thyroxine has been researched along with Sleep Apnea Syndromes in 19 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
Sleep Apnea Syndromes: Disorders characterized by multiple cessations of respirations during sleep that induce partial arousals and interfere with the maintenance of sleep. Sleep apnea syndromes are divided into central (see SLEEP APNEA, CENTRAL), obstructive (see SLEEP APNEA, OBSTRUCTIVE), and mixed central-obstructive types.
Excerpt | Relevance | Reference |
---|---|---|
"This study shows that subclinical hypothyroidism and treatment with levothyroxine do not influence the prevalence and severity of OSA, while sleep propensity is increased by untreated subclinical hypothyroidism." | 5.11 | Influence of subclinical hypothyroidism and T4 treatment on the prevalence and severity of obstructive sleep apnoea syndrome (OSAS). ( Carpagnano, GE; Carratù, P; De Pergola, G; Di Gioia, G; Giorgino, R; Lacedonia, D; Maniscalco, M; Resta, O, 2005) |
"Lingual thyroid is a rare developmental abnormality." | 1.32 | Lingual thyroid as a cause of snoring and sleep apnea. ( Majeed, S; Niwaz, A; Rashid, M; Saeed, A; Tariq, KM, 2004) |
"Obstructive sleep apnea (OSA) and hypothyroidism are relatively common disorders that have similar clinical features and are thought to be causally linked." | 1.30 | Association of hypothyroidism and obstructive sleep apnea. ( deMaine, J; Hert, R; Kapur, VK; Koepsell, TD; Psaty, BM; Sandblom, RE, 1998) |
"There is an association of sleep apnea among patients with untreated hypothyroidism." | 1.30 | Sleep apnea syndrome among patients with hypothyroidism. ( Hira, HS; Sibal, L, 1999) |
"We studied the effects of sleep apnea on neuroendocrine function in a cross-sectional study of 225 consecutive men undergoing sleep studies and in a longitudinal study of 43 men with severe obstructive sleep apnea before and after 3 months of successful treatment with nasal continuous positive airways pressure to eliminate upper airways obstruction." | 1.28 | Neuroendocrine dysfunction in sleep apnea: reversal by continuous positive airways pressure therapy. ( Blackwell, C; Caterson, ID; Grunstein, RR; Handelsman, DJ; Lawrence, SJ; Sullivan, CE, 1989) |
"After irradiation of the neck for a squamous cell carcinoma of the tonsillar pillar and vocal cord, a 71-year-old man presented with a rapidly progressive sleep apnea syndrome." | 1.28 | Sleep apnea syndrome after irradiation of the neck. ( Dietrich, RA; Herlihy, JP; Shaw, T; Whitlock, WL, 1989) |
"There is a high incidence of sleep apnea in patients with untreated hypothyroidism." | 1.27 | Sleep apnea and hypothyroidism: mechanisms and management. ( Grunstein, RR; Sullivan, CE, 1988) |
"A 58-yr-old man with hypothyroidism and sleep apnea syndrome was studied to determine the cause of the nocturnal obstructive apnea and oxygen desaturation." | 1.26 | Disordered breathing during sleep in hypothyroidism. ( Ewart, R; Iber, C; Rasmussen, H; Schultze, B; Skatrud, J; Thomas, G, 1981) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 11 (57.89) | 18.7374 |
