tiaprofenic acid has been researched along with Arthritis, Rheumatoid in 30 studies
tiaprofenic acid: RN given refers to parent cpd; structure
tiaprofenic acid : An aromatic ketone that is thiophene substituted at C-2 by benzoyl and at C-4 by a 1-carboxyethyl group.
Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A double blind, randomized, parallel group clinical therapeutic trial, comparing a sustained release formulation with a standard preparation of tiaprofenic acid (Surgam), was performed in 119 patients with rheumatoid arthritis." | 9.07 | Clinical evaluation of a sustained release compared to a standard formulation of tiaprofenic acid (Surgam) in rheumatoid arthritis: a Canadian multicenter study. ( Buchanan, WW; Elie, R; Gerecz-Simon, E; Kean, WF; St-Jean, J, 1991) |
| " We have investigated patients suffering from rheumatoid arthritis to determine how synovial fluid levels of PGE2 are affected by tiaprofenic acid or indomethacin medication." | 9.06 | Reduction of prostaglandin E2 concentrations in synovial fluid of patients suffering from rheumatoid arthritis following tiaprofenic acid or indomethacin treatment. ( Daymond, TJ; Rowell, FJ, 1988) |
| "In a randomized double-blind, multicentre crossover study, the short-term efficacy and tolerance of tiaprofenic acid (TA) conventional tablet 300 mg twice daily was compared with a sustained release preparation of tiaprofenic acid 600 mg once daily and with a placebo in 146 patients with rheumatoid arthritis." | 9.06 | A comparison of a sustained release preparation of tiaprofenic acid with the conventional tablet formulation and a placebo in rheumatoid arthritis. ( Essigman, W; Lambert, J; Sheldon, P; Sweetman, BJ; Wojtulewski, J, 1987) |
| "Two multi-centre studies were carried out in general practice comparing tiaprofenic acid ('Surgam') with five other non-steroidal anti-inflammatory agents (ibuprofen, indomethacin, naproxen, piroxicam and benoxaprofen), one in rheumatoid arthritis and one in osteoarthritis." | 9.05 | A multi-centre study of tiaprofenic acid ('Surgam') and five comparative drugs in rheumatoid arthritis and osteoarthritis in general practice. ( Clarke, TK; Mungavin, JM, 1983) |
| "Two multi-centre, placebo-controlled, crossover trials of tiaprofenic acid were conducted to an identical design: one in 80 patients suffering from rheumatoid arthritis, the other in 60 patients suffering from osteoarthritis." | 9.05 | Short-term efficacy and tolerance of tiaprofenic acid ('Surgam') in rheumatoid arthritis and osteoarthritis: multi-centre, placebo-controlled trials. ( Daymond, TJ; Essigman, WK; Huskisson, EC; Thompson, M; Wojtulewski, JA, 1982) |
| "A multicentre double-blind crossover study of tiaprofenic acid 600 mg daily against indomethacin 75 mg daily was carried out in 68 patients with rheumatoid arthritis to compare short-term efficacy and tolerance." | 9.05 | A controlled trial of tiaprofenic acid against indomethacin in patients with rheumatoid arthritis. ( Daymond, TJ; Nichol, FE; Pandit, NA; Sheldon, P; Swannell, AJ, 1985) |
| "Tiaprofenic acid, 200 mg three times a day, was compared with ibuprofen, 400 mg three times a day, in 41 patients suffering from rheumatoid arthritis and already receiving nonsteroidal anti-inflammatory drugs in a double-blind controlled study." | 9.04 | A controlled trial of tiaprofenic acid versus ibuprofen in rheumatoid arthritis. ( Akbar, FA; Chestney, V; Daymond, TJ; Thompson, M, 1979) |
