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tibolone and Age-Related Osteoporosis

tibolone has been researched along with Age-Related Osteoporosis in 29 studies

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19904 (13.79)18.7374
1990's4 (13.79)18.2507
2000's17 (58.62)29.6817
2010's2 (6.90)24.3611
2020's2 (6.90)2.80

Authors

AuthorsStudies
Fait, T1
Elgebaly, Z; Elliott, J; Naik-Panvelkar, P; Norman, S; Pollack, A; Seibel, MJ; Thistlethwaite, J; Weston, C1
Barik, A; Byram, PK; Chakravorty, N; Ray, SK; Sinha, R1
Beckmann, MW; Bundred, NJ; Foidart, JM; Galta, RE; Kenemans, P; Kubista, E; Lieshout, EV; Mol-Arts, M; Planellas, J; Schoultz, Bv; Sismondi, P; Vassilopoulou-Sellin, R; Yip, CH1
Biskobing, DM; Downs, R; Novy, AM1
Krieg, MA; Lamy, O1
Ederveen, AG; Kloosterboer, HJ3
Bilezikian, JP; Rubin, MR1
Lakatos, P1
Bots, ML; Evans, GW; Grobbee, DE; Helmond, FA; McBride, KH; Meijer, R; Paskett, ED; Riley, W1
Jin, Y; Kloosterboer, HJ; Oyesanmi, B; Penning, TM; Steckelbroeck, S1
Bruce, D; Fentiman, I; McWilliams, S; Reddy, M; Robinson, J; Rymer, J1
Jeong, KA; Lee, BS; Park, JH; Park, KH; Yoon, HK1
Parfitt, AM; Riggs, BL1
Bots, ML; Evans, GW; Grobbee, DE; Helmond, FA; McBride, KH; Paskett, ED; Riley, W1
Qiao, L; Tian, Y; Xu, KH1
Helmond, FA; Landgren, BM; Langer, RD; Rymer, J1
Bors, K1
Farish, E; Fletcher, CD; Hart, DM; Leggate, J; Lindsay, R1
Coope, J1
Schreiber, V; Stĕpán, JJ1
Buhur, A; Burak, F; Kucuk, S; Taskin, O; Uryan, I; Yalcinoglu, AI1
Luzuy, F; Martin-Du Pan, RC1
Ederveen, AG; Kloosterboer, HJ; Quaijtaal, JH; Spanjers, CP1
Goorissen, EM; Kicovic, PM; Tax, L1
van der Vies, J1

Reviews

9 review(s) available for tibolone and Age-Related Osteoporosis

ArticleYear
Novel therapeutic options for osteoporosis.
    Current opinion in rheumatology, 2002, Volume: 14, Issue:4

    Topics: Animals; Controlled Clinical Trials as Topic; Diphosphonates; Disease Models, Animal; Evidence-Based Medicine; Fractures, Spontaneous; Glycoproteins; Humans; Ibandronic Acid; Imidazoles; Norpregnenes; Osteoporosis; Osteoprotegerin; Piperidines; Receptors, Cytoplasmic and Nuclear; Receptors, Tumor Necrosis Factor; Selective Estrogen Receptor Modulators; Thiophenes; Zoledronic Acid

2002
[Hormone replacement therapy and its derivatives in the prevention and treatment of osteoporosis].
    Revue medicale de la Suisse romande, 2002, Volume: 122, Issue:8

    Topics: Aged; Bone Density; Bone Resorption; Dose-Response Relationship, Drug; Estrogen Receptor Modulators; Female; Fractures, Bone; Hormone Replacement Therapy; Humans; Middle Aged; Norpregnenes; Osteoporosis; Randomized Controlled Trials as Topic

2002
Pros and cons of existing treatment modalities in osteoporosis: a comparison between tibolone, SERMs and estrogen (+/-progestogen) treatments.
    The Journal of steroid biochemistry and molecular biology, 2002, Volume: 83, Issue:1-5

    Topics: Bone and Bones; Endometrium; Estrogen Receptor Modulators; Estrogens; Female; Humans; Models, Chemical; Norpregnenes; Osteoporosis; Postmenopause; Progestins; Receptors, Estrogen; Selective Estrogen Receptor Modulators