1990's | 3 (15.79) | 18.2507 |
2000's | 5 (26.32) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Lanfranco, F | 1 |
Gianotti, L | 1 |
Pivetti, S | 1 |
Navone, F | 1 |
Rossetto, R | 1 |
Tassone, F | 1 |
Gai, V | 1 |
Ghigo, E | 1 |
Maccario, M | 1 |
Rashid, M | 1 |
Majeed, S | 1 |
Tariq, KM | 1 |
Niwaz, A | 1 |
Saeed, A | 1 |
Jha, A | 1 |
Sharma, SK | 1 |
Tandon, N | 1 |
Lakshmy, R | 1 |
Kadhiravan, T | 1 |
Handa, KK | 1 |
Gupta, R | 1 |
Pandey, RM | 1 |
Chaturvedi, PK | 1 |
Resta, O | 1 |
Carratù, P | 1 |
Carpagnano, GE | 1 |
Maniscalco, M | 1 |
Di Gioia, G | 1 |
Lacedonia, D | 1 |
Giorgino, R | 1 |
De Pergola, G | 1 |
Rajagopal, KR | 1 |
Abbrecht, PH | 1 |
Derderian, SS | 1 |
Pickett, C | 1 |
Hofeldt, F | 1 |
Tellis, CJ | 1 |
Zwillich, CW | 2 |
Mackay, D | 1 |
Cooper, RA | 1 |
Bradbury, S | 1 |
Gawkrodger, DJ | 1 |
Prowse, K | 1 |
Van't Hoff, W | 1 |
Skatrud, J | 1 |
Iber, C | 1 |
Ewart, R | 1 |
Thomas, G | 1 |
Rasmussen, H | 1 |
Schultze, B | 1 |
Orr, WC | 1 |
Males, JL | 1 |
Imes, NK | 1 |
Kapur, VK | 1 |
Koepsell, TD | 1 |
deMaine, J | 1 |
Hert, R | 1 |
Sandblom, RE | 1 |
Psaty, BM | 1 |
Hira, HS | 1 |
Sibal, L | 1 |
Sutor, GC | 1 |
Klocke, M | 1 |
Hamm, M | 1 |
Fabel, H | 1 |
Schuppert, F | 1 |
Bai, Y | 1 |
Grunstein, RR | 2 |
Handelsman, DJ | 1 |
Lawrence, SJ | 1 |
Blackwell, C | 1 |
Caterson, ID | 1 |
Sullivan, CE | 2 |
Herlihy, JP | 1 |
Whitlock, WL | 1 |
Dietrich, RA | 1 |
Shaw, T | 1 |
Robinson, RW | 1 |
Kittle, WM | 1 |
Chaudhary, BA | 1 |
Shiomi, T | 1 |
Yano, Y | 1 |
Kobayashi, T | 1 |
Watanabe, T | 1 |
Kojima, H | 1 |
McNamara, ME | 1 |
Southwick, SM | 1 |
Fogel, BS | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Improvement in Hypothalamic-Pituitary-Adrenal Axis Function After Continuous Positive Airway Pressure Therapy in Obstructive Sleep Apnea Syndrome[NCT00435643] | 45 participants (Actual) | Interventional | 2004-10-31 | Completed | |||
Healthy Sleep for Children With Down Syndrome[NCT03922165] | 26 participants (Actual) | Observational | 2019-05-22 | Completed | |||
Positive Airway Pressure for the Treatment of the Obstructive Sleep Apnea Syndrome in Children With Down Syndrome (Stage 1)[NCT04124471] | 42 participants (Actual) | Interventional | 2019-08-02 | Completed | |||
Sleepiness and the Effects of CPAP on Salivary Cortisol and Alpha-Amylase Levels in Patients With Sleep Apnea[NCT01196117] | 18 participants (Actual) | Interventional | 2004-11-15 | Completed | |||
Sexual Dysfunction And Hypotestosteronemia In Patients With Obstructive Sleep Apnea Syndrome And Its Effects With CPAP Therapy[NCT00832065] | 0 participants (Actual) | Observational | 2009-01-31 | Withdrawn (stopped due to No patients enrolled in study) | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Epworth Sleepiness Score (ESS) is a scale to assess sleepiness during waking hours. The scale ranges from 0-24 with higher scores indicative of greater sleepiness. (NCT01196117)
Timeframe: Difference between Baseline(Day 0) and Average of Day 1,7,14.
