Page last updated: 2024-11-06

thyroxine and Preterm Birth

thyroxine has been researched along with Preterm Birth in 62 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Research Excerpts

ExcerptRelevanceReference
"Currently, there is no consensus on universal thyroid screening and levothyroxine (LT4) treatment of pregnant women with subclinical hypothyroidism (SCH) who are negative for thyroid peroxidase antibody (TPOAb-)."9.27Effects of Levothyroxine on Pregnant Women With Subclinical Hypothyroidism, Negative for Thyroid Peroxidase Antibodies. ( Azizi, F; Minooee, S; Nazarpour, S; Rahmati, M; Ramezani Tehrani, F; Simbar, M; Tohidi, M, 2018)
"Levothyroxine sodium in the treatment of SCH can significantly reduce the incidence of premature birth, miscarriage, postpartum hemorrhage, and low birth weight infants."9.22Systematic review and meta-analysis of the efficacy and pregnancy outcomes of levothyroxine sodium tablet administration in pregnant women complicated with hypothyroidism. ( Chen, Y; Geng, X; Li, N; Ma, J; Sun, C; Wang, W; Wu, W, 2022)
"Several systematic reviews and meta-analyses have investigated the effect of levothyroxine (LT4) therapy in pregnant women with subclinical hypothyroidism (SCH)."9.22The impact of levothyroxine therapy on the pregnancy, neonatal and childhood outcomes of subclinical hypothyroidism during pregnancy: An updated systematic review, meta-analysis and trial sequential analysis. ( Chen, J; Jiao, XF; Li, H; Liu, D; Wei, Q; Zeng, L; Zhang, C; Zhang, L; Zhang, M; Zou, K, 2022)
"To evaluate the effect of levothyroxine therapy on pregnancy outcomes compared with placebo or no treatment in women without overt hypothyroidism with presence of thyroid peroxidase antibodies (TPOAb) and/or thyroglobulin antibodies (TgAb)."9.12Impact of levothyroxine in women with positive thyroid antibodies on pregnancy outcomes: a systematic review and meta-analysis of randomised controlled trials. ( Benham, JL; Donovan, LE; Lau, L; Lemieux, P; Yamamoto, J, 2021)
" The following terms were used for the search: [subclinical hypothyroidism OR thyroid autoimmunity OR thyroperoxidase antibody (TPO-Ab) OR thyroglobulin antibodies (Tg-Ab)] AND (levothyroxine OR euthyrox) AND [pregnancy outcome OR miscarriage OR abortion OR pregnancy loss OR preterm birth OR premature delivery OR early labo(u)r]."9.01Effect of levothyroxine supplementation on pregnancy loss and preterm birth in women with subclinical hypothyroidism and thyroid autoimmunity: a systematic review and meta-analysis. ( Liu, J; Rao, M; Su, C; Su, Z; Tang, L; Wang, H; Wang, R; Wen, Y; Yang, Z; Zeng, Z; Zhao, S; Zhou, F, 2019)
"To study the effects of third trimester maternal isolated hypothyroxinemia (serum low free thyroxine and normal thyroid stimulating hormone level) on pregnancy outcomes, we performed a retrospective cohort study in women with singleton pregnancy between February 2009 and June 2012."8.31Association between third trimester maternal isolated hypothyroxinemia and adverse pregnancy outcomes. ( Chen, L; Lin, D; Lin, H; Lin, Z; Lu, X; Peng, M; Sun, M; Ye, E; Yu, L, 2023)
"This study was undertaken to test the therapeutic effect of extra-low dose of levothyroxine (LT4; 25 mcg/day) to preconception and pregnant women with subclinical hypothyroidism (SCH)."8.31Effect of extra-low dose levothyroxine supplementation on pregnancy outcomes in women with subclinical hypothyroidism undergoing in vitro fertilization and embryo transfer. ( Chen, YT; Chung, MT; Ho, CH; Hsiao, TW; Lin, YL; Tsai, YC; Wen, JY, 2023)
"The influence of maternal levothyroxine treatment during pregnancy remains unclear."8.12Association of maternal levothyroxine use during pregnancy with offspring birth and neurodevelopmental outcomes: a population-based cohort study. ( Cheung, CL; Cheung, ECL; Ge, GM; Ip, P; Kung, AWC; Leung, WC; Li, GHY; Man, KKC; Wong, ICK, 2022)
"The aims were to establish a gestational-age specific curve for serum total thyroxine (T4) levels and to compare pregnancy outcomes of euthyroid women with those identified to have subclinical hypothyroidism (SCH) defined by an elevated thyroid-stimulating hormone (TSH) level in conjunction with either total T4 or free T4 determinations."7.80Is total thyroxine better than free thyroxine during pregnancy? ( Casey, BM; Cunningham, FG; McIntire, DD; Wilson, KL, 2014)
"This was a secondary analysis of two parallel multicenter clinical trials of thyroxine therapy for subclinical hypothyroid disorders in pregnancy."5.51Association between Hypertensive Disorders of Pregnancy and Long-Term Neurodevelopmental Outcomes in the Offspring. ( Caritis, SN; Casey, BM; Costantine, MM; Mele, L; Mercer, BM; Palatnik, A; Reddy, UM; Rouse, DJ; Saade, GR; Sibai, B; Sorokin, Y; Thorp, JM; Tita, ATN; Tolosa, JE; Varner, MW; Wapner, RJ, 2022)
"Currently, there is no consensus on universal thyroid screening and levothyroxine (LT4) treatment of pregnant women with subclinical hypothyroidism (SCH) who are negative for thyroid peroxidase antibody (TPOAb-)."5.27Effects of Levothyroxine on Pregnant Women With Subclinical Hypothyroidism, Negative for Thyroid Peroxidase Antibodies. ( Azizi, F; Minooee, S; Nazarpour, S; Rahmati, M; Ramezani Tehrani, F; Simbar, M; Tohidi, M, 2018)
"Several systematic reviews and meta-analyses have investigated the effect of levothyroxine (LT4) therapy in pregnant women with subclinical hypothyroidism (SCH)."5.22The impact of levothyroxine therapy on the pregnancy, neonatal and childhood outcomes of subclinical hypothyroidism during pregnancy: An updated systematic review, meta-analysis and trial sequential analysis. ( Chen, J; Jiao, XF; Li, H; Liu, D; Wei, Q; Zeng, L; Zhang, C; Zhang, L; Zhang, M; Zou, K, 2022)
