tiaprofenic acid has been researched along with Rheumatoid Arthritis in 30 studies
tiaprofenic acid: RN given refers to parent cpd; structure
tiaprofenic acid : An aromatic ketone that is thiophene substituted at C-2 by benzoyl and at C-4 by a 1-carboxyethyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A double blind, randomized, parallel group clinical therapeutic trial, comparing a sustained release formulation with a standard preparation of tiaprofenic acid (Surgam), was performed in 119 patients with rheumatoid arthritis." | 9.07 | Clinical evaluation of a sustained release compared to a standard formulation of tiaprofenic acid (Surgam) in rheumatoid arthritis: a Canadian multicenter study. ( Buchanan, WW; Elie, R; Gerecz-Simon, E; Kean, WF; St-Jean, J, 1991) |
| " We have investigated patients suffering from rheumatoid arthritis to determine how synovial fluid levels of PGE2 are affected by tiaprofenic acid or indomethacin medication." | 9.06 | Reduction of prostaglandin E2 concentrations in synovial fluid of patients suffering from rheumatoid arthritis following tiaprofenic acid or indomethacin treatment. ( Daymond, TJ; Rowell, FJ, 1988) |
| "In a randomized double-blind, multicentre crossover study, the short-term efficacy and tolerance of tiaprofenic acid (TA) conventional tablet 300 mg twice daily was compared with a sustained release preparation of tiaprofenic acid 600 mg once daily and with a placebo in 146 patients with rheumatoid arthritis." | 9.06 | A comparison of a sustained release preparation of tiaprofenic acid with the conventional tablet formulation and a placebo in rheumatoid arthritis. ( Essigman, W; Lambert, J; Sheldon, P; Sweetman, BJ; Wojtulewski, J, 1987) |
| "Two multi-centre studies were carried out in general practice comparing tiaprofenic acid ('Surgam') with five other non-steroidal anti-inflammatory agents (ibuprofen, indomethacin, naproxen, piroxicam and benoxaprofen), one in rheumatoid arthritis and one in osteoarthritis." | 9.05 | A multi-centre study of tiaprofenic acid ('Surgam') and five comparative drugs in rheumatoid arthritis and osteoarthritis in general practice. ( Clarke, TK; Mungavin, JM, 1983) |
| "Two multi-centre, placebo-controlled, crossover trials of tiaprofenic acid were conducted to an identical design: one in 80 patients suffering from rheumatoid arthritis, the other in 60 patients suffering from osteoarthritis." | 9.05 | Short-term efficacy and tolerance of tiaprofenic acid ('Surgam') in rheumatoid arthritis and osteoarthritis: multi-centre, placebo-controlled trials. ( Daymond, TJ; Essigman, WK; Huskisson, EC; Thompson, M; Wojtulewski, JA, 1982) |
| "A multicentre double-blind crossover study of tiaprofenic acid 600 mg daily against indomethacin 75 mg daily was carried out in 68 patients with rheumatoid arthritis to compare short-term efficacy and tolerance." | 9.05 | A controlled trial of tiaprofenic acid against indomethacin in patients with rheumatoid arthritis. ( Daymond, TJ; Nichol, FE; Pandit, NA; Sheldon, P; Swannell, AJ, 1985) |
| "Tiaprofenic acid, 200 mg three times a day, was compared with ibuprofen, 400 mg three times a day, in 41 patients suffering from rheumatoid arthritis and already receiving nonsteroidal anti-inflammatory drugs in a double-blind controlled study." | 9.04 | A controlled trial of tiaprofenic acid versus ibuprofen in rheumatoid arthritis. ( Akbar, FA; Chestney, V; Daymond, TJ; Thompson, M, 1979) |
