Page last updated: 2024-11-07

thyroxine and Polycystic Ovarian Syndrome

thyroxine has been researched along with Polycystic Ovarian Syndrome in 29 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Research Excerpts

ExcerptRelevanceReference
"Thirty-three patients with PCOS were specifically selected for being either treated with levothyroxine for a previous diagnosis of hypothyroidism (n = 7), untreated subclinically hypothyroid (n = 2) or euthyroid without levothyroxine treatment (n = 24) before the starting of metformin."9.15Thyroidal effect of metformin treatment in patients with polycystic ovary syndrome. ( Botta, R; Cappelli, C; Castellano, M; Chiovato, L; De Cata, P; Dionisio, R; Iacobello, C; Magri, F; Nappi, RE; Rotondi, M, 2011)
"The objective of the present study was to investigate the effect of melatonin and L-thyroxine (T4) on the expression of various receptors, and some metabolic, reproductive, and gonadotropic hormones in letrozole-induced polycystic ovary syndrome (PCOS) in rats."8.12Differential expression and interaction of melatonin and thyroid hormone receptors with estrogen receptor α improve ovarian functions in letrozole-induced rat polycystic ovary syndrome. ( Brown, GM; Cardinali, DP; Ghosh, H; Manzar, MD; Pandi-Perumal, SR; Rai, S; Reiter, RJ, 2022)
"This observational, retrospective study utilized EHR data from 52 hospitals for COVID-19 patients with PCOS or prediabetes treated with metformin or levothyroxine/ondansetron (controls)."8.12Metformin is associated with reduced COVID-19 severity in patients with prediabetes. ( Antony, B; Blau, H; Bramante, C; Casiraghi, E; Chan, LE; Coleman, B; Gargano, M; Haendel, M; Harris, NL; Laraway, B; Reese, J; Robinson, PN; Sahner, D; Valentini, G; Wilkins, K; Zaman, A, 2022)
"Our study aimed to describe levothyroxine prescription patterns and trends over time among pregnant women with subclinical hypothyroidism (SCH) in the United Kingdom."8.02Use of levothyroxine among pregnant women with subclinical hypothyroidism in the United Kingdom: A population-based assessment. ( Filion, KB; Grandi, SM; Platt, RW; Reynier, P; Yu, OHY; Yu, YH, 2021)
"Our aim was to determine whether serum leptin level is regulated by thyroid hormones, lipid metabolic products and insulin resistance status in women with polycystic ovary syndrome (PCOS)."7.72Is serum leptin level regulated by thyroid functions, lipid metabolism and insulin resistance in polycystic ovary syndrome? ( Baysal, B; Erel, CT; Gezer, A; Kaleli, S; Senturk, LM; Tasan, E, 2003)
"The purpose of this study was to determine whether polycystic ovary syndrome (PCOS) and nonclassic 21-hydroxylase deficiency (CAH) are related to hyperhomocysteinemia, and to investigate if there is a correlation between homocysteine levels and insulin sensitivity in women with PCOS and CAH."7.72Plasma homocysteine levels in polycystic ovary syndrome and congenital adrenal hyperplasia. ( Bayraktar, F; Dereli, D; Ozgen, AG; Yilmaz, C, 2004)
"Thirty-three patients with PCOS were specifically selected for being either treated with levothyroxine for a previous diagnosis of hypothyroidism (n = 7), untreated subclinically hypothyroid (n = 2) or euthyroid without levothyroxine treatment (n = 24) before the starting of metformin."5.15Thyroidal effect of metformin treatment in patients with polycystic ovary syndrome. ( Botta, R; Cappelli, C; Castellano, M; Chiovato, L; De Cata, P; Dionisio, R; Iacobello, C; Magri, F; Nappi, RE; Rotondi, M, 2011)
