Page last updated: 2024-11-06

thyroxine and Sleep Apnea Syndromes

thyroxine has been researched along with Sleep Apnea Syndromes in 19 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Sleep Apnea Syndromes: Disorders characterized by multiple cessations of respirations during sleep that induce partial arousals and interfere with the maintenance of sleep. Sleep apnea syndromes are divided into central (see SLEEP APNEA, CENTRAL), obstructive (see SLEEP APNEA, OBSTRUCTIVE), and mixed central-obstructive types.

Research Excerpts

ExcerptRelevanceReference
"This study shows that subclinical hypothyroidism and treatment with levothyroxine do not influence the prevalence and severity of OSA, while sleep propensity is increased by untreated subclinical hypothyroidism."5.11Influence of subclinical hypothyroidism and T4 treatment on the prevalence and severity of obstructive sleep apnoea syndrome (OSAS). ( Carpagnano, GE; Carratù, P; De Pergola, G; Di Gioia, G; Giorgino, R; Lacedonia, D; Maniscalco, M; Resta, O, 2005)
"Lingual thyroid is a rare developmental abnormality."1.32Lingual thyroid as a cause of snoring and sleep apnea. ( Majeed, S; Niwaz, A; Rashid, M; Saeed, A; Tariq, KM, 2004)
"Obstructive sleep apnea (OSA) and hypothyroidism are relatively common disorders that have similar clinical features and are thought to be causally linked."1.30Association of hypothyroidism and obstructive sleep apnea. ( deMaine, J; Hert, R; Kapur, VK; Koepsell, TD; Psaty, BM; Sandblom, RE, 1998)
"There is an association of sleep apnea among patients with untreated hypothyroidism."1.30Sleep apnea syndrome among patients with hypothyroidism. ( Hira, HS; Sibal, L, 1999)
"We studied the effects of sleep apnea on neuroendocrine function in a cross-sectional study of 225 consecutive men undergoing sleep studies and in a longitudinal study of 43 men with severe obstructive sleep apnea before and after 3 months of successful treatment with nasal continuous positive airways pressure to eliminate upper airways obstruction."1.28Neuroendocrine dysfunction in sleep apnea: reversal by continuous positive airways pressure therapy. ( Blackwell, C; Caterson, ID; Grunstein, RR; Handelsman, DJ; Lawrence, SJ; Sullivan, CE, 1989)
"After irradiation of the neck for a squamous cell carcinoma of the tonsillar pillar and vocal cord, a 71-year-old man presented with a rapidly progressive sleep apnea syndrome."1.28Sleep apnea syndrome after irradiation of the neck. ( Dietrich, RA; Herlihy, JP; Shaw, T; Whitlock, WL, 1989)
"There is a high incidence of sleep apnea in patients with untreated hypothyroidism."1.27Sleep apnea and hypothyroidism: mechanisms and management. ( Grunstein, RR; Sullivan, CE, 1988)
"A 58-yr-old man with hypothyroidism and sleep apnea syndrome was studied to determine the cause of the nocturnal obstructive apnea and oxygen desaturation."1.26Disordered breathing during sleep in hypothyroidism. ( Ewart, R; Iber, C; Rasmussen, H; Schultze, B; Skatrud, J; Thomas, G, 1981)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-199011 (57.89)18.7374
1990's3 (15.79)18.2507
2000's5 (26.32)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lanfranco, F1
Gianotti, L1
Pivetti, S1
Navone, F1
Rossetto, R1
Tassone, F1
Gai, V1
Ghigo, E1
Maccario, M1
Rashid, M1
Majeed, S1
Tariq, KM1
Niwaz, A1
Saeed, A1
Jha, A1
Sharma, SK1
Tandon, N1
Lakshmy, R1
Kadhiravan, T1
Handa, KK1
Gupta, R1
Pandey, RM1
Chaturvedi, PK1
Resta, O1
Carratù, P1
Carpagnano, GE1
Maniscalco, M1
Di Gioia, G1
Lacedonia, D1
Giorgino, R1
De Pergola, G1
Rajagopal, KR1
Abbrecht, PH1
Derderian, SS1
Pickett, C1
Hofeldt, F1
Tellis, CJ1
Zwillich, CW2
Mackay, D1
Cooper, RA1
Bradbury, S1
Gawkrodger, DJ1
Prowse, K1
Van't Hoff, W1
Skatrud, J1
Iber, C1
Ewart, R1
Thomas, G1
Rasmussen, H1
Schultze, B1
Orr, WC1
Males, JL1
Imes, NK1
Kapur, VK1
Koepsell, TD1
deMaine, J1
Hert, R1
Sandblom, RE1
Psaty, BM1
Hira, HS1
Sibal, L1
Sutor, GC1
Klocke, M1
Hamm, M1
Fabel, H1
Schuppert, F1
Bai, Y1
Grunstein, RR2
Handelsman, DJ1
Lawrence, SJ1
Blackwell, C1
Caterson, ID1
Sullivan, CE2
Herlihy, JP1
Whitlock, WL1
Dietrich, RA1
Shaw, T1
Robinson, RW1
Kittle, WM1
Chaudhary, BA1
Shiomi, T1
Yano, Y1
Kobayashi, T1
Watanabe, T1
Kojima, H1
McNamara, ME1
Southwick, SM1
Fogel, BS1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Improvement in Hypothalamic-Pituitary-Adrenal Axis Function After Continuous Positive Airway Pressure Therapy in Obstructive Sleep Apnea Syndrome[NCT00435643]45 participants (Actual)Interventional2004-10-31Completed
Healthy Sleep for Children With Down Syndrome[NCT03922165]26 participants (Actual)Observational2019-05-22Completed
Positive Airway Pressure for the Treatment of the Obstructive Sleep Apnea Syndrome in Children With Down Syndrome (Stage 1)[NCT04124471]42 participants (Actual)Interventional2019-08-02Completed
Sleepiness and the Effects of CPAP on Salivary Cortisol and Alpha-Amylase Levels in Patients With Sleep Apnea[NCT01196117]18 participants (Actual)Interventional2004-11-15Completed
Sexual Dysfunction And Hypotestosteronemia In Patients With Obstructive Sleep Apnea Syndrome And Its Effects With CPAP Therapy[NCT00832065]0 participants (Actual)Observational2009-01-31Withdrawn (stopped due to No patients enrolled in study)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Epworth Sleepiness Score (ESS)

