJ | 1 |
| Can, MM | 1 |
| Pershukov, IV | 1 |
| Kuliczkowski, W | 1 |
| Park, IC | 1 |
| Baek, YH | 1 |
| Han, SY | 1 |
| Lee, SW | 2 |
| Chung, WT | 1 |
| Kang, SH | 1 |
| Cho, DS | 1 |
| Kapila, A | 1 |
| Chhabra, L | 1 |
| Locke, AD | 1 |
| Patel, P | 1 |
| Khanna, A | 1 |
| Reddy, CM | 1 |
| Young, MF | 2 |
| Zhai, Y | 1 |
| Wang, L | 1 |
| Yang, F | 1 |
| Feng, G | 1 |
| Feng, S | 1 |
| Cui, T | 1 |
| An, L | 1 |
| He, X | 1 |
| Etxeberria-Lekuona, D | 1 |
| Méndez-López, I | 1 |
| Mercado, MR | 1 |
| Oteiza, J | 1 |
| Arteaga, M | 1 |
| Jarne, V | 1 |
| Joshi, N | 1 |
| Kopec, AK | 1 |
| Ray, JL | 1 |
| Luyendyk, JP | 1 |
| Nicoletti, P | 1 |
| Aithal, GP | 1 |
| Bjornsson, ES | 1 |
| Andrade, RJ | 1 |
| Sawle, A | 1 |
| Arrese, M | 1 |
| Barnhart, HX | 1 |
| Bondon-Guitton, E | 1 |
| Hayashi, PH | 1 |
| Bessone, F | 1 |
| Carvajal, A | 2 |
| Cascorbi, I | 1 |
| Cirulli, ET | 1 |
| Chalasani, N | 1 |
| Conforti, A | 1 |
| Coulthard, SA | 1 |
| Daly, MJ | 1 |
| Day, CP | 1 |
| Dillon, JF | 1 |
| Fontana, RJ | 1 |
| Grove, JI | 1 |
| Hallberg, P | 1 |
| Hernández, N | 1 |
| Ibáñez, L | 1 |
| Kullak-Ublick, GA | 1 |
| Laitinen, T | 1 |
| Larrey, D | 2 |
| Lucena, MI | 1 |
| Maitland-van der Zee, AH | 1 |
| Martin, JH | 1 |
| Molokhia, M | 1 |
| Pirmohamed, M | 1 |
| Powell, EE | 1 |
| Qin, S | 1 |
| Serrano, J | 1 |
| Stephens, C | 1 |
| Stolz, A | 1 |
| Wadelius, M | 1 |
| Watkins, PB | 1 |
| Floratos, A | 1 |
| Shen, Y | 1 |
| Nelson, MR | 1 |
| Urban, TJ | 1 |
| Kowalski, R | 1 |
| Dropiński, J | 1 |
| Brzostek, T | 1 |
| Szot, P | 1 |
| Rzeszutko, M | 1 |
| Kasper, M | 1 |
| Sawicka, A | 1 |
| Szczeklik, A | 1 |
| Goyal, RK | 1 |
| Srivastava, D | 1 |
| Lessnau, KD | 1 |
| Blombery, PA | 1 |
| Russell, PA | 1 |
| Daffy, JR | 1 |
| Kastalli, S | 1 |
| El Aïdli, S | 1 |
| Zaïem, A | 1 |
| ben Abdallah, H | 1 |
| Daghfous, R | 1 |
| Anselmino, M | 1 |
| Moretti, C | 1 |
| Ravera, L | 1 |
| Sheiban, I | 1 |
| Ariyoshi, N | 1 |
| Iga, Y | 1 |
| Hirata, K | 2 |
| Sato, Y | 1 |
| Miura, G | 1 |
| Ishii, I | 1 |
| Nagamori, S | 1 |
| Kitada, M | 1 |
| Shimizu, S | 2 |
| Atsumi, R | 1 |
| Nakazawa, T | 1 |
| Izumi, T | 1 |
| Sudo, K | 1 |
| Okazaki, O | 1 |
| Saji, H | 1 |
| Leighton, SP | 1 |
| Gordon, C | 1 |
| Shand, A | 1 |
| Darwish, OS | 1 |
| Iqbal, E | 1 |
| Yoshikado, T | 1 |
| Takada, T | 1 |
| Yamamoto, H | 1 |