"The objective of the present study was to investigate the effect of melatonin and L-thyroxine (T4) on the expression of various receptors, and some metabolic, reproductive, and gonadotropic hormones in letrozole-induced polycystic ovary syndrome (PCOS) in rats."4.12Differential expression and interaction of melatonin and thyroid hormone receptors with estrogen receptor α improve ovarian functions in letrozole-induced rat polycystic ovary syndrome. ( Brown, GM; Cardinali, DP; Ghosh, H; Manzar, MD; Pandi-Perumal, SR; Rai, S; Reiter, RJ, 2022)
"This observational, retrospective study utilized EHR data from 52 hospitals for COVID-19 patients with PCOS or prediabetes treated with metformin or levothyroxine/ondansetron (controls)."4.12Metformin is associated with reduced COVID-19 severity in patients with prediabetes. ( Antony, B; Blau, H; Bramante, C; Casiraghi, E; Chan, LE; Coleman, B; Gargano, M; Haendel, M; Harris, NL; Laraway, B; Reese, J; Robinson, PN; Sahner, D; Valentini, G; Wilkins, K; Zaman, A, 2022)
"Our study aimed to describe levothyroxine prescription patterns and trends over time among pregnant women with subclinical hypothyroidism (SCH) in the United Kingdom."4.02Use of levothyroxine among pregnant women with subclinical hypothyroidism in the United Kingdom: A population-based assessment. ( Filion, KB; Grandi, SM; Platt, RW; Reynier, P; Yu, OHY; Yu, YH, 2021)
"To describe 2 cases of primary hypothyroidism, precocious puberty, large multicystic ovaries, possible diagnostic dilemma, unilateral oophorectomies, and subsequent response to levothyroxine replacement therapy."3.74Precocious puberty and large multicystic ovaries in young girls with primary hypothyroidism. ( Deepak, T; Sanjay, S; Sanjeevaiah, AR; Sharada, A; Srikanta, SS, 2007)
"Our aim was to determine whether serum leptin level is regulated by thyroid hormones, lipid metabolic products and insulin resistance status in women with polycystic ovary syndrome (PCOS)."3.72Is serum leptin level regulated by thyroid functions, lipid metabolism and insulin resistance in polycystic ovary syndrome? ( Baysal, B; Erel, CT; Gezer, A; Kaleli, S; Senturk, LM; Tasan, E, 2003)
"The purpose of this study was to determine whether polycystic ovary syndrome (PCOS) and nonclassic 21-hydroxylase deficiency (CAH) are related to hyperhomocysteinemia, and to investigate if there is a correlation between homocysteine levels and insulin sensitivity in women with PCOS and CAH."3.72Plasma homocysteine levels in polycystic ovary syndrome and congenital adrenal hyperplasia. ( Bayraktar, F; Dereli, D; Ozgen, AG; Yilmaz, C, 2004)
"Thus, autoimmune thyroiditis (AIT) could be more prevalent among women with PCOS."1.42Polycystic ovary syndrome and chronic autoimmune thyroiditis. ( Benetti-Pinto, CL; Garmes, HM; Jales, RM; Juliato, CR; Novais, Jde S, 2015)
" No correlation was found between duration or dosage of treatment and BMI-SDS, height-SDS, or androgen level."1.34Endocrine effects of valproate in adolescent girls with epilepsy. ( de Vries, L; Goldberg-Stern, H; Karasik, A; Kiviti, S; Landau, Z; Phillip, M, 2007)
"During a 30 months period, two women of primary hypothyroidism (2/13; 1."1.29Hypothyroidism presenting with polycystic ovary syndrome. ( Nagamani, G; Sridhar, GR, 1993)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19905 (17.24)18.7374
1990's3 (10.34)18.2507
2000's8 (27.59)29.6817
2010's9 (31.03)24.3611
2020's4 (13.79)2.80