Epworth Sleepiness Score (ESS) is a scale to assess sleepiness during waking hours. The scale ranges from 0-24 with higher scores indicative of greater sleepiness. (NCT01196117)
Timeframe: Difference between Baseline(Day 0) and Average of Day 1,7,14.

Interventionunits on a scale (Median)
14 Days of Placebo Therapy, Then CPAP10.7
14 Days of CPAP Therapy8.9

Salivary Cortisol in Participants Who Used Continuous Positive Airway Pressure (CPAP) at ~ 7am, Day 7

Salivary Cortisol was measured by enzyme-linked immunosorbent assay. The reference range for healthy adults is <4.2 nmol/l. (NCT01196117)
Timeframe: Day 7, 7am

Interventionnmol/l (Mean)
CPAP>= 3 Hours Per Night9.9
CPAP<3 Hours Per Night13.3

Salivary Cortisol in Participants Who Used Continuous Positive Airway Pressure (CPAP) at ~11pm, Day 0

Salivary Cortisol was measured by enzyme-linked immunosorbent assay. The reference range for healthy adults is <4.2 nmol/l. (NCT01196117)
Timeframe: Day 0, 11pm

Interventionnmol/l (Median)
CPAP>= 3 Hours Per Night3.2
CPAP<3 Hours Per Night1.2

Salivary Cortisol in Participants Who Used Continuous Positive Airway Pressure (CPAP) at ~11pm, Day 1

Salivary Cortisol was measured by enzyme-linked immunosorbent assay. The reference range for healthy adults is <4.2 nmol/l. (NCT01196117)
Timeframe: Day 1, 11pm

Interventionnmol/l (Median)
CPAP>= 3 Hours Per Night2.2
CPAP<3 Hours Per Night1.8

Salivary Cortisol in Participants Who Used Continuous Positive Airway Pressure (CPAP) at ~11pm, Day 14

Salivary Cortisol was measured by enzyme-linked immunosorbent assay. The reference range for healthy adults is <4.2 nmol/l. (NCT01196117)
Timeframe: Day 14, 11pm

Interventionnmol/l (Median)
CPAP>= 3 Hours Per Night1.9
CPAP<3 Hours Per Night2.2

Salivary Cortisol in Participants Who Used Continuous Positive Airway Pressure (CPAP) at ~11pm, Day 7

Salivary Cortisol was measured by enzyme-linked immunosorbent assay. The reference range for healthy adults is <4.2 nmol/l. (NCT01196117)
Timeframe: Day 7, 11pm

Interventionnmol/l (Median)
CPAP>= 3 Hours Per Night3.0
CPAP<3 Hours Per Night2.5