Intervention | units on a scale (Median) |
---|---|
14 Days of Placebo Therapy, Then CPAP | 10.7 |
14 Days of CPAP Therapy | 8.9 |
Salivary Cortisol was measured by enzyme-linked immunosorbent assay. The reference range for healthy adults is <4.2 nmol/l. (NCT01196117)
Timeframe: Day 7, 7am
Intervention | nmol/l (Mean) |
---|---|
CPAP>= 3 Hours Per Night | 9.9 |
CPAP<3 Hours Per Night | 13.3 |
Salivary Cortisol was measured by enzyme-linked immunosorbent assay. The reference range for healthy adults is <4.2 nmol/l. (NCT01196117)
Timeframe: Day 0, 11pm
Intervention | nmol/l (Median) |
---|---|
CPAP>= 3 Hours Per Night | 3.2 |
CPAP<3 Hours Per Night | 1.2 |
Salivary Cortisol was measured by enzyme-linked immunosorbent assay. The reference range for healthy adults is <4.2 nmol/l. (NCT01196117)
Timeframe: Day 1, 11pm
Intervention | nmol/l (Median) |
---|---|
CPAP>= 3 Hours Per Night | 2.2 |
CPAP<3 Hours Per Night | 1.8 |
Salivary Cortisol was measured by enzyme-linked immunosorbent assay. The reference range for healthy adults is <4.2 nmol/l. (NCT01196117)
Timeframe: Day 14, 11pm
Intervention | nmol/l (Median) |
---|---|
CPAP>= 3 Hours Per Night | 1.9 |
CPAP<3 Hours Per Night | 2.2 |
Salivary Cortisol was measured by enzyme-linked immunosorbent assay. The reference range for healthy adults is <4.2 nmol/l. (NCT01196117)
Timeframe: Day 7, 11pm
Intervention | nmol/l (Median) |
---|---|
CPAP>= 3 Hours Per Night | 3.0 |
CPAP<3 Hours Per Night | 2.5 |
Salivary Cortisol was measured by enzyme-linked immunosorbent assay. The reference range for healthy adults is <4.2 nmol/l. (NCT01196117)
Timeframe: Day 0, 7am
Intervention | nmol/l (Median) |
---|---|
CPAP>= 3 Hours Per Night | 12.5 |
CPAP<3 Hours Per Night | 12.1 |
Salivary Cortisol was measured by enzyme-linked immunosorbent assay. The reference range for healthy adults is <4.2 nmol/l. (NCT01196117)
Timeframe: Day 1, 7am
Intervention | nmol/l (Median) |
---|---|
CPAP>= 3 Hours Per Night | 7.4 |
CPAP<3 Hours Per Night | 13.6 |
Salivary Cortisol was measured by enzyme-linked immunosorbent assay. The reference range for healthy adults is <4.2 nmol/l. (NCT01196117)
Timeframe: Day 14, 7am
Intervention | nmol/l (Median) |
---|---|
CPAP>= 3 Hours Per Night | 9.2 |
CPAP<3 Hours Per Night | 15.0 |
1 review available for thyroxine and Sleep Apnea Syndromes
Article | Year |
---|---|
Sleep apnea and hypothyroidism.
Topics: Humans; Hypothyroidism; Myxedema; Obesity; Positive-Pressure Respiration; Sleep Apnea Syndromes; Thy | 1988 |
1 trial available for thyroxine and Sleep Apnea Syndromes
Article | Year |
---|---|
Influence of subclinical hypothyroidism and T4 treatment on the prevalence and severity of obstructive sleep apnoea syndrome (OSAS).
Topics: Adult; Aged; Body Mass Index; Female; Humans; Hypothyroidism; Male; Middle Aged; Neck; Prevalence; S | 2005 |
17 other studies available for thyroxine and Sleep Apnea Syndromes
Article | Year |
---|---|
Obese patients with obstructive sleep apnoea syndrome show a peculiar alteration of the corticotroph but not of the thyrotroph and lactotroph function.
Topics: Adrenocorticotropic Hormone; Adult; Area Under Curve; Case-Control Studies; Corticotropin-Releasing | 2004 |
Lingual thyroid as a cause of snoring and sleep apnea.
Topics: Adult; Female; Humans; Lingual Thyroid; Sleep Apnea Syndromes; Snoring; Thyroid Hormones; Thyroidect | 2004 |
Thyroxine replacement therapy reverses sleep-disordered breathing in patients with primary hypothyroidism.
Topics: Adult; Anthropometry; Blood Glucose; Fasting; Female; Humans; Hypothyroidism; Male; Polysomnography; | 2006 |
Obstructive sleep apnea in hypothyroidism.
Topics: Adult; Humans; Hypothyroidism; Middle Aged; Obesity; Respiratory Function Tests; Sleep Apnea Syndrom | 1984 |
Obstructive sleep apnea in hypothyroidism.