"Levothyroxine sodium in the treatment of SCH can significantly reduce the incidence of premature birth, miscarriage, postpartum hemorrhage, and low birth weight infants."5.22Systematic review and meta-analysis of the efficacy and pregnancy outcomes of levothyroxine sodium tablet administration in pregnant women complicated with hypothyroidism. ( Chen, Y; Geng, X; Li, N; Ma, J; Sun, C; Wang, W; Wu, W, 2022)
"To evaluate the effect of levothyroxine therapy on pregnancy outcomes compared with placebo or no treatment in women without overt hypothyroidism with presence of thyroid peroxidase antibodies (TPOAb) and/or thyroglobulin antibodies (TgAb)."5.12Impact of levothyroxine in women with positive thyroid antibodies on pregnancy outcomes: a systematic review and meta-analysis of randomised controlled trials. ( Benham, JL; Donovan, LE; Lau, L; Lemieux, P; Yamamoto, J, 2021)
"Among pregnant women without overt thyroid disease, subclinical hypothyroidism, isolated hypothyroxinemia, and TPO antibody positivity were significantly associated with higher risk of preterm birth."5.01Association of Thyroid Function Test Abnormalities and Thyroid Autoimmunity With Preterm Birth: A Systematic Review and Meta-analysis. ( Alexander, EK; Auvinen, J; Bassols, J; Bliddal, S; Boucai, L; Bramer, WM; Brown, SJ; Carty, DM; Chaker, L; Chatzi, L; Chen, L; Dayan, C; Delles, C; Derakhshan, A; Feldt-Rasmussen, U; Ghafoor, F; Grineva, EN; Guxens, M; Hisada, A; Jiménez-Zabala, A; Korevaar, TIM; López-Bermejo, A; Lu, X; Männistö, T; Meems, M; Meima, M; Mosso, L; Mukhtar, S; Murcia, M; Nelson, SM; Oken, E; Pearce, EN; Peeters, RP; Pop, VJM; Popova, PV; Riaño, I; Shields, B; Steegers, EAP; Sunyer, J; Suvanto, E; Taylor, PN; Tkachuck, AS; Vafeiadi, M; Vaidya, B; Vrijkotte, TG; Walsh, JP; Yoshinaga, J, 2019)
" The following terms were used for the search: [subclinical hypothyroidism OR thyroid autoimmunity OR thyroperoxidase antibody (TPO-Ab) OR thyroglobulin antibodies (Tg-Ab)] AND (levothyroxine OR euthyrox) AND [pregnancy outcome OR miscarriage OR abortion OR pregnancy loss OR preterm birth OR premature delivery OR early labo(u)r]."5.01Effect of levothyroxine supplementation on pregnancy loss and preterm birth in women with subclinical hypothyroidism and thyroid autoimmunity: a systematic review and meta-analysis. ( Liu, J; Rao, M; Su, C; Su, Z; Tang, L; Wang, H; Wang, R; Wen, Y; Yang, Z; Zeng, Z; Zhao, S; Zhou, F, 2019)
"The impact of subclinical hypothyroidism (SCH) and of levothyroxine replacement in pregnant women with SCH is unclear."4.93Subclinical Hypothyroidism in Pregnancy: A Systematic Review and Meta-Analysis. ( Coddington, CC; Erwin, PJ; Espinosa De Ycaza, AE; Gionfriddo, MR; Maraka, S; Montori, VM; Murad, MH; O'Keeffe, DT; Ospina, NM; Stan, MN, 2016)
" In one trial of 115 women, levothyroxine therapy to treat pregnant euthyroid (normal thyroid function) women with thyroid peroxidase antibodies was not shown to reduce pre-eclampsia significantly (risk ratio (RR) 0."4.89Interventions for clinical and subclinical hypothyroidism pre-pregnancy and during pregnancy. ( Bain, E; Cossich, MC; Crowther, CA; Middleton, P; Reid, SM, 2013)
" To assess the effect of treatment with levothyroxine on pregnancy outcomes in this group of women."4.87Association between thyroid autoantibodies and miscarriage and preterm birth: meta-analysis of evidence. ( Coomarasamy, A; Franklyn, J; Kilby, MD; Knox, E; Tan, A; Thangaratinam, S, 2011)
" In one trial of 115 women, levothyroxine therapy to treat pregnant euthyroid women with thyroid peroxidase antibodies was not shown to reduce pre-eclampsia significantly (risk ratio (RR) 0."4.86Interventions for clinical and subclinical hypothyroidism in pregnancy. ( Cossich, MC; Crowther, CA; Middleton, P; Reid, SM, 2010)
"92 mIU/L; these women may benefit from Levothyroxine (LT4) therapy for preventing preterm birth."4.31A Bayesian model to estimate the cutoff value of TSH for management of preterm birth. ( Azizi, F; Behboudi-Gandevani, S; Minooee, S; Nazarpour, S; Rahmati, M; Tehrani, FR, 2023)
"To study the effects of third trimester maternal isolated hypothyroxinemia (serum low free thyroxine and normal thyroid stimulating hormone level) on pregnancy outcomes, we performed a retrospective cohort study in women with singleton pregnancy between February 2009 and June 2012."4.31Association between third trimester maternal isolated hypothyroxinemia and adverse pregnancy outcomes. ( Chen, L; Lin, D; Lin, H; Lin, Z; Lu, X; Peng, M; Sun, M; Ye, E; Yu, L, 2023)
"This study was undertaken to test the therapeutic effect of extra-low dose of levothyroxine (LT4; 25 mcg/day) to preconception and pregnant women with subclinical hypothyroidism (SCH)."4.31Effect of extra-low dose levothyroxine supplementation on pregnancy outcomes in women with subclinical hypothyroidism undergoing in vitro fertilization and embryo transfer. ( Chen, YT; Chung, MT; Ho, CH; Hsiao, TW; Lin, YL; Tsai, YC; Wen, JY, 2023)
"The influence of maternal levothyroxine treatment during pregnancy remains unclear."4.12Association of maternal levothyroxine use during pregnancy with offspring birth and neurodevelopmental outcomes: a population-based cohort study. ( Cheung, CL; Cheung, ECL; Ge, GM; Ip, P; Kung, AWC; Leung, WC; Li, GHY; Man, KKC; Wong, ICK, 2022)
" There is insufficient evidence to recommend for or against therapy with triiodothyronine (T3), apart from in pregnancy when only levothyroxine is indicated, as T3 does not sufficiently cross fetal blood‑brain barrier."4.12Hashimoto thyroiditis: an evidence-based guide to etiology, diagnosis and treatment. ( Klubo-Gwiezdzinska, J; Wartofsky, L, 2022)