| "Tiaprofenic acid is a new non-steroidal anti-inflammatory agent advocated for use in rheumatoid arthritis, osteoarthritis, musculoskeletal disorders, soft-tissue injuries and inflammatory conditions and acute pain of varying origin." | 8.77 | Tiaprofenic acid. A review of its pharmacological properties and therapeutic efficacy in rheumatic diseases and pain states. ( Brogden, RN; Sorkin, EM, 1985) |
| "In a multicentre trial, tiaprofenic acid was administered in a dosage of 600 mg/day for 12 months to 109 patients with rheumatoid arthritis." | 7.67 | Efficacy and tolerance of tiaprofenic acid during long term administration to rheumatoid arthritis patients. ( Harada, S; Konishi, Y; Nagaya, T; Niwa, S, 1988) |
| "Tiaprofenic acid is a new non-steroidal anti-inflammatory agent." | 6.65 | Tiaprofenic acid in the treatment of rheumatoid arthritis. ( Camp, AV, 1981) |
| "Treatment with tiaprofenic acid appreciably reduced the level of plasminogen activators in the medium of 3T3-Balb mouse fibroblasts, as revealed by both a fibrin plate assay and amidolytic determination with chromogenic substrates." | 5.27 | Plasminogen activators and tiaprofenic acid in inflammation. A preliminary study. ( Caldini, R; Del Rosso, M; Fibbi, G; Magnelli, L; Pucci, M; Serni, U, 1988) |
| "Tiaprofenic acid is a potent non-steroidal anti-inflammatory drug which, in conventional tablet form, has been shown to be rapidly absorbed and eliminated from the plasma, while synovial fluid concentrations remain constant for at least 8 hours." | 5.27 | Synovial fluid and plasma kinetics of repeat dose sustained action tiaprofenic acid in patients with rheumatoid arthritis. ( Nichol, FE; Rose, CM; Samanta, A, 1988) |
| "A double blind, randomized, parallel group clinical therapeutic trial, comparing a sustained release formulation with a standard preparation of tiaprofenic acid (Surgam), was performed in 119 patients with rheumatoid arthritis." | 5.07 | Clinical evaluation of a sustained release compared to a standard formulation of tiaprofenic acid (Surgam) in rheumatoid arthritis: a Canadian multicenter study. ( Buchanan, WW; Elie, R; Gerecz-Simon, E; Kean, WF; St-Jean, J, 1991) |
| " We have investigated patients suffering from rheumatoid arthritis to determine how synovial fluid levels of PGE2 are affected by tiaprofenic acid or indomethacin medication." | 5.06 | Reduction of prostaglandin E2 concentrations in synovial fluid of patients suffering from rheumatoid arthritis following tiaprofenic acid or indomethacin treatment. ( Daymond, TJ; Rowell, FJ, 1988) |
| "The results of a double blind crossover comparative trial of the nonsteroidal antiinflammatory drug tiaprofenic acid with placebo in the treatment of rheumatoid arthritis are reported." | 5.06 | A double blind comparison of tiaprofenic acid with placebo. ( Highton, J; Palmer, DG; Palmer, M, 1988) |
| "In a randomized double-blind, multicentre crossover study, the short-term efficacy and tolerance of tiaprofenic acid (TA) conventional tablet 300 mg twice daily was compared with a sustained release preparation of tiaprofenic acid 600 mg once daily and with a placebo in 146 patients with rheumatoid arthritis." | 5.06 | A comparison of a sustained release preparation of tiaprofenic acid with the conventional tablet formulation and a placebo in rheumatoid arthritis. ( Essigman, W; Lambert, J; Sheldon, P; Sweetman, BJ; Wojtulewski, J, 1987) |
| "Two multi-centre studies were carried out in general practice comparing tiaprofenic acid ('Surgam') with five other non-steroidal anti-inflammatory agents (ibuprofen, indomethacin, naproxen, piroxicam and benoxaprofen), one in rheumatoid arthritis and one in osteoarthritis." | 5.05 | A multi-centre study of tiaprofenic acid ('Surgam') and five comparative drugs in rheumatoid arthritis and osteoarthritis in general practice. ( Clarke, TK; Mungavin, JM, 1983) |
