Page last updated: 2024-11-06

thyroxine and Renal Insufficiency

thyroxine has been researched along with Renal Insufficiency in 19 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Renal Insufficiency: Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.

Research Excerpts

ExcerptRelevanceReference
" They were classified into 5 groups: 1) subclinical-hypothyroid (SHY), 2) overt-hypothyroid (OHY), 3) subclinical-hyperthyroid (SHE), 4) overt-hyperthyroid (OHE), 5) patients under thyroxine therapy (EU), and normal controls."3.80Dyslipidemia and serum mineral profiles in patients with thyroid disorders. ( Abdel-Gayoum, AA, 2014)
"A 35-year-old Asian male, treated for hyperthyroidism, systemic lupus erythematosis, and uremia presented with low serum total thyroxine (T4) and normal serum thyrotropin (TSH) levels."3.72Assessing thyroid hormone status in a patient with thyroid disease and renal failure: from theory to practice. ( Kaptein, EM; Nelson, JC; Wilcox, RB, 2004)
" With the impression of primary hypothyroidism, the patient was started on levothyroxine supplementation at which point he developed a classic gouty arthritis of right first metatarsophalangial joint."3.70Reversible renal insufficiency, hyperuricemia and gouty arthritis in a case of hypothyroidism. ( Bastani, B; Mooraki, A, 1998)
"Hypothyroidism is often accompanied with decline of kidney function, or inability to maintain electrolyte balance."1.38Reversal deterioration of renal function accompanied with primary hypothyrodism. ( Dragović, T, 2012)
"Hyperthyroidism is a common endocrinopathy of older cats and is associated with an increased glomerular filtration rate (gfr)."1.34Changes in the glomerular filtration rate of 27 cats with hyperthyroidism after treatment with radioactive iodine. ( Boag, AK; Church, DB; Haller, M; Neiger, R; Slater, L; Stevens, KB, 2007)
"Primary hypothyroidism is known to be associated with a consistent elevation in serum creatinine levels."1.32Renal failure and acquired hypothyroidism. ( del-Río Camacho, G; Hortas Nieto, ML; Picazo Angelín, B; Romero González, J; Ruiz Moreno, JA; Tapia Ceballos, L, 2003)
"A case of acute-on-chronic renal failure in a 70-year-old woman with ischemic nephropathy and primary hypothyroidism is presented."1.31Exacerbation of renal failure due to hypothyroidism in a patient with ischemic nephropathy. ( Fujii, T; Inenaga, T; Kawano, Y; Kuroda, S; Makino, Y; Takishita, S, 2000)
"Wegener's granulomatosis is a well-defined systemic vasculitic syndrome that primarily affects the upper and lower respiratory tracts and the kidney."1.29Case report: Hashimoto's thyroiditis associated with Wegener's granulomatosis. ( Gal, AA; LiVolsi, VA; Masor, JJ, 1994)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (10.53)18.2507
2000's10 (52.63)29.6817
2010's5 (26.32)24.3611
2020's2 (10.53)2.80

Authors

AuthorsStudies
Mikkaichi, T1
Suzuki, T1
Onogawa, T1
Tanemoto, M1
Mizutamari, H1
Okada, M1
Chaki, T1
Masuda, S1
Tokui, T1
Eto, N1
Abe, M1
Satoh, F1
Unno, M1
Hishinuma, T1
Inui, K1
Ito, S1
Goto, J1
Abe, T1
Peters, J1
Roumeliotis, S1
Mertens, PR1
Liakopoulos, V1
Lubas, A1
Grzywacz, A1
Niemczyk, S1
Kamiński, G1
Saracyn, M1
Doggui, R1
Mahjoub, R1
Aissa, WL1
Tounsi, I1
Allagui, Z1
Cherif, Z1
Haj Sassi, S1
Ennigrou, S1
Edriss, D1
El Ati, J1
Bibi, A1
McDonnell, P1
Pittman-Moore, S1
Abdel-Gayoum, AA1
Somwaru, LL1
Arnold, AM1
Joshi, N1
Fried, LP1
Cappola, AR1
Dragović, T1
Gheissari, A1
Hashemipour, M1
Khosravi, P1
Adibi, A1
del-Río Camacho, G1
Tapia Ceballos, L1
Picazo Angelín, B1
Ruiz Moreno, JA1
Hortas Nieto, ML1
Romero González, J1
Kaptein, EM1
Wilcox, RB1
Nelson, JC1
Piccoli, GB1
Mezza, E1
Burdese, M1
Terzolo, M1
Grassi, G1
Bermond, F1
Soragna, G1
Gai, M1
Dani, F1
Jeantet, A1
Segoloni, GP1
Piccoli, G1
Phanish, MK1
Andrews, PA1
Driedger, AA1
Quirk, S1
McDonald, TJ1
Ledger, S1
Gray, D1
Wall, W1
Yoo, J1
Boag, AK1
Neiger, R1
Slater, L1
Stevens, KB1
Haller, M1
Church, DB1
Masor, JJ1
Gal, AA1
LiVolsi, VA1
Mooraki, A1
Bastani, B1
Makino, Y1
Fujii, T1
Kuroda, S1
Inenaga, T1
Kawano, Y1
Takishita, S1
Sousa, MM1
Norden, AG1
Jacobsen, C1
Willnow, TE1
Christensen, EI1
Thakker, RV1
Verroust, PJ1
Moestrup, SK1
Saraiva, MJ1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Relation Between Thyroid , Parathyroid Hormones and Estimated Glomerular Filtration Rate in Chronic Kidney Disease Patients in Assiut[NCT05243979]80 participants (Anticipated)Observational2022-03-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

19 other studies available for thyroxine and Renal Insufficiency

ArticleYear
Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney.
    Proceedings of the National Academy of Sciences of the United States of America, 2004, Mar-09, Volume: 101, Issue:10

    Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cloning, Molecular; Digoxin; DNA, Complement

2004
Thyroid hormone status in patients with impaired kidney function.
    International urology and nephrology, 2021, Volume: 53, Issue:11

    Topics: Aged; Female; Glomerular Filtration Rate; Humans; Kidney; Male; Middle Aged; Prospective Studies; Re

2021
Renal Cortical Perfusion Estimated in Color Doppler Dynamic Tissue Perfusion Measurement in Patients Treated with Levothyroxine Following Total Thyroidectomy for Resectable Thyroid Cancer Is Independently Associated with Free Thyroxine: A Single-Center Pr
    Medical science monitor : international medical journal of experimental and clinical research, 2021, Aug-12, Volume: 27

    Topics: Adolescent; Adult; Feasibility Studies; Female; Glomerular Filtration Rate; Humans; Kidney Cortex; M

2021
Evaluation of free thyroxine determination based on one-step fluorometric immunoassay technique and the suboptimal concordance with two-step immunoassay.
    Journal of pharmaceutical and biomedical analysis, 2018, Oct-25, Volume: 160

    Topics: Diabetes Mellitus; Evaluation Studies as Topic; Female; Fluorometry; Humans; Immunoassay; Limit of D

2018
My aching muscles.
    Journal of the Mississippi State Medical Association, 2014, Volume: 55, Issue:4

    Topics: Adult; Creatine Kinase; Diagnosis, Differential; Female; Fluid Therapy; Hormone Replacement Therapy;

2014
Dyslipidemia and serum mineral profiles in patients with thyroid disorders.
    Saudi medical journal, 2014, Volume: 35, Issue:12

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asymptomatic Diseases; Blood Glucose; Child; Cholesterol

2014
High frequency of and factors associated with thyroid hormone over-replacement and under-replacement in men and women aged 65 and over.
    The Journal of clinical endocrinology and metabolism, 2009, Volume: 94, Issue:4

    Topics: Aged; Body Mass Index; Body Weight; Diabetes Mellitus; Dose-Response Relationship, Drug; Drug Therap

2009
Reversal deterioration of renal function accompanied with primary hypothyrodism.
    Vojnosanitetski pregled, 2012, Volume: 69, Issue:2

    Topics: Adult; Aged, 80 and over; Female; Humans; Hypothyroidism; Male; Renal Insufficiency; Thyroxine; Youn

2012
Different aspects of kidney function in well-controlled congenital hypothyroidism.
    Journal of clinical research in pediatric endocrinology, 2012, Volume: 4, Issue:4

    Topics: Adolescent; Albuminuria; Algorithms; Case-Control Studies; Child; Child, Preschool; Congenital Hypot

2012
Renal failure and acquired hypothyroidism.
    Pediatric nephrology (Berlin, Germany), 2003, Volume: 18, Issue:3

    Topics: Adolescent; Creatinine; Humans; Hypothyroidism; Male; Renal Insufficiency; Thyroiditis, Autoimmune;

2003
Assessing thyroid hormone status in a patient with thyroid disease and renal failure: from theory to practice.
    Thyroid : official journal of the American Thyroid Association, 2004, Volume: 14, Issue:5

    Topics: Adult; Antithyroid Agents; Humans; Hyperthyroidism; Male; Methimazole; Renal Insufficiency; Thyrotro

2004
Progression of renal failure without proteinuria in a patient with type 1 diabetes.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2004, Volume: 19, Issue:12

    Topics: Adult; Biopsy; Creatine Kinase; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Disease Progressi

2004
A rare and reversible cause of anaemia and renal impairment.
    Lancet (London, England), 2006, Apr-08, Volume: 367, Issue:9517

    Topics: Adult; Anemia; Humans; Hypothyroidism; Male; Renal Insufficiency; Thyroxine

2006
A pragmatic protocol for I-131 rhTSH-stimulated ablation therapy in patients with renal failure.
    Clinical nuclear medicine, 2006, Volume: 31, Issue:8

    Topics: Adult; Aged; Clinical Protocols; Diabetes Mellitus, Type 1; Female; Granulomatosis with Polyangiitis

2006
Changes in the glomerular filtration rate of 27 cats with hyperthyroidism after treatment with radioactive iodine.
    The Veterinary record, 2007, Nov-24, Volume: 161, Issue:21

    Topics: Animals; Cat Diseases; Cats; Female; Glomerular Filtration Rate; Hyperthyroidism; Iodine Radioisotop

2007
Case report: Hashimoto's thyroiditis associated with Wegener's granulomatosis.
    The American journal of the medical sciences, 1994, Volume: 308, Issue:2

    Topics: Azathioprine; Eye Diseases; Female; Granulomatosis with Polyangiitis; Humans; Kidney; Middle Aged; P

1994
Reversible renal insufficiency, hyperuricemia and gouty arthritis in a case of hypothyroidism.
    Clinical nephrology, 1998, Volume: 49, Issue:1

    Topics: Adult; Arthritis, Gouty; Creatinine; Humans; Hypercholesterolemia; Hypothyroidism; Male; Renal Insuf

1998
Exacerbation of renal failure due to hypothyroidism in a patient with ischemic nephropathy.
    Nephron, 2000, Volume: 84, Issue:3

    Topics: Aged; Creatine Kinase; Creatinine; Female; Humans; Hypothyroidism; Ischemia; Kidney; Renal Insuffici

2000
Evidence for the role of megalin in renal uptake of transthyretin.
    The Journal of biological chemistry, 2000, Dec-08, Volume: 275, Issue:49

    Topics: Animals; Biological Transport; Cells, Cultured; Heymann Nephritis Antigenic Complex; Humans; Kidney;

2000