2002
New anabolic therapies in osteoporosis.
    Endocrinology and metabolism clinics of North America, 2003, Volume: 32, Issue:1

    Topics: Aged; Bone and Bones; Bone Density; Female; Fluorides; Growth Hormone; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin-Like Growth Factor I; Male; Middle Aged; Norpregnenes; Osteoporosis; Osteoporosis, Postmenopausal; Parathyroid Hormone; Strontium

2003
[Treatment of osteoporosis].
    Orvosi hetilap, 2003, Aug-03, Volume: 144, Issue:31

    Topics: Bone Density; Calcitonin; Calcium Compounds; Diphosphonates; Estrogen Replacement Therapy; Female; Humans; Male; Norpregnenes; Osteoporosis; Osteoporosis, Postmenopausal; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Vitamin D

2003
Osteoporosis in Korea.
    Clinical calcium, 2004, Volume: 14, Issue:9

    Topics: Absorptiometry, Photon; Biomarkers; Calcitonin; Calcitriol; Calcium, Dietary; Diagnostic Imaging; Diphosphonates; Estrogen Replacement Therapy; Exercise; Female; Hip Fractures; Humans; Korea; Male; Norpregnenes; Osteoporosis; Prevalence; Selective Estrogen Receptor Modulators; Smoking Cessation

2004
Drugs used to treat osteoporosis: the critical need for a uniform nomenclature based on their action on bone remodeling.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2005, Volume: 20, Issue:2

    Topics: Adult; Age Factors; Aged; Aging; Anabolic Agents; Bone and Bones; Bone Density; Bone Development; Bone Remodeling; Bone Resorption; Female; Humans; Middle Aged; Models, Biological; Norpregnenes; Organometallic Compounds; Osteoblasts; Osteoporosis; Osteoporosis, Postmenopausal; Teriparatide; Terminology as Topic; Testosterone; Thiophenes; Time Factors

2005
[Up-to-date treatments for osteoporosis].
    Orvosi hetilap, 2006, Feb-19, Volume: 147, Issue:7

    Topics: Bone Density; Bone Density Conservation Agents; Bone Regeneration; Calcitonin; Calcium Compounds; Diphosphonates; Drugs, Investigational; Estrogen Replacement Therapy; Fluorides; Fractures, Bone; Humans; Norpregnenes; Organometallic Compounds; Osteoporosis; Osteoporosis, Postmenopausal; Selective Estrogen Receptor Modulators; Teriparatide; Testosterone; Thiophenes; Vitamin D

2006
[What's new in hormone replacement therapy for postmenopausal women? I. Advantages of hormone replacement therapy (HRT)].
    Revue medicale de la Suisse romande, 2000, Volume: 120, Issue:6

    Topics: Aged; Alzheimer Disease; Cardiovascular Diseases; Cholesterol, HDL; Depression; Dyspareunia; Estrogen Replacement Therapy; Female; Humans; Male; Megestrol; Middle Aged; Norpregnenes; Osteoporosis; Postmenopause; Progesterone Congeners

2000

Trials

6 trial(s) available for tibolone and Age-Related Osteoporosis

ArticleYear
Tibolone increases bone mineral density but also relapse in breast cancer survivors: LIBERATE trial bone substudy.
    Breast cancer research : BCR, 2012, Jan-17, Volume: 14, Issue:1

    Topics: Adult; Aged; Analysis of Variance; Body Mass Index; Bone Density; Bone Density Conservation Agents; Breast Neoplasms; Double-Blind Method; Estrogen Replacement Therapy; Female; Humans; Middle Aged; Neoplasm Recurrence, Local; Norpregnenes; Osteoporosis; Selective Estrogen Receptor Modulators; Survivors

2012
The Osteoporosis Prevention and Arterial effects of tiboLone (OPAL) study: design and baseline characteristics.
    Controlled clinical trials, 2003, Volume: 24, Issue:6

    Topics: Aged; Bone Density; Carotid Arteries; Disease Progression; Double-Blind Method; Estrogens, Conjugated (USP); Female; Humans; Middle Aged; Norpregnenes; Osteoporosis; Postmenopause; Random Allocation; Randomized Controlled Trials as Topic; Surveys and Questionnaires; Ultrasonography