| "Tiaprofenic acid is a new non-steroidal anti-inflammatory agent advocated for use in rheumatoid arthritis, osteoarthritis, musculoskeletal disorders, soft-tissue injuries and inflammatory conditions and acute pain of varying origin." | 8.77 | Tiaprofenic acid. A review of its pharmacological properties and therapeutic efficacy in rheumatic diseases and pain states. ( Brogden, RN; Sorkin, EM, 1985) |
| "In a multicentre trial, tiaprofenic acid was administered in a dosage of 600 mg/day for 12 months to 109 patients with rheumatoid arthritis." | 7.67 | Efficacy and tolerance of tiaprofenic acid during long term administration to rheumatoid arthritis patients. ( Harada, S; Konishi, Y; Nagaya, T; Niwa, S, 1988) |
| "Tiaprofenic acid is a new non-steroidal anti-inflammatory agent." | 6.65 | Tiaprofenic acid in the treatment of rheumatoid arthritis. ( Camp, AV, 1981) |
| "Treatment with tiaprofenic acid appreciably reduced the level of plasminogen activators in the medium of 3T3-Balb mouse fibroblasts, as revealed by both a fibrin plate assay and amidolytic determination with chromogenic substrates." | 5.27 | Plasminogen activators and tiaprofenic acid in inflammation. A preliminary study. ( Caldini, R; Del Rosso, M; Fibbi, G; Magnelli, L; Pucci, M; Serni, U, 1988) |
| "Tiaprofenic acid is a potent non-steroidal anti-inflammatory drug which, in conventional tablet form, has been shown to be rapidly absorbed and eliminated from the plasma, while synovial fluid concentrations remain constant for at least 8 hours." | 5.27 | Synovial fluid and plasma kinetics of repeat dose sustained action tiaprofenic acid in patients with rheumatoid arthritis. ( Nichol, FE; Rose, CM; Samanta, A, 1988) |
| "A double blind, randomized, parallel group clinical therapeutic trial, comparing a sustained release formulation with a standard preparation of tiaprofenic acid (Surgam), was performed in 119 patients with rheumatoid arthritis." | 5.07 | Clinical evaluation of a sustained release compared to a standard formulation of tiaprofenic acid (Surgam) in rheumatoid arthritis: a Canadian multicenter study. ( Buchanan, WW; Elie, R; Gerecz-Simon, E; Kean, WF; St-Jean, J, 1991) |
| " We have investigated patients suffering from rheumatoid arthritis to determine how synovial fluid levels of PGE2 are affected by tiaprofenic acid or indomethacin medication." | 5.06 | Reduction of prostaglandin E2 concentrations in synovial fluid of patients suffering from rheumatoid arthritis following tiaprofenic acid or indomethacin treatment. ( Daymond, TJ; Rowell, FJ, 1988) |
| "The results of a double blind crossover comparative trial of the nonsteroidal antiinflammatory drug tiaprofenic acid with placebo in the treatment of rheumatoid arthritis are reported." | 5.06 | A double blind comparison of tiaprofenic acid with placebo. ( Highton, J; Palmer, DG; Palmer, M, 1988) |
| "In a randomized double-blind, multicentre crossover study, the short-term efficacy and tolerance of tiaprofenic acid (TA) conventional tablet 300 mg twice daily was compared with a sustained release preparation of tiaprofenic acid 600 mg once daily and with a placebo in 146 patients with rheumatoid arthritis." | 5.06 | A comparison of a sustained release preparation of tiaprofenic acid with the conventional tablet formulation and a placebo in rheumatoid arthritis. ( Essigman, W; Lambert, J; Sheldon, P; Sweetman, BJ; Wojtulewski, J, 1987) |
| "Two multi-centre studies were carried out in general practice comparing tiaprofenic acid ('Surgam') with five other non-steroidal anti-inflammatory agents (ibuprofen, indomethacin, naproxen, piroxicam and benoxaprofen), one in rheumatoid arthritis and one in osteoarthritis." | 5.05 | A multi-centre study of tiaprofenic acid ('Surgam') and five comparative drugs in rheumatoid arthritis and osteoarthritis in general practice. ( Clarke, TK; Mungavin, JM, 1983) |