| "Two multi-centre, placebo-controlled, crossover trials of tiaprofenic acid were conducted to an identical design: one in 80 patients suffering from rheumatoid arthritis, the other in 60 patients suffering from osteoarthritis." | 5.05 | Short-term efficacy and tolerance of tiaprofenic acid ('Surgam') in rheumatoid arthritis and osteoarthritis: multi-centre, placebo-controlled trials. ( Daymond, TJ; Essigman, WK; Huskisson, EC; Thompson, M; Wojtulewski, JA, 1982) |
| "A multicentre double-blind crossover study of tiaprofenic acid 600 mg daily against indomethacin 75 mg daily was carried out in 68 patients with rheumatoid arthritis to compare short-term efficacy and tolerance." | 5.05 | A controlled trial of tiaprofenic acid against indomethacin in patients with rheumatoid arthritis. ( Daymond, TJ; Nichol, FE; Pandit, NA; Sheldon, P; Swannell, AJ, 1985) |
| "Tiaprofenic acid, 200 mg three times a day, was compared with ibuprofen, 400 mg three times a day, in 41 patients suffering from rheumatoid arthritis and already receiving nonsteroidal anti-inflammatory drugs in a double-blind controlled study." | 5.04 | A controlled trial of tiaprofenic acid versus ibuprofen in rheumatoid arthritis. ( Akbar, FA; Chestney, V; Daymond, TJ; Thompson, M, 1979) |
| "Tiaprofenic acid is a new non-steroidal anti-inflammatory agent advocated for use in rheumatoid arthritis, osteoarthritis, musculoskeletal disorders, soft-tissue injuries and inflammatory conditions and acute pain of varying origin." | 4.77 | Tiaprofenic acid. A review of its pharmacological properties and therapeutic efficacy in rheumatic diseases and pain states. ( Brogden, RN; Sorkin, EM, 1985) |
| "The effect of therapeutic and pharmacological concentrations of tiaprofenic acid, a non-steroidal anti-inflammatory drug (NSAID), on the synthesis of the plasminogen activators, urokinase plasminogen activator (uPA) and tissue plasminogen activator (tPA), and the plasminogen activator inhibitors 1 and 2 (PAI-1 and PAI-2), by human synovial membranes isolated from osteoarthritis (OA) and rheumatoid arthritis (RA) sufferers was evaluated." | 3.68 | Effects of tiaprofenic acid on plasminogen activators and inhibitors in human OA and RA synovium. ( Cloutier, JM; Martel-Pelletier, J; McCollum, R; Pelletier, JP, 1992) |
| "In a multicentre trial, tiaprofenic acid was administered in a dosage of 600 mg/day for 12 months to 109 patients with rheumatoid arthritis." | 3.67 | Efficacy and tolerance of tiaprofenic acid during long term administration to rheumatoid arthritis patients. ( Harada, S; Konishi, Y; Nagaya, T; Niwa, S, 1988) |
| "The efficacy of intramuscular tiaprofenic acid (TA) was investigated in 3 separate studies: a multicentre open study involving 487 patients with various rheumatic conditions: an open study of 31 patients with active osteoarthritis of the knee; and an open comparative study with ketoprofen involving 30 patients with acute gout." | 3.67 | Clinical experiences with the intramuscular injection of tiaprofenic acid in rheumatic diseases, with particular emphasis on time of onset and duration of the analgesic effect. ( Burgos-Vargas, R; Katona, G, 1988) |
| "Tiaprofenic acid is a new non-steroidal anti-inflammatory agent." | 2.65 | Tiaprofenic acid in the treatment of rheumatoid arthritis. ( Camp, AV, 1981) |
| "Oxaprozin (Wy-21743) is a novel and unique compound among NSAIDs: it bears an aliphatic propionic acid function as a side chain in contrast to the large group of acetic acids and profens." | 1.28 | The transsynovial distribution of oxaprozin. ( Kurowski, M; Thabe, H, 1989) |