| Tan, JK | 1 |
| Ito, K | 1 |
| Santa, T | 1 |
| Suzuki, H | 1 |
| Zapater, P | 1 |
| Such, J | 1 |
| Pérez-Mateo, M | 1 |
| Horga, JF | 1 |
| Ramos Ramos, JC | 1 |
| Sanz Moreno, J | 1 |
| Calvo Carrasco, L | 1 |
| García Díaz, Jde D | 1 |
| Skurnik, YD | 1 |
| Tcherniak, A | 1 |
| Edlan, K | 1 |
| Sthoeger, Z | 1 |
| Gandolfi, A | 1 |
| Mengoli, M | 1 |
| Rota, E | 1 |
| Tolomelli, S | 1 |
| Zanghieri, G | 1 |
| Bernini, MV | 1 |
| Lusetti, L | 1 |
| Beltran-Robles, M | 1 |
| Marquez Saavedra, E | 1 |
| Sanchez-Muñoz, D | 1 |
| Romero-Gomez, M | 1 |
| Chau, TN | 1 |
| Yim, KF | 1 |
| Mok, NS | 1 |
| Chan, WK | 1 |
| Leung, VK | 1 |
| Leung, MF | 1 |
| Lai, ST | 1 |
| Höllmüller, I | 1 |
| Stadlmann, S | 1 |
| Graziadei, I | 1 |
| Vogel, W | 1 |
| Ng, JA | 1 |
| Goldberg, N | 1 |
| Tafreshi, MJ | 1 |
| Takagi, H | 1 |
| Yamamoto, M | 1 |
| Matsumoto, T | 1 |
| Nishiya, T | 1 |
| Mori, K | 1 |
| Masumoto, H | 1 |
| Okutani, Y | 1 |
| Fukushima, K | 1 |
| Kobayashi, Y | 1 |
| Okuno, T | 1 |
| Nakamura, Y | 1 |
| Sakakibara, M | 1 |
| Nakayama, T | 1 |
| Kuroda, N | 1 |
| Miyazaki, A | 1 |
| Shimizu, Y | 1 |
| Komuro, I | 1 |
| López-Vicente, J | 1 |
| Garfia, C | 1 |
| López-Medrano, F | 1 |
| Yela, C | 1 |
| Mambelli, E | 1 |
| Mancini, E | 1 |
| Casanova, S | 1 |
| Di Felice, A | 1 |
| Santoro, A | 1 |
| Lee, JY | 1 |
| Park, EB | 1 |
| Ahn, JH | 1 |
| Suh, SJ | 1 |
| Jung, YK | 1 |
| Kim, JH | 1 |
| Shin, BK | 1 |
| Yang, JH | 1 |
| Yeon, JE | 1 |
| Byun, KS | 1 |
| Eugene, C | 1 |
| Lefebvre, JF | 1 |
| Gury, B | 1 |
| Quevauvilliers, J | 1 |
| Miras Parra, FJ | 1 |
| Gómez Jiménez, FJ | 1 |
| García Contreras, T | 1 |
| Valverde Romera, M | 1 |
| Naschitz, JE | 1 |
| Khamessi, R | 1 |
| Elias, N | 1 |
| Yeshurun, D | 1 |
| Ruiz-Valverde, P | 1 |
| Zafon, C | 1 |
| Segarra, A | 1 |
| Ribera, R | 1 |
| Piera, L | 1 |
| Cassidy, LJ | 1 |
| Schuster, BG | 1 |
| Halparin, LS | 1 |
| Weber, E | 1 |
| Donckier, J | 1 |
| López, P | 1 |
| Castiella, A | 1 |
| Bujanda, L | 1 |
| Arenas, JI | 1 |
| Pascual, S | 1 |
| Sarrión, JV | 1 |
| Jarque, I | 1 |
| Argüello, L | 1 |
| Berenguer, J | 1 |
| Bruguera, M | 1 |
| Shimizu, A | 1 |
| Koyama, M | 1 |
| Miyazaki, K | 1 |
| Tagawa, S | 1 |
| Takase, K | 1 |
| Nakano, T | 1 |
| Tameda, Y | 1 |
| Kosaka, Y | 1 |
| Friedman, ND | 1 |
| Sitlington, R | 1 |
| Lodge, RS | 1 |
| Artímez, ML | 1 |
