ticagrelor and Cheyne-Stokes-Respiration

Topics: Aged; Cheyne-Stokes Respiration; Clopidogrel; Dyspnea; Humans; Male; Myocardial Infarction; Polysomnography; Ticagrelor

Topics: Cheyne-Stokes Respiration; Coronary Artery Disease; Humans; Platelet Aggregation Inhibitors; Polysomnography; Purinergic P2Y Receptor Antagonists; Sleep Apnea, Central; Ticagrelor

Dyspnea and bradyarrhythmias are frequent adverse effects (AEs) of ticagrelor. AEs commonly occur within the first week of therapy, are dose related and usually mild, but sometimes they may cause drug discontinuation. Currently, the exact mechanisms of ticagrelor-related AEs have not been definitively explained. In addition to the prevalent theory of adenosine overload, other reasonable mechanism like a direct central stimulation hypothesis was suggested. We present a case of incessant Cheyne-Stokes respiration associated with heart rate instability in patient with congestive heart failure and non-ST-segment elevation myocardial infarction, supporting the use of aminophylline as a potential reversal agent of ticagrelor-related AEs.

Topics: Adenosine; Aged; Aminophylline; Arrhythmias, Cardiac; Cardiotonic Agents; Cheyne-Stokes Respiration; Humans; Infusions, Intravenous; Male; Phosphodiesterase Inhibitors; Purinergic P2Y Receptor Antagonists; Ticagrelor

Topics: Adenosine; Cheyne-Stokes Respiration; Dyspnea; Humans; Hypercapnia; Myocardial Infarction; Purinergic P2Y Receptor Antagonists; Respiratory Function Tests; Ticagrelor