| "Treatment with tiaprofenic acid appreciably reduced the level of plasminogen activators in the medium of 3T3-Balb mouse fibroblasts, as revealed by both a fibrin plate assay and amidolytic determination with chromogenic substrates." | 1.27 | Plasminogen activators and tiaprofenic acid in inflammation. A preliminary study. ( Caldini, R; Del Rosso, M; Fibbi, G; Magnelli, L; Pucci, M; Serni, U, 1988) |
| "Tiaprofenic acid is a potent non-steroidal anti-inflammatory drug which, in conventional tablet form, has been shown to be rapidly absorbed and eliminated from the plasma, while synovial fluid concentrations remain constant for at least 8 hours." | 1.27 | Synovial fluid and plasma kinetics of repeat dose sustained action tiaprofenic acid in patients with rheumatoid arthritis. ( Nichol, FE; Rose, CM; Samanta, A, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (86.67) | 18.7374 |
| 1990's | 4 (13.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jamali, F | 2 |
| Russell, AS | 2 |
| Berry, BW | 2 |
| Lehmann, C | 2 |
| Mungavin, JM | 1 |
| Clarke, TK | 1 |
| Poletto, B | 1 |
| Diffey, BL | 1 |
| Daymond, TJ | 5 |
| Fairgreaves, H | 1 |
| Thompson, M | 2 |
| Essigman, WK | 1 |
| Huskisson, EC | 1 |
| Wojtulewski, JA | 1 |
| Mathies, H | 1 |
| Wolff, E | 1 |
| Graml, W | 1 |
| Marx-Heep, I | 1 |
| Camp, AV | 1 |
| Zgradić, I | 1 |
| Popović, M | 1 |
| Lasić, G | 1 |
| Akbar, FA | 1 |
| Chestney, V | 1 |
| Pelletier, JP | 1 |
| McCollum, R | 1 |
| Cloutier, JM | 1 |
| Martel-Pelletier, J | 1 |
| Ghosh, P | 1 |
| Wells, C | 1 |
| Smith, M | 1 |
| Hutadilok, N | 1 |
| Buchanan, WW | 1 |
| Kean, WF | 1 |
| St-Jean, J | 1 |
| Gerecz-Simon, E | 1 |
| Elie, R | 1 |
| Kurowski, M | 1 |
| Thabe, H | 1 |
| Shinmei, M | 1 |
| Kikuchi, T | 1 |
| Masuda, K | 1 |
| Shimomura, Y | 1 |
| Fibbi, G | 1 |
| Serni, U | 1 |
| Pucci, M | 1 |
| Caldini, R | 1 |
| Magnelli, L | 1 |
| Del Rosso, M | 1 |
| Rowell, FJ | 1 |
| Famaey, JP | 1 |
| Palmer, M | 1 |
| Highton, J | 1 |
| Palmer, DG | 1 |
| Nagaya, T | 1 |
| Niwa, S | 1 |
| Harada, S | 1 |
| Konishi, Y | 1 |
| Nichol, FE | 2 |
| Samanta, A | 1 |
| Rose, CM | 1 |
| Katona, G | 1 |
| Burgos-Vargas, R | 1 |
| Valentini, G | 1 |
| Tirri, G | 1 |
| Longatti, S | 1 |
| Meirovich, CI | 1 |
| Montrull, HL | 1 |
| Strusberg, AM | 1 |
| Brizuela, NY | 1 |
| Essigman, W | 1 |
| Lambert, J | 1 |
| Sheldon, P | 2 |
| Sweetman, BJ | 1 |
| Wojtulewski, J | 1 |
| Sorkin, EM | 1 |
| Brogden, RN | 1 |
| Pandit, NA | 1 |
| Swannell, AJ | 1 |
| Reginster, JY | 1 |
| Gysen, P | 1 |
| Malaise, M | 1 |
| Franchimont, P | 1 |
3 reviews available for tiaprofenic acid and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Tiaprofenic acid.
Topics: Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cartilage, Articular | 1984 |
Symposium on therapeutic aspects of tiaprofenic acid.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Rheumatoid; Gastric Mucosa; Humans; P | 1988 |
Tiaprofenic acid. A review of its pharmacological properties and therapeutic efficacy in rheumatic diseases and pain states.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Blood Platelets; Drug Evalu | 1985 |
13 trials available for tiaprofenic acid and Arthritis, Rheumatoid
| Article | Year |
|---|---|
A multi-centre study of tiaprofenic acid ('Surgam') and five comparative drugs in rheumatoid arthritis and osteoarthritis in general practice.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthriti | 1983 |
Short-term efficacy and tolerance of tiaprofenic acid ('Surgam') in rheumatoid arthritis and osteoarthritis: multi-centre, placebo-controlled trials.
