Page last updated: 2024-11-07

thyroxine and Pregnancy in Diabetes

thyroxine has been researched along with Pregnancy in Diabetes in 22 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Research Excerpts

ExcerptRelevanceReference
"Our study aimed to describe levothyroxine prescription patterns and trends over time among pregnant women with subclinical hypothyroidism (SCH) in the United Kingdom."8.02Use of levothyroxine among pregnant women with subclinical hypothyroidism in the United Kingdom: A population-based assessment. ( Filion, KB; Grandi, SM; Platt, RW; Reynier, P; Yu, OHY; Yu, YH, 2021)
" During pregnancy, mildly elevated maternal free thyroxine levels less than 20% above the upper limit may not be harmful to unaffected fetuses."4.98Resistance to thyroid hormone β in autoimmune thyroid disease: a case report and review of literature. ( Guan, H; Guo, H; Guo, R; Li, Y; Shan, Z; Wu, D, 2018)
"Our study aimed to describe levothyroxine prescription patterns and trends over time among pregnant women with subclinical hypothyroidism (SCH) in the United Kingdom."4.02Use of levothyroxine among pregnant women with subclinical hypothyroidism in the United Kingdom: A population-based assessment. ( Filion, KB; Grandi, SM; Platt, RW; Reynier, P; Yu, OHY; Yu, YH, 2021)
" Free T4 (thyroxine), thyroid-stimulating hormone (TSH), TPO-Abs, and HbA1c were assayed before gestation; during the first, second, and third trimester of pregnancy; and 3 months postpartum."3.69Thyroid peroxidase autoantibodies predict poor metabolic control and need for thyroid treatment in pregnant IDDM women. ( Escobar-Jiménez, F; Fernandez-Soto, L; Gonzalez, A; Lobón, JA; Lopez, JA; Peterson, CM, 1997)
"There was a 73% less chance of gestational hypertension for thyroid autoimmune groups."1.62Association of thyroid antibodies status on the outcomes of pregnant women with hypothyroidism (maternal hypothyroidism on pregnancy outcomes, MHPO-4). ( Islam, N; Kiran, Z; Sheikh, A, 2021)
"In pregnant women with type 1 diabetes, we evaluated whether the presence of thyroid peroxidase autoantibodies (anti-TPO) was associated with changes in thyroid function, metabolic control and pregnancy outcome."1.35Thyroid peroxidase antibodies in pregnant women with type 1 diabetes: impact on thyroid function, metabolic control and pregnancy outcome. ( Damm, P; Mathiesen, ER; Nielsen, LR; Rasmussen, AK; Vestgaard, M, 2008)
"The health status of a woman with type 1 diabetes was followed during pregnancy in a maternity hospital."1.35[No thyroxin dose seemed sufficient--why?]. ( Fanta, S; Laitinen, K; Sane, T, 2009)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19909 (40.91)18.7374
1990's3 (13.64)18.2507
2000's4 (18.18)29.6817
2010's4 (18.18)24.3611
2020's2 (9.09)2.80

Authors

AuthorsStudies
Kiran, Z1
Sheikh, A1
Islam, N1
Yu, YH1
Filion, KB1
Reynier, P1
Platt, RW1
Yu, OHY1
Grandi, SM1
Wu, D1
Guo, R1
Guo, H1
Li, Y1
Guan, H1
Shan, Z1
Benhalima, K1
Van Crombrugge, P1
Verhaeghe, J1
Vandeginste, S1
Verlaenen, H1
Vercammen, C1
Dufraimont, E1
De Block, C1
Jacquemyn, Y1
Mekahli, F1
De Clippel, K1
Devlieger, R1
Mathieu, C1
Vestgaard, M1
Nielsen, LR1
Rasmussen, AK1
Damm, P1
Mathiesen, ER1
Laitinen, K1
Sane, T1
Fanta, S1
Kini, U1
Hurst, JA1
Byren, JC1
Wall, SA1
Johnson, D1
Wilkie, AO1
Velkoska Nakova, V1
Krstevska, B1
Dimitrovski, Ch1
Simeonova, S1
Hadzi-Lega, M1
Serafimoski, V1
Jaber, SM1
Gossain, VV1
Rovner, DR1
Rhodes, CE1
Wilker, RE1
Fleischman, AR1
Saenger, P1
Pan, C1
Surks, MI1
Dudkiewicz, J1
Oslislo, A1
Calvo, R1
Morreale de Escobar, G1
Escobar del Rey, F1
Obregón, MJ1
Fernandez-Soto, L1
Gonzalez, A1
Lobón, JA1
Lopez, JA1
Peterson, CM2
Escobar-Jiménez, F1
Müller, T1
Rehn, M1
Girschick, G1
Kristen, P1
Dietl, J1
Gross, I1
Jovanovic-Peterson, L1
Saltzman, DH1
Barbieri, RL1
Frigoletto, FD1
Pisarek-Miedzińska, D1
Janczewska, E1
Czech, W1
van Riet, HG1
Kal, J1
Haspels, AA1
Wilber, JF1
Samaan, N1
Yen, SC1
Gonzalez, D1
Pearson, OH1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Prospective and Multi-centric Study on Diabetes During Pregnancy in Belgium[NCT02036619]2,006 participants (Actual)Observational2014-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for thyroxine and Pregnancy in Diabetes

ArticleYear
Resistance to thyroid hormone β in autoimmune thyroid disease: a case report and review of literature.
    BMC pregnancy and childbirth, 2018, Dec-03, Volume: 18, Issue:1

    Topics: Adult; Diabetes Mellitus, Type 2; Female; Hashimoto Disease; Humans; Hypothyroidism; Mutation; Postp

2018
[Diabetes and pregnancy].
    Nederlands tijdschrift voor geneeskunde, 1974, Jan-26, Volume: 118, Issue:4

    Topics: Abortion, Spontaneous; Congenital Abnormalities; Estrogens; Female; Fetal Death; Growth Hormone; Hum

1974
Alterations of endocrine function in pregnancy.
    The Medical clinics of North America, 1968, Volume: 52, Issue:2

    Topics: Blood Glucose; Carbohydrate Metabolism; Chorionic Gonadotropin; Endocrine Glands; Estrogens; Female;

1968

Trials

1 trial available for thyroxine and Pregnancy in Diabetes

ArticleYear
The effect of intraamniotically administered L-thyroxin on pulmonary efficacy of newborns delivered prematurely.
    Zentralblatt fur Gynakologie, 1995, Volume: 117, Issue:3

    Topics: Adolescent; Adult; Amnion; Cause of Death; Diabetes Mellitus, Type 1; Female; Fetal Organ Maturity;

1995

Other Studies

18 other studies available for thyroxine and Pregnancy in Diabetes

ArticleYear
Association of thyroid antibodies status on the outcomes of pregnant women with hypothyroidism (maternal hypothyroidism on pregnancy outcomes, MHPO-4).
    BMC pregnancy and childbirth, 2021, Feb-15, Volume: 21, Issue:1

    Topics: Abortion, Spontaneous; Abruptio Placentae; Adult; Apgar Score; Autoantibodies; Autoimmune Diseases;

2021
Use of levothyroxine among pregnant women with subclinical hypothyroidism in the United Kingdom: A population-based assessment.
    Pharmacology research & perspectives, 2021, Volume: 9, Issue:5

    Topics: Adult; Asymptomatic Diseases; Diabetes Mellitus; Female; Humans; Hypothyroidism; Infertility, Female

2021
The Belgian Diabetes in Pregnancy Study (BEDIP-N), a multi-centric prospective cohort study on screening for diabetes in pregnancy and gestational diabetes: methodology and design.
    BMC pregnancy and childbirth, 2014, Jul-11, Volume: 14

    Topics: Adolescent; Adult; Belgium; Blood Glucose; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female;

2014
Thyroid peroxidase antibodies in pregnant women with type 1 diabetes: impact on thyroid function, metabolic control and pregnancy outcome.
    Acta obstetricia et gynecologica Scandinavica, 2008, Volume: 87, Issue:12

    Topics: Adult; Autoantibodies; Blood Glucose; Diabetes Mellitus, Type 1; Female; Glycated Hemoglobin; Humans

2008
[No thyroxin dose seemed sufficient--why?].
    Duodecim; laaketieteellinen aikakauskirja, 2009, Volume: 125, Issue:13

    Topics: Adult; Diabetes Mellitus, Type 1; Female; Humans; Pregnancy; Pregnancy in Diabetics; Proteinuria; Th

2009
Etiological heterogeneity and clinical characteristics of metopic synostosis: Evidence from a tertiary craniofacial unit.
    American journal of medical genetics. Part A, 2010, Volume: 152A, Issue:6

    Topics: Adolescent; Anticoagulants; Child; Child, Preschool; Chromosome Aberrations; Craniosynostoses; Enoxa

2010
Prevalence of thyroid dysfunction and autoimmunity in pregnant women with gestational diabetes and diabetes type 1.
    Prilozi, 2010, Volume: 31, Issue:2

    Topics: Adult; Diabetes Mellitus, Type 1; Diabetes, Gestational; Female; Humans; Pregnancy; Pregnancy in Dia

2010
Metabolic hormones profile in 2 weeks old healthy infants of diabetic mothers.
    Saudi medical journal, 2006, Volume: 27, Issue:9

    Topics: Anthropometry; Blood Glucose; Diabetes, Gestational; Female; Humans; Hydrocortisone; Infant, Newborn

2006
Recurrent transient hyperthyroidism and hypothyroidism associated with pregnancy.
    Southern medical journal, 1983, Volume: 76, Issue:6

    Topics: Adult; Autoantibodies; Autoimmune Diseases; Female; Humans; Hyperthyroidism; Hypothyroidism; Insulin

1983
Thyroid hormone levels in diabetic mothers and their neonates.
    American journal of perinatology, 1984, Volume: 1, Issue:3

    Topics: Adult; Female; Fetal Blood; Humans; Infant, Newborn; Pregnancy; Pregnancy in Diabetics; Thyroid Horm

1984
Maternal diabetes mellitus, a rat model for nonthyroidal illness: correction of hypothyroxinemia with thyroxine treatment does not improve fetal thyroid hormone status.
    Thyroid : official journal of the American Thyroid Association, 1997, Volume: 7, Issue:1

    Topics: Animals; Brain Chemistry; Diabetes Mellitus, Experimental; Female; Fetus; Hypothyroidism; Iodide Per

1997
Thyroid peroxidase autoantibodies predict poor metabolic control and need for thyroid treatment in pregnant IDDM women.
    Diabetes care, 1997, Volume: 20, Issue:10

    Topics: Adult; Autoantibodies; Blood Glucose; Female; Glycated Hemoglobin; Humans; Hypothyroidism; Iodide Pe

1997
Normalisation of a severely abnormal ductus venosus Doppler flow velocity waveform in a growth-retarded fetus with absent end-diastolic flow in the umbilical artery and congenital anomalies.
    Journal of perinatal medicine, 2001, Volume: 29, Issue:2

    Topics: Adult; Blood Flow Velocity; Congenital Abnormalities; Diabetes Mellitus, Type 1; Diastole; Fatal Out

2001
The hormonal regulation of fetal lung maturation.
    Clinics in perinatology, 1979, Volume: 6, Issue:2

    Topics: Adrenal Cortex Hormones; Aminophylline; Animals; Caffeine; Cyclic AMP; Estrogens; Female; Fetus; Hor

1979
De novo clinical hypothyroidism in pregnancies complicated by type I diabetes, subclinical hypothyroidism, and proteinuria: a new syndrome.
    American journal of obstetrics and gynecology, 1988, Volume: 159, Issue:2

    Topics: Adult; Diabetes Mellitus, Type 1; Female; Humans; Hypothyroidism; Insulin; Pregnancy; Pregnancy Comp

1988
Decreased fetal cord prolactin concentration in diabetic pregnancies.
    American journal of obstetrics and gynecology, 1986, Volume: 154, Issue:5

    Topics: Amniotic Fluid; Estradiol; Estrone; Female; Fetal Blood; Fetal Organ Maturity; Humans; Infant, Newbo

1986
[Thyroid function tests: erythrocytes (ET3) and resin (WZ-T3), thyroxine iodine and the free thyroxine index in pregnant women with diabetes mellitus, treated with insulin].
    Ginekologia polska, 1974, Volume: 45, Issue:10

    Topics: Adolescent; Adult; Diabetes Mellitus; Erythrocytes; Female; Humans; Insulin; Pregnancy; Pregnancy in

1974
Metabolic effects of placental lactogen (HPL) in man.
    The Journal of clinical endocrinology and metabolism, 1968, Volume: 28, Issue:4

    Topics: Adult; Aged; Blood Glucose; Cortisone; Diabetes Mellitus; Electrolytes; Female; Glucose Tolerance Te

1968