"At median 10, 18, and 26 weeks of gestation, we observed significant inverse associations between free thyroxine (FT4) and birth weight z scores, with the strongest association detected at median 10 weeks, at which time a 10% increase in FT4 was associated with a 0."3.88Subclinical Changes in Maternal Thyroid Function Parameters in Pregnancy and Fetal Growth. ( Cantonwine, DE; Ferguson, KK; Johns, LE; McElrath, TF; Meeker, JD; Mukherjee, B, 2018)
"The isolated hypothyroxinemia of pregnancy (IHP) has gained specific attention in the specialized literature during the recent years as the possible factor impeding the intellectual development of fetus and increasing the risk of complications related with pregnancy, delivery and perinatal period."3.88IMPORTANCE OF ISOLATED GESTATIONAL HYPOTHYROXINEMIA IN THE DEVELOPMENT OF OBSTETRIC AND SOMATIC PATHOLOGIES. ( Gagua, D; Gagua, T; Morchiladze, N; Tkeshelashvili, B, 2018)
"Thyrotropin (TSH), free thyroxine (FT4), TPOAbs, and/or hCG concentrations were measured in early and late pregnancy of 7587 pregnant women from 2 Dutch population-based prospective cohorts (n = 5924, Generation R study; n = 1663, Holistic Approach to Pregnancy and the First Postpartum Year study)."3.85Thyroid Autoimmunity Impairs the Thyroidal Response to Human Chorionic Gonadotropin: Two Population-Based Prospective Cohort Studies. ( Broeren, MA; Chaker, L; de Rijke, YB; Jaddoe, VW; Korevaar, TI; Medici, M; Peeters, RP; Pop, VJ; Steegers, EA; Tiemeier, H; Visser, TJ, 2017)
"The aims were to establish a gestational-age specific curve for serum total thyroxine (T4) levels and to compare pregnancy outcomes of euthyroid women with those identified to have subclinical hypothyroidism (SCH) defined by an elevated thyroid-stimulating hormone (TSH) level in conjunction with either total T4 or free T4 determinations."3.80Is total thyroxine better than free thyroxine during pregnancy? ( Casey, BM; Cunningham, FG; McIntire, DD; Wilson, KL, 2014)
" All women were treated with levothyroxine (L-T₄) during pregnancy."3.79Pregnancy outcomes in women with severe hypothyroidism. ( Hirsch, D; Kopel, V; Levy, S; Nadler, V; Shainberg, B; Toledano, Y, 2013)
"Pregnancy is a complex state with many endocrinological challenges to a woman's physiology."2.72Understanding the Pathogenesis of Gestational Hypothyroidism. ( Li, X; Mallawa Kankanamalage, O; Zhou, Q, 2021)
"Hypothyroidism in pregnancy is defined as the presence of an elevated thyroid stimulating hormone during gestation, affecting 2% to 3% of the population."2.61Hypothyroidism in Pregnancy. ( Sullivan, SA, 2019)
"Hypothyroidism is one of the most prevalent diseases in pregnancy, but there is no consensus about its management in pregnant women."2.58Pregnancy Complications Associated With Maternal Hypothyroidism: A Systematic Review. ( Aristides, SMA; de Carvalho, HC; Demarchi, IG; Günther, LSA; Lopes, LCB; Santos, TDS; Shinohara, DR; Teixeira, JJV, 2018)
"Subclinical hypothyroidism has been found to be associated with adverse reproductive outcomes, such as infertility, miscarriage, preterm birth, and complications of pregnancy."2.53The Impact and Management of Subclinical Hypothyroidism for Improving Reproductive Outcomes such as Fertility and Miscarriage. ( Seungdamrong, A, 2016)
"If left untreated, both hypothyroidism and hyperthyroidism are associated with adverse effects on pregnancy and fetal outcomes."2.48Thyroid disorders during pregnancy. ( Sullivan, SD; Yazbeck, CF, 2012)
"Although the frequency of miscarriage in the AT group was greater (4."1.72Thyroid Function Rather Than Thyroid Antibodies Affects Pregnancy and Perinatal Outcomes: Results of a Prospective Study. ( Bagattini, B; Benelli, E; Fiore, E; Gianetti, E; Montanelli, L; Orsolini, F; Terrenzio, C; Tonacchera, M, 2022)
"Hyperthyroidism was associated with an increased risk of preterm birth (PTB, adjusted OR: 2."1.62Impact of maternal thyroid hormone in late pregnancy on adverse birth outcomes: A retrospective cohort study in China. ( Gao, Y; Wang, H; Wang, J; Yu, B; Yuan, X, 2021)
"Maternal hypothyroidism has been reported to have concerns over neonatal outcomes, not only in the context of neurocognitive development but also in the short term as birth weight and neonatal jaundice."1.62Neonatal outcomes and congenital anomalies in pregnancies affected by hypothyroidism. ( Humayun, KN; Islam, N; Kiran, Z; Sheikh, A, 2021)
"Gestational hypertension was least likely to occur in thyroid autoimmune groups."1.62Association of thyroid antibodies status on the outcomes of pregnant women with hypothyroidism (maternal hypothyroidism on pregnancy outcomes, MHPO-4). ( Islam, N; Kiran, Z; Sheikh, A, 2021)
"Maternal hypothyroidism is associated with several pregnancy and perinatal complications, but consistent LT4 use may reduce many of the risks."1.51Pregnancy and Perinatal Outcome Among Hypothyroid Mothers: A Population-Based Cohort Study. ( Gissler, M; Hartikainen, AL; Lahesmaa-Korpinen, AM; Männistö, T; Suvanto, E; Turunen, S; Vääräsmäki, M, 2019)
"The rate of miscarriage did not differ between the 3 groups (11."1.43Impact of Levothyroxine in Miscarriage and Preterm Delivery Rates in First Trimester Thyroid Antibody-Positive Women With TSH Less Than 2.5 mIU/L. ( Negro, R; Schwartz, A; Stagnaro-Green, A, 2016)
"The incidence of the pregnancy complications in the TPOAb (+) treated group was higher than those in the control group, but the differences were not statistically significant (P > 0."1.42[Effect of the treatment acceptance on the perinatal outcomes in women with subclinical hypothyroidism, positive thyroid gland peroxidase antibody in early pregnancy]. ( Ding, S; Guo, H; Tao, B; Yang, J; Zhang, X, 2015)

