thyroxine has been researched along with Phenylketonurias in 11 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
Phenylketonurias: A group of autosomal recessive disorders marked by a deficiency of the hepatic enzyme PHENYLALANINE HYDROXYLASE or less frequently by reduced activity of DIHYDROPTERIDINE REDUCTASE (i.e., atypical phenylketonuria). Classical phenylketonuria is caused by a severe deficiency of phenylalanine hydroxylase and presents in infancy with developmental delay; SEIZURES; skin HYPOPIGMENTATION; ECZEMA; and demyelination in the central nervous system. (From Adams et al., Principles of Neurology, 6th ed, p952).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The standard, lifelong therapy of phenylketonuria (PKU) is a natural protein-restricted diet complemented with phenylalanine (Phe)-free L-amino acid mixtures that provide the daily necessary micronutrients." | 1.51 | The Association of Therapy Adherence and Thyroid Function in Adult Patients with Phenylketonuria. ( Galgoczi, E; Kiss, E; Kovacs, B; Nagy, EV; Patocs, A; Reismann, P; Simon, E; Soos, A; Sumanszki, C, 2019) |
| "Free triiodothyronine was higher in both patient groups than in control subjects, whereas free thyroxine was higher in the PKU patients only." | 1.31 | Antioxidant and thyroid hormone status in selenium-deficient phenylketonuric and hyperphenylalaninemic patients. ( Printzen, G; van Bakel, MM; Wermuth, B; Wiesmann, UN, 2000) |
| "Eight cases of primary hypothyroidism were confirmed by the state, for an incidence of one in 5,941." | 1.27 | Newborn hypothyroid screening. The private sector. ( Coldwell, JG; Wilson, DP, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (72.73) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sumanszki, C | 1 |
| Kiss, E | 1 |
| Simon, E | 1 |
| Galgoczi, E | 1 |
| Soos, A | 1 |
| Patocs, A | 1 |
| Kovacs, B | 1 |
| Nagy, EV | 1 |
| Reismann, P | 1 |
| Levy, HL | 1 |
| Mitchell, ML | 1 |
| Larsson, A | 1 |
| Ljunggren, JG | 1 |
| Ekman, K | 1 |
| Nilsson, A | 1 |
| Olin, P | 1 |
| Terwolbeck, K | 1 |
| Behne, D | 1 |
| Meinhold, H | 1 |
| Menzel, H | 1 |
| Lombeck, I | 1 |
| van Bakel, MM | 1 |
| Printzen, G | 1 |
| Wermuth, B | 1 |
| Wiesmann, UN | 1 |
| Stewart, RM | 1 |
| Hemli, S | 1 |
| Daniels, GH | 1 |
| Kolodny, EH | 1 |
| Maloof, F | 1 |
| Wilson, DP | 1 |
| Coldwell, JG | 1 |
| Tishler, PV | 1 |
| Ingbar, SH | 1 |
| Gjessing, LR | 1 |
| Nishimura, T | 1 |
| Borud, O | 1 |
| Ammaniti, M | 1 |
11 other studies available for thyroxine and Phenylketonurias
| Article | Year |
|---|---|
The Association of Therapy Adherence and Thyroid Function in Adult Patients with Phenylketonuria.
Topics: Adult; Case-Control Studies; Diet, Protein-Restricted; Female; Humans; Hungary; Iodine; Male; Patien | 2019 |
The current status of newborn screening.
Topics: Bacteriological Techniques; Blood Specimen Collection; Congenital Hypothyroidism; Humans; Hypothyroi | 1982 |
Screening for congenital hypothyroidism. I. Laboratory results of a pilot study based on dried blood samples collected for PKU screening.
Topics: Congenital Hypothyroidism; Follow-Up Studies; Humans; Hypothyroidism; Infant, Newborn; Mass Screenin | 1981 |
Increased plasma T4-levels in children with low selenium state due to reduced type I iodothyronine 5'deiodinase activity?
Topics: Adolescent; Child; Child, Preschool; Glutathione Peroxidase; Humans; Iodide Peroxidase; Oxidation-Re | 1993 |
Antioxidant and thyroid hormone status in selenium-deficient phenylketonuric and hyperphenylalaninemic patients.
Topics: Adolescent; Adult; Antioxidants; Child; Child, Preschool; Diet, Protein-Restricted; Female; Glutathi | 2000 |
Tyrosine deficiency and retardation.
Topics: Child; Female; Humans; Infant, Newborn; Intellectual Disability; Maternal-Fetal Exchange; Phenylketo | 1978 |
The pituitary-thyroid axis in adults with phenylketonuria.
Topics: Adolescent; Adult; Female; Humans; Male; Middle Aged; Phenylketonurias; Pituitary Gland; Thyroid Gla | 1976 |
Newborn hypothyroid screening. The private sector.
Topics: Cost-Benefit Analysis; Hospitals, Proprietary; Humans; Hypothyroidism; Infant, Newborn; Mass Screeni | 1985 |
Studies of thyroid economy in two patients with phenylketonuria.
Topics: Adult; Female; Humans; Male; Phenylketonurias; Thyroid Function Tests; Thyrotropin; Thyroxine | 1966 |
Studies on urinary phenolic compounds in man. I. Excretion of p-hydroxy-mandelic acid by man.
Topics: Amino Acid Metabolism, Inborn Errors; Chromatography; Disulfiram; Humans; In Vitro Techniques; Mande | 1965 |
[Phenylpyruvic oligophrenia: clinical diagnosis in relation to laboratory findings].
Topics: Amino Acids; Child; Child, Preschool; Chromatography, Ion Exchange; Female; Humans; Male; Phenylalan | 1968 |