Authors

AuthorsStudies
Ghosh, H1
Rai, S1
Manzar, MD1
Pandi-Perumal, SR1
Brown, GM1
Reiter, RJ1
Cardinali, DP1
Chan, LE3
Casiraghi, E3
Laraway, B3
Coleman, B3
Blau, H3
Zaman, A3
Harris, NL3
Wilkins, K3
Antony, B3
Gargano, M3
Valentini, G3
Sahner, D3
Haendel, M3
Robinson, PN3
Bramante, C3
Reese, J3
Riaz, M1
Ibrahim, MN1
Laghari, TM1
Hanif, MI1
Raza, J1
Yu, YH1
Filion, KB1
Reynier, P1
Platt, RW1
Yu, OHY1
Grandi, SM1
Kim, SH1
Liu, M1
Jin, HS1
Park, S1
Grolmusz, VK1
Stenczer, B1
Fekete, T1
Szendei, G1
Patócs, A1
Rácz, K1
Reismann, P1
Novais, Jde S1
Benetti-Pinto, CL1
Garmes, HM1
Jales, RM1
Juliato, CR1
Calvar, CE1
Bengolea, SV1
Deutsch, SI1
Hermes, R1
Ramos, G1
Loyato, M1
Muscogiuri, G1
Palomba, S1
Caggiano, M1
Tafuri, D1
Colao, A1
Orio, F1
Yin, D1
Ruan, X1
Tian, X1
Du, J1
Zhao, Y1
Cui, Y1
Li, Y1
Mueck, AO1
Rotondi, M1
Cappelli, C1
Magri, F1
Botta, R1
Dionisio, R1
Iacobello, C1
De Cata, P1
Nappi, RE1
Castellano, M1
Chiovato, L1
Petríková, J1
Figurová, J1
Dravecká, I1
Lazúrová, I1
Zou, S1
Sang, Q1
Wang, H1
Feng, R1
Li, Q1
Zhao, X1
Xing, Q1
Jin, L1
He, L1
Wang, L1
Erel, CT1
Senturk, LM1
Kaleli, S1
Gezer, A1
Baysal, B1
Tasan, E1
Chattopadhyay, A1
Kumar, V1
Marulaiah, M1
Bayraktar, F1
Dereli, D1
Ozgen, AG1
Yilmaz, C1
de Vries, L1
Karasik, A1
Landau, Z1
Phillip, M1
Kiviti, S1
Goldberg-Stern, H1
Mohsin, F1
Nahar, N1
Azad, K1
Nahar, J1
Sanjeevaiah, AR1
Sanjay, S1
Deepak, T1
Sharada, A1
Srikanta, SS1
Puleo, JG1
Ory, SJ1
Sridhar, GR1
Nagamani, G1
Geary, M1
Hindmarsh, PC1
Eagleson, CA1
Gingrich, MB1
Pastor, CL1
Arora, TK1
Burt, CM1
Evans, WS1
Marshall, JC1
Dhanwal, D1
Tandon, N1
Andersen, RN1
Givens, JR1
Wiser, WL1
Umstot, ES1
Malarkey, WB1
Beck, P1
Marsh, M1
Burger, HG1
Akopian, SS1
Mirimanova, RP1
Kazarian, LS1
Benjamin, F1
Deutsch, S1
Saperstein, H1
Seltzer, VL1

Reviews

2 reviews available for thyroxine and Polycystic Ovarian Syndrome

ArticleYear
Childhood influences on adult disease.
    Hospital medicine (London, England : 1998), 1998, Volume: 59, Issue:4

    Topics: Adult; Age Factors; Antineoplastic Agents; Asthma; Child; Congenital Hypothyroidism; Diabetes Mellit

1998
Update on endocrinology.
    Australian family physician, 1992, Volume: 21, Issue:4

    Topics: Calcitonin; Diphosphonates; Female; Humans; Osteitis Deformans; Polycystic Ovary Syndrome; Thyroid F

1992

Trials

3 trials available for thyroxine and Polycystic Ovarian Syndrome

ArticleYear
Lack of association between C385A functional polymorphism of the fatty acid amide hydrolase gene and polycystic ovary syndrome.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2013, Volume: 121, Issue:6

    Topics: Adult; Alleles; Amidohydrolases; DNA Mutational Analysis; Female; Gene Frequency; Humans; Insulin; P

2013
Thyroidal effect of metformin treatment in patients with polycystic ovary syndrome.
    Clinical endocrinology, 2011, Volume: 75, Issue:3

    Topics: Adult; Female; Humans; Hypoglycemic Agents; Hypothyroidism; Metformin; Polycystic Ovary Syndrome; Th

2011
Polycystic ovarian syndrome: evidence that flutamide restores sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone.
    The Journal of clinical endocrinology and metabolism, 2000, Volume: 85, Issue:11

    Topics: 17-alpha-Hydroxyprogesterone; Activity Cycles; Adult; Androgen Antagonists; Body Mass Index; Dehydro

2000

Other Studies

24 other studies available for thyroxine and Polycystic Ovarian Syndrome

ArticleYear
Differential expression and interaction of melatonin and thyroid hormone receptors with estrogen receptor α improve ovarian functions in letrozole-induced rat polycystic ovary syndrome.
    Life sciences, 2022, Apr-15, Volume: 295

    Topics: Animals; Disease Models, Animal; Estrogen Receptor alpha; Female; Gene Expression; Gene Expression R

2022
Metformin is associated with reduced COVID-19 severity in patients with prediabetes.
    Diabetes research and clinical practice, 2022, Volume: 194