Research

Studies (62)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (3.23)29.6817
2010's32 (51.61)24.3611
2020's28 (45.16)2.80

Authors

AuthorsStudies
Nazarpour, S5
Ramezani Tehrani, F4
Rahmati, M4
Amiri, M3
Azizi, F6
Kiran, Z2
Sheikh, A2
Humayun, KN1
Islam, N2
Palatnik, A1
Mele, L1
Casey, BM2
Varner, MW1
Sorokin, Y1
Reddy, UM1
Wapner, RJ1
Thorp, JM1
Saade, GR1
Tita, ATN1
Rouse, DJ1
Sibai, B1
Costantine, MM1
Mercer, BM1
Tolosa, JE1
Caritis, SN1
Ding, Z1
Liu, Y1
Maraka, S3
Abdelouahab, N1
Huang, HF2
Fraser, WD2
Fan, J3
Meng, Y1
Lin, J1
Klubo-Gwiezdzinska, J1
Wartofsky, L1
Sheidaei, A1
Geng, X1
Chen, Y1
Wang, W1
Ma, J1
Wu, W1
Li, N2
Sun, C1
Korevaar, TIM2
Jiao, XF1
Zhang, M1
Chen, J1
Wei, Q1
Zeng, L1
Liu, D1
Zhang, C3
Li, H1
Zou, K1
Zhang, L2
Orsolini, F1
Gianetti, E1
Terrenzio, C1
Montanelli, L1
Benelli, E1
Bagattini, B1
Fiore, E1
Tonacchera, M2
Xie, T1
Tan, M1
Jiang, X1
Feng, Y1
Chen, Q1
Mei, H1
Cai, Y1
Zou, H1
Huang, Y1
Ge, GM1
Cheung, ECL1
Man, KKC1
Ip, P1
Leung, WC1
Li, GHY1
Kung, AWC1
Cheung, CL1
Wong, ICK1
Zhuo, L3
Wang, Z3
Yang, Y3
Liu, Z3
Wang, S3
Song, Y3
Han, Y1
Gao, X1
Wang, X1
Gong, B1
Peng, B1
Li, J1
Liu, A1
Shan, Z1
Minooee, S2
Behboudi-Gandevani, S1
Tehrani, FR1
Chen, L2
Ye, E1
Sun, M1
Lin, H1
Yu, L1
Lin, Z1
Peng, M1
Lin, D1
Lu, X2
Yu, M1
Long, Y1
Wang, Y2
Zhang, R1
Tao, L1
Chen, YT1
Ho, CH1
Chung, MT1
Wen, JY1
Lin, YL1
Hsiao, TW1
Tsai, YC1
Derakhshan, A1
Taylor, PN1
Meima, M1
Bliddal, S2
Carty, DM1
Meems, M1
Vaidya, B1
Shields, B1
Ghafoor, F1
Popova, PV1
Mosso, L1
Oken, E1
Suvanto, E2
Hisada, A1
Yoshinaga, J1
Brown, SJ1
Bassols, J1
Auvinen, J1
Bramer, WM1
López-Bermejo, A1
Dayan, C1
Boucai, L1
Vafeiadi, M1
Grineva, EN1
Tkachuck, AS1
Pop, VJM1
Vrijkotte, TG1
Guxens, M1
Chatzi, L1
Sunyer, J1
Jiménez-Zabala, A1
Riaño, I1
Murcia, M2
Mukhtar, S1
Delles, C1
Feldt-Rasmussen, U2
Nelson, SM1
Alexander, EK1
Chaker, L2
Männistö, T2
Walsh, JP1
Pearce, EN2
Steegers, EAP1
Peeters, RP3
Tosun, G1
Kose, S1
İşbilen Başok, B1
Altunyurt, S1
Cigrovski Berković, M1
Herman Mahečić, D1
Marinković Radošević, J1
Strinović Morić, M1
Bilić-Ćurčić, I1
Yang, X1
Yu, Y1
Zhang, Y1
Chen, Z1
Dubois, L1
Yuan, X1
Wang, J1
Gao, Y1
Wang, H2
Yu, B1
Cheng, WL1
Liu, XR1
Zuo, Y1
Zheng, W1
Wu, SS1
Jiang, B1
Lau, L1
Benham, JL1
Lemieux, P1
Yamamoto, J1
Donovan, LE1
Mallawa Kankanamalage, O1
Zhou, Q1
Li, X1
Aung, MT1
Johns, LE2
Ferguson, KK2
Mukherjee, B2
McElrath, TF2
Meeker, JD2
Plowden, TC1
Schisterman, EF1
Sjaarda, LA1
Perkins, NJ1
Silver, R1
Radin, R1
Kim, K1
Galai, N1
DeCherney, AH1
Mumford, SL1
Simbar, M1
Tohidi, M1
Cantonwine, DE1
Eerdekens, A1
Langouche, L1
Güiza, F1
Verhaeghe, J1
Naulaers, G1
Vanhole, C1
Van den Berghe, G1
Shinohara, DR1
Santos, TDS1
de Carvalho, HC1
Lopes, LCB1
Günther, LSA1
Aristides, SMA1
Teixeira, JJV1
Demarchi, IG1
Morchiladze, N1
Tkeshelashvili, B1
Gagua, T1
Gagua, D1
Turunen, S1
Vääräsmäki, M1
Hartikainen, AL1
Lahesmaa-Korpinen, AM1
Gissler, M1
Rao, M1
Zeng, Z1
Zhou, F1
Liu, J1
Wang, R1
Wen, Y1
Yang, Z1
Su, C1
Su, Z1
Zhao, S1
Tang, L1
Sullivan, SA1
Reid, SM2
Middleton, P2
Cossich, MC2
Crowther, CA2
Bain, E1
Hirsch, D1
Levy, S1
Nadler, V1
Kopel, V1
Shainberg, B1
Toledano, Y1
Korevaar, TI2
Schalekamp-Timmermans, S1
de Rijke, YB2
Visser, WE1
Visser, W1
de Muinck Keizer-Schrama, SM1
Hofman, A1
Ross, HA1
Hooijkaas, H1
Tiemeier, H2
Bongers-Schokking, JJ1
Jaddoe, VW2
Visser, TJ2
Steegers, EA2
Medici, M2
Wilson, KL1
McIntire, DD1
Cunningham, FG1
León, G1
Rebagliato, M1
Álvarez-Pedrerol, M1
Castilla, AM1
Basterrechea, M1
Iñiguez, C1
Fernández-Somoano, A1
Blarduni, E1
Foradada, CM1
Tardón, A1
Vioque, J1
Boas, M1
Hilsted, L1
Friis-Hansen, L1
Tabor, A1
Hou, J1
Yu, P1
Zhu, H1
Pan, H1
Yang, H1
Jiang, Y1
Wang, L1
Wang, B1
You, L1
Chen, S1
Yang, J1
Guo, H1
Ding, S1
Tao, B1
Zhang, X1
Ospina, NM1
O'Keeffe, DT2
Espinosa De Ycaza, AE2
Gionfriddo, MR1
Erwin, PJ1
Coddington, CC2
Stan, MN2
Murad, MH1
Montori, VM2
Singh Ospina, NM1
Rodriguez-Gutierrez, R1
Wi, CI1
Juhn, YJ1
Zhang, SC1
Wang, SW1
Zhao, XD1
Zhang, JR1
Negro, R1
Schwartz, A1
Stagnaro-Green, A1
Seungdamrong, A1
Pop, VJ1
Broeren, MA1
Benvenga, S1
Ordookhani, A1
Braverman, LE1
Tierney, K1
Delpachitra, P1
Grossmann, M1
Onwude, J1
Sikaris, K1
Wallace, EM1
Hamilton, EJ1
Tong, S1
Simic, N1
Westall, C1
Astzalos, EV1
Rovet, J1
Ashoor, G1
Maiz, N1
Rotas, M1
Jawdat, F1
Nicolaides, KH1
Thangaratinam, S1
Tan, A1
Knox, E1
Kilby, MD1
Franklyn, J1
Coomarasamy, A1
Leitner, AY1
Pellegrini, F1
Beck-Peccoz, P1
Wanker, P1
Persani, L1
Radetti, G1
Yazbeck, CF1
Sullivan, SD1
Williams, F1
Watson, J1
Ogston, S1
Hume, R1
Willatts, P1
Visser, T1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effects of Aspirin in Gestation and Reproduction: A Multi-center, Controlled, Double-blind Randomized Trial.[NCT00467363]1,228 participants (Actual)Interventional2007-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Abruption