| "Two multi-centre, placebo-controlled, crossover trials of tiaprofenic acid were conducted to an identical design: one in 80 patients suffering from rheumatoid arthritis, the other in 60 patients suffering from osteoarthritis." | 5.05 | Short-term efficacy and tolerance of tiaprofenic acid ('Surgam') in rheumatoid arthritis and osteoarthritis: multi-centre, placebo-controlled trials. ( Daymond, TJ; Essigman, WK; Huskisson, EC; Thompson, M; Wojtulewski, JA, 1982) |
| "A multicentre double-blind crossover study of tiaprofenic acid 600 mg daily against indomethacin 75 mg daily was carried out in 68 patients with rheumatoid arthritis to compare short-term efficacy and tolerance." | 5.05 | A controlled trial of tiaprofenic acid against indomethacin in patients with rheumatoid arthritis. ( Daymond, TJ; Nichol, FE; Pandit, NA; Sheldon, P; Swannell, AJ, 1985) |
| "Tiaprofenic acid, 200 mg three times a day, was compared with ibuprofen, 400 mg three times a day, in 41 patients suffering from rheumatoid arthritis and already receiving nonsteroidal anti-inflammatory drugs in a double-blind controlled study." | 5.04 | A controlled trial of tiaprofenic acid versus ibuprofen in rheumatoid arthritis. ( Akbar, FA; Chestney, V; Daymond, TJ; Thompson, M, 1979) |
| "Tiaprofenic acid is a new non-steroidal anti-inflammatory agent advocated for use in rheumatoid arthritis, osteoarthritis, musculoskeletal disorders, soft-tissue injuries and inflammatory conditions and acute pain of varying origin." | 4.77 | Tiaprofenic acid. A review of its pharmacological properties and therapeutic efficacy in rheumatic diseases and pain states. ( Brogden, RN; Sorkin, EM, 1985) |
| "The effect of therapeutic and pharmacological concentrations of tiaprofenic acid, a non-steroidal anti-inflammatory drug (NSAID), on the synthesis of the plasminogen activators, urokinase plasminogen activator (uPA) and tissue plasminogen activator (tPA), and the plasminogen activator inhibitors 1 and 2 (PAI-1 and PAI-2), by human synovial membranes isolated from osteoarthritis (OA) and rheumatoid arthritis (RA) sufferers was evaluated." | 3.68 | Effects of tiaprofenic acid on plasminogen activators and inhibitors in human OA and RA synovium. ( Cloutier, JM; Martel-Pelletier, J; McCollum, R; Pelletier, JP, 1992) |
| "In a multicentre trial, tiaprofenic acid was administered in a dosage of 600 mg/day for 12 months to 109 patients with rheumatoid arthritis." | 3.67 | Efficacy and tolerance of tiaprofenic acid during long term administration to rheumatoid arthritis patients. ( Harada, S; Konishi, Y; Nagaya, T; Niwa, S, 1988) |
| "The efficacy of intramuscular tiaprofenic acid (TA) was investigated in 3 separate studies: a multicentre open study involving 487 patients with various rheumatic conditions: an open study of 31 patients with active osteoarthritis of the knee; and an open comparative study with ketoprofen involving 30 patients with acute gout." | 3.67 | Clinical experiences with the intramuscular injection of tiaprofenic acid in rheumatic diseases, with particular emphasis on time of onset and duration of the analgesic effect. ( Burgos-Vargas, R; Katona, G, 1988) |
| "Tiaprofenic acid is a new non-steroidal anti-inflammatory agent." | 2.65 | Tiaprofenic acid in the treatment of rheumatoid arthritis. ( Camp, AV, 1981) |
| "Oxaprozin (Wy-21743) is a novel and unique compound among NSAIDs: it bears an aliphatic propionic acid function as a side chain in contrast to the large group of acetic acids and profens." | 1.28 | The transsynovial distribution of oxaprozin. ( Kurowski, M; Thabe, H, 1989) |
