thyroxine has been researched along with Porphyrias in 8 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
Porphyrias: A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The role of thyroid status in hexachlorobenzene (HBC) induced porphyria was studied in normal, thyroidectomized and thyroxine (T4) treated rats." | 7.69 | Effect of thyroidectomy and thyroxine on hexachlorobenzene induced porphyria. ( Ferramola de Sancovich, AM; Kleiman de Pisarev, DL; Sancovich, HA; Sopena de Kracoff, YE, 1994) |
| "The effects of hexachlorobenzene (HCB) administration on the development of porphyria and on changes in thyroid function and thyroid hormone metabolism were examined." | 7.68 | Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria. ( Kleiman de Pisarev, DL; Rios de Molina, MC; San Martin de Viale, LC, 1990) |
| "1% hexachlorobenzene (HCB) for 55 days on mortality, body weight, urinary porphyrin excretion, serum thyroid hormones and induction of liver microsomal enzymes was studied in female Sprague-Dawley rats." | 7.67 | Reduced serum thyroid hormone levels in hexachlorobenzene-induced porphyria. ( Gorski, JR; Parkinson, A; Rozman, K; Rozman, P, 1986) |
| "The role of thyroid status in hexachlorobenzene (HBC) induced porphyria was studied in normal, thyroidectomized and thyroxine (T4) treated rats." | 3.69 | Effect of thyroidectomy and thyroxine on hexachlorobenzene induced porphyria. ( Ferramola de Sancovich, AM; Kleiman de Pisarev, DL; Sancovich, HA; Sopena de Kracoff, YE, 1994) |
| "The effects of hexachlorobenzene (HCB) administration on the development of porphyria and on changes in thyroid function and thyroid hormone metabolism were examined." | 3.68 | Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria. ( Kleiman de Pisarev, DL; Rios de Molina, MC; San Martin de Viale, LC, 1990) |
| " Here, we report a case of acute intermittent porphyria with attacks of abdominal pain, an elevated serum thyroxine level, and hypercholesterolemia with an increased level of high-density lipoprotein-cholesterol concentration." | 3.67 | Abnormal thyroid function and hypercholesterolemia in a case of acute intermittent porphyria. ( Hsiao, KJ; Lee, FY; Lee, SD; Shiue, JW; Tsai, YT; Wu, SJ, 1989) |
| "1% hexachlorobenzene (HCB) for 55 days on mortality, body weight, urinary porphyrin excretion, serum thyroid hormones and induction of liver microsomal enzymes was studied in female Sprague-Dawley rats." | 3.67 | Reduced serum thyroid hormone levels in hexachlorobenzene-induced porphyria. ( Gorski, JR; Parkinson, A; Rozman, K; Rozman, P, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (75.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| GROGG, E | 1 |
| HELLMAN, ES | 1 |
| TSCHUDY, DP | 1 |
| ROBBINS, J | 1 |
| RALL, JE | 1 |
| Sopena de Kracoff, YE | 1 |
| Ferramola de Sancovich, AM | 1 |
| Sancovich, HA | 1 |
| Kleiman de Pisarev, DL | 2 |
| Brodie, MJ | 2 |
| Goldberg, A | 2 |
| Beastall, GH | 2 |
| Yeo, PP | 2 |
| Ratcliffe, JG | 2 |
| Graham, DJ | 1 |
| Ratcliffe, WA | 1 |
| Rios de Molina, MC | 1 |
| San Martin de Viale, LC | 1 |
| Shiue, JW | 1 |
| Lee, FY | 1 |
| Hsiao, KJ | 1 |
| Tsai, YT | 1 |
| Lee, SD | 1 |
| Wu, SJ | 1 |
| Rozman, K | 1 |
| Gorski, JR | 1 |
| Rozman, P | 1 |
| Parkinson, A | 1 |
8 other studies available for thyroxine and Porphyrias
| Article | Year |
|---|---|
[On the drug modification of experimental porphyria in rabbits].
Topics: Animals; Ascorbic Acid; Chloroquine; Lagomorpha; Porphyrias; Rabbits; Thyroxine; Vitamins | 1960 |
ELEVATION OF THE SERUM PROTEIN-BOUND IODINE IN ACUTE INTERMITTENT PORPHYRIA.
Topics: Alkaline Phosphatase; Aspartate Aminotransferases; Basal Metabolism; Cholesterol; Chromatography; Er | 1963 |
Effect of thyroidectomy and thyroxine on hexachlorobenzene induced porphyria.
Topics: Animals; Carboxy-Lyases; Female; Hexachlorobenzene; Porphyrias; Rats; Rats, Wistar; Thyroidectomy; T | 1994 |
Abnormal thyroid function in symptomatic acute intermittent porphyria [proceedings].
Topics: Female; Humans; Hyperthyroidism; Porphyrias; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine | 1977 |
Thyroid function in acute intermittent porphyria: a neurogenic cause of hyperthyroidism?
Topics: Adult; Female; Humans; Hyperthyroidism; Male; Porphyrias; Pregnancy; Thyroid Gland; Thyroxine; Triio | 1978 |
Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria.
Topics: 5-Aminolevulinate Synthetase; Animals; Body Weight; Chlorobenzenes; Dose-Response Relationship, Drug | 1990 |
Abnormal thyroid function and hypercholesterolemia in a case of acute intermittent porphyria.
Topics: Acute Disease; Adult; Female; Humans; Hypercholesterolemia; Liver Diseases; Porphyrias; Thyroid Glan | 1989 |
Reduced serum thyroid hormone levels in hexachlorobenzene-induced porphyria.
Topics: Administration, Oral; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Chlorobenzenes; | 1986 |