thyroxine has been researched along with Scleroderma, Systemic in 9 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
Scleroderma, Systemic: A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of this study was therefore to evaluate the effect of propylthiouracil (PTU), and of the hypothyroidism induced by it, on the development of cutaneous and pulmonary fibrosis in the oxidant stress murine model of SSc." | 7.79 | Propylthiouracil prevents cutaneous and pulmonary fibrosis in the reactive oxygen species murine model of systemic sclerosis. ( Altavilla, D; Atteritano, M; Bagnato, G; Bitto, A; Cinquegrani, M; Irrera, N; Pizzino, G; Roberts, W; Saitta, A; Sangari, D; Squadrito, F, 2013) |
| " The aim of this study was therefore to evaluate the effect of propylthiouracil (PTU), and of the hypothyroidism induced by it, on the development of cutaneous and pulmonary fibrosis in the oxidant stress murine model of SSc." | 3.79 | Propylthiouracil prevents cutaneous and pulmonary fibrosis in the reactive oxygen species murine model of systemic sclerosis. ( Altavilla, D; Atteritano, M; Bagnato, G; Bitto, A; Cinquegrani, M; Irrera, N; Pizzino, G; Roberts, W; Saitta, A; Sangari, D; Squadrito, F, 2013) |
| " In order to determine the prevalence of thyroid function and autoimmune abnormalities, we compared serum thyrotropin (TSH, serum free thyroxine (T4) levels, thyroid antithyroglobulin (TgAb) and antithyroperoxidase (TPOAb) levels of 25 patients with systemic sclerosis, 25 patients with rheumatoid arthritis and 13 patients with antiphospholipid syndrome to a control group of 113 healthy individuals." | 3.72 | Thyroid autoantibodies in autoimmune diseases. ( Innocencio, RM; Romaldini, JH; Ward, LS, 2004) |
| "All this activity in the therapy of systemic sclerosis will certainly lead to improvement in the overall management of disease." | 2.38 | Treatment of systemic sclerosis. ( Steen, V, 1991) |
| "Impotence was reported by 6 of the patients with scleroderma and none with rheumatoid arthritis." | 1.27 | Impotence in scleroderma. ( Brick, JE; Carlson, HE; Judd, HL; Lu, JK; Nowlin, NS; Weaver, DJ; Wilson, DA, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (44.44) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bagnato, G | 2 |
| Bitto, A | 1 |
| Irrera, N | 1 |
| Pizzino, G | 1 |
| Sangari, D | 1 |
| Cinquegrani, M | 1 |
| Roberts, W | 1 |
| Atteritano, M | 1 |
| Altavilla, D | 1 |
| Squadrito, F | 1 |
| Saitta, A | 1 |
| Innocencio, RM | 1 |
| Romaldini, JH | 1 |
| Ward, LS | 1 |
| Kotyla, PJ | 1 |
| Gozdzik, J | 1 |
| Lewicki, M | 1 |
| Kotulska, AT | 1 |
| Kucharz, EJ | 1 |
| Marasini, B | 1 |
| Ferrari, PA | 1 |
| Solaro, N | 1 |
| Selmi, C | 1 |
| Sasaki, M | 1 |
| Asboe-Hansen, G | 1 |
| Steen, V | 1 |
| Serup, J | 1 |
| Hangdrup, H | 1 |
| Nowlin, NS | 1 |
| Brick, JE | 1 |
| Weaver, DJ | 1 |
| Wilson, DA | 1 |
| Judd, HL | 1 |
| Lu, JK | 1 |
| Carlson, HE | 1 |
1 review available for thyroxine and Scleroderma, Systemic
| Article | Year |
|---|---|
Treatment of systemic sclerosis.
Topics: Calcitonin; Humans; Iloprost; Scleroderma, Systemic; Thyroxine | 1991 |
8 other studies available for thyroxine and Scleroderma, Systemic
| Article | Year |
|---|---|
Propylthiouracil prevents cutaneous and pulmonary fibrosis in the reactive oxygen species murine model of systemic sclerosis.
Topics: Actins; Animals; Antithyroid Agents; Blotting, Western; Disease Models, Animal; Extracellular Signal | 2013 |
Thyroid autoantibodies in autoimmune diseases.
Topics: Adult; Arthritis, Rheumatoid; Autoantibodies; Autoimmune Diseases; Case-Control Studies; Female; Hum | 2004 |
Serum lipid profile in patients with systemic sclerosis: relationship to the thyreometabolic state.
Topics: Adult; Case-Control Studies; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cohort Studies; Female | 2006 |
Thyroid dysfunction in women with systemic sclerosis.
Topics: Autoantibodies; Biomarkers; Female; Humans; Iodide Peroxidase; Mass Screening; Middle Aged; Risk Fac | 2007 |
[Drug therapy of various collagen diseases based on connective tissue metabolism--with special reference to systemic scleroderma].
Topics: Adult; Connective Tissue; Drug Evaluation; Female; Humans; Male; Middle Aged; Penicillamine; Plant E | 1977 |
[Treatment of generalized scleroderma with connective tissue inhibitors].
Topics: Adrenal Cortex Hormones; Adult; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydral | 1976 |
Thyroid hormones in generalized scleroderma. A controlled study.
Topics: Adolescent; Adult; Aged; Female; Humans; Immunoglobulin G; Immunoglobulins, Thyroid-Stimulating; Mal | 1986 |
Impotence in scleroderma.
Topics: Adult; Aged; Arthritis, Rheumatoid; Blood Pressure; Erectile Dysfunction; Estradiol; Gonadotropins, | 1986 |