| Fernández, E | 1 |
| Rodríguez, M | 1 |
| González, M | 1 |
| Rodrigo, L | 1 |
| San Juan Portugal, F | 1 |
| Jiménez Saez, J | 1 |
| Naya Manchado, J | 1 |
| Fuentes Solsona, F | 1 |
| Wegmann, C | 1 |
| Münzenmaier, R | 1 |
| Dormann, AJ | 1 |
| Huchzermeyer, H | 1 |
| Pittau, S | 1 |
| Morelli, S | 1 |
| Venturini, E | 1 |
| Boldorini, R | 1 |
| Sartori, M | 1 |
| Grieco, A | 1 |
| Vecchio, FM | 1 |
| Greco, AV | 1 |
| Gasbarrini, G | 1 |
| Iqbal, M | 1 |
| Goenka, P | 1 |
| Thomas, E | 1 |
| Borthwick, TR | 1 |
| Ceylan, C | 1 |
| Kirimli, O | 1 |
| Akarsu, M | 1 |
| Undar, B | 1 |
| Güneri, S | 1 |
| Ennamany, R | 1 |
| Bingen, A | 1 |
| Creppy, EE | 1 |
| Kretz, O | 1 |
| Gut, JP | 1 |
| Dubuisson, L | 1 |
| Balabaud, C | 1 |
| Bioulac Sage, P | 1 |
| Kirn, A | 1 |
| Sossai, P | 1 |
| Corte, GD | 1 |
| Marenzi, R | 1 |
| Remy, AJ | 1 |
| Heran, B | 1 |
| Galindo, G | 1 |
| Tapie, C | 1 |
| Khemissa, F | 1 |
| Carvajal García-Pando, A | 1 |
| García Ortega, P | 2 |
| Rueda de Castro, AM | 1 |
| García del Pozo, J | 2 |
| Torrano Larrión, F | 1 |
| Kubin, CJ | 1 |
| Sherman, O | 1 |
| Hussain, KB | 1 |
| Feinman, L | 1 |
| Zeolla, MM | 1 |
| Carson, JJ | 1 |
| Meyer, MI | 1 |
| Kuhn, M | 1 |
| Bühler, H | 1 |
| Bertschinger, P | 1 |
| Berent, R | 1 |
| Hinterholzer, G | 1 |
| Höbling, W | 1 |
| Auer, J | 1 |
| Haidenthaler, A | 1 |
| Knoflach, P | 1 |
| Wu, MS | 1 |
| Chan, P | 1 |
| Lien, GS | 1 |
| Cheng, YS | 1 |
| Pan, S | 1 |
| Tsai, MH | 1 |
| Tsai, SL | 1 |
| Chen, TC | 1 |
| Liaw, YF | 1 |
| José Navarro, J | 1 |
| Chen, LK | 1 |
| Hsieh, BH | 1 |
| Chen, WC | 1 |
| Tsai, ST | 1 |
| Hou, MC | 1 |
| Willens, HJ | 1 |
| Blanco, JR | 1 |
| Márquez, M | 1 |
| Salcedo, J | 1 |
| Zabala, M | 1 |
| López López, M | 1 |
| Martín López, A | 1 |
| Moreno Feliu, R | 1 |
| Placci, A | 1 |
| Melandri, G | 1 |
| Cecilioni, L | 1 |
| Valgimigli, M | 1 |
| Bolondi, L | 1 |
| Branzi, A | 1 |
| Rivera Vaquerizo, P | 1 |
| Solís García del Pozo, J | 1 |
| Villanueva Hernández, P | 1 |
| Durán Quintana, JA | 1 |
| Jiménez Sáenz, M | 1 |
| Montero, AR | 1 |
| Gutiérrez, MH | 1 |
| Adams, L | 1 |
| Jeffrey, GP | 1 |
| Deboer, B | 1 |
| Garas, G | 1 |
9 reviews available for ticlopidine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Pharmacogenomics of severe cutaneous adverse reactions and drug-induced liver injury.