    Topics: COVID-19; Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Prediabetic Sta

2022
Metformin is associated with reduced COVID-19 severity in patients with prediabetes.
    Diabetes research and clinical practice, 2022, Volume: 194

    Topics: COVID-19; Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Prediabetic Sta

2022
Metformin is associated with reduced COVID-19 severity in patients with prediabetes.
    Diabetes research and clinical practice, 2022, Volume: 194

    Topics: COVID-19; Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Prediabetic Sta

2022
Metformin is associated with reduced COVID-19 severity in patients with prediabetes.
    Diabetes research and clinical practice, 2022, Volume: 194

    Topics: COVID-19; Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Prediabetic Sta

2022
Metformin is associated with reduced COVID-19 severity in patients with prediabetes.
    Diabetes research and clinical practice, 2022, Volume: 194

    Topics: COVID-19; Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Prediabetic Sta

2022
Metformin is associated with reduced COVID-19 severity in patients with prediabetes.
    Diabetes research and clinical practice, 2022, Volume: 194

    Topics: COVID-19; Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Prediabetic Sta

2022
Metformin is associated with reduced COVID-19 severity in patients with prediabetes.
    Diabetes research and clinical practice, 2022, Volume: 194

    Topics: COVID-19; Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Prediabetic Sta

2022
Metformin is associated with reduced COVID-19 severity in patients with prediabetes.
    Diabetes research and clinical practice, 2022, Volume: 194

    Topics: COVID-19; Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Prediabetic Sta

2022
Metformin is associated with reduced COVID-19 severity in patients with prediabetes.
    Diabetes research and clinical practice, 2022, Volume: 194

    Topics: COVID-19; Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Prediabetic Sta

2022
Van Wyk Grumbach Syndrome.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2020, Volume: 30, Issue:12

    Topics: Child; Female; Humans; Hypothyroidism; Ovarian Cysts; Polycystic Ovary Syndrome; Puberty, Precocious

2020
Use of levothyroxine among pregnant women with subclinical hypothyroidism in the United Kingdom: A population-based assessment.
    Pharmacology research & perspectives, 2021, Volume: 9, Issue:5

    Topics: Adult; Asymptomatic Diseases; Diabetes Mellitus; Female; Humans; Hypothyroidism; Infertility, Female

2021
High Genetic Risk Scores of ASIC2, MACROD2, CHRM3, and C2orf83 Genetic Variants Associated with Polycystic Ovary Syndrome Impair Insulin Sensitivity and Interact with Energy Intake in Korean Women.
    Gynecologic and obstetric investigation, 2019, Volume: 84, Issue:3

    Topics: Acid Sensing Ion Channels; Adult; Blood Glucose; Body Mass Index; C-Reactive Protein; Cohort Studies

2019
Polycystic ovary syndrome and chronic autoimmune thyroiditis.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2015, Volume: 31, Issue:1

    Topics: Adult; Autoantibodies; Comorbidity; Cross-Sectional Studies; Female; Humans; Polycystic Ovary Syndro

2015
[High frequency of thyroid abnormalities in polycystic ovary syndrome].
    Medicina, 2015, Volume: 75, Issue:4

    Topics: Adolescent; Adult; Blood Glucose; Case-Control Studies; Female; Homeostasis; Humans; Insulin; Polycy

2015
Low 25 (OH) vitamin D levels are associated with autoimmune thyroid disease in polycystic ovary syndrome.
    Endocrine, 2016, Volume: 53, Issue:2

    Topics: Adolescent; Adult; Autoantibodies; Female; Humans; Iodide Peroxidase; Polycystic Ovary Syndrome; Thy

2016
The relationship between thyroid function and metabolic changes in Chinese women with polycystic ovary syndrome.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2017, Volume: 33, Issue:4

    Topics: Adult; Apolipoproteins A; Apolipoproteins B; Body Mass Index; China; Cholesterol; Female; Follicle S

2017
[Is polycystic ovary syndrome associated with autoimmune thyroiditis?].
    Vnitrni lekarstvi, 2012, Volume: 58, Issue:11

    Topics: Adult; Autoantibodies; Female; Humans; Iodide Peroxidase; Middle Aged; Polycystic Ovary Syndrome; Th

2012
Common genetic variation in CYP1B1 is associated with concentrations of T₄, FT₃ and FT₄ in the sera of polycystic ovary syndrome patients.
    Molecular biology reports, 2013, Volume: 40, Issue:4