Partial or complete abruption (ie, premature separation of the placenta) (NCT00467363)
Timeframe: until delivery

Interventionparticipants (Number)
Aspirin7
Placebo5

Clinically Recognized Pregnancy

(NCT00467363)
Timeframe: 8-weeks

Interventionpregnancy (Number)
Aspirin374
Placebo346

Early Pregnancy Loss (EPL)

Implantation failures (NCT00467363)
Timeframe: 8 weeks

Interventionpregnancy (Number)
Aspirin28
Placebo27

Ectopic Pregnancy

(NCT00467363)
Timeframe: within 6 weeks

Interventionpregnancy (Number)
Aspirin3
Placebo3

Fetal Pregnancy Loss

(NCT00467363)
Timeframe: until 40 weeks

Interventionpregnancy (Number)
Aspirin4
Placebo6

hCG Recognized Pregnancy

(NCT00467363)
Timeframe: within 8-weeks of gestation

Interventionpregnancy (Number)
Aspirin394
Placebo363

Live Birth

Live birth was obtained prospectively by maternal report and abstraction from medical records by trained staff . (NCT00467363)
Timeframe: after delivery

Interventionlivebirths (Number)
Aspirin309
Placebo286

Molar Pregnancy

(NCT00467363)
Timeframe: 8 weeks

Interventionpregnancy (Number)
Aspirin0
Placebo0

Preeclampsia

(NCT00467363)
Timeframe: until delivery

Interventionparticipants (Number)
Aspirin32
Placebo30

Pregnancy Losses Occurring Less Than 10 Weeks

Includes preembryonic and embryonic losses (exclusive of implantation failures) (NCT00467363)
Timeframe: less than 10-weeks

Interventionpregnancy (Number)
Aspirin56
Placebo53

Preterm Birth

(NCT00467363)
Timeframe: until delivery

Interventioninfants (Number)
Aspirin22
Placebo31

Small for Gestational Age Infant

birthweight (NCT00467363)
Timeframe: until delivery

Interventiongrams (Mean)
Aspirin3327
Placebo3315

Stillbirth

(NCT00467363)
Timeframe: 40 weeks

Interventionparticipants (Number)
Aspirin2
Placebo2

Reviews

21 reviews available for thyroxine and Preterm Birth

ArticleYear
Pregnancy and Neonatal Outcomes With Levothyroxine Treatment in Women With Subclinical Hypothyroidism Based on New Diagnostic Criteria: A Systematic Review and Meta-Analysis.
    Frontiers in endocrinology, 2021, Volume: 12

    Topics: Abortion, Spontaneous; Female; Humans; Hypothyroidism; Infant, Newborn; Pregnancy; Pregnancy Outcome

2021
Systematic review and meta-analysis of the efficacy and pregnancy outcomes of levothyroxine sodium tablet administration in pregnant women complicated with hypothyroidism.
    Annals of palliative medicine, 2022, Volume: 11, Issue:4

    Topics: Abortion, Spontaneous; Female; Humans; Hypertension, Pregnancy-Induced; Hypothyroidism; Infant, Newb

2022
The impact of levothyroxine therapy on the pregnancy, neonatal and childhood outcomes of subclinical hypothyroidism during pregnancy: An updated systematic review, meta-analysis and trial sequential analysis.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Abortion, Spontaneous; Child; Female; Humans; Hypothyroidism; Infant, Newborn; Pregnancy; Pregnancy

2022
Obstetric and offspring outcomes in isolated maternal hypothyroxinaemia: a systematic review and meta-analysis.
    Journal of endocrinological investigation, 2023, Volume: 46, Issue:6

    Topics: Birth Weight; Diabetes, Gestational; Female; Humans; Infant, Newborn; Pre-Eclampsia; Pregnancy; Prem

2023
Obstetric and offspring outcomes in isolated maternal hypothyroxinaemia: a systematic review and meta-analysis.
    Journal of endocrinological investigation, 2023, Volume: 46, Issue:6

    Topics: Birth Weight; Diabetes, Gestational; Female; Humans; Infant, Newborn; Pre-Eclampsia; Pregnancy; Prem

2023
Obstetric and offspring outcomes in isolated maternal hypothyroxinaemia: a systematic review and meta-analysis.
    Journal of endocrinological investigation, 2023, Volume: 46, Issue:6

    Topics: Birth Weight; Diabetes, Gestational; Female; Humans; Infant, Newborn; Pre-Eclampsia; Pregnancy; Prem

2023
Obstetric and offspring outcomes in isolated maternal hypothyroxinaemia: a systematic review and meta-analysis.
    Journal of endocrinological investigation, 2023, Volume: 46, Issue:6

    Topics: Birth Weight; Diabetes, Gestational; Female; Humans; Infant, Newborn; Pre-Eclampsia; Pregnancy; Prem

2023
Obstetric and offspring outcomes in isolated maternal hypothyroxinaemia: a systematic review and meta-analysis.
    Journal of endocrinological investigation, 2023, Volume: 46, Issue:6

    Topics: Birth Weight; Diabetes, Gestational; Female; Humans; Infant, Newborn; Pre-Eclampsia; Pregnancy; Prem

2023
Obstetric and offspring outcomes in isolated maternal hypothyroxinaemia: a systematic review and meta-analysis.
    Journal of endocrinological investigation, 2023, Volume: 46, Issue:6

    Topics: Birth Weight; Diabetes, Gestational; Female; Humans; Infant, Newborn; Pre-Eclampsia; Pregnancy; Prem

2023
Obstetric and offspring outcomes in isolated maternal hypothyroxinaemia: a systematic review and meta-analysis.
    Journal of endocrinological investigation, 2023, Volume: 46, Issue:6

    Topics: Birth Weight; Diabetes, Gestational; Female; Humans; Infant, Newborn; Pre-Eclampsia; Pregnancy; Prem