| "Treatment with tiaprofenic acid appreciably reduced the level of plasminogen activators in the medium of 3T3-Balb mouse fibroblasts, as revealed by both a fibrin plate assay and amidolytic determination with chromogenic substrates." | 1.27 | Plasminogen activators and tiaprofenic acid in inflammation. A preliminary study. ( Caldini, R; Del Rosso, M; Fibbi, G; Magnelli, L; Pucci, M; Serni, U, 1988) |
| "Tiaprofenic acid is a potent non-steroidal anti-inflammatory drug which, in conventional tablet form, has been shown to be rapidly absorbed and eliminated from the plasma, while synovial fluid concentrations remain constant for at least 8 hours." | 1.27 | Synovial fluid and plasma kinetics of repeat dose sustained action tiaprofenic acid in patients with rheumatoid arthritis. ( Nichol, FE; Rose, CM; Samanta, A, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (86.67) | 18.7374 |
| 1990's | 4 (13.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jamali, F | 2 |
| Russell, AS | 2 |
| Berry, BW | 2 |
| Lehmann, C | 2 |
| Mungavin, JM | 1 |
| Clarke, TK | 1 |
| Poletto, B | 1 |
| Diffey, BL | 1 |
| Daymond, TJ | 5 |
| Fairgreaves, H | 1 |
| Thompson, M | 2 |
| Essigman, WK | 1 |
| Huskisson, EC | 1 |
| Wojtulewski, JA | 1 |
| Mathies, H | 1 |
| Wolff, E | 1 |
| Graml, W | 1 |
| Marx-Heep, I | 1 |
| Camp, AV | 1 |
| Zgradić, I | 1 |
| Popović, M | 1 |
| Lasić, G | 1 |
| Akbar, FA | 1 |
| Chestney, V | 1 |
| Pelletier, JP | 1 |
| McCollum, R | 1 |
| Cloutier, JM | 1 |
| Martel-Pelletier, J | 1 |
| Ghosh, P | 1 |
| Wells, C | 1 |
| Smith, M | 1 |
| Hutadilok, N | 1 |
| Buchanan, WW | 1 |
| Kean, WF | 1 |
| St-Jean, J | 1 |
| Gerecz-Simon, E | 1 |
| Elie, R | 1 |
| Kurowski, M | 1 |
| Thabe, H | 1 |
| Shinmei, M | 1 |
| Kikuchi, T | 1 |
| Masuda, K | 1 |
| Shimomura, Y | 1 |
| Fibbi, G | 1 |
| Serni, U | 1 |
| Pucci, M | 1 |
| Caldini, R | 1 |
| Magnelli, L | 1 |
| Del Rosso, M | 1 |
| Rowell, FJ | 1 |
| Famaey, JP | 1 |
| Palmer, M | 1 |
| Highton, J | 1 |
| Palmer, DG | 1 |
| Nagaya, T | 1 |
| Niwa, S | 1 |
| Harada, S | 1 |
| Konishi, Y | 1 |
| Nichol, FE | 2 |
| Samanta, A | 1 |
| Rose, CM | 1 |
| Katona, G | 1 |
| Burgos-Vargas, R | 1 |
| Valentini, G | 1 |
| Tirri, G | 1 |
| Longatti, S | 1 |
| Meirovich, CI | 1 |
| Montrull, HL | 1 |
| Strusberg, AM | 1 |
| Brizuela, NY | 1 |
| Essigman, W | 1 |
| Lambert, J | 1 |
| Sheldon, P | 2 |
| Sweetman, BJ | 1 |
| Wojtulewski, J | 1 |
| Sorkin, EM | 1 |
| Brogden, RN | 1 |
| Pandit, NA | 1 |
| Swannell, AJ | 1 |
| Reginster, JY | 1 |
| Gysen, P | 1 |
| Malaise, M | 1 |
| Franchimont, P | 1 |
3 reviews available for tiaprofenic acid and Rheumatoid Arthritis
| Article | Year |
|---|---|
Tiaprofenic acid.
Topics: Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cartilage, Articular | 1984 |
Symposium on therapeutic aspects of tiaprofenic acid.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Rheumatoid; Gastric Mucosa; Humans; P | 1988 |
Tiaprofenic acid. A review of its pharmacological properties and therapeutic efficacy in rheumatic diseases and pain states.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Blood Platelets; Drug Evalu | 1985 |
13 trials available for tiaprofenic acid and Rheumatoid Arthritis
| Article | Year |
|---|---|
A multi-centre study of tiaprofenic acid ('Surgam') and five comparative drugs in rheumatoid arthritis and osteoarthritis in general practice.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthriti | 1983 |
Short-term efficacy and tolerance of tiaprofenic acid ('Surgam') in rheumatoid arthritis and osteoarthritis: multi-centre, placebo-controlled trials.