Salivary Cortisol in Participants Who Used Continuous Positive Airway Pressure (CPAP) at ~7am, Day 0

Salivary Cortisol was measured by enzyme-linked immunosorbent assay. The reference range for healthy adults is <4.2 nmol/l. (NCT01196117)
Timeframe: Day 0, 7am

Interventionnmol/l (Median)
CPAP>= 3 Hours Per Night12.5
CPAP<3 Hours Per Night12.1

Salivary Cortisol in Participants Who Used Continuous Positive Airway Pressure (CPAP) at ~7am, Day 1

Salivary Cortisol was measured by enzyme-linked immunosorbent assay. The reference range for healthy adults is <4.2 nmol/l. (NCT01196117)
Timeframe: Day 1, 7am

Interventionnmol/l (Median)
CPAP>= 3 Hours Per Night7.4
CPAP<3 Hours Per Night13.6

Salivary Cortisol in Participants Who Used Continuous Positive Airway Pressure (CPAP) at ~7am, Day 14

Salivary Cortisol was measured by enzyme-linked immunosorbent assay. The reference range for healthy adults is <4.2 nmol/l. (NCT01196117)
Timeframe: Day 14, 7am

Interventionnmol/l (Median)
CPAP>= 3 Hours Per Night9.2
CPAP<3 Hours Per Night15.0

Reviews

1 review available for thyroxine and Sleep Apnea Syndromes

ArticleYear
Sleep apnea and hypothyroidism.
    Southern medical journal, 1988, Volume: 81, Issue:11

    Topics: Humans; Hypothyroidism; Myxedema; Obesity; Positive-Pressure Respiration; Sleep Apnea Syndromes; Thy

1988

Trials

1 trial available for thyroxine and Sleep Apnea Syndromes

ArticleYear
Influence of subclinical hypothyroidism and T4 treatment on the prevalence and severity of obstructive sleep apnoea syndrome (OSAS).
    Journal of endocrinological investigation, 2005, Volume: 28, Issue:10

    Topics: Adult; Aged; Body Mass Index; Female; Humans; Hypothyroidism; Male; Middle Aged; Neck; Prevalence; S

2005

Other Studies

17 other studies available for thyroxine and Sleep Apnea Syndromes

ArticleYear
Obese patients with obstructive sleep apnoea syndrome show a peculiar alteration of the corticotroph but not of the thyrotroph and lactotroph function.
    Clinical endocrinology, 2004, Volume: 60, Issue:1

    Topics: Adrenocorticotropic Hormone; Adult; Area Under Curve; Case-Control Studies; Corticotropin-Releasing

2004
Lingual thyroid as a cause of snoring and sleep apnea.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2004, Volume: 14, Issue:11

    Topics: Adult; Female; Humans; Lingual Thyroid; Sleep Apnea Syndromes; Snoring; Thyroid Hormones; Thyroidect

2004
Thyroxine replacement therapy reverses sleep-disordered breathing in patients with primary hypothyroidism.
    Sleep medicine, 2006, Volume: 7, Issue:1

    Topics: Adult; Anthropometry; Blood Glucose; Fasting; Female; Humans; Hypothyroidism; Male; Polysomnography;

2006
Obstructive sleep apnea in hypothyroidism.
    Annals of internal medicine, 1984, Volume: 101, Issue:4

    Topics: Adult; Humans; Hypothyroidism; Middle Aged; Obesity; Respiratory Function Tests; Sleep Apnea Syndrom

1984
Obstructive sleep apnea in hypothyroidism.
    Annals of internal medicine, 1984, Volume: 101, Issue:4

    Topics: Adult; Humans; Hypothyroidism; Middle Aged; Obesity; Respiratory Function Tests; Sleep Apnea Syndrom

1984
Obstructive sleep apnea in hypothyroidism.
    Annals of internal medicine, 1984, Volume: 101, Issue:4

    Topics: Adult; Humans; Hypothyroidism; Middle Aged; Obesity; Respiratory Function Tests; Sleep Apnea Syndrom

1984
Obstructive sleep apnea in hypothyroidism.
    Annals of internal medicine, 1984, Volume: 101, Issue:4

    Topics: Adult; Humans; Hypothyroidism; Middle Aged; Obesity; Respiratory Function Tests; Sleep Apnea Syndrom

1984
Sleep apnoea in myxoedema.
    Journal of the Royal College of Physicians of London, 1984, Volume: 18, Issue:4

    Topics: Adolescent; Adult; Aged; Disorders of Excessive Somnolence; Female; Humans; Male; Middle Aged; Myxed