Topics: Alleles; Allopurinol; Amoxicillin-Potassium Clavulanate Combination; Azetidines; Benzylamines; Carba | 2013 |
[Cholestasic toxic hepatitis due to clopidogrel in a patient with multiple conditions].
Topics: Chemical and Drug Induced Liver Injury; Clopidogrel; Coronary Artery Disease; Humans; Platelet Aggre | 2016 |
Clopidogrel-induced hepatocellular injury and cholestatic jaundice in an elderly patient: case report and review of the literature.
Topics: Aged; Angioplasty, Balloon, Coronary; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; | 2009 |
Clinico-histopathological characteristics of clopidogrel-induced hepatic injury: case report and review of literature.
Topics: Aged, 80 and over; Chemical and Drug Induced Liver Injury; Clopidogrel; Humans; Male; Platelet Aggre | 2006 |
[A case report of drug induced hepatitis and pancreatitis].
Topics: Aged; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; Fibrinolytic Agents; Hu | 1997 |
Cholestatic hepatitis due to ticlopidine: clinical and histological recovery after drug withdrawal. Case report and review of the literature.
Topics: Aged; Biopsy; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Female; Fibrinolyti | 1998 |
Ticlopidine-induced cholestatic hepatitis: report of three cases and review of the literature.
Topics: Aged; Aged, 80 and over; Cerebrovascular Disorders; Chemical and Drug Induced Liver Injury; Cholesta | 1998 |
[Cholestatic hepatitis as a rare side effect of therapy with ticlopidine].
Topics: Aged; Atrial Fibrillation; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Cholestasis; Chro | 2000 |
72 other studies available for ticlopidine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Reduced multidrug resistance-associated protein 2 in ticlopidine-induced cholestatic liver injury.
Topics: Aged, 80 and over; Biomarkers; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Humans; | 2020 |
HLA-A*33:03-Restricted Activation of Ticlopidine-Specific T-Cells from Human Donors.
Topics: CD8-Positive T-Lymphocytes; Cell Proliferation; Chemical and Drug Induced Liver Injury; Genotype; HL | 2018 |
Inhibition of cytochrome P450s enhances (+)-usnic acid cytotoxicity in primary cultured rat hepatocytes.
Topics: Animals; Benzoflavones; Benzofurans; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytoch | 2014 |
Gastrointestinal adverse events after dual antiplatelet therapy: clopidogrel is safer than ticagrelor, but prasugrel data are lacking or inconclusive.
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Chemical and Drug Induced Liver Injury; Clinical Trials | 2013 |
Simultaneous intrahepatic and subgaleal hemorrhage in antiphospholipid syndrome following anticoagulation therapy.
Topics: Adolescent; Anticoagulants; Antiphospholipid Syndrome; Chemical and Drug Induced Liver Injury; Clopi | 2013 |
An idiosyncratic reaction to clopidogrel.