2003
The effect of tibolone and continuous combined conjugated equine oestrogens plus medroxyprogesterone acetate on progression of carotid intima-media thickness: the Osteoporosis Prevention and Arterial effects of tiboLone (OPAL) study.
    European heart journal, 2006, Volume: 27, Issue:6

    Topics: Aged; Atherosclerosis; Double-Blind Method; Estrogen Receptor Modulators; Estrogens, Conjugated (USP); Female; Humans; Medroxyprogesterone Acetate; Middle Aged; Norpregnenes; Osteoporosis; Treatment Outcome; Tunica Intima; Tunica Media

2006
Effects of tibolone and continuous combined conjugated equine estrogen/medroxyprogesterone acetate on the endometrium and vaginal bleeding: results of the OPAL study.
    American journal of obstetrics and gynecology, 2006, Volume: 195, Issue:5

    Topics: Aged; Biopsy; Contraceptive Agents, Female; Double-Blind Method; Drug Combinations; Drug-Related Side Effects and Adverse Reactions; Endometrium; Estrogen Receptor Modulators; Estrogens, Conjugated (USP); Female; Humans; Medroxyprogesterone Acetate; Middle Aged; Norpregnenes; Osteoporosis; Ultrasonography; Uterine Hemorrhage

2006
Effectiveness of tibolone on hypoestrogenic symptoms induced by goserelin treatment in patients with endometriosis.
    Fertility and sterility, 1997, Volume: 67, Issue:1

    Topics: Adult; Anabolic Agents; Double-Blind Method; Endometriosis; Estradiol; Female; Follicle Stimulating Hormone; Goserelin; Humans; Norpregnenes; Osteoporosis; Prospective Studies

1997
Clinical profile of Org OD 14.
    Maturitas, 1987, Volume: Suppl 1

    Topics: Carbohydrate Metabolism; Climacteric; Clinical Trials as Topic; Endometrium; Female; Hemostasis; Hormones; Humans; Kinetics; Lipid Metabolism; Norpregnenes; Osteoporosis; Receptors, Steroid

1987

Other Studies

14 other study(ies) available for tibolone and Age-Related Osteoporosis

ArticleYear
Tibolon - the only one member of STEARs group.
    Casopis lekaru ceskych, 2019,Summer, Volume: 158, Issue:3-4

    Topics: Breast Neoplasms; Climate; Estrogen Receptor Modulators; Estrogens; Female; Humans; Menopause; Norpregnenes; Osteoporosis; Progestins

2019
Osteoporosis management in Australian general practice: an analysis of current osteoporosis treatment patterns and gaps in practice.
    BMC family practice, 2020, 02-12, Volume: 21, Issue:1

    Topics: Aged; Aged, 80 and over; Attitude of Health Personnel; Australia; Bone Density Conservation Agents; Denosumab; Deprescriptions; Diphosphonates; Drug Substitution; Female; General Practice; General Practitioners; Humans; Longitudinal Studies; Male; Middle Aged; Norpregnenes; Osteoporosis; Osteoporotic Fractures; Practice Patterns, Physicians'; Raloxifene Hydrochloride; Retrospective Studies; Teriparatide; Thiophenes

2020
Extensive early mineralization of pre-osteoblasts, inhibition of osteoclastogenesis and faster peri-implant bone healing in osteoporotic rat model: principle effectiveness of bone-specific delivery of Tibolone as evaluated in vitro and in vivo.
    Biomedical materials (Bristol, England), 2020, 11-21, Volume: 15, Issue:6

    Topics: Alkaline Phosphatase; Animals; Bone and Bones; Bone Regeneration; Bone Resorption; Cell Line, Tumor; Cell Survival; Curcumin; Drug Delivery Systems; Female; Humans; In Vitro Techniques; Metals; Mice; Norpregnenes; Osteoblasts; Osteogenesis; Osteoporosis; Ovariectomy; Prostheses and Implants; Rats; Rats, Wistar; RAW 264.7 Cells; Surface Properties; Titanium

2020
Tibolone is metabolized by the 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four human isozymes of the aldo-keto reductase 1C subfamily: inversion of stereospecificity with a delta5(10)-3-ketosteroid.
    Molecular pharmacology, 2004, Volume: 66, Issue:6