    Topics: Adult; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1B1; Estrogens, Catechol; Female; Genetic

2013
Is serum leptin level regulated by thyroid functions, lipid metabolism and insulin resistance in polycystic ovary syndrome?
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2003, Volume: 17, Issue:3

    Topics: Adult; Blood Glucose; Body Mass Index; Case-Control Studies; Cholesterol; Cholesterol, HDL; Choleste

2003
Polycystic ovaries, precocious puberty and acquired hypothyroidism: The Van Wyk and Grumbach syndrome.
    Journal of pediatric surgery, 2003, Volume: 38, Issue:9

    Topics: Child; Female; Hormone Replacement Therapy; Humans; Hypothyroidism; Polycystic Ovary Syndrome; Puber

2003
Plasma homocysteine levels in polycystic ovary syndrome and congenital adrenal hyperplasia.
    Endocrine journal, 2004, Volume: 51, Issue:6

    Topics: Adrenal Hyperplasia, Congenital; Adult; Blood Glucose; Cholesterol; Estradiol; Female; Follicle Stim

2004
Endocrine effects of valproate in adolescent girls with epilepsy.
    Epilepsia, 2007, Volume: 48, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Body Height; Body Mass Index; Child; Comorbidity; Epilepsy; Fema

2007
Vaginal bleeding with multicystic ovaries and a pituitary mass in a child with severe hypothyroidism.
    Mymensingh medical journal : MMJ, 2007, Volume: 16, Issue:2 Suppl

    Topics: Child; Female; Humans; Hypothyroidism; Metrorrhagia; Pituitary Neoplasms; Polycystic Ovary Syndrome;

2007
Precocious puberty and large multicystic ovaries in young girls with primary hypothyroidism.
    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2007, Volume: 13, Issue:6

    Topics: Adolescent; Child, Preschool; Female; Humans; Hypothyroidism; Ovariectomy; Polycystic Ovary Syndrome

2007
Nonpuerperal mastitis associated with galactorrhea.
    Obstetrics and gynecology, 1983, Volume: 61, Issue:3 Suppl

    Topics: Adult; Bromocriptine; Female; Follicle Stimulating Hormone; Galactorrhea; Humans; Lactation Disorder

1983
Hypothyroidism presenting with polycystic ovary syndrome.
    The Journal of the Association of Physicians of India, 1993, Volume: 41, Issue:2

    Topics: Adult; Female; Humans; Hypothalamo-Hypophyseal System; Hypothyroidism; Ovary; Polycystic Ovary Syndr

1993
Isolated menarche and multicystic ovaries in a 7 1/2 year girl with hypothyroidism.
    Indian pediatrics, 2001, Volume: 38, Issue:4

    Topics: Child; Female; Follow-Up Studies; Humans; Hypothyroidism; Menarche; Polycystic Ovary Syndrome; Puber

2001
Response of the binding capacity of plasma testosterone-estradiol-binding globulin to norethindrone, 2 mg., and mestranol, 0.1 mg., in polycystic ovarian disease.
    American journal of obstetrics and gynecology, 1976, May-15, Volume: 125, Issue:2

    Topics: Carrier Proteins; Estradiol; Estrone; Female; Gonadal Steroid Hormones; Mestranol; Norethindrone; Po

1976
Twenty-four-hour prolactin profiles in normal and disease states: failure of thyroxine to modify prolactin secretion.
    The Journal of clinical endocrinology and metabolism, 1975, Volume: 40, Issue:4

    Topics: Adult; Female; Galactorrhea; Humans; Lactation Disorders; Pituitary Neoplasms; Polycystic Ovary Synd

1975
[Thyroxine, triiodothyronine and thyrotropic hormone levels in the blood of patients with sclerocystic ovary syndrome of central origin].
    Akusherstvo i ginekologiia, 1986, Issue:2

    Topics: Adolescent; Adult; Female; Humans; Hypothalamo-Hypophyseal System; Polycystic Ovary Syndrome; Thyrot

1986
Prevalence of and markers for the attenuated form of congenital adrenal hyperplasia and hyperprolactinemia masquerading as polycystic ovarian disease.
    Fertility and sterility, 1986, Volume: 46, Issue:2

    Topics: 17-alpha-Hydroxyprogesterone; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Dehydroe

1986