2023
Obstetric and offspring outcomes in isolated maternal hypothyroxinaemia: a systematic review and meta-analysis.
    Journal of endocrinological investigation, 2023, Volume: 46, Issue:6

    Topics: Birth Weight; Diabetes, Gestational; Female; Humans; Infant, Newborn; Pre-Eclampsia; Pregnancy; Prem

2023
Obstetric and offspring outcomes in isolated maternal hypothyroxinaemia: a systematic review and meta-analysis.
    Journal of endocrinological investigation, 2023, Volume: 46, Issue:6

    Topics: Birth Weight; Diabetes, Gestational; Female; Humans; Infant, Newborn; Pre-Eclampsia; Pregnancy; Prem

2023
A Systematic Review and Meta-Analysis Examining the Risk of Adverse Pregnancy and Neonatal Outcomes in Women with Isolated Hypothyroxinemia in Pregnancy.
    Thyroid : official journal of the American Thyroid Association, 2023, Volume: 33, Issue:5

    Topics: Diabetes, Gestational; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Outcome; Premature Birt

2023
Effect of levothyroxine on the pregnancy outcomes in recurrent pregnancy loss women with subclinical hypothyroidism and thyroperoxidase antibody positivity: a systematic review and meta-analysis.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2023, Volume: 36, Issue:2

    Topics: Abortion, Habitual; Female; Humans; Hypothyroidism; Pregnancy; Pregnancy Outcome; Premature Birth; T

2023
Association of Thyroid Function Test Abnormalities and Thyroid Autoimmunity With Preterm Birth: A Systematic Review and Meta-analysis.
    JAMA, 2019, 08-20, Volume: 322, Issue:7

    Topics: Adult; Autoantibodies; Autoimmune Diseases; Female; Gestational Age; Humans; Hypothyroidism; Infant,

2019
[Effect of levothyroxine treatment on pregnancy outcomes in euthyroid women with thyroid autoantibody positive: a Meta-analysis].
    Zhonghua fu chan ke za zhi, 2021, Jan-25, Volume: 56, Issue:1

    Topics: Autoantibodies; China; Female; Humans; Hypothyroidism; Infant, Newborn; Pregnancy; Pregnancy Complic

2021
Impact of levothyroxine in women with positive thyroid antibodies on pregnancy outcomes: a systematic review and meta-analysis of randomised controlled trials.
    BMJ open, 2021, 02-23, Volume: 11, Issue:2

    Topics: Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complications; Premature Birth; Randomized Con

2021
Understanding the Pathogenesis of Gestational Hypothyroidism.
    Frontiers in endocrinology, 2021, Volume: 12

    Topics: Abortion, Spontaneous; Abruptio Placentae; Animals; Estrogens; Female; Fetal Death; Humans; Hypothyr

2021
Pregnancy Complications Associated With Maternal Hypothyroidism: A Systematic Review.
    Obstetrical & gynecological survey, 2018, Volume: 73, Issue:4

    Topics: Abortion, Spontaneous; Female; Fetal Death; Humans; Hypothyroidism; Infant, Newborn; Maternal-Fetal

2018
Effect of levothyroxine supplementation on pregnancy loss and preterm birth in women with subclinical hypothyroidism and thyroid autoimmunity: a systematic review and meta-analysis.
    Human reproduction update, 2019, 05-01, Volume: 25, Issue:3

    Topics: Abortion, Spontaneous; Autoantibodies; Autoimmunity; Dietary Supplements; Female; Humans; Hypothyroi

2019
Hypothyroidism in Pregnancy.
    Clinical obstetrics and gynecology, 2019, Volume: 62, Issue:2

    Topics: Abortion, Spontaneous; Antibodies; Clinical Trials as Topic; Female; Fetal Development; Humans; Hypo

2019
Interventions for clinical and subclinical hypothyroidism pre-pregnancy and during pregnancy.
    The Cochrane database of systematic reviews, 2013, May-31, Issue:5

    Topics: Abortion, Spontaneous; Female; Hormone Replacement Therapy; Humans; Hypothyroidism; Pre-Eclampsia; P

2013
The impact of maternal hypothyroidism during pregnancy on neonatal outcomes: a systematic review and meta-analysis.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2016, Volume: 32, Issue:1

    Topics: Birth Weight; Female; Fetal Macrosomia; Hormone Replacement Therapy; Humans; Hypothyroidism; Infant,

2016
Subclinical Hypothyroidism in Pregnancy: A Systematic Review and Meta-Analysis.
    Thyroid : official journal of the American Thyroid Association, 2016, Volume: 26, Issue:4

    Topics: Abortion, Spontaneous; Female; Humans; Hypothyroidism; Pregnancy; Pregnancy Complications; Pregnancy

2016
[Obstetrical complications of thyroid peroxidase antibody positive during pregnancy and effects of intervention: a meta-analysis].
    Zhonghua fu chan ke za zhi, 2016, Apr-25, Volume: 51, Issue:4

    Topics: Abortion, Spontaneous; Autoantibodies; China; Cohort Studies; Female; Humans; Iodide Peroxidase; Pre

2016
The Impact and Management of Subclinical Hypothyroidism for Improving Reproductive Outcomes such as Fertility and Miscarriage.
    Seminars in reproductive medicine, 2016, Volume: 34, Issue:6

    Topics: Abortion, Spontaneous; Biomarkers; Developmental Disabilities; Female; Fertility; Humans; Hypothyroi

2016
Interventions for clinical and subclinical hypothyroidism in pregnancy.
    The Cochrane database of systematic reviews, 2010, Jul-07, Issue:7

    Topics: Abortion, Spontaneous; Female; Hormone Replacement Therapy; Humans; Hypothyroidism; Pre-Eclampsia; P

2010
Association between thyroid autoantibodies and miscarriage and preterm birth: meta-analysis of evidence.
    BMJ (Clinical research ed.), 2011, May-09, Volume: 342

    Topics: Abortion, Spontaneous; Autoantibodies; Female; Humans; Maternal Age; Pregnancy; Pregnancy Outcome; P

2011
Thyroid disorders during pregnancy.
    The Medical clinics of North America, 2012, Volume: 96, Issue:2

    Topics: Abortion, Spontaneous; Diet; Female; Hormone Replacement Therapy; Humans; Hypothyroidism; Iodine; Ma

2012

Trials

2 trials available for thyroxine and Preterm Birth

ArticleYear
Association between Hypertensive Disorders of Pregnancy and Long-Term Neurodevelopmental Outcomes in the Offspring.
    American journal of perinatology, 2022, Volume: 39, Issue:9

    Topics: Female; Humans; Hypertension, Pregnancy-Induced; Infant, Newborn; Language Development Disorders; Pr