Topics: Aged; Chemical and Drug Induced Liver Injury; Clopidogrel; Female; Humans; Platelet Aggregation Inhi | 2015 |
The mechanism and risk factors of clopidogrel-induced liver injury.
Topics: Animals; Chemical and Drug Induced Liver Injury; Clopidogrel; Cytochrome P-450 CYP2B6; Cytochrome P- | 2016 |
Inhibition of PAR-4 and P2Y12 receptor-mediated platelet activation produces distinct hepatic pathologies in experimental xenobiotic-induced cholestatic liver disease.
Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Cholestasis; Clopidogrel; | 2016 |
Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study.
Topics: Alleles; Antidepressive Agents; Antifungal Agents; Chemical and Drug Induced Liver Injury; Chromosom | 2017 |
[Cholestatic hepatitis as a ticlopidine-induced complication of treatment - a case report].
Topics: Aged; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Female; Humans; Hypertensio | 2008 |
An unusual case of recurrent fever, jaundice and right upper quadrant pain.
Topics: Abdominal Pain; Aged; Chemical and Drug Induced Liver Injury; Clopidogrel; Fever; Humans; Jaundice; | 2009 |
Fatal liver injury associated with clopidogrel.
Topics: Chemical and Drug Induced Liver Injury; Clopidogrel; Fatal Outcome; Humans; Liver Function Tests; Ma | 2010 |
Clopidogrel treatment in a patient with ticlopidine-induced hepatitis following percutaneous coronary stenting.
Topics: Aged, 80 and over; Angioplasty, Balloon, Coronary; Chemical and Drug Induced Liver Injury; Clopidogr | 2010 |
Enhanced susceptibility of HLA-mediated ticlopidine-induced idiosyncratic hepatotoxicity by CYP2B6 polymorphism in Japanese.
Topics: Aryl Hydrocarbon Hydroxylases; Biotransformation; Case-Control Studies; Chemical and Drug Induced Li | 2010 |
Ticlopidine-induced hepatotoxicity in a GSH-depleted rat model.
Topics: Animals; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dru | 2011 |
Clopidogrel, Turkey and a red herring?
Topics: Chemical and Drug Induced Liver Injury; Clopidogrel; Diagnosis, Differential; Hepatitis E; Humans; M | 2011 |
Dual antiplatelet agent-induced spontaneous liver hematoma.
Topics: Aged; Aspirin; Chemical and Drug Induced Liver Injury; Clopidogrel; Coronary Artery Disease; Drug Th | 2012 |
Ticlopidine, a cholestatic liver injury-inducible drug, causes dysfunction of bile formation via diminished biliary secretion of phospholipids: involvement of biliary-excreted glutathione-conjugated ticlopidine metabolites.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Bile; Bil | 2013 |
A new Poisson and Bayesian-based method to assign risk and causality in patients with suspected hepatic adverse drug reactions: a report of two new cases of ticlopidine-induced hepatotoxicity.
Topics: Adult; Aged; Bayes Theorem; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Female | 2002 |
[Clopidogrel-induced hepatotoxicity].
Topics: Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Clopidogrel; Female; Humans; Liver | 2003 |
Ticlopidine-induced cholestatic hepatitis.
Topics: Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Cholestasis; Humans; Male; Platelet | 2003 |
[Ticlopidine-induced acute cholestatic hepatitis. A case report].
Topics: Acute Disease; Aged; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Humans; Male | 2004 |
Hepatotoxicity induced by clopidogrel.
Topics: Chemical and Drug Induced Liver Injury; Clopidogrel; Humans; Male; Middle Aged; Platelet Aggregation | 2004 |
Clopidogrel-induced hepatotoxicity after percutaneous coronary stenting.
Topics: Aged; Chemical and Drug Induced Liver Injury; Clopidogrel; Combined Modality Therapy; Coronary Disea | 2005 |
Clopidogrel-induced hepatotoxicity and fever.