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Digestive System; Drug Tolerance; Fema | 1982 |
[Prednisolone-saving effect of tiaprofenic acid. Clinical trial].
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Dose-Respons | 1982 |
Tiaprofenic acid in the treatment of rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Female; Humans; M | 1981 |
[Evaluation of the effect of therapy with Turganil in 1,240 patients].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheu | 1993 |
A controlled trial of tiaprofenic acid versus ibuprofen in rheumatoid arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind | 1979 |
Clinical evaluation of a sustained release compared to a standard formulation of tiaprofenic acid (Surgam) in rheumatoid arthritis: a Canadian multicenter study.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Delayed-Action Preparat | 1991 |
Reduction of prostaglandin E2 concentrations in synovial fluid of patients suffering from rheumatoid arthritis following tiaprofenic acid or indomethacin treatment.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Dinoprostone; Female; H | 1988 |
A double blind comparison of tiaprofenic acid with placebo.
Topics: Activities of Daily Living; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical | 1988 |
Relative efficacy and tolerance of tiaprofenic acid and ketoprofen in rheumatoid arthritis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Tolerance; Female; Human | 1988 |
[Clinical pharmacodynamics of tiaprofenic acid].
Topics: Acid Phosphatase; Adult; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Humans; L-Lactate | 1986 |
A comparison of a sustained release preparation of tiaprofenic acid with the conventional tablet formulation and a placebo in rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Dela | 1987 |
A controlled trial of tiaprofenic acid against indomethacin in patients with rheumatoid arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind | 1985 |
14 other studies available for tiaprofenic acid and Rheumatoid Arthritis
| Article | Year |
|---|---|
High-performance liquid chromatographic analysis of tiaprofenic acid and its metabolites in plasma and urine by direct injection.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Body Fluids; Chromatography, High Pr | 1984 |
Phototoxic reactions to piroxicam, naproxen and tiaprofenic acid.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Female; Humans; Male; Naproxen; Osteoarthritis; Pho | 1983 |
[Therapy of painful soft tissue rheumatic diseases].
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Hum | 1982 |
Effects of tiaprofenic acid on plasminogen activators and inhibitors in human OA and RA synovium.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Culture Techniques; Depression, Chem | 1992 |
Chondroprotection, myth or reality: an experimental approach.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cartilage, Articular; Cells | 1990 |
The transsynovial distribution of oxaprozin.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Humans; Male; M | 1989 |
Effects of interleukin-1 and anti-inflammatory drugs on the degradation of human articular cartilage.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Rheumatoid; Cartilage, Articular; Cel | 1988 |
Plasminogen activators and tiaprofenic acid in inflammation. A preliminary study.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cells, Cultured; Chromatogr | 1988 |
Symposium on therapeutic aspects of tiaprofenic acid. Proceedings of a satellite symposium, 11th EULAR Congress, Athens, Greece, 28 June to 4 July, 1987.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Humans; Propionates | 1988 |
Efficacy and tolerance of tiaprofenic acid during long term administration to rheumatoid arthritis patients.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug | 1988 |
Synovial fluid and plasma kinetics of repeat dose sustained action tiaprofenic acid in patients with rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Delayed-Action Preparations; Female; | 1988 |
Clinical experiences with the intramuscular injection of tiaprofenic acid in rheumatic diseases, with particular emphasis on time of onset and duration of the analgesic effect.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheu | 1988 |
[Changes in articular proteoglycans in treatment with tiaprofenic acid].
Topics: Arthritis, Rheumatoid; Cartilage, Articular; Humans; Joint Diseases; Propionates; Proteoglycans; Rad | 1985 |
Pharmacokinetics of tiaprofenic acid in healthy and arthritic subjects.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Creatinine; Dialysis; Female; Half-Lif | 1985 |