2022
Effects of Levothyroxine on Pregnant Women With Subclinical Hypothyroidism, Negative for Thyroid Peroxidase Antibodies.
    The Journal of clinical endocrinology and metabolism, 2018, 03-01, Volume: 103, Issue:3

    Topics: Adult; Autoantibodies; Autoantigens; Female; Gestational Age; Humans; Hypothyroidism; Infant, Newbor

2018

Other Studies

39 other studies available for thyroxine and Preterm Birth

ArticleYear
Effects of isolated maternal hypothyroxinemia on adverse pregnancy outcomes.
    Archives of gynecology and obstetrics, 2022, Volume: 305, Issue:4

    Topics: Female; Humans; Infant, Newborn; Iran; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Premat

2022
Neonatal outcomes and congenital anomalies in pregnancies affected by hypothyroidism.
    Annals of medicine, 2021, Volume: 53, Issue:1

    Topics: Adult; Birth Weight; Cesarean Section; Cross-Sectional Studies; Female; Fetal Distress; Humans; Hypo

2021
A Novel Nomogram for Predicting the Risk of Premature Delivery Based on the Thyroid Function in Pregnant Women.
    Frontiers in endocrinology, 2021, Volume: 12

    Topics: Adolescent; Adult; Autoantibodies; China; Clinical Decision Rules; Diabetes, Gestational; Female; Hu

2021
Hashimoto thyroiditis: an evidence-based guide to etiology, diagnosis and treatment.
    Polish archives of internal medicine, 2022, 03-30, Volume: 132, Issue:3

    Topics: Female; Hashimoto Disease; Humans; Hypothyroidism; Infant, Newborn; Male; Pregnancy; Premature Birth

2022
The targeted high-risk case-finding approach versus universal screening for thyroid dysfunction during pregnancy: thyroid-stimulating hormone (TSH) and/or thyroid peroxidase antibody (TPOAb) test?
    Journal of endocrinological investigation, 2022, Volume: 45, Issue:9

    Topics: Autoantibodies; Female; Humans; Hypothyroidism; Infant, Newborn; Iodide Peroxidase; Iran; Pregnancy;

2022
Euthyroid Thyroperoxidase Antibody Positivity during Pregnancy, to Treat or Not to Treat?
    Endocrinology and metabolism (Seoul, Korea), 2022, Volume: 37, Issue:3

    Topics: Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complications; Premature Birth; Thyroid Diseas

2022
Thyroid Function Rather Than Thyroid Antibodies Affects Pregnancy and Perinatal Outcomes: Results of a Prospective Study.
    The Journal of clinical endocrinology and metabolism, 2022, 11-23, Volume: 107, Issue:11

    Topics: Abortion, Spontaneous; Autoantibodies; Female; Humans; Infant, Newborn; Pregnancy; Premature Birth;

2022
Maternal subclinical hyperthyroidism and adverse pregnancy outcomes considering the iodine status: Tehran thyroid and pregnancy study.
    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2022, Volume: 74

    Topics: Female; Humans; Hyperthyroidism; Infant, Newborn; Iodide Peroxidase; Iodides; Iodine; Iran; Pregnanc

2022
Clinical features and outcomes of 31 children with congenital hypothyroidism missed by neonatal screening.
    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2022, 06-25, Volume: 51, Issue:3

    Topics: Child, Preschool; Congenital Hypothyroidism; Dual Oxidases; Female; Humans; Infant, Newborn; Neonata

2022
Association of maternal levothyroxine use during pregnancy with offspring birth and neurodevelopmental outcomes: a population-based cohort study.
    BMC medicine, 2022, 11-08, Volume: 20, Issue:1

    Topics: Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Cohort Studies; Female; Hum

2022
A Bayesian model to estimate the cutoff value of TSH for management of preterm birth.
    PloS one, 2023, Volume: 18, Issue:3

    Topics: Bayes Theorem; Female; Humans; Infant, Newborn; Iodide Peroxidase; Iodine; Iran; Pregnancy; Prematur

2023
Association between third trimester maternal isolated hypothyroxinemia and adverse pregnancy outcomes.
    Endocrine journal, 2023, Jun-28, Volume: 70, Issue:6

    Topics: Adult; Female; Fetal Distress; Humans; Infant, Newborn; Pregnancy; Pregnancy Complications; Pregnanc

2023
Effect of extra-low dose levothyroxine supplementation on pregnancy outcomes in women with subclinical hypothyroidism undergoing in vitro fertilization and embryo transfer.
    Taiwanese journal of obstetrics & gynecology, 2023, Volume: 62, Issue:6

    Topics: Abortion, Spontaneous; Adult; Dietary Supplements; Embryo Transfer; Female; Fertilization in Vitro;

2023
First-trimester placental function in levothyroxine-using pregnant women: a case-control study.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2020, Volume: 36, Issue:3

    Topics: Adolescent; Adult; Birth Weight; Case-Control Studies; Cesarean Section; Chorionic Gonadotropin, bet

2020
Hypothyroidism and pregnancy: still a controversial issue.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2020, Volume: 36, Issue:9

    Topics: Adult; Autoantibodies; Cohort Studies; Female; Hormone Replacement Therapy; Humans; Hypothyroidism;

2020
The Association Between Isolated Maternal Hypothyroxinemia in Early Pregnancy and Preterm Birth.
    Thyroid : official journal of the American Thyroid Association, 2020, Volume: 30, Issue:12

    Topics: Adult; Biomarkers; Case-Control Studies; Down-Regulation; Female; Gestational Age; Humans; Hypothyro

2020
Impact of maternal thyroid hormone in late pregnancy on adverse birth outcomes: A retrospective cohort study in China.
    Endocrine journal, 2021, Mar-28, Volume: 68, Issue:3

    Topics: Adult; China; Cohort Studies; Female; Fetal Macrosomia; Humans; Hyperthyroidism; Hyperthyroxinemia;

2021
Association of thyroid antibodies status on the outcomes of pregnant women with hypothyroidism (maternal hypothyroidism on pregnancy outcomes, MHPO-4).
    BMC pregnancy and childbirth, 2021, Feb-15, Volume: 21, Issue:1

    Topics: Abortion, Spontaneous; Abruptio Placentae; Adult; Apgar Score; Autoantibodies; Autoimmune Diseases;

2021
Thyroid hormone parameters during pregnancy in relation to urinary bisphenol A concentrations: A repeated measures study.
    Environment international, 2017, Volume: 104

    Topics: Adolescent; Adult; Benzhydryl Compounds; Case-Control Studies; Environmental Pollutants; Female; Hum

2017
Thyroid-stimulating hormone, anti-thyroid antibodies, and pregnancy outcomes.
    American journal of obstetrics and gynecology, 2017, Volume: 217, Issue:6

