tiazofurin and Neoplasm-Metastasis

Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Clinical Trials as Topic; Drug Evaluation; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Ribavirin; Ribonucleosides

The authors studied the metastasis-inhibiting effect of various dosages of tiazofurin in mice inoculated with a low (LLT) and a highly (LLT-HH) metastatic variant of the Lewis lung carcinoma. The tumor cells were inoculated intravenously (lung colony assay), intramuscularly (muscle-lung metastasis model), and intrasplenically (spleen-liver metastasis model), respectively. In the lung colony assay the tiazofurin proved to be curative. In the muscle-lung and the spleen-liver model the tiazofurin treatment, started after the removal of the parent tumor, drastically decreased the number of metastases in both model systems and brought about a significant prolongation of the survival time in the spleen-liver model. Authors suggest that tiazofurin as one of the most promising candidates for metastasis prevention and inhibition in human beings, too.

Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Lung Neoplasms; Mice; Models, Biological; Neoplasm Metastasis; Ribavirin; Ribonucleosides; Tumor Cells, Cultured

Topics: Animals; Antineoplastic Agents; Carcinoma, Bronchogenic; Lung Neoplasms; Mice; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Ribavirin; Ribonucleosides