Topics: Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Chemical and Drug Induced L | 2006 |
Ticlopidine-induced hepatotoxicity is associated with specific human leukocyte antigen genomic subtypes in Japanese patients: a preliminary case-control study.
Topics: Biotransformation; Case-Control Studies; Chemical and Drug Induced Liver Injury; Cholestasis, Intrah | 2008 |
Incidence of side-effects of ticlopidine after sirolimus-eluting stent implantation.
Topics: Aged; Blood Vessel Prosthesis Implantation; Chemical and Drug Induced Liver Injury; Coronary Thrombo | 2007 |
[Hepatic toxicity and clopidogrel-induced systemic inflammatory response syndrome].
Topics: Chemical and Drug Induced Liver Injury; Clopidogrel; Humans; Male; Middle Aged; Platelet Aggregation | 2007 |
Severe ticlopidine-induced cholestatic syndrome.
Topics: Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Humans; Kidney Failure, Chronic; | 2007 |
[A case of ticlopidine induced acute cholestatic hepatitis and pure red cell aplasia].
Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Humans; Liver Function T | 2008 |
[Cholestatic hepatitis. Presumptive role of ticlopidine].
Topics: Aged; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Humans; Thiophenes; Ticlopidine | 1983 |
[Ticlopidine-induced cholestatic hepatitis].
Topics: Aged; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Humans; Thrombophlebitis; Ticlopi | 1995 |
Ticlopidine-induced prolonged cholestasis.
Topics: Aged; Chemical and Drug Induced Liver Injury; Cholestasis; Cholestyramine Resin; Female; Humans; Tic | 1995 |
Ticlopidine-induced granulomatous hepatitis.
Topics: Aged; Chemical and Drug Induced Liver Injury; Granuloma; Humans; Male; Ticlopidine | 1995 |
Probable ticlopidine-induced cholestatic hepatitis.
Topics: Aged; Chemical and Drug Induced Liver Injury; Cholestasis; Humans; Male; Ticlopidine | 1995 |
[Cholestatic jaundice due to ticlopidine: a new case].
Topics: Chemical and Drug Induced Liver Injury; Cholestasis; Coronary Disease; Diagnosis, Differential; Huma | 1994 |
[Ticlopidine-induced cholestatic hepatitis. A case report].
Topics: Aged; Chemical and Drug Induced Liver Injury; Cholestasis; Fibrinolytic Agents; Humans; Male; Ticlop | 1995 |
[Cholestatic hepatitis and anemia induced by ticlopidine].
Topics: Acute Disease; Aged; Anemia; Cerebrovascular Disorders; Chemical and Drug Induced Liver Injury; Chol | 1996 |
[Cholestatic hepatitis associated with ticlopidine].
Topics: Aged; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Humans; Middle Aged; Platelet Agg | 1997 |
Thrombocytopenia and hepatitis complicating ticlopidine therapy.
Topics: Aged; Chemical and Drug Induced Liver Injury; Humans; Male; Platelet Aggregation Inhibitors; Thrombo | 1997 |
[Toxic hepatitis by ticlopidine. Three new cases].
Topics: Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Female; Fibrinolytic Agents; Humans | 1997 |
[Cholestatic hepatitis due to ticlopidine: a report of a new case].
Topics: Chemical and Drug Induced Liver Injury; Cholestasis; Humans; Male; Middle Aged; Platelet Aggregation | 1997 |
[Ticlopidine-induced acute cholestatic hepatitis].
Topics: Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Biopsy; Cerebell | 1998 |
[Post-infantile giant cell hepatitis. Clinical and histological response to immunosuppressive therapy].
Topics: Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Fibrinolytic Agents; Glucocorticoids; H | 1998 |
Early ticlopidine-induced hepatic dysfunction, dermatitis and irreversible aplastic anemia after coronary artery stenting.