    Topics: Adult; Asymptomatic Diseases; Autoantibodies; Cohort Studies; Diabetes, Gestational; Female; Humans;

2017
Subclinical Changes in Maternal Thyroid Function Parameters in Pregnancy and Fetal Growth.
    The Journal of clinical endocrinology and metabolism, 2018, 04-01, Volume: 103, Issue:4

    Topics: Adolescent; Adult; Asymptomatic Diseases; Birth Weight; Case-Control Studies; Female; Fetal Developm

2018
Maternal and placental responses before preterm birth: adaptations to increase fetal thyroid hormone availability?
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2019, Volume: 32, Issue:16

    Topics: Adult; Case-Control Studies; Female; Humans; Hypothyroidism; Infant, Newborn; Male; Placenta; Pregna

2019
IMPORTANCE OF ISOLATED GESTATIONAL HYPOTHYROXINEMIA IN THE DEVELOPMENT OF OBSTETRIC AND SOMATIC PATHOLOGIES.
    Georgian medical news, 2018, Issue:278

    Topics: Abortion, Spontaneous; Adolescent; Adult; Alopecia; Case-Control Studies; Diabetes Mellitus; Female;

2018
Pregnancy and Perinatal Outcome Among Hypothyroid Mothers: A Population-Based Cohort Study.
    Thyroid : official journal of the American Thyroid Association, 2019, Volume: 29, Issue:1

    Topics: Adult; Cesarean Section; Diabetes, Gestational; Female; Humans; Hypertension, Pregnancy-Induced; Hyp

2019
Pregnancy outcomes in women with severe hypothyroidism.
    European journal of endocrinology, 2013, Volume: 169, Issue:3

    Topics: Abortion, Spontaneous; Adult; Female; Graves Disease; Hashimoto Disease; Hormone Replacement Therapy

2013
Hypothyroxinemia and TPO-antibody positivity are risk factors for premature delivery: the generation R study.
    The Journal of clinical endocrinology and metabolism, 2013, Volume: 98, Issue:11

    Topics: Adult; Autoantibodies; Female; Fetal Membranes, Premature Rupture; Humans; Hyperthyroidism; Hypothyr

2013
Is total thyroxine better than free thyroxine during pregnancy?
    American journal of obstetrics and gynecology, 2014, Volume: 211, Issue:2

    Topics: Abruptio Placentae; Adult; Female; Gestational Age; Humans; Hypothyroidism; Pregnancy; Pregnancy Com

2014
Maternal thyroid dysfunction during gestation, preterm delivery, and birthweight. The Infancia y Medio Ambiente Cohort, Spain.
    Paediatric and perinatal epidemiology, 2015, Volume: 29, Issue:2

    Topics: Adult; Birth Weight; Female; Gestational Age; Humans; Hypothyroidism; Infant, Newborn; Iodine; Mothe

2015
Thyroid function and autoimmunity in Danish pregnant women after an iodine fortification program and associations with obstetric outcomes.
    European journal of endocrinology, 2015, Volume: 173, Issue:6

    Topics: Adult; Autoantibodies; Autoimmunity; Cohort Studies; Denmark; Female; Food, Fortified; Gestational A

2015
[Effect of the treatment acceptance on the perinatal outcomes in women with subclinical hypothyroidism, positive thyroid gland peroxidase antibody in early pregnancy].
    Zhonghua fu chan ke za zhi, 2015, Volume: 50, Issue:9

    Topics: Abortion, Spontaneous; Autoantibodies; Case-Control Studies; Diabetes, Gestational; Female; Humans;

2015
Effects of Levothyroxine Therapy on Pregnancy Outcomes in Women with Subclinical Hypothyroidism.
    Thyroid : official journal of the American Thyroid Association, 2016, Volume: 26, Issue:7

    Topics: Abortion, Spontaneous; Adult; Apgar Score; Asymptomatic Diseases; Case-Control Studies; Diabetes, Ge

2016
Impact of Levothyroxine in Miscarriage and Preterm Delivery Rates in First Trimester Thyroid Antibody-Positive Women With TSH Less Than 2.5 mIU/L.
    The Journal of clinical endocrinology and metabolism, 2016, Volume: 101, Issue:10

    Topics: Abortion, Spontaneous; Adolescent; Adult; Autoantibodies; Autoantigens; Female; Humans; Iodide Perox

2016
Thyroid Autoimmunity Impairs the Thyroidal Response to Human Chorionic Gonadotropin: Two Population-Based Prospective Cohort Studies.
    The Journal of clinical endocrinology and metabolism, 2017, 01-01, Volume: 102, Issue:1

    Topics: Adult; Autoantibodies; Autoantigens; Autoimmunity; Chorionic Gonadotropin; Female; Follow-Up Studies

2017
Detection of circulating autoantibodies against thyroid hormones in an infant with permanent congenital hypothyroidism and her twin with transient congenital hypothyroidism: possible contribution of thyroid hormone autoantibodies to neonatal and infant hy
    Journal of pediatric endocrinology & metabolism : JPEM, 2008, Volume: 21, Issue:10

    Topics: Autoantibodies; Autoantigens; Body Height; Body Weight; Child, Preschool; Congenital Hypothyroidism;

2008
Thyroid function and autoantibody status among women who spontaneously deliver under 35 weeks of gestation.
    Clinical endocrinology, 2009, Volume: 71, Issue:6

    Topics: Adult; Autoantibodies; Case-Control Studies; Female; Humans; Iodide Peroxidase; Pregnancy; Pregnancy

2009
Visual abilities at 6 months in preterm infants: impact of thyroid hormone deficiency and neonatal medical morbidity.
    Thyroid : official journal of the American Thyroid Association, 2010, Volume: 20, Issue:3

    Topics: Analysis of Variance; Color Perception; Contrast Sensitivity; Female; Humans; Hypothyroidism; Infant

2010
Maternal thyroid function at 11-13 weeks of gestation and spontaneous preterm delivery.
    Obstetrics and gynecology, 2011, Volume: 117, Issue:2 Pt 1

    Topics: Adult; Antibodies; Female; Humans; Iodide Peroxidase; Pregnancy; Pregnancy Trimester, First; Prematu

2011
The natural history of the hyperthyrotropinemia of children born prematurely.
    Journal of endocrinological investigation, 2012, Volume: 35, Issue:3

    Topics: Adolescent; Autoantibodies; Autoantigens; Blood Glucose; Child; Child, Preschool; Congenital Hypothy

2012
Mild maternal thyroid dysfunction at delivery of infants born ≤34 weeks and neurodevelopmental outcome at 5.5 years.
    The Journal of clinical endocrinology and metabolism, 2012, Volume: 97, Issue:6

    Topics: Adult; Autoantibodies; Brain; Child Development; Child, Preschool; Cognition; Female; Follow-Up Stud

2012