1984
Disordered breathing during sleep in hypothyroidism.
    The American review of respiratory disease, 1981, Volume: 124, Issue:3

    Topics: Carbon Dioxide; Humans; Hypothyroidism; Male; Medroxyprogesterone; Middle Aged; Sleep Apnea Syndrome

1981
Myxedema and obstructive sleep apnea.
    The American journal of medicine, 1981, Volume: 70, Issue:5

    Topics: Cholesterol; Creatine Kinase; Female; Humans; Male; Middle Aged; Myxedema; Oxygen; Sleep Apnea Syndr

1981
Association of hypothyroidism and obstructive sleep apnea.
    American journal of respiratory and critical care medicine, 1998, Volume: 158, Issue:5 Pt 1

    Topics: Adult; Case-Control Studies; Confidence Intervals; Cross-Sectional Studies; Female; Humans; Hypothyr

1998
Sleep apnea syndrome among patients with hypothyroidism.
    The Journal of the Association of Physicians of India, 1999, Volume: 47, Issue:6

    Topics: Humans; Hypothyroidism; Respiration; Respiratory Center; Sleep Apnea Syndromes; Thyroxine

1999
[A young man with adynamia, subepicardial ischemia and sleep apnea].
    Deutsche medizinische Wochenschrift (1946), 2001, Feb-09, Volume: 126, Issue:6

    Topics: Adult; Angina, Unstable; Asthenia; Electrocardiography; Follow-Up Studies; Humans; Hypothyroidism; M

2001
[Primary hypothyroidism with obstructive sleep apnea syndrome].
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 1992, Volume: 14, Issue:4

    Topics: Adult; Aged; Female; Humans; Hypothyroidism; Male; Middle Aged; Polysomnography; Sleep Apnea Syndrom

1992
Neuroendocrine dysfunction in sleep apnea: reversal by continuous positive airways pressure therapy.
    The Journal of clinical endocrinology and metabolism, 1989, Volume: 68, Issue:2

    Topics: Adult; Age Factors; Aged; Follicle Stimulating Hormone; Humans; Insulin-Like Growth Factor I; Lutein

1989
Neuroendocrine dysfunction in sleep apnea: reversal by continuous positive airways pressure therapy.
    The Journal of clinical endocrinology and metabolism, 1989, Volume: 68, Issue:2

    Topics: Adult; Age Factors; Aged; Follicle Stimulating Hormone; Humans; Insulin-Like Growth Factor I; Lutein

1989
Neuroendocrine dysfunction in sleep apnea: reversal by continuous positive airways pressure therapy.
    The Journal of clinical endocrinology and metabolism, 1989, Volume: 68, Issue:2

    Topics: Adult; Age Factors; Aged; Follicle Stimulating Hormone; Humans; Insulin-Like Growth Factor I; Lutein

1989
Neuroendocrine dysfunction in sleep apnea: reversal by continuous positive airways pressure therapy.
    The Journal of clinical endocrinology and metabolism, 1989, Volume: 68, Issue:2

    Topics: Adult; Age Factors; Aged; Follicle Stimulating Hormone; Humans; Insulin-Like Growth Factor I; Lutein

1989
Sleep apnea syndrome after irradiation of the neck.
    Archives of otolaryngology--head & neck surgery, 1989, Volume: 115, Issue:12

    Topics: Aged; Carcinoma, Squamous Cell; Humans; Hypothyroidism; Laryngeal Edema; Laryngeal Neoplasms; Male;

1989
The effect of drugs on breathing during sleep.
    Clinics in chest medicine, 1985, Volume: 6, Issue:4

    Topics: Almitrine; Anesthetics; Dose-Response Relationship, Drug; Ethanol; Humans; Hypnotics and Sedatives;

1985
Sleep apnea and hypothyroidism: mechanisms and management.
    The American journal of medicine, 1988, Volume: 85, Issue:6

    Topics: Aged; Female; Humans; Hypothyroidism; Male; Middle Aged; Positive-Pressure Respiration; Respiratory

1988
[A case of myxedema of the heart with sleep apnea syndrome].
    Kokyu to junkan. Respiration & circulation, 1988, Volume: 36, Issue:9

    Topics: Cardiomyopathies; Electrocardiography; Humans; Male; Middle Aged; Monitoring, Physiologic; Myxedema;

1988
Sleep apnea and hypothyroidism presenting as depression in two patients.
    The Journal of clinical psychiatry, 1987, Volume: 48, Issue:4

    Topics: Aged; Depressive Disorder; Diagnosis, Differential; Humans; Hypothyroidism; Male; Middle Aged; Sleep

1987