    Topics: 20-Hydroxysteroid Dehydrogenases; Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Estrogen Receptor Modulators; Humans; Isoenzymes; Ketosteroids; Kinetics; Norpregnenes; Osteoporosis; Recombinant Proteins; Substrate Specificity

2004
Long-term effects of tibolone on mammographic density.
    Fertility and sterility, 2004, Volume: 82, Issue:5

    Topics: Administration, Oral; Breast; Case-Control Studies; Estrogen Replacement Therapy; Female; Humans; Longitudinal Studies; Mammography; Middle Aged; Norpregnenes; Osteoporosis; Pilot Projects; Single-Blind Method

2004
[Comparative study of effects of hormonal therapies on the healing of fracture in ovariectomized rats and Rats' endometria].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2006, Volume: 37, Issue:3

    Topics: Animals; Endometrium; Estradiol; Estrogen Receptor Modulators; Estrogens; Estrogens, Conjugated (USP); Female; Femoral Fractures; Fracture Healing; Norpregnenes; Osteoporosis; Random Allocation; Rats; Rats, Sprague-Dawley

2006
Org OD 14: long-term effects on serum lipoproteins.
    Maturitas, 1984, Volume: 6, Issue:3

    Topics: Cholesterol; Female; Humans; Lipoproteins; Menopause; Middle Aged; Norpregnenes; Osteoporosis; Time Factors; Triglycerides

1984
Trial of synthetic steroid for preventing postmenopausal osteoporosis.
    British medical journal, 1980, Aug-09, Volume: 281, Issue:6237

    Topics: Anabolic Agents; Body Weight; Female; Humans; Menopause; Norpregnenes; Osteoporosis

1980
Anabolic effects of progestogens in bone remodelling.
    Sbornik lekarsky, 1995, Volume: 96, Issue:4

    Topics: Alkaline Phosphatase; Bone and Bones; Bone Density; Bone Remodeling; Estradiol; Female; Follow-Up Studies; Humans; Hydroxyproline; Norethindrone; Norpregnenes; Osteoporosis; Ovariectomy; Progestins; Prospective Studies

1995
Tibolone. KB 889, ORG OD 14, ORG OD14, Livial, Livifem, Boltin.
    Drugs in R&D, 1999, Volume: 1, Issue:3

    Topics: Anabolic Agents; Drug Interactions; Drugs, Investigational; Female; Hormone Replacement Therapy; Hormones; Humans; Norpregnenes; Osteoporosis

1999
Tibolone, a steroid with a tissue-specific hormonal profile, completely prevents ovariectomy-induced bone loss in sexually mature rats.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1999, Volume: 14, Issue:11

    Topics: Anabolic Agents; Animals; Body Weight; Bone Density; Estrogens; Female; Humans; Norpregnenes; Osteoporosis; Ovariectomy; Rats; Rats, Wistar; Sexual Maturation

1999
Tibolone exerts its protective effect on trabecular bone loss through the estrogen receptor.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2001, Volume: 16, Issue:9

    Topics: Amino Acids; Anabolic Agents; Androgen Antagonists; Animals; Biomarkers; Bone and Bones; Bone Density; Creatinine; Estrogen Receptor Modulators; Female; Norpregnenes; Osteocalcin; Osteoporosis; Ovariectomy; Progestins; Rats; Rats, Wistar; Receptors, Estrogen

2001
Effect of 16 months of treatment with tibolone on bone mass, turnover, and biomechanical quality in mature ovariectomized rats.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2001, Volume: 16, Issue:9

    Topics: Alkaline Phosphatase; Amino Acids; Anabolic Agents; Animals; Biomarkers; Bone Density; Creatinine; Disease Models, Animal; Female; Femur; Liver; Norpregnenes; Osteocalcin; Osteoporosis; Ovariectomy; Rats; Rats, Wistar; Tibia; Time Factors

2001
Pharmacological studies with (7 alpha,17 alpha)-17-hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one (Org OD 14).
    Maturitas, 1987, Volume: Suppl 1

    Topics: Androgens; Animals; Estrogens; Female; Genitalia, Male; Male; Norpregnenes; Organ Size; Osteoporosis; Ovulation; Progestins; Rabbits; Rats; Sexual Behavior, Animal; Uterus; Vagina

1987