Topics: Adult; Humans; Hypothyroidism; Middle Aged; Obesity; Respiratory Function Tests; Sleep Apnea Syndrom | 1984 |
Obstructive sleep apnea in hypothyroidism.
Topics: Adult; Humans; Hypothyroidism; Middle Aged; Obesity; Respiratory Function Tests; Sleep Apnea Syndrom | 1984 |
Obstructive sleep apnea in hypothyroidism.
Topics: Adult; Humans; Hypothyroidism; Middle Aged; Obesity; Respiratory Function Tests; Sleep Apnea Syndrom | 1984 |
Sleep apnoea in myxoedema.
Topics: Adolescent; Adult; Aged; Disorders of Excessive Somnolence; Female; Humans; Male; Middle Aged; Myxed | 1984 |
Disordered breathing during sleep in hypothyroidism.
Topics: Carbon Dioxide; Humans; Hypothyroidism; Male; Medroxyprogesterone; Middle Aged; Sleep Apnea Syndrome | 1981 |
Myxedema and obstructive sleep apnea.
Topics: Cholesterol; Creatine Kinase; Female; Humans; Male; Middle Aged; Myxedema; Oxygen; Sleep Apnea Syndr | 1981 |
Association of hypothyroidism and obstructive sleep apnea.
Topics: Adult; Case-Control Studies; Confidence Intervals; Cross-Sectional Studies; Female; Humans; Hypothyr | 1998 |
Sleep apnea syndrome among patients with hypothyroidism.
Topics: Humans; Hypothyroidism; Respiration; Respiratory Center; Sleep Apnea Syndromes; Thyroxine | 1999 |
[A young man with adynamia, subepicardial ischemia and sleep apnea].
Topics: Adult; Angina, Unstable; Asthenia; Electrocardiography; Follow-Up Studies; Humans; Hypothyroidism; M | 2001 |
[Primary hypothyroidism with obstructive sleep apnea syndrome].
Topics: Adult; Aged; Female; Humans; Hypothyroidism; Male; Middle Aged; Polysomnography; Sleep Apnea Syndrom | 1992 |
Neuroendocrine dysfunction in sleep apnea: reversal by continuous positive airways pressure therapy.
Topics: Adult; Age Factors; Aged; Follicle Stimulating Hormone; Humans; Insulin-Like Growth Factor I; Lutein | 1989 |
Neuroendocrine dysfunction in sleep apnea: reversal by continuous positive airways pressure therapy.
Topics: Adult; Age Factors; Aged; Follicle Stimulating Hormone; Humans; Insulin-Like Growth Factor I; Lutein | 1989 |
Neuroendocrine dysfunction in sleep apnea: reversal by continuous positive airways pressure therapy.
Topics: Adult; Age Factors; Aged; Follicle Stimulating Hormone; Humans; Insulin-Like Growth Factor I; Lutein | 1989 |
Neuroendocrine dysfunction in sleep apnea: reversal by continuous positive airways pressure therapy.
Topics: Adult; Age Factors; Aged; Follicle Stimulating Hormone; Humans; Insulin-Like Growth Factor I; Lutein | 1989 |
Sleep apnea syndrome after irradiation of the neck.
Topics: Aged; Carcinoma, Squamous Cell; Humans; Hypothyroidism; Laryngeal Edema; Laryngeal Neoplasms; Male; | 1989 |
The effect of drugs on breathing during sleep.
Topics: Almitrine; Anesthetics; Dose-Response Relationship, Drug; Ethanol; Humans; Hypnotics and Sedatives; | 1985 |
Sleep apnea and hypothyroidism: mechanisms and management.
Topics: Aged; Female; Humans; Hypothyroidism; Male; Middle Aged; Positive-Pressure Respiration; Respiratory | 1988 |
[A case of myxedema of the heart with sleep apnea syndrome].
Topics: Cardiomyopathies; Electrocardiography; Humans; Male; Middle Aged; Monitoring, Physiologic; Myxedema; | 1988 |
Sleep apnea and hypothyroidism presenting as depression in two patients.
Topics: Aged; Depressive Disorder; Diagnosis, Differential; Humans; Hypothyroidism; Male; Middle Aged; Sleep | 1987 |