Topics: Aged; Anemia, Aplastic; Angioplasty, Balloon, Coronary; Chemical and Drug Induced Liver Injury; Drug | 1998 |
Aspirin and heparin prevent hepatic blood stasis and thrombosis induced by the toxic glycoprotein Bolesatine in mice.
Topics: Agglutination; Animals; Aspirin; Blood Platelets; Chemical and Drug Induced Liver Injury; Dose-Respo | 1998 |
Liver injury with the use of ticlopidine.
Topics: Chemical and Drug Induced Liver Injury; Humans; Liver Function Tests; Male; Middle Aged; Platelet Ag | 1998 |
[A new drug responsible for microvesicular steatosis: ticlopidine].
Topics: Aged; Aged, 80 and over; Biopsy; Chemical and Drug Induced Liver Injury; Fatty Liver; Female; Humans | 1999 |
[Ticlopidine and hepatic adverse reactions. Data from the Spanish drug surveillance system].
Topics: Aged; Aged, 80 and over; Cerebrovascular Disorders; Chemical and Drug Induced Liver Injury; Female; | 1999 |
[Cholestatic hepatitis from ticlopidine].
Topics: Aged; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Fibrinolytic Agents; Humans; Ticl | 1999 |
Delayed-onset ticlopidine-induced cholestatic jaundice.
Topics: Aged; Chemical and Drug Induced Liver Injury; Cholestasis; Humans; Liver Function Tests; Male; Plate | 1999 |
Successful use of clopidogrel for cerebrovascular accident in a patient with suspected ticlopidine-induced hepatotoxicity.
Topics: Aged; Cerebrovascular Disorders; Chemical and Drug Induced Liver Injury; Clopidogrel; Female; Humans | 1999 |
[Ticlopidine-induced cholestasis].
Topics: Aged; Aged, 80 and over; Angina Pectoris; Aspirin; Chemical and Drug Induced Liver Injury; Cholestas | 1999 |
Ticlopidine-induced severe cholestatic hepatitis.
Topics: Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Humans; Platel | 2000 |
Ticlopidine-induced cholestatic hepatitis with anti-nuclear antibody in serum.
Topics: Antibodies, Antinuclear; Chemical and Drug Induced Liver Injury; Cholestasis; Humans; Liver; Male; M | 2000 |
[Cholestatic hepatitis by ticlopidin].
Topics: Chemical and Drug Induced Liver Injury; Cholestasis; Humans; Male; Middle Aged; Platelet Aggregation | 2001 |
Ticlopidine-induced hepatitis.
Topics: Aged; Alanine Transaminase; Alkaline Phosphatase; Chemical and Drug Induced Liver Injury; Humans; Ma | 2001 |
Clopidogrel-induced mixed hepatocellular and cholestatic liver injury.
Topics: Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Hepatocytes; H | 2000 |
[Early hepatopathy induced by ticlopidine].
Topics: Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Humans; Male; Platelet Aggregation | 2001 |
[Ticlopidine, cholestasis and hepatic nodules].
Topics: Chemical and Drug Induced Liver Injury; Cholestasis; Humans; Male; Middle Aged; Ticlopidine | 2001 |
[Late-appearing cholestatic icterus after a month of treatment with ticlopidine].
Topics: Aged; Angioplasty, Balloon, Coronary; Chemical and Drug Induced Liver Injury; Coronary Stenosis; Hum | 2001 |
[Ticlopidine-induced hepatitis. Report of a new case].
Topics: Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Platelet Aggregation Inhibitors; Ticlo | 2002 |
[Clopidogrel probably induced hepatic toxicity].
Topics: Aged; Chemical and Drug Induced Liver Injury; Clopidogrel; Humans; Male; Platelet Aggregation Inhibi | 2002 |
Ticlopidine-associated cholestatic hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Cholestasis; Diagnosis, Differential; Humans; Male; Middle A | 2002 |