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Digestive System; Drug Tolerance; Fema | 1982 |
[Prednisolone-saving effect of tiaprofenic acid. Clinical trial].
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Dose-Respons | 1982 |
Tiaprofenic acid in the treatment of rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Female; Humans; M | 1981 |
[Evaluation of the effect of therapy with Turganil in 1,240 patients].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheu | 1993 |
A controlled trial of tiaprofenic acid versus ibuprofen in rheumatoid arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind | 1979 |
Clinical evaluation of a sustained release compared to a standard formulation of tiaprofenic acid (Surgam) in rheumatoid arthritis: a Canadian multicenter study.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Delayed-Action Preparat | 1991 |
Reduction of prostaglandin E2 concentrations in synovial fluid of patients suffering from rheumatoid arthritis following tiaprofenic acid or indomethacin treatment.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Dinoprostone; Female; H | 1988 |
A double blind comparison of tiaprofenic acid with placebo.
Topics: Activities of Daily Living; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical | 1988 |
Relative efficacy and tolerance of tiaprofenic acid and ketoprofen in rheumatoid arthritis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Tolerance; Female; Human | 1988 |
[Clinical pharmacodynamics of tiaprofenic acid].
Topics: Acid Phosphatase; Adult; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Humans; L-Lactate | 1986 |
A comparison of a sustained release preparation of tiaprofenic acid with the conventional tablet formulation and a placebo in rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Dela | 1987 |
A controlled trial of tiaprofenic acid against indomethacin in patients with rheumatoid arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind | 1985 |
14 other studies available for tiaprofenic acid and Arthritis, Rheumatoid
| Article | Year |
|---|---|
High-performance liquid chromatographic analysis of tiaprofenic acid and its metabolites in plasma and urine by direct injection.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Body Fluids; Chromatography, High Pr | 1984 |
Phototoxic reactions to piroxicam, naproxen and tiaprofenic acid.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Female; Humans; Male; Naproxen; Osteoarthritis; Pho | 1983 |
[Therapy of painful soft tissue rheumatic diseases].
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Hum | 1982 |
Effects of tiaprofenic acid on plasminogen activators and inhibitors in human OA and RA synovium.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Culture Techniques; Depression, Chem | 1992 |
Chondroprotection, myth or reality: an experimental approach.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cartilage, Articular; Cells | 1990 |
The transsynovial distribution of oxaprozin.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Humans; Male; M | 1989 |
Effects of interleukin-1 and anti-inflammatory drugs on the degradation of human articular cartilage.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Rheumatoid; Cartilage, Articular; Cel | 1988 |
Plasminogen activators and tiaprofenic acid in inflammation. A preliminary study.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cells, Cultured; Chromatogr | 1988 |
Symposium on therapeutic aspects of tiaprofenic acid. Proceedings of a satellite symposium, 11th EULAR Congress, Athens, Greece, 28 June to 4 July, 1987.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Humans; Propionates | 1988 |
Efficacy and tolerance of tiaprofenic acid during long term administration to rheumatoid arthritis patients.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug | 1988 |
Synovial fluid and plasma kinetics of repeat dose sustained action tiaprofenic acid in patients with rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Delayed-Action Preparations; Female; | 1988 |
Clinical experiences with the intramuscular injection of tiaprofenic acid in rheumatic diseases, with particular emphasis on time of onset and duration of the analgesic effect.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheu | 1988 |
[Changes in articular proteoglycans in treatment with tiaprofenic acid].
Topics: Arthritis, Rheumatoid; Cartilage, Articular; Humans; Joint Diseases; Propionates; Proteoglycans; Rad | 1985 |
Pharmacokinetics of tiaprofenic acid in healthy and arthritic subjects.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Creatinine; Dialysis; Female; Half-Lif | 1985 |