Page last updated: 2024-11-06

thyroxine and Psoriasis

thyroxine has been researched along with Psoriasis in 12 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Psoriasis: A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.

Research Excerpts

ExcerptRelevanceReference
"ADA activities were measured in plasma, erythrocyte and tissue samples of patients with psoriasis before and after 2 months of treatment with either PTU 100 mg three times daily or PTU plus thyroxine 25 microg once daily (to prevent possible hypothyroidism, which may be induced by PTU) as well as in healthy controls."9.09Effect of propylthiouracil on adenosine deaminase activity and thyroid function in patients with psoriasis. ( Akdaş, A; Keleştimur, F; Köse, K; Utaş, S; Yazici, C, 2001)
"PTU may be considered as treatment model in psoriasis, in particular for resistant cases, because of its antioxidant potential, and also antiproliferative and immunomodulatory effects."6.70Antioxidant potential of propylthiouracil in patients with psoriasis. ( Akdaş, A; Keleştimur, F; Köse, K; Utaş, S; Yazici, C, 2002)
"ADA activities were measured in plasma, erythrocyte and tissue samples of patients with psoriasis before and after 2 months of treatment with either PTU 100 mg three times daily or PTU plus thyroxine 25 microg once daily (to prevent possible hypothyroidism, which may be induced by PTU) as well as in healthy controls."5.09Effect of propylthiouracil on adenosine deaminase activity and thyroid function in patients with psoriasis. ( Akdaş, A; Keleştimur, F; Köse, K; Utaş, S; Yazici, C, 2001)
"To determine the relationship between psoriasis, thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triodothyronine (FT3), thyroid peroxidase antibodies (TPOAb), and subclinical thyroid dysfunctions in middle-aged and older adults."4.31Association between psoriasis and thyroid function: results from the Brazilian Longitudinal Study of Adults Health (ELSA-Brasil). ( Bensenor, IM; de Almeida-Pititto, B; Goulart, AC; Lotufo, PA; Meneghini, V; Silva Janovsky, CCP; Souza Santos, I; Tebar, WR, 2023)
"PTU may be considered as treatment model in psoriasis, in particular for resistant cases, because of its antioxidant potential, and also antiproliferative and immunomodulatory effects."2.70Antioxidant potential of propylthiouracil in patients with psoriasis. ( Akdaş, A; Keleştimur, F; Köse, K; Utaş, S; Yazici, C, 2002)
"Psoriasis is related to thyroid dysfunction, especially in patients with atypical psoriasis types."1.62Relationship between Different Psoriasis Types and Thyroid Dysfunction: A Retrospective Analysis. ( Chen, S; Du, J; Gao, L; Lin, L; Lu, X; Ma, C; Wang, R, 2021)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19903 (25.00)18.7374
1990's2 (16.67)18.2507
2000's3 (25.00)29.6817
2010's1 (8.33)24.3611
2020's3 (25.00)2.80

Authors

AuthorsStudies
Du, J1
Ma, C1
Wang, R1
Lin, L1
Gao, L1
Chen, S1
Lu, X1
Meneghini, V1
Tebar, WR1
Souza Santos, I1
Silva Janovsky, CCP1
de Almeida-Pititto, B1
Lotufo, PA1
Goulart, AC1
Bensenor, IM1
Namiki, K1
Kamata, M1
Shimizu, T1
Chijiwa, C1
Uchida, H1
Okinaga, S1
Harafuji, M1
Nagata, M1
Fukaya, S1
Hayashi, K1
Fukuyasu, A1
Tanaka, T1
Ishikawa, T1
Ohnishi, T1
Tada, Y1
Hansen, PR1
Isaksen, JL1
Jemec, GB1
Ellervik, C1
Kanters, JK1
Angioni, AR1
Lania, A1
Cattaneo, A1
Beck-Peccoz, P1
Spada, A1
Weismann, K1
Verdich, J1
Howitz, J1
Hummer, L1
Pelkowitz, D1
Kano, Y1
Chiba, M1
Yagita, A1
Shiohara, T1
Giasuddin, AS1
El-Sherif, AI1
El-Ojali, SI1
Köse, K2
Utaş, S2
Yazici, C2
Akdaş, A2
Keleştimur, F2
Baltabaev, TS1

Trials

2 trials available for thyroxine and Psoriasis

ArticleYear
Effect of propylthiouracil on adenosine deaminase activity and thyroid function in patients with psoriasis.
    The British journal of dermatology, 2001, Volume: 144, Issue:6

    Topics: Adenosine Deaminase; Adolescent; Adult; Aged; Biomarkers; Dermatologic Agents; Erythrocytes; Female;

2001
Antioxidant potential of propylthiouracil in patients with psoriasis.
    Clinical biochemistry, 2002, Volume: 35, Issue:3

    Topics: Adolescent; Adult; Aged; Antioxidants; Antithyroid Agents; Female; Glutathione Peroxidase; Humans; M

2002

Other Studies

10 other studies available for thyroxine and Psoriasis

ArticleYear
Relationship between Different Psoriasis Types and Thyroid Dysfunction: A Retrospective Analysis.
    Scanning, 2021, Volume: 2021

    Topics: Humans; Psoriasis; Retrospective Studies; Thyroid Gland; Thyrotropin; Thyroxine

2021
Association between psoriasis and thyroid function: results from the Brazilian Longitudinal Study of Adults Health (ELSA-Brasil).
    Archives of endocrinology and metabolism, 2023, Jun-19, Volume: 67, Issue:6

    Topics: Aged; Brazil; Cross-Sectional Studies; Female; Humans; Hypothyroidism; Longitudinal Studies; Male; M

2023
Thyroid dysfunction in patients with psoriasis: Higher prevalence of thyroid dysfunction in patients with generalized pustular psoriasis.
    The Journal of dermatology, 2020, Volume: 47, Issue:2

    Topics: Adult; Aged; C-Reactive Protein; Female; Humans; Male; Middle Aged; Prevalence; Psoriasis; Retrospec

2020
Thyroid function in psoriasis.
    The British journal of dermatology, 2019, Volume: 181, Issue:1

    Topics: Adult; Aged; Autoantibodies; Female; Humans; Iodide Peroxidase; Male; Middle Aged; Psoriasis; Severi

2019
Effects of chronic retinoid administration on pituitary function.
    Journal of endocrinological investigation, 2005, Volume: 28, Issue:11

    Topics: Acitretin; Adult; Follicle Stimulating Hormone; Humans; Hydrocortisone; Insulin-Like Growth Factor I

2005
Normal function of the thyroid gland in PUVA-treated psoriatics.
    Acta dermato-venereologica, 1980, Volume: 60, Issue:5

    Topics: Adolescent; Adult; Aged; Female; Humans; Male; Middle Aged; Photochemotherapy; Psoriasis; PUVA Thera

1980
A new treatment for psoriasis.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1981, Nov-21, Volume: 60, Issue:21

    Topics: Drug Therapy, Combination; Humans; Propranolol; Psoriasis; Thyroxine

1981
Complete resolution of psoriasis vulgaris after excision of thyroid cancer.
    International journal of dermatology, 1997, Volume: 36, Issue:4

    Topics: Adenocarcinoma; Ampicillin; Cefazolin; Female; Humans; Middle Aged; Psoriasis; Thyroid Neoplasms; Th

1997
Prolactin: does it have a role in the pathogenesis of psoriasis?
    Dermatology (Basel, Switzerland), 1998, Volume: 197, Issue:2

    Topics: Adolescent; Adult; Analysis of Variance; Child; Dermatitis, Atopic; Female; Humans; Male; Middle Age

1998
[Radioimmunologic study of the hormonal and immune status in eczema, psoriasis and neurodermatitis].
    Meditsinskaia radiologiia, 1989, Volume: 34, Issue:8

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; C-Peptide; Eczema; Female; Humans; Hydrocortisone; Immun

1989