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thyroxine and Porphyrias

thyroxine has been researched along with Porphyrias in 8 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Porphyrias: A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.

Research Excerpts

ExcerptRelevanceReference
"The role of thyroid status in hexachlorobenzene (HBC) induced porphyria was studied in normal, thyroidectomized and thyroxine (T4) treated rats."7.69Effect of thyroidectomy and thyroxine on hexachlorobenzene induced porphyria. ( Ferramola de Sancovich, AM; Kleiman de Pisarev, DL; Sancovich, HA; Sopena de Kracoff, YE, 1994)
"The effects of hexachlorobenzene (HCB) administration on the development of porphyria and on changes in thyroid function and thyroid hormone metabolism were examined."7.68Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria. ( Kleiman de Pisarev, DL; Rios de Molina, MC; San Martin de Viale, LC, 1990)
"1% hexachlorobenzene (HCB) for 55 days on mortality, body weight, urinary porphyrin excretion, serum thyroid hormones and induction of liver microsomal enzymes was studied in female Sprague-Dawley rats."7.67Reduced serum thyroid hormone levels in hexachlorobenzene-induced porphyria. ( Gorski, JR; Parkinson, A; Rozman, K; Rozman, P, 1986)
"The role of thyroid status in hexachlorobenzene (HBC) induced porphyria was studied in normal, thyroidectomized and thyroxine (T4) treated rats."3.69Effect of thyroidectomy and thyroxine on hexachlorobenzene induced porphyria. ( Ferramola de Sancovich, AM; Kleiman de Pisarev, DL; Sancovich, HA; Sopena de Kracoff, YE, 1994)
"The effects of hexachlorobenzene (HCB) administration on the development of porphyria and on changes in thyroid function and thyroid hormone metabolism were examined."3.68Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria. ( Kleiman de Pisarev, DL; Rios de Molina, MC; San Martin de Viale, LC, 1990)
" Here, we report a case of acute intermittent porphyria with attacks of abdominal pain, an elevated serum thyroxine level, and hypercholesterolemia with an increased level of high-density lipoprotein-cholesterol concentration."3.67Abnormal thyroid function and hypercholesterolemia in a case of acute intermittent porphyria. ( Hsiao, KJ; Lee, FY; Lee, SD; Shiue, JW; Tsai, YT; Wu, SJ, 1989)
"1% hexachlorobenzene (HCB) for 55 days on mortality, body weight, urinary porphyrin excretion, serum thyroid hormones and induction of liver microsomal enzymes was studied in female Sprague-Dawley rats."3.67Reduced serum thyroid hormone levels in hexachlorobenzene-induced porphyria. ( Gorski, JR; Parkinson, A; Rozman, K; Rozman, P, 1986)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19906 (75.00)18.7374
1990's2 (25.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
GROGG, E1
HELLMAN, ES1
TSCHUDY, DP1
ROBBINS, J1
RALL, JE1
Sopena de Kracoff, YE1
Ferramola de Sancovich, AM1
Sancovich, HA1
Kleiman de Pisarev, DL2
Brodie, MJ2
Goldberg, A2
Beastall, GH2
Yeo, PP2
Ratcliffe, JG2
Graham, DJ1
Ratcliffe, WA1
Rios de Molina, MC1
San Martin de Viale, LC1
Shiue, JW1
Lee, FY1
Hsiao, KJ1
Tsai, YT1
Lee, SD1
Wu, SJ1
Rozman, K1
Gorski, JR1
Rozman, P1
Parkinson, A1

Other Studies

8 other studies available for thyroxine and Porphyrias

ArticleYear
[On the drug modification of experimental porphyria in rabbits].
    Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften, 1960, Volume: 16

    Topics: Animals; Ascorbic Acid; Chloroquine; Lagomorpha; Porphyrias; Rabbits; Thyroxine; Vitamins

1960
ELEVATION OF THE SERUM PROTEIN-BOUND IODINE IN ACUTE INTERMITTENT PORPHYRIA.
    The Journal of clinical endocrinology and metabolism, 1963, Volume: 23

    Topics: Alkaline Phosphatase; Aspartate Aminotransferases; Basal Metabolism; Cholesterol; Chromatography; Er

1963
Effect of thyroidectomy and thyroxine on hexachlorobenzene induced porphyria.
    Journal of endocrinological investigation, 1994, Volume: 17, Issue:5

    Topics: Animals; Carboxy-Lyases; Female; Hexachlorobenzene; Porphyrias; Rats; Rats, Wistar; Thyroidectomy; T

1994
Abnormal thyroid function in symptomatic acute intermittent porphyria [proceedings].
    The Journal of endocrinology, 1977, Volume: 75, Issue:3

    Topics: Female; Humans; Hyperthyroidism; Porphyrias; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine

1977
Thyroid function in acute intermittent porphyria: a neurogenic cause of hyperthyroidism?
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1978, Volume: 10, Issue:4

    Topics: Adult; Female; Humans; Hyperthyroidism; Male; Porphyrias; Pregnancy; Thyroid Gland; Thyroxine; Triio

1978
Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria.
    Biochemical pharmacology, 1990, Mar-01, Volume: 39, Issue:5

    Topics: 5-Aminolevulinate Synthetase; Animals; Body Weight; Chlorobenzenes; Dose-Response Relationship, Drug

1990
Abnormal thyroid function and hypercholesterolemia in a case of acute intermittent porphyria.
    Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association, 1989, Volume: 88, Issue:7

    Topics: Acute Disease; Adult; Female; Humans; Hypercholesterolemia; Liver Diseases; Porphyrias; Thyroid Glan

1989
Reduced serum thyroid hormone levels in hexachlorobenzene-induced porphyria.
    Toxicology letters, 1986, Volume: 30, Issue:1

    Topics: Administration, Oral; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